KR100424661B1 - The composition of supplementary health-food comprising Bacillus polyfermenticus KCCM 10104 effectively for prevention of intestinal disorders - Google Patents
The composition of supplementary health-food comprising Bacillus polyfermenticus KCCM 10104 effectively for prevention of intestinal disorders Download PDFInfo
- Publication number
- KR100424661B1 KR100424661B1 KR10-2000-0054316A KR20000054316A KR100424661B1 KR 100424661 B1 KR100424661 B1 KR 100424661B1 KR 20000054316 A KR20000054316 A KR 20000054316A KR 100424661 B1 KR100424661 B1 KR 100424661B1
- Authority
- KR
- South Korea
- Prior art keywords
- weight
- kccm
- bacillus polyfermenticus
- composition
- bacillus
- Prior art date
Links
- 241001226430 Bacillus polyfermenticus Species 0.000 title claims abstract description 27
- 229940104704 bacillus polyfermenticus Drugs 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 title claims abstract description 17
- 208000028774 intestinal disease Diseases 0.000 title abstract description 3
- 235000013402 health food Nutrition 0.000 title description 4
- 230000002265 prevention Effects 0.000 title 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 19
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 18
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims abstract description 18
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000011575 calcium Substances 0.000 claims abstract description 15
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 15
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 14
- 239000000796 flavoring agent Substances 0.000 claims abstract description 12
- 235000019634 flavors Nutrition 0.000 claims abstract description 12
- 235000015872 dietary supplement Nutrition 0.000 claims abstract description 10
- 235000001543 Corylus americana Nutrition 0.000 claims abstract description 9
- 235000007466 Corylus avellana Nutrition 0.000 claims abstract description 9
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 9
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 9
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 9
- 229940013618 stevioside Drugs 0.000 claims abstract description 9
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000019202 steviosides Nutrition 0.000 claims abstract description 9
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 9
- 239000011718 vitamin C Substances 0.000 claims abstract description 9
- 240000008042 Zea mays Species 0.000 claims abstract description 8
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 7
- 239000000600 sorbitol Substances 0.000 claims abstract description 7
- 241001474374 Blennius Species 0.000 claims abstract description 6
- 240000009226 Corylus americana Species 0.000 claims abstract 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 3
- 235000005822 corn Nutrition 0.000 claims description 3
- 239000000843 powder Substances 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 7
- 241000193830 Bacillus <bacterium> Species 0.000 abstract description 5
- 230000004060 metabolic process Effects 0.000 abstract description 5
- 230000001965 increasing effect Effects 0.000 abstract description 4
- 230000001079 digestive effect Effects 0.000 abstract description 2
- 230000002175 menstrual effect Effects 0.000 abstract description 2
- 230000006806 disease prevention Effects 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 16
- 241000894006 Bacteria Species 0.000 description 12
- 239000004310 lactic acid Substances 0.000 description 8
- 235000014655 lactic acid Nutrition 0.000 description 8
- 235000019629 palatability Nutrition 0.000 description 8
- 241000723382 Corylus Species 0.000 description 7
- 230000002708 enhancing effect Effects 0.000 description 5
- 230000000968 intestinal effect Effects 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 241000195493 Cryptophyta Species 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000000529 probiotic effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010016952 Food poisoning Diseases 0.000 description 2
