KR100253108B1 - 심장보호용 토코페롤 유사체 - Google Patents

심장보호용 토코페롤 유사체 Download PDF

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Publication number
KR100253108B1
KR100253108B1 KR1019920018013A KR920018013A KR100253108B1 KR 100253108 B1 KR100253108 B1 KR 100253108B1 KR 1019920018013 A KR1019920018013 A KR 1019920018013A KR 920018013 A KR920018013 A KR 920018013A KR 100253108 B1 KR100253108 B1 KR 100253108B1
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KR
South Korea
Prior art keywords
compound
alkyl
formula
acid
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019920018013A
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English (en)
Korean (ko)
Inventor
마틴 그리사 조핸
앤 페티 마가렛
볼케니우스 프랭크
Original Assignee
슈테펜엘.네스비트
메렐 다우 파마슈티칼스 인크.
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Application granted granted Critical
Publication of KR100253108B1 publication Critical patent/KR100253108B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
  • Noodles (AREA)
  • Credit Cards Or The Like (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Cosmetics (AREA)
  • Fire-Detection Mechanisms (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019920018013A 1991-10-02 1992-10-01 심장보호용 토코페롤 유사체 Expired - Fee Related KR100253108B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91402630.7 1991-10-02
EP91402630A EP0535283A1 (en) 1991-10-02 1991-10-02 Cardioprotective tocopherol analogs

Publications (1)

Publication Number Publication Date
KR100253108B1 true KR100253108B1 (ko) 2000-05-01

Family

ID=8208620

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920018013A Expired - Fee Related KR100253108B1 (ko) 1991-10-02 1992-10-01 심장보호용 토코페롤 유사체

Country Status (17)

Country Link
EP (2) EP0535283A1 (cg-RX-API-DMAC10.html)
JP (1) JP3230699B2 (cg-RX-API-DMAC10.html)
KR (1) KR100253108B1 (cg-RX-API-DMAC10.html)
AT (1) ATE163421T1 (cg-RX-API-DMAC10.html)
AU (1) AU652077B2 (cg-RX-API-DMAC10.html)
CA (1) CA2079289C (cg-RX-API-DMAC10.html)
DE (1) DE69224501T2 (cg-RX-API-DMAC10.html)
DK (1) DK0536036T3 (cg-RX-API-DMAC10.html)
ES (1) ES2115656T3 (cg-RX-API-DMAC10.html)
FI (1) FI105552B (cg-RX-API-DMAC10.html)
GR (1) GR3026242T3 (cg-RX-API-DMAC10.html)
HU (1) HU215123B (cg-RX-API-DMAC10.html)
IL (1) IL103305A0 (cg-RX-API-DMAC10.html)
NO (1) NO923840L (cg-RX-API-DMAC10.html)
NZ (1) NZ244549A (cg-RX-API-DMAC10.html)
TW (1) TW224970B (cg-RX-API-DMAC10.html)
ZA (1) ZA927429B (cg-RX-API-DMAC10.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5545660A (en) * 1992-04-07 1996-08-13 Merrell Pharmaceuticals Inc. Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
CN1318434C (zh) * 1997-11-25 2007-05-30 安迪珀蒂恩生物工艺学有限公司 线粒体靶向的抗氧剂
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
MXPA04000654A (es) 2001-07-27 2004-03-19 Vital Health Sciences Pty Ltd Terapia dermica usando derivados de fosfato de agente de transferencia de electrones.
EP1374882B1 (de) * 2002-06-19 2008-10-01 Cognis IP Management GmbH Verwendung von Wirkstoffgemischen zur Herstellung eines Medikamentes gegen rheumatische Arthritis
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
KR101003960B1 (ko) 2003-08-22 2010-12-30 안티포딘 파마슈티칼스, 인코포레이티드 미토콘드리아 표적화 산화방지제로서 사용되는 미토퀴논 유도체를 포함하는 약제학적 조성물
US7888334B2 (en) 2003-08-22 2011-02-15 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
WO2005033092A1 (en) 2003-09-19 2005-04-14 Galileo Pharmaceuticals, Inc. Chroman derivatives
RU2477136C2 (ru) 2004-03-03 2013-03-10 Вайтал Хэлф Сайнсис Пти Лтд Алкалоидные составы
US9168216B2 (en) 2005-06-17 2015-10-27 Vital Health Sciences Pty. Ltd. Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
US7813042B2 (en) 2005-09-12 2010-10-12 Sharp Kabushiki Kaisha Multiple-view directional display
WO2008029891A1 (en) 2006-09-07 2008-03-13 Sharp Kabushiki Kaisha Image display device, electronic device, and parallax barrier element
WO2011094814A1 (en) 2010-02-05 2011-08-11 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
CA2794734C (en) 2010-03-30 2017-12-12 Phosphagenics Limited Transdermal delivery patch
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
US10973761B2 (en) 2015-12-09 2021-04-13 Phosphagenics Limited Pharmaceutical formulation
JP7198754B2 (ja) 2016-12-21 2023-01-04 アベーチョ バイオテクノロジー リミテッド 方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62205091A (ja) * 1986-03-04 1987-09-09 Senjiyu Seiyaku Kk 新規なリン酸ジエステルならびにその塩、その製造法およびそれを含有する製剤
CA2002649C (en) * 1988-11-14 2000-06-06 Margaret Petty Cardioprotective tocopherol analogs
US5500444A (en) 1989-11-14 1996-03-19 Hoechst Marion Roussel, Inc. Cardioprotective tocopherol analogs
US5135945A (en) 1991-06-05 1992-08-04 Merrell Dow Pharmaceuticals Inc. Cholesterol-lowering tocopherol analogs

Also Published As

Publication number Publication date
NO923840L (no) 1993-04-05
CA2079289C (en) 2003-02-18
FI924424A0 (fi) 1992-10-01
JPH05310763A (ja) 1993-11-22
FI105552B (fi) 2000-09-15
HU9203134D0 (en) 1992-12-28
TW224970B (cg-RX-API-DMAC10.html) 1994-06-11
HUT62592A (en) 1993-05-28
EP0536036B1 (en) 1998-02-25
EP0536036A1 (en) 1993-04-07
EP0535283A1 (en) 1993-04-07
DE69224501T2 (de) 1998-06-25
IL103305A0 (en) 1993-02-21
ES2115656T3 (es) 1998-07-01
JP3230699B2 (ja) 2001-11-19
DK0536036T3 (da) 1998-03-16
ATE163421T1 (de) 1998-03-15
CA2079289A1 (en) 1993-04-03
AU2538392A (en) 1993-04-08
NZ244549A (en) 1994-07-26
FI924424L (fi) 1993-04-03
NO923840D0 (no) 1992-10-01
GR3026242T3 (en) 1998-05-29
ZA927429B (en) 1993-04-07
AU652077B2 (en) 1994-08-11
HU215123B (hu) 1998-09-28
DE69224501D1 (de) 1998-04-02

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