KR100266743B1 - 캄토테신 유도체의 제조방법 - Google Patents

캄토테신 유도체의 제조방법 Download PDF

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Publication number
KR100266743B1
KR100266743B1 KR1019980027267A KR19980027267A KR100266743B1 KR 100266743 B1 KR100266743 B1 KR 100266743B1 KR 1019980027267 A KR1019980027267 A KR 1019980027267A KR 19980027267 A KR19980027267 A KR 19980027267A KR 100266743 B1 KR100266743 B1 KR 100266743B1
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KR
South Korea
Prior art keywords
acid
represents hydrogen
hydroxy
formula
camptothecin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1019980027267A
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English (en)
Korean (ko)
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KR19990013649A (ko
Inventor
홍청일
김정우
이상준
안순길
최남송
김계광
정병선
Original Assignee
김용규
주식회사종근당
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 김용규, 주식회사종근당 filed Critical 김용규
Priority to KR1019980027267A priority Critical patent/KR100266743B1/ko
Publication of KR19990013649A publication Critical patent/KR19990013649A/ko
Application granted granted Critical
Publication of KR100266743B1 publication Critical patent/KR100266743B1/ko
Assigned to 주식회사 종근당 reassignment 주식회사 종근당 권리의 전부이전등록 Assignors: 주식회사 종근당홀딩스
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019980027267A 1997-07-09 1998-07-07 캄토테신 유도체의 제조방법 Expired - Lifetime KR100266743B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019980027267A KR100266743B1 (ko) 1997-07-09 1998-07-07 캄토테신 유도체의 제조방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1997-31710 1997-07-09
KR1019970031710 1997-07-09
KR19970031710 1997-07-09
KR1019980027267A KR100266743B1 (ko) 1997-07-09 1998-07-07 캄토테신 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR19990013649A KR19990013649A (ko) 1999-02-25
KR100266743B1 true KR100266743B1 (ko) 2000-12-01

Family

ID=19513816

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980027267A Expired - Lifetime KR100266743B1 (ko) 1997-07-09 1998-07-07 캄토테신 유도체의 제조방법

Country Status (9)

Country Link
US (1) US6310207B1 (https=)
KR (1) KR100266743B1 (https=)
AU (1) AU8244998A (https=)
BR (1) BRPI9813001B8 (https=)
CH (1) CH693877A8 (https=)
ES (1) ES2163365B2 (https=)
IN (1) IN189180B (https=)
RU (1) RU2181122C2 (https=)
WO (1) WO1999002530A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109165B2 (en) * 2001-05-18 2006-09-19 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
AU2005233456A1 (en) * 2004-04-12 2005-10-27 Taisho Pharmaceutical Co., Ltd. Cyclic amine compound
CN101522686A (zh) * 2006-08-11 2009-09-02 克里斯特斯斯特林癌症研究基金会 制备喜树碱酯的方法
HUE060364T2 (hu) 2019-03-29 2023-02-28 Medimmune Ltd Vegyületek és konjugátumaik
TW202116356A (zh) 2019-07-10 2021-05-01 美商斯布雷克薩三號公司 作為治療劑之微管靶向藥劑之肽結合物
CN114341162B (zh) 2019-07-10 2025-10-17 赛博克萨2公司 作为治疗剂的细胞毒素的肽缀合物
CN121064209A (zh) * 2022-09-09 2025-12-05 杭州爱科瑞思生物医药有限公司 喜树碱-7-乙基胺衍生物及其制备方法和应用
CN116478051B (zh) * 2023-04-13 2024-06-21 戊言医药科技（上海）有限公司 一种贝洛替康盐酸盐及其关键中间体的制备方法
CN120058720A (zh) * 2024-01-08 2025-05-30 杭州爱科瑞思生物医药有限公司 7-含羟胺结构取代的烷基喜树碱衍生物的制备及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
HU213136B (en) * 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
IS4152A (is) * 1993-04-29 1994-10-30 Glaxo Inc. Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra
KR960029336A (ko) * 1995-01-09 1996-08-17 김충환 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제

Also Published As

Publication number Publication date
IN189180B (https=) 2003-01-04
ES2163365A1 (es) 2002-01-16
RU2181122C2 (ru) 2002-04-10
BRPI9813001B1 (pt) 2011-11-01
AU8244998A (en) 1999-02-08
BRPI9813001B8 (pt) 2021-07-06
US6310207B1 (en) 2001-10-30
BRPI9813001A (pt) 2000-08-15
WO1999002530A1 (en) 1999-01-21
CH693877A8 (de) 2004-05-28
CH693877A5 (de) 2004-03-31
ES2163365B2 (es) 2002-11-01
KR19990013649A (ko) 1999-02-25

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