- 208000019331 Foodborne disease Diseases 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000002036 drum drying Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 150000004671 saturated fatty acids Chemical class 0.000 description 2
- 238000004513 sizing Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- IRHVLQMEQPABHG-ZLYSWTFPSA-N (3r,4r,5r,6r,7r,8r,9s,10r,13r,14r,17r)-3,4,6,7-tetrahydroxy-17-[(1s)-1-[(2s,4s)-6-hydroxy-4-propan-2-yloxan-2-yl]ethyl]-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,16,17-tetradecahydrocyclopenta[a]phenanthren-15-one Chemical compound C1[C@H](C(C)C)CC(O)O[C@@H]1[C@@H](C)[C@@H]1[C@@]2(C)CC[C@@H]3[C@@]4(C)CC[C@@H](O)[C@H](O)[C@@H]4[C@@H](O)[C@H](O)[C@H]3[C@H]2C(=O)C1 IRHVLQMEQPABHG-ZLYSWTFPSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 241000206572 Rhodophyta Species 0.000 description 1
- 241000482268 Zea mays subsp. mays Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000001270 agonistic effect Effects 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000007882 dietary composition Nutrition 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 235000020007 pale lager Nutrition 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000011164 primary particle Substances 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/24—Non-sugar sweeteners
- A23V2250/262—Stevioside
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/60—Sugars, e.g. mono-, di-, tri-, tetra-saccharides
- A23V2250/64—Sugar alcohols
- A23V2250/642—Sorbitol
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/70—Vitamins
- A23V2250/708—Vitamin C
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
본 발명은 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104 를 함유하는 정장기능성 건강보조식품 조성물에 관한 것으로, 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104 10 중량%, 맥주효모 70 중량%, 비타민C 0.5 중량%, 해조칼슘 5.0 중량%, 솔비톨 9.0 중량%, 군옥수수맛 분말 4.0 중량%, 헤이즐넛 향 0.4 중량%, 스테비오사이드 0.1 중량% 및 스테아린산 마그네슘 1.0 중량%로 조성됨을 특징으로 하는 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104 함유 정장기능성 건강보조식품 조성물은 뛰어난 정장작용, 소화 증대효과 및 장질환 예방효과가 있을 뿐만 아니라 인체의 골격 및 생리대사에 필요한 칼슘을 강화하여 중장년층의 인체대사의 기능성을 증대시키는 뛰어난 효과가 있다.The present invention relates to a functional dietary supplement composition containing Bacillus polyfermenticus KCCM 10104, Bacillus polyfermenticus KCCM 10104 10% by weight, beer yeast 70% by weight, vitamin C Bacillus polyperitium, characterized in that the composition is 0.5% by weight, 5.0% by weight of seaweed, 9.0% by weight of sorbitol, 4.0% by weight of corn corn powder, 0.4% by weight of hazelnut flavor, 0.1% by weight of stevioside and 1.0% by weight of magnesium stearate Formal functional health supplement composition containing Bacillus polyfermenticus KCCM 10104 not only has excellent suitability , digestive effect and intestinal disease prevention effect, but also strengthens the calcium required for skeletal and menstrual metabolism of the human body to improve the function of metabolism in the elderly. There is an excellent effect of increasing.
Description
본 발명은 정장작용 및 소화 증대효과를 갖는 바실러스 폴리퍼멘티쿠스 (Bacillus polyfermenticus) KCCM 10104를 유효성분으로 하는 건강보조식품 조성물에 관한 것으로 더욱 상세하게는 바실러스 폴리퍼멘티쿠스 (Bacillus polyfermenticus) KCCM 10104에 생균활성 증진성분 및 기타 기호성 증진 성분이 첨가된 바실러스 폴리퍼멘티쿠스 (Bacillus polyfermenticus) KCCM 10104 함유 건강보조식품 조성물에 관한 것이다.The present invention relates to a dietary supplement composition comprising Bacillus polyfermenticus KCCM 10104 as an active ingredient having an agonistic and digestive effect. More specifically, the present invention relates to Bacillus polyfermenticus KCCM 10104. The present invention relates to a Bacillus polyfermenticus KCCM 10104-containing dietary supplement composition to which a probiotic activity enhancing ingredient and other palatability enhancing ingredients are added.
종래의 건강보조식품으로 정장작용을 나타내는 제품들은 젖산균을 이용하거나 식이섬유나 알로에와 같은 식물 추출물을 이용하여 왔다.Products that exhibit formal action as a conventional dietary supplement have been using lactic acid bacteria or plant extracts such as dietary fiber or aloe.
