KR100372233B1 - Skin-whitening powder, preparation process thereof and skin-whitening makeup cosmetic containing the same powder - Google Patents

Abstract

PURPOSE: A skin-whitening powder, a preparation process thereof and a skin-whitening makeup cosmetic containing the same powder are provided to prepare the skin-whitening cosmetic having improved skin-whitening effect, makeup effect and utility. CONSTITUTION: The skin-whitening powder is prepared by adsorbing a skin-whitening material to titanium dioxide silica, and coating the skin-whitening material adsorbed with silicone copolymer, wherein the skin-whitening material is harounoside; the silicone copolymer is selected from trimethyl polysiloxane, methyl hydrogen polysiloxane, and bridge type methyl polysiloxane. The process for preparing the skin-whitening powder comprises the steps of: adsorbing 5 to 25 wt.% of 50% whitening material to 70 to 94.5 wt.% of titanium dioxide silica having particle diameter of 2 to 30 micrometer; coating it with 0.5 to 5 wt.% of silica copolymer; maturing the whitening material complex at 100 to 150 deg. C and the atmospheric pressure of 800 to 1000 for 24 to 48 hours; and pulverizing the matured whitening material complex in twice and hydrophobic treating it. The skin-whitening makeup cosmetic contains 1 to 20 wt.% of the skin-whitening powder.

Description

Whitening powder, preparation method thereof, and makeup whitening cosmetic containing same

The present invention relates to a whitening powder, and more particularly, to a whitening powder having an excellent whitening effect and excellent make-up effect and usability, a preparation method thereof, and a makeup whitening cosmetic containing the same.

The skin has the function of protecting the body from ultraviolet rays. That is, when the ultraviolet light is irradiated, the activity of tyrosinase is increased in melanocytes, which produce and release black melanin pigments, which are distributed on the epidermal cells, thereby blocking the natural screening function. Will be. At this time, ultraviolet rays and tyrosinase play a key role in the melanin production pathway. In particular, when the activity of tyrosinase is promoted in melanin-forming cells, melanin production is increased and eventually the skin becomes black to block ultraviolet rays.

However, excessive production and deposition of melanin pigment causes skin diseases such as blackening of the skin, blemishes, and freckles.

Accordingly, whitening cosmetics are required to prevent skin diseases such as blackening of the skin, blemishes, and freckles.

However, the existing whitening cosmetics have a problem of poor stability and thereby the whitening effect is unclear and the stability is inferior. In particular, the conventional makeup whitening cosmetics has a problem of decreasing the whitening effect. Currently, whitening cosmetics are whitening substances, mainly ascorbic acid (JP-A 4-9320), koji-san (JP-A-56-18569), kojic acid derivatives (JP-A-56-7710), and hydroquinone (JP-A 6-192062). , Arbutin (JP-A 4-9315) and some plant extracts are used. Kojic acid and ascorbic acid are very unstable, and cosmetics containing small amounts of browning occur for several weeks at room temperature. It raises, and safety is a problem. In addition, the existing make-up whitening cosmetics to reduce the effect of inhibiting melanin production by causing the existing whitening materials to adsorb or react with the pigment of the makeup cosmetics.

On the other hand, make-up make-up generally should have excellent makeup effects such as concealment, color expression, moisturizing and whitening effect by UV protection, and should have good usability such as persistence of makeup effect, skin adhesion or skin flexibility. It should be excellent in water resistance, such as not being easily erased by sweat, and high stability is required.

Conventionally, oil-in-water oil-based cosmetics have been mainly used, but the cosmetic effect has not lasted for a long time, and especially water resistance is inadequate to make stains or to easily remove makeup after makeup. Water-in-oil emulsified make-up cosmetics were used to compensate for these shortcomings, but the water resistance was greatly increased, but the water resistance was not enough during the summer or exercise when there was a lot of sweat and contact with water, and the persistence and stability of the makeup was not satisfactory. When used, there was a disadvantage such as poor skin touch.

On the other hand, Korean Patent Publication No. 85-1298 discloses a technique for preparing foundations by spray-pulverizing oil conjugates to inorganic pigments or inorganic pigments treated to have a lipophilic surface, and then spray-pulverizing and compressing silicone oil. Introduced, but it only brought an increase in water resistance, there was a problem that the stability is very poor due to poor compatibility with other pigments, it was more difficult to use a hydrophilized whitening material in cosmetics.

