KR0153202B1 - Preparation method of wound curing compositions comprising sunscreen agents - Google Patents

Abstract

The present invention relates to a method for producing a composition having excellent therapeutic ability to treat wounds of the skin, the method comprising: a base component; Sunscreens consisting of ultraviolet scatterers and ultraviolet absorbers; A method for preparing a wound healing composition comprising a wound healing agent and water, the method comprising: (a) mixing a base component and an ultraviolet absorbent to melt under heating; (b) adding and mixing an ultraviolet scattering agent to the melt mixture obtained in step (a); (c) heating the water to 70-90 ° C. and then adding and mixing to the mixture of step (b); And (d) adding a wound healing agent to the mixture obtained in step (c) and mixing the wound healing agent.

The composition obtained by the above method is a well-mixed sunscreen agent and wound healing agent with different physicochemical properties shows effective skin wound healing effect when used for skin wounds.

Description

Method for producing skin wound treatment containing sunscreen

1 is a graph comparing the therapeutic effect of a skin wound treatment agent prepared according to the method of the present invention and a conventional treatment agent (Experimental Example 1).

2 is a graph comparing the therapeutic effect of the skin wound therapeutic agent prepared according to the method of the present invention and a conventional therapeutic agent (Experimental Example 2).

The present invention relates to a method for preparing a skin wound therapeutic agent containing a sunscreen agent that blocks ultraviolet rays that are harmful to wound healing.

In general, a skin wound treatment agent is used to prevent an infection, heal the wound, and prevent scars when the skin is injured. In order to effectively treat such skin wounds, the wound area must be protected from ultraviolet rays damaging the skin. To this end, the wound is covered with a band-aid or gauze to block UV rays. However, in particular, when the skin dermabrasion is performed on the face to remove scars on the face or to remove skin defects (freckles, blemishes, and wrinkles), the skin is injured. There is a defect in appearance that protects the wound with a band-aid or gauze.

Ultraviolet rays not only cause skin aging, but also cause skin defects (freckles, spots, spots, wrinkles). In general, the skin exfoliated with tricloacetic acid or laser in order to remove the defects of the skin is easily damaged by ultraviolet rays, especially when the skin spots are removed, the ultraviolet rays are black again. Therefore, when the skin is removed, the ultraviolet rays are black again when irradiated to the area. Therefore, in order to effectively treat skin wounds, ultraviolet rays must be blocked in addition to wound healing and infection prevention.

However, when a sunscreen product is used on a facial wound to block ultraviolet rays, it is difficult to use both products at the same time because the physical and chemical properties of the skin wound treatment agent and the sunscreen product do not match.

In general UV protection, an ultraviolet absorber and an ultraviolet scattering agent are blended.

When such a sunscreen is applied directly on the wound of the skin there is a risk of causing inflammation on the skin. In addition, since the general sunscreen contains a large amount of oil, applying a water-soluble wound healing agent to the skin and then applying the sunscreen to the same site causes poor application of the sunscreen and poor adsorption to the skin. There is this. The same phenomenon occurs even if the order of application of the sunscreen and the wound healing agent is different, and this phenomenon makes the original action of the sunscreen and the wound healing agent insufficient.

In addition, when the sunscreen and the wound healing agent are mixed by a general emulsification method to form a single dosage form, talc, titanium dioxide, zinc oxide, kaolin, etc., which are used as ultraviolet scattering agents, adsorb the wound healing agent component to the wound healing agent. Since the ingredients are inhibited from acting on the skin, the desired purpose cannot be achieved.

Accordingly, it is an object of the present invention to provide a method for preparing a sunscreen containing a sunscreen which can act on the wound site without damaging the mutual function of the sunscreen and the wound healing agent at the same time.

That is, an object of the present invention is a base component; Sunscreens consisting of ultraviolet scatterers and ultraviolet absorbers; A method of preparing a wound healing composition comprising a wound healing agent and water, the method comprising the steps of: (a) mixing the base component and the ultraviolet absorbent to melt under heating; (b) adding and mixing an ultraviolet scattering agent to the melt mixture obtained in step (a); (c) heating the water to 70-90 ° C., then adding and mixing the mixture in step (b), and (d) adding and mixing the wound healing agent to the mixture obtained in step (c). It provides a method for producing a wound healing composition characterized in that.