대한민국 특허등록번호 제 1997-134559호에서는 유산균의 배양과정 중에 필수미량 광물질인 아연을 첨가함으로써 기능성이 증진된 유산균제조방법이 공지된 바 있다. 또한 대한민국 특허공개번호 제 1998-63570호에서는 동결 건조된 유산균을 한가지 이상의 올리고당과 혼합하여 제조한 정장기능성 식이용 조성물에 대해 공지된 바 있다.Korean Patent Registration No. 1997-134559 discloses a method for producing lactic acid bacteria with enhanced functionality by adding zinc, an essential trace mineral, during the culture of lactic acid bacteria. In addition, the Republic of Korea Patent Publication No. 1998-63570 has been known for the formal functional dietary composition prepared by mixing the freeze-dried lactic acid bacteria with one or more oligosaccharides.
상기와 같은 젖산균을 이용한 정장효과는 장내에서 젖산 및 기타 항균물질을 분비함으로써 그 효과가 있으나 일반적인 젖산균은 장내 도달 과정 중 위산이나 담즙산에 의하여 사멸되는 경우가 많다.Intestinal effects using lactic acid bacteria as described above are effective by secreting lactic acid and other antimicrobial substances in the intestine, but general lactic acid bacteria are often killed by gastric or bile acids during the intestinal uptake process.
본 발명에 사용한 바실러스 폴리퍼멘티쿠스 KCCM 10104(Bacillus polypermenticus)는 정장작용이 뛰어나며 장내의 소화율을 증대시키고 항생물질을 생산함으로써 병원성균이나 식중독균의 성장을 저해하는 효과가 있으며 상기와 같은 젖산균에 비하여 내산성 및 내담즙성이 뛰어난 장점이 있고 알려져 있다.그러나, 상기 균의 정장기능성에 대해서만 알려져 있을뿐, 상기 균을 유효성분으로 함유하고 여기에 여러 생균활성 촉진 성분 및 기호성 증진 성분이 추가적으로 함유되어 바실러스 폴리퍼멘티쿠스(Bacillus polypermenticus) KCCM 10104이 실질적으로 장내에서 유용한 정장기능을 발휘하게 하는 조성물에 대해서는 알려진바 없다. Bacillus polypermenticus KCCM 10104 ( Bacillus polypermenticus ) used in the present invention is excellent in intestinal action, has an effect of inhibiting the growth of pathogenic bacteria or food poisoning bacteria by increasing the digestibility of the intestine and producing antibiotics, acid resistance compared to the lactic acid bacteria as described above However, it is known and superior in bile resistance. However, it is only known for the functional function of the bacterium, which contains the bacterium as an active ingredient, and further contains various probiotic activity promoting ingredients and palatability enhancing ingredients. There is no known composition that allows Bacillus polypermenticus KCCM 10104 to function substantially in the gut.
한편, 맥주효모의 경우 맥주효모내에 인체에 유익한 비타민, 미량원소가 다량 함유되어 있는 것으로 알려져 있으며 맥주효모를 건조시켜 제약원료로 사용하거나 맥주효모의 우수한 단백질 성분으로 인해 가축사료용으로 이용되기도 한다. 건조맥주효모는 맥주발효 후 생성되는 맥주효모를 드럼건조(Drum drying)방법 등으로 건조시킨 후 위생적으로 포장하여 제조된다.On the other hand, beer yeast is known to contain a large amount of vitamins and trace elements beneficial to the human body in beer yeast, it is also used as a pharmaceutical raw material by drying the beer yeast or used for livestock feed due to the excellent protein components of beer yeast. Dry beer yeast is manufactured by hygienically packing the beer yeast produced after beer fermentation by drum drying (Drum drying) method.
칼슘은 신경전달, 혈액응고, 적절한 세포작용 및 근육수축과 같은 대사 작용뿐 아니라 뼈의 생성 및 유지를 위하여 매우 중요한 성분이다. 해조칼슘은 바다 홍조류로부터 추출된 식물성 칼슘으로써 인체에 칼슘을 공급하여 여러 가지 생리작용을 조절하고 골다공증 등의 질병을 예방하는 기능을 한다.Calcium is a very important component for the production and maintenance of bone as well as metabolic actions such as neurotransmission, blood coagulation, proper cellular and muscle contraction. Algae calcium is a vegetable calcium extracted from sea red algae, it supplies calcium to the human body to regulate various physiological functions and prevent diseases such as osteoporosis.