Therefore, the present inventors have selected a melanin production inhibitor as a whitening material and a method of stably compounding it in makeup cosmetics, methods for increasing the water resistance and skin adhesion, and the whitening effect, UV protection effect, water resistance and spreadability, We tried to develop new makeup whitening cosmetics with excellent makeup effect and usability.

An object of the present invention is to provide a new makeup whitening cosmetics with excellent whitening effect and at the same time improved makeup and usability.

The whitening powder of the present invention is a powder in which a whitening material is adsorbed on titanium dioxide silica and a double coated silicone copolymer thereon (FIG. 1).

In this case, the whitening substance may be selected from melanin production inhibitors such as harunoside, ascorbic acid, kojic acid, kojic acid derivatives, hydroquinone, arbutin and plant extracts known for whitening effects, and are preferably harunosides.

Titanium dioxide silica is hydrophilic and has a high UV protection effect.

The silica copolymer is a polysiloxane copolymer, and one of trimethyl polysiloxane, methylhydrogen polysiloxane, and crosslinked methyl polysiloxane is selected, and water resistance and skin adhesion are strong.

Therefore, the whitening powder of the present invention is excellent in whitening effect, high UV protection effect, excellent in water resistance and skin adhesion.

In addition, the method for producing a whitening powder of the present invention is adsorbed 5-25% by weight of a solution of 50% whitening material to 70-94.5% by weight of titanium dioxide silica having a particle size of 2-30 ㎛, 0.5-5 weight of silica copolymer Coated in%, aged at 100-150 ° C. and 800-1000 atm for 24-43 hours, followed by grinding twice and lipophilic.

In addition, the solvent of the 50% whitening solution is selected from ethanol, methanol, propylene glycol, 1.3 butylene glycol and calcium chloride solution.

In addition, the makeup whitening cosmetic of the present invention provides a makeup whitening cosmetic containing 1-20% by weight of the whitening powder.

In this case, the makeup whitening cosmetic may be an emulsion type foundation, an oil cake type foundation, or a two-way cake. When the whitening cosmetic is an emulsified foundation, the whitening powder content is preferably 1-15% by weight, and when the whitening powder is 1% by weight or less, the object of the present invention cannot be achieved, and when the amount is 15% by weight or more, the water resistance is further increased. Only stability is impaired.

When the whitening cosmetic is an oil cake type foundation or a two-way cake, the content of the whitening powder is preferably 2 to 20% by weight. If the whitening powder is 2% by weight or less, the whitening effect, the sunscreen effect, and the water resistance are not included, and the two-way is more than 20% by weight. The cake's ability to mold cake is reduced and the water resistance of the oil cake-type foundation no longer increases.

Makeup whitening cosmetics of the present invention is excellent in whitening effect, cosmetic effect and usability.

Hereinafter, the present invention will be described in detail with reference to Examples and Experimental Examples, but the content of the present invention is not limited thereto.

Example 1

80% by weight of titanium dioxide silica was mixed and stirred at room temperature for 20 minutes using a propeller mixer, and then 50% by weight of 50% by weight of Harunoside and 50% by weight of 5% calcium chloride solution were slowly added thereto. The mixture was dispersed and adsorbed while adsorbing Harunoside to titanium dioxide silica, 5% by weight of trimethyl polysiloxane was added thereto, followed by coating with stirring and dispersion, followed by drying at 120 ° C for 24 hours. The obtained powder was pulverized twice with a grinder to obtain a whitening powder.

Example 2

Except for 90% by weight of titanium dioxide silica and 5% by weight of 50% Harunoside solution, it was prepared in the same manner as in Example 1.

Example 3

Except for 70% by weight of titanium dioxide silica and 25% by weight of 50% Harunoside solution, it was prepared in the same manner as in Example 1.

Example 4

It was prepared in the same manner as in Example 1, except 19.5% by weight of 50% Harunoside solution and 0.5% by weight of trimethyl polysiloxane.

Example 5

It was prepared in the same manner as in Example 1, except that methyl hydrogen polysiloxane was used instead of trimethyl polysiloxane.

Example 6

It was prepared in the same manner as in Example 1 except for using crosslinked methyl siloxane instead of trimethyl polysiloxane.

Example 7

It was prepared in the same manner as in Example 1, except that methanol was used instead of the 5% calcium chloride solution as the solvent of the 50% Harunoside solution.

Example 8

It was prepared in the same manner as in Example 1 except that ethanol was used instead of 5% calcium chloride solution as the solvent of the 50% Harunoside solution.

Example 9

It was prepared in the same manner as in Example 1 except for using propylene glycol instead of 5% calcium chloride solution as the solvent of the 50% Harunoside solution.