Other objects, features and applications of the present invention will become apparent to those skilled in the art by the following detailed description.

Hereinafter, the present invention will be described in more detail.

Skin wound treatment agents that can be added to the wound healing agent of the present invention include centella asiatica extract, sodium fusidate, hydrocortisone acetate, which are used for direct wound healing purposes. , Dexapanthenol, allantoin and neomycin sulfate, gentamicin sulfate, bacitracin, polymyxin B sulfate used to prevent infection Nitrofurazone, oxytetracycline hydrochloric acid (oxyteracycline HCI), and the like.

Sunscreens include ultraviolet scatterers and ultraviolet absorbers. Examples of UV blockers include talc, titanium dioxide, zinc oxide, and kaolin. UV absorbers include allantoin PABA. , 3,4-Methylbenzylidene Gampo (3,4-Methylbenzylidene Camphor), Cinoxate, DEA-Methoxycinnamate, Octocrylene, Benzophenone-1 (Benzophenone-1) -1), Benzophenone-2, Benzophenone-3, Benzophenone-4, Benzophenone - 5, and Benzophenone-6 -6), Benzophenone-7, Benzophenone-8, Benzophenone-11, Octrizole, Octyldimethyl methyl PABA, Octyl Methoxycinnamate, Ethyl Dihydroxypropyl PA BA, PABA, PEG-25 PABA, Pentyl Dimethyl PABA, Phenyl Benjimi Sol seokpo Nick Acid (Phenylbenzimidazole Sulfonic Ac id). Glyceryl PABA, Glycol Salicylate, Sodium Urocanate, Benzophenone-12, Homosalate, TEA-Salicylate , 3-Benzophenone Camphor, Isoamyl p-Methoxycinnamate, Benzyl Salicylate, Isopropylbenzyl Salicyiate, Eurokenic Acid (Urocanic Acid), Isopr opyl Methozycinnamate, Butyl methoxydibenzoylmethan e.

These components may be used alone or in combination of two or more thereof. The amount and type of the wound treatment component is determined according to the type and condition of the infection, but preferably, two or more kinds may be combined to 0.01 to about the total weight of the wound healing composition. Used in amounts of 10.0% by weight. The sunscreen may be used individually or in combination with the ultraviolet scattering agent and the ultraviolet absorber, it is used in an amount of 0.5 to 30% by weight based on the total weight of the composition.

The wound healing composition according to the present invention may have a formulation suitable for application to the skin, such as a lotion, ointment, cream or the like, and may be applied topically to methods and doses well known to those skilled in the art at the site where the wound is to be treated. Can be.

Since the composition of the present invention exhibits a remarkable effect when the skin is exposed to ultraviolet rays as described below, it may be advantageously used for wound healing of exposed areas of the skin, particularly in areas where it is difficult to block ultraviolet rays by a physical method using a band-aid or the like. have.

Hereinafter, the present invention will be described in more detail with reference to various examples, but the present invention is not limited to these examples.

[Example 1-3]

Manufacturing method

1) The raw material 1-11 is heated to 80-90 ° C. to dissolve it, and the raw material 12-14 is added and stirred for 30 minutes.

2) The raw material 20 is heated to 73 ° C. and stirred for 15 minutes while slowly adding to 1), and the raw material 19 is added and cooled to 60 ° C. while stirring.

3) The raw materials 15-18 were slowly added to 2), stirred and mixed, and cooled to room temperature to obtain an ointment.

Example 4-5 and Comparative Example 1-2

Manufacturing method

1) The raw material 1-11 is heated to 80-90 ° C. to dissolve it, and the raw material 12-13 is added and stirred for 30 minutes.

2) The raw material 18 was heated to 73 ° C. and stirred for 15 minutes while slowly adding to 1).

3) The raw material 14-16 was slowly added to 2), stirred and mixed, and cooled to room temperature to obtain an ointment.