본 발명자는 상기와 같은 점을 착안하여 정장기능성을 지닌 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104를 유효성분으로 하고 여기에 건조효모, 비타민, 해조칼슘 및 미네랄 등을 일정한 비율로 혼합한 다음 정제형태로 제조함으로써 본 발명을 완성하였다.In view of the above, the present inventors use Bacillus polyfermenticus KCCM 10104 having the functional function as an active ingredient, and then, dry yeast, vitamins, algae calcium and minerals are mixed in a constant ratio, and then purified. The present invention has been completed by manufacturing in the form.
따라서 본 발명의 목적은 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104를 유효성분으로 하고 여기에 여러 성분을 첨가함으로써, 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104의 활성을 증진되고 여러 기호성이 증진된 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104함유 정장기능성 건강보조식품 조성물을 제공함에 있다.Accordingly, an object of the present invention is to use Bacillus polyfermenticus KCCM 10104 as an active ingredient and to add various components to it, thereby enhancing the activity of Bacillus polyfermenticus KCCM 10104 and enhancing various palatability. Bacillus polyfermenticus ( Bacillus polyfermenticus ) KCCM 10104 containing a formal functional dietary supplement composition.
본 발명의 목적은 바실러스 폴리퍼멘티쿠스(Bacillus polyfermen- ticus) KCCM 10104 10 중량%에 맥주효모 70 중량%, 비타민C 0.5 중량%, 스테비오사이드 0.1 중량%, 스테아린산 마그네슘 1.0 중량%, 해조칼슘 5.0 중량%, 솔비톨 9.0 중량%, 군옥수수맛 분말 4.0 중량% 및 헤이즐넛향 0.4 중량%을 칭량한 다음 혼합하고 유도층 분리기 및 정립기에서 직경 5mm이하의 크기로 입자를 형성한 후 타정기로 입자의 중량이 개당 300mg 되도록 정제형태로 제조하고 병입하여 포장함으로써 달성하였다.An object of the present invention is Bacillus polyfermenticus KCCM 10104 10% by weight of beer yeast 70% by weight, vitamin C 0.5% by weight, stevioside 0.1% by weight, magnesium stearate 1.0% by weight, seaweed calcium 5.0 weight %, Sorbitol 9.0% by weight, 4.0% by weight of corn corn powder and 0.4% by weight of hazelnut flavor were mixed, mixed and formed into particles having a diameter of 5 mm or less in an induction bed separator and sizer, and then This was achieved by preparing, bottling and packaging the tablet to 300 mg each.
본 발명은 일정한 배합 비율에 따라 바실러스 폴리퍼멘티쿠스 (Bacillus polyfermenticus) KCCM 10104 10 중량%에 맥주효모 70 중량%, 비타민C 0.5 중량%, 해조칼슘 5.0 중량%, 솔비톨 9.0 중량%, 군옥수수맛 분말 4.0 중량%, 헤이즐넛 향 0.4%, 스테비오사이드 0.1% 및 스테아린산 마그네슘 1.0 중량%를 칭량하고 믹서기로 혼합하는 단계; 상기 단계의 혼합물에 적정량의 수분을 첨가하고 유동층 분리기 및 정립기에서 직경이 5mm이하의 입자를 형성하는 단계; 상기 시료를 타정기에서 일시적인 압력을 가하여 입자의 중량이 개당 300mg정도 되도록 정제를 형성시키는 단계 및; 병입하여 포장하는 단계로 구성된다.According to the present invention, Bacillus polyfermenticus ( Bcillus polyfermenticus ) KCCM 10104 10% by weight beer yeast 70% by weight, vitamin C 0.5% by weight, seaweed calcium 5.0% by weight, sorbitol 9.0% by weight, corn corn flavor powder Weighing 4.0% by weight, hazelnut flavor 0.4%, stevioside 0.1% and magnesium stearate 1.0% by weight and mixing with a blender; Adding an appropriate amount of water to the mixture of the step and forming particles having a diameter of 5 mm or less in a fluidized bed separator and a sizing machine; Applying a temporary pressure on the sample in a tablet press to form tablets such that the weight of the particles is about 300 mg per piece; It consists of bottling and packaging.