Example 10

It was prepared in the same manner as in Example 1, except that 1,3 butylene glycol was used instead of 5% calcium chloride solution as the solvent of the 50% Harunoside solution.

Comparative Example 1

Titanium dioxide silica powder was used as the powder containing no Harunosides.

Experimental Example 1 Harunoside Adsorption and Coating Confirmation of Silicone Copolymer

In preparing the whitening powder by adsorbing Harunoside on titanium dioxide silica and coating the copolymer with silicone, the experiment was carried out as follows to confirm the adsorption of Harunoside and the coating state of the silicone copolymer.

Adsorption of Harunoside was confirmed by dissolving the whitening powder prepared in Example in 0.1N hydrochloric acid or ethanol to remove the silicone polymer and then titrating the amount of the Harunoside flowing to the water.

The coating of the silicone copolymer was confirmed by the presence or absence of powder precipitated by soaking the whitening powder in 20% 10% sodium chloride solution to 20%, which precipitates, indicating that the coating is lipophilic.

As a result, it was confirmed that Harunoside was adsorbed on all the whitening powders, and that the silicone copolymer was coated secondary.

Experimental Example 2: Confirmation of the inhibitory effect of tyrosinase activity

Harunoside measured the inhibitory effect of tyrosinase activity.

Tyrosinase was purified from mushrooms and used by Sigma. Tyrosine, a substrate, was dissolved in 0.05 M sodium phosphate buffer (pH 6.8) and used as a 0.1 mg / ml solution. Harunoside was used by diluting the whitening powder prepared in Example in ethanol and then releasing the extracted Harunoside solution in a buffer solution.

0.5 ml of tyrosine solution was added to a test tube, and 0.5 ml of a Harunoside sample solution was added thereto, and left at 37 ° C. for 10 minutes. Then, 0.5 ml of 300 U / ml tyrosinase was added thereto and reacted at 37 ° C. for 10 minutes. At this time, the control group is 0.5ml of buffer solution. The test tube containing the reaction solution was placed in ice and quenched to stop the reaction, and the absorbance at 475 nm was measured with a spectrophotometer.

The inhibitory effect of tyrosinase activity of Harunoside is obtained by the following formula.

% Inhibition of tyrosinase activity = 100-[(absorbance of sample / control absorbance) × 100]

The experimental results are shown in Table 1 below.

Table 1. Inhibitory Effects of Harunosides on Tyrosinase Activity in Whitening Powders

Experimental Example 3: Confirmation of cytotoxicity and melanin production inhibitory effect

Cytotoxicity and melanogenesis inhibitory effects on pigment cells were measured.

MB-16 melanoma cells were inoculated in DMEM medium containing 10% serum with 5 × 10 ⁴ cells and incubated for 24 hours in a T-flask (75 cm ² ), followed by adding fresh medium and the whitening powder of Example to the culture cells. Incubate for 2 days. After incubation, the medium is removed, washed with phosphate buffer and trypsin treated to separate cells. Cells are collected by centrifuge and some are measured for cytotoxicity by MTT assay. Some cells are treated with 5% trichloroacetic acid and then lysed with 1N NaOH to measure melanin content at 475 nm.

Experimental results are shown in Table 2 below.

Table 2. Cytotoxicity and Melanin Inhibition Rate

* Cytotoxicity is calculated as 100% with 100 cells

Prescription Example 1-3: Emulsion Type Foundation

Next, an emulsion type foundation is prepared according to the components and the composition ratios of Table 3, which is prepared by dispersing the pigment in an oil phase, emulsifying by adding an aqueous phase, and cooling and defoaming. At this time, Comparative Example 1 is prepared using the powder of the comparative example instead of the whitening powder of Example 1.

Table 3. Composition ratio of emulsion type foundation of Formulation Examples 1-3

Prescription 4-6: Oil Cake-type Foundation

Next, an oil cake-type foundation is prepared according to the components and the composition ratios of Table 4, and the pigment is dispersed in an oil phase, and then charged to a dish by adding flavor and then cooled to prepare. At this time, Comparative Prescription 2 was prepared using the powder of Comparative Example instead of the whitening powder of Example 1.

Table 4. Composition ratio of oil cake type foundation of prescription example 4-6

Prescription 7-9: Two-way cake

Next, the two-way cake (water-in-oil cake-based foundation) is prepared according to the ingredients and composition ratios of Table 5, and after mixing and grinding the pigments, the oil-based ingredients, additives, and flavors are added to prepare the tablets after mixing and grinding. At this time, Comparative Preparation Example 3 is prepared using the powder of Comparative Example instead of the whitening powder of Example 1.