Experimental Example 1

The back skin of a hairless mouse (Skh-1) was cut in the longitudinal direction of the mouse with an anatomical knife to make a 2.5 cm wound, and three surgical sutures were closed and then wound on the wound site with Example 4-5. Comparative Example 1-2 The healing agent was applied twice daily. Ten test animals were used per test group. At the same time, ultraviolet rays A and B were irradiated at 100 ml / cm 2 once a day after sample application. The wounds were observed daily and the tissues were compared by biopsy on the 15th day. The appearance of scars in the wound was divided by 0 to 5, and the number of inflammatory cells according to histological findings was divided into three (3), medium (2), and small (1). The results are shown in Table 1. The total score was obtained by multiplying the number of scars in the wound and the number of inflammatory cells and the number of animals. The lower the total score, the higher the healing effect.

Experimental Example 2

The wound healing effects were compared when the wound healing agent and the sunscreen agent were used independently, and when the sunscreen agent prepared according to the method of the present invention and the preparation containing the wound healing agent were used simultaneously.

As a composition of Example 3 or Comparative Example 3, a sunscreen product having a sunscreen index of 15 and a wound healing agent (sodium fusidate-containing study) commonly used were mixed and used in a 1: 1 weight ratio.

Comparative evaluation and evaluation of the wound healing effect in the same manner as in Experimental Example 1, the results are shown in Table 2 below.

From the above results, the composition of Example 3-5 prepared according to the method of the present invention when comparing the wound healing ability with the composition of the comparative example containing only the existing wound healing agent or by simply using a wound healing agent and a sunscreen , If there is no difference in the wound healing effect between them when not irradiated with ultraviolet rays, it can be seen that when irradiated with ultraviolet rays to the wound site, scar healing and inflammation does not occur better than conventional skin wound treatment of the composition of the present invention.

In addition, it was found that the wound healing was more effective when the composition prepared according to the method of the present invention was used to increase the compatibility than when the separate sunscreen and the wound healing agent were simply mixed. This prevents the aging of UV skin as well as the healing of wounds. Therefore, by adding a sunscreen to existing skin wound treatments, it is possible to increase the wound healing effect on the face or abdomen which may be exposed to ultraviolet rays. It is also useful for cosmetics.

The results shown in Table 1 and Table 2 are shown graphically in FIGS. 1 and 2, respectively.

Claims (4)

Base component; Sunscreens consisting of ultraviolet scatterers and ultraviolet absorbers; A method of preparing a wound healing composition comprising a wound healing agent and water, the method comprising the steps of: (a) mixing the base component and the ultraviolet absorbent to melt under heating; (b) adding and mixing an ultraviolet scattering agent to the melt mixture obtained in step (a); (c) heating the water to 70-90 ° C. and then adding and mixing to the mixture of step (b); And (d) adding the wound healing agent to the mixture obtained in the step (c) and mixing the wound healing agent. The method of claim 1, wherein the ultraviolet absorber Allantoin PABA, 3,4-methylbenzylidene camphor (3,4-Methylbenzylidene Camphor), Sinoxate (Cinoxate), DE A-methoxycinnamate (DEA- Methoxycinnamate, Octocrylene, Benzophenone-4, Benzophenone-2, Benzophenone-3, Benzophenone-4, Benzophenone-5, Benzophenone-6, Benzophenone-7, Benzophenone-8, Benzophenone-11, Octrizole, Octyl Dimethyl PABA, Octyl Methoxycinnamate, Ethyl Dihydroxypropyl PABA, PEG-25 Pava (PEG-25, PABA) Pentyl Dimethyl PABA, Phenylbenzimidazole Sulfonic Acid. Glyceryl PABA, Glycol Salicylate, Sodium Eurocanate, Benzophenone-12, Homosalate, TEA-Salicylate ), 3-Benzophenone Camphor, Isoamylp-Methoxycinnamate, Benzyl Salicylate, Isopropylbenzyl Salicyiate, Eurokenic Acid (Urocanic ACid), Isopropyl Methozycinnamate, and Butyl methoxydibenzoylmethane. The method of claim 1, wherein the ultraviolet scattering agent is one or two or more selected from talc, titanium dioxide (titaniu, dioxid e), zinc oxide, and kaolin. . The method of claim 1, wherein the wound healing agent centella asia ticaextract (sodium fusidate), sodium fusidate (sodiu, fusidate), hydrocortisone acetate (hydrocortisone acetate), dexapantenol (dexapathenol), allantoin (allantoin) Neomycin sulfate, gentamicin sulfate, bacitracin, polymyxin B sulfate, nitro furazone, and oxytetracycline HCI Method characterized in that one or two or more selected from.