상기단계에서 맥주효모 60∼90 중량%, 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104 1.0∼40.0 중량%를 첨가하였으며 바람직하게는 맥주효모 70 중량%, 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104 10 중량%를 첨가하였다.Beer yeast 60-90% by weight, Bacillus polyfermenticus ( Bacillus polyfermenticus ) KCCM 10104 1.0-40.0% by weight was added, preferably beer yeast 70% by weight, Bacillus polyfermenticus KCCM 10104 10 wt% was added.
상기단계에서 비타민C 0.1∼1.0 중량%, 해조칼슘 1∼10 중량%, 솔비톨 5∼15 중량%, 군옥수수맛 분말 1∼10 중량%, 헤이즐넛 향 0.1∼1.0 중량%, 스테비오사이드 0.05∼0.15 중량% 및 스테아린산 마그네슘 0.5∼1.5 중량%를 첨가하였으며 바람직하게는 비타민C 0.5중량%, 해조칼슘 5.0 중량%, 솔비톨 9.0 중량%, 군옥수수맛 분말 4.0 중량%, 헤이즐넛 향 0.4 중량%, 스테비오사이드 0.1 중량% 및 스테아린산 마그네슘 1.0 중량%를 첨가하였다.0.1-1.0 wt% of vitamin C, 1-10 wt% of algae calcium, 5-15 wt% of sorbitol, 1-10 wt% of corn corn powder, 0.1-1.0 wt% of hazelnut flavor, 0.05-0.15 weight of stevioside % And 0.5 to 1.5% by weight of magnesium stearate were added, preferably 0.5% by weight of vitamin C, 5.0% by weight of seaweed calcium, 9.0% by weight of sorbitol, 4.0% by weight of corn corn powder, 0.4% by weight of hazelnut flavor, and 0.1% of stevioside. % And 1.0% by weight magnesium stearate were added.
본 발명에서 사용한 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104는 바이넥스(주)로부터 구입하여 사용하였고, 제품명은 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) n.sp이었다. 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) n.sp는 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104의 포자형태이며, 2.0×109CFU/g 의 함유량을 갖는다.본 발명은 정장작용의 기능성을 가진 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104를 함유하는 건강보조식품으로서 섭취 시 정제(tablet)로서의 소비자의 기호성을 높이기 위하여 스테비오 사이드, 군옥수수맛 분말, 헤이즐넛향을 첨가하고, 통상 복용하는 제품으로서 인체 내 생균의 활성 및 인체 내 영양 보급의 부수적인 효과를 위하여 건조효모 이외에 인체 주요 미네랄 성분인 칼슘과 항산화 기능이 있는 비타민C가 보강된 조성물이다.이때 첨가되는 건조효모는 제약원료로 사용하거나 맥주효모의 우수한 단백질 성분으로 인해 가축사료용으로 이용되는데, 본원발명에서는 비스판균이 장내에서 성장 또는 대사하는데 비타민 및 아미노산을 공급하는 역할을 한다. 이때, 그 첨가량이 90 중량%를 초과하는 경우에는 과도한 핵산의 함량으로 인하여 통풍 환자에게 역효과를 나타내며, 60 중량% 미만으로 첨가되는 경우에는 첨가되는 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus)에 충분한 비타민 및 아미노산을 공급하지 못하는 문제가 발생하게 된다.스테비오 사이드는 맛의 기호성을 위하여 단맛을 위한 첨가물이며 0.05 중량% 미만에서는 단맛의 정도가 약하고 0.15 중량% 초과에서는 높은 농도에서는 오히려 쓴맛을 나타낸다.스테아린산 마그네슘은 포화 지방산의 일종으로 조제 시 유연성을 나타내며 섭취 시 씹었을 때 부드러운 조직감을 주기 위하여 첨가되었다. 0.5 중량% 미만에서는 부드러운 조직감이 대조군과 차이가 없었으며 1.5 중량% 초과에서는 제품의 포화지방산의 함량을 높이는 것으로 동맥경화증과 같은 질병에 유해한 영향을 줄 수 있다.해조칼슘은 미네랄로서의 칼슘을 공급하기 위함이며, 맥주효모 만으로 부족한 칼슘을 보강하기 위하여 첨가되었다. 하지만, 10 중량% 초과에서는 맛에 대한 기호성이 저하된다.비타민 C는 천연 항산화제로서 널리 알려져 있으며 인체에서 피로회복, 노화 방지 등의 역할을 하는 것으로 널리 알려져 있다. 산화가 잘 되는 물질로서 1.0 중량% 초과에서는 저장시 갈변화 반응으로 제품의 변색에 의한 품질이 떨어진다.솔비톨은 수분을 흡수하는 성질을 이용 정제의 타정시 응집력을 가하게 하는 역할을 하며, 인체내에서는 간장에서 과당으로 대사된다. 5 중량% 미만에서는 그 타정시 응집력이 떨어지고 15 중량% 초과에서는 과잉 섭취로 설사를 유발할 수 있다.