Table 5. Composition ratio of two-way cake of Prescription Example 7-9

Pigmentation Inhibitory Effect of Prescription Example 1-9

A 2 × 2 cm ² site was set in the lower arms of both arms of 20 healthy men and women. The foil was put on the arm so that ultraviolet rays were irradiated only to the test target site, and the FL 20S BLB lamp of Toshiba, Japan was irradiated at a distance of 10 cm for 4 minutes at 1 m w / cm ² / sec once. Before the irradiation, the test site was washed well with 70% isopropyl alcohol solution. After irradiation, a prescription example and a comparative prescription containing the Example powder were applied to the UV irradiation site three times a day. After three weeks of application, the degree of pigmentation was visually determined, and the degree of inhibition of pigmentation was evaluated in three steps: remarkable effect, effectiveness, and side effect.

The results are shown in Table 6 below.

Table 6. Effects of Skin Pigmentation on Makeup Whitening Cosmetics

Cosmetic effect and usability evaluation

In evaluating the cosmetic effect and usability of the cosmetic according to the prescription example, the sunscreen effect and the persistence, water resistance and stability were measured mechanically and the sensory evaluation of 100 women aged 20 to 30 for usability and stability. Also carried out simultaneously.

(1) UV protection effect

The quartz plate was regarded as skin, and a sample was applied on the quartz plate to a certain thickness to form a thin film, and then the absorbance and transmittance of the membrane were measured with a spectrophotometer. In addition, the sample was prepared at 10% and concentration based on castor oil, and then a film having a uniform thickness (0.005 to 0.01) was formed to obtain absorbance and transmittance. do.

(2) lasting effect

The color change was measured using a colorimeter at regular time intervals. At this time, the arm was divided into 10 sites and the same amount (0.05 g) was applied to the same area (25 cm ² ) to evaluate the sustainability, and sensory evaluation was also performed at the same time.

(3) water resistance effect

1) The degree of color change before and after cosmetic application was measured at regular time intervals using a colorimeter. The skin color was measured before application by dividing the arm into 10 parts and applying the same amount to the same area. After application, the skin color was soaked for 1 minute in water every 10 minutes and dried to measure the degree of color change. Also carried out simultaneously.

2) The cosmetics were uniformly applied on the glass plate, and then the amount of cosmetics remaining after the flow of saline at 40 ° C. for 30 minutes was measured and evaluated.

(4) stability

Cosmetics were observed using a circulating temperature method that was left at 40 ° C. and minus 10 ° C. for one day, and evaluated according to the number of cycles at which emulsification was destroyed.

The results are shown in Tables 7, 8 and 9 below.

Table 7. Cosmetic Effect and Usability of Emulsion Type Foundation of Formulation Examples 1-3

Table 8. Cosmetic Effect and Usability of Oil Cake-based Foundation of Prescription 4-6

Table 9. Cosmetic Effect and Usability of Two-Way Cake of Prescription Example 7-9

Putting together the above formulations, the coating of silicone copolymer on powder adsorbed Harunoside on titanium dioxide silica, used in make-up cosmetics (emulsion foundation, oil cake type, two-way cake), inhibiting pigmentation and sustainability, water resistance It was excellent in both usability and usability.

1 is a diagram showing a cross section of the whitening powder.

Claims (7)

Whitening powder with whitening material adsorbed on titanium dioxide silica and double coated silicone copolymer on it. 2. The whitening powder of claim 1, wherein the whitening material is harunoside. 2. The whitening powder of claim 1, wherein the silicone copolymer is selected from trimethyl polysiloxane, methyl hydrogen polysiloxane and crosslinked methyl polysiloxane. After adsorbing 5-25% by weight of a 50% whitening solution on 70-94.5% by weight of titanium dioxide silica having a particle size of 2-30 μm, it was coated with 0.5-5% by weight of a silica copolymer, and then 100-150 ° C. and 800 Method of producing a whitening powder which is aged at -1000 atm for 24-48 hours and then pulverized twice and lipophilic. The method for producing a whitening powder according to claim 4, wherein the solvent of the solution of the whitening material is ethane, one selected from methanol, propylene glycol, 1,3 butylene glycol, and calcium chloride solution. Makeup whitening cosmetic containing 1-20 weight% of whitening powder of Claim 1. The makeup whitening cosmetic according to claim 6, wherein the makeup whitening cosmetic is selected from an emulsion type foundation, an oil cake type foundation, and a two-way cake.

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