군옥수수 분말 및 헤이즐넛 향은 기호성을 위하여 첨가되었으며, 건조효모의 구수한 맛과 조화를 이루어 그 기호도가 높은 것으로 나타난다. Bacillus polyfermenticus KCCM 10104 used in the present invention was purchased from Binex Co., Ltd., and the product name was Bacillus polyfermenticus n.sp. Bacillus polyfermenticus n.sp is a spore form of Bacillus polyfermenticus KCCM 10104 and has a content of 2.0 × 10 9 CFU / g. As a health supplement containing Bacillus polyfermenticus KCCM 10104, stevioside, sweet corn powder, and hazelnut flavor are added to enhance consumer's palatability as a tablet when ingested. In addition to dry yeast, it is a composition supplemented with calcium, which is the main mineral component of the human body, and vitamin C with antioxidant function for the active effect of live bacteria and supplementation of nutrients in the human body. Due to the excellent protein composition of yeast, it is used for livestock feed. In the present invention, bispan For growth or metabolism in the intestinal serves to supply the vitamins and amino acids. At this time, when the amount is more than 90% by weight has an adverse effect on the gout patient due to the excessive content of nucleic acids, when added to less than 60% by weight sufficient vitamin and Bacillus polyfermenticus ( Bacillus polyfermenticus ) is added Stevioside is an additive for sweet taste for taste palatability, and the sweetness is weak at less than 0.05% by weight, but bitter at high concentrations above 0.15% by weight. It is a kind of saturated fatty acid, which shows flexibility in preparation and added to give a soft texture when chewed. At less than 0.5% by weight, the soft texture was not different from that of the control, and at more than 1.5% by weight, the saturated fatty acid content of the product was increased, which may have a detrimental effect on diseases such as atherosclerosis. For the sake of brewer's yeast, it was added to reinforce calcium lacked only by brewer's yeast. However, at more than 10% by weight, the palatability to taste is lowered. Vitamin C is widely known as a natural antioxidant and widely known to play a role in fatigue recovery, anti-aging, and the like in the human body. It is a well-oxidized substance, and when it is more than 1.0 wt%, it loses its quality due to discoloration of the product due to browning reaction during storage. Metabolized in the liver to fructose. At less than 5% by weight, the cohesion at the time of tableting decreases, and if it is more than 15% by weight, excessive diarrhea may cause diarrhea. The group corn powder and the hazelnut flavor are added for palatability, and the palatability of dry yeast in harmony Appears to be high.
본 발명 건강보조식품 조성물은 통상적인 제조방법에 의해 제품의 개당 무게가 0.1∼1.0g 되도록 정제형태로 제조하였으며 이외에도 과립제, 캡슐제의 형태로 제조될 수 있다. 본 발명 정제형태로 제조된 건강식품은 바로 씹어서 복용하거나 물과 함께 복용할 수 있다.The health supplement food composition of the present invention was prepared in the form of tablets so that the weight per product of 0.1 to 1.0g by a conventional manufacturing method in addition to the granules, capsules can be prepared in the form of capsules. The health food prepared in the tablet form of the present invention can be directly chewed or taken with water.
실시예 1: 본 발명 생균제첨가에 의한 정장기능성 건강보조식품의 제조Example 1: Preparation of functional functional dietary supplement by the present invention probiotic added
제 1공정 : 원료의 칭량 및 혼합Step 1: Weighing and Mixing the Raw Materials
각 원료를 표 1에 나타낸 바와 같은 중량비율로 칭량하고 믹서로 혼합한다.Each raw material is weighed in a weight ratio as shown in Table 1 and mixed with a mixer.
제 2공정 : 1차 입자의 형성 및 건조Second Process: Formation and Drying of Primary Particles
상기 제 1공정에서 제조한 혼합물에 적당히 수분을 첨가한 다음 유동층 분리기 및 정립기를 사용하여 직경이 5mm이하가 되도록 입자를 형성한 다음 건조시킨다.Water is appropriately added to the mixture prepared in the first step, and then particles are formed to have a diameter of 5 mm or less using a fluidized bed separator and a sizing machine, and then dried.
제 3공정 : 정제의 제조Third Step: Preparation of Tablet
상기 제 2공정에서 제조한 시료를 타정기에 넣고 일시적인 압력을 가하여 입자의 중량이 개당 300mg 정도 되도록 정제를 형성한다.The sample prepared in the second step is placed in a tablet press and subjected to a temporary pressure to form a tablet such that the weight of the particles is about 300 mg per piece.
제 4공정 : 병입 및 포장4th process: Bottling and packaging
상기 제 3공정에서 제조한 정제를 1∼3개월 복용분량으로 병당 50∼500g 되도록 병입하여 포장하였다.The tablet prepared in the third step was bottled and packaged in a dose amount of 1 to 3 months to 50 to 500 g per bottle.
이상, 상기 실시 예를 통하여 설명한 바와 같이 본 발명 바실러스 폴리퍼멘티쿠스(Bacillus polyfermenticus) KCCM 10104에 여러성분을 혼합함으로서 조성되는 정장기능성 건강보조식품 조성물로서 음식물의 장내 소화와 흡수를 증대시키는 효과가 있으며 항생물질을 생산함으로써 병원성 균이나 식중독균의 성장을 저해하여 장질환을 예방할 수 있는 효과가 있을 뿐 만 아니라 인체의 골격 및 생리대사에 필요한 칼슘을 강화하여 중장년 층의 인체대사의 기능성을 증대시키는 뛰어난 효과가 있으므로 건강보조식품산업상 매우 유용한 발명인 것이다.As described above, the functional functional health food composition is prepared by mixing various components in the present invention Bacillus polyfermenticus KCCM 10104 as described above has the effect of increasing the intestinal digestion and absorption of food. By producing antibiotics, it not only prevents the growth of pathogenic bacteria and food poisoning bacteria, but also prevents intestinal diseases. It also enhances the functions of metabolism in the elderly by strengthening calcium necessary for skeletal and menstrual metabolism. Since it is a very useful invention in the health food industry.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2000-0054316A KR100424661B1 (en) | 2000-09-15 | 2000-09-15 | The composition of supplementary health-food comprising Bacillus polyfermenticus KCCM 10104 effectively for prevention of intestinal disorders |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2000-0054316A KR100424661B1 (en) | 2000-09-15 | 2000-09-15 | The composition of supplementary health-food comprising Bacillus polyfermenticus KCCM 10104 effectively for prevention of intestinal disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20010000325A KR20010000325A (en) | 2001-01-05 |
| KR100424661B1 true KR100424661B1 (en) | 2004-03-24 |
Family
ID=19688849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-2000-0054316A KR100424661B1 (en) | 2000-09-15 | 2000-09-15 | The composition of supplementary health-food comprising Bacillus polyfermenticus KCCM 10104 effectively for prevention of intestinal disorders |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR100424661B1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100518261B1 (en) * | 2002-11-21 | 2005-10-04 | 학교법인 한마학원 | Composition comprising Bacillus polyfermenticus SCD (KCCM 10104) for usage as anti-oxidant |
| KR20200001964U (en) | 2019-02-26 | 2020-09-04 | 지이 일렉트리컬 엔지니어링 컴퍼니., 리미티드. | Canned motor pump device |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030069231A (en) * | 2002-02-02 | 2003-08-27 | 비앤아이티(주) | The improvement product of intestianl function by means of constipation type |
| KR100458487B1 (en) * | 2002-05-03 | 2004-12-03 | 주식회사 바이넥스 | Animals fodder for composition Bacillus polyfermenticus |
| KR100811615B1 (en) * | 2006-11-17 | 2008-03-11 | 건국대학교 산학협력단 | A method for inhibiting browning of soybean paste by using the an ethanol extract of bacillus polyfermenticus |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11233616A (en) * | 1998-02-17 | 1999-08-27 | Toshiba Corp | Semiconductor device and its manufacturing method |
-
2000
- 2000-09-15 KR KR10-2000-0054316A patent/KR100424661B1/en not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11233616A (en) * | 1998-02-17 | 1999-08-27 | Toshiba Corp | Semiconductor device and its manufacturing method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100518261B1 (en) * | 2002-11-21 | 2005-10-04 | 학교법인 한마학원 | Composition comprising Bacillus polyfermenticus SCD (KCCM 10104) for usage as anti-oxidant |
| KR20200001964U (en) | 2019-02-26 | 2020-09-04 | 지이 일렉트리컬 엔지니어링 컴퍼니., 리미티드. | Canned motor pump device |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010000325A (en) | 2001-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101120720B (en) | Composite feed for pig | |
| US20090169682A1 (en) | Functional Masticatory Material, Method Of Producing The Same And Method Of Using The Same | |
| CN101166429A (en) | Alimentation composition | |
| KR0151138B1 (en) | Gourd powder composition | |
| WO2007000985A1 (en) | Prophylactic or therapeutic composition for hemoglobinuria or myoglobinuria | |
| JPWO2009011288A1 (en) | Calcium ion sustained release agent | |
| US6537543B1 (en) | Intestinal activation food using natto powder | |
| CN115671132B (en) | Composition of probiotics and prebiotics and application thereof | |
| KR101616748B1 (en) | Functional Pills and method for preparing thereof | |
| JP2005097161A (en) | Anti-fatigue composition and food containing the same | |
| KR100424661B1 (en) | The composition of supplementary health-food comprising Bacillus polyfermenticus KCCM 10104 effectively for prevention of intestinal disorders | |
| KR100424660B1 (en) | Vitamin-enriched nutritional food composition comprising Bacillus polyfermenticus KCCM 10104 effectively for prevention of intestinal disorders | |
| JP3462535B2 (en) | Mineral absorption promoting composition | |
| WO2015137387A1 (en) | Muscle enhancing drug | |
| CN107397032A (en) | A kind of fruits and vegetables pressed candy and preparation method thereof | |
| JPH1189539A (en) | Food, drink, feed and chinese medicine material containing leaf, stem and branch of stevia plant | |
| CN1102026C (en) | Production method of fish eucommia feed | |
| CA3045764A1 (en) | Isomalto-oligosaccharide prebiotic formulations | |
| KR20080054912A (en) | The process of manufacturing fermented soybeans pill | |
| JP2003061618A (en) | Mineral-containing food composition | |
| US5112611A (en) | Pharmaceutical compositions for aiding human digestion | |
| KR100899556B1 (en) | Functional Foods Adding Sargassum spp. Extracts | |
| CN110810849A (en) | Composition for increasing bone mineral density and application thereof | |
| KR101660382B1 (en) | The manufacturing method of safflower drinking using powder fermentation for safflower seeds | |
| RU2142240C1 (en) | Biologically-active additive |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| LAPS | Lapse due to unpaid annual fee |