KR0143385B1 - Collegen capsule for cosmetics - Google Patents

Abstract

The present invention provides a cosmetic collagen capsule having excellent pressure disintegration properties and excellent dispersibility, the cosmetic collagen capsule comprising a collagen and its derivative as a coating material, and having a compound having 2 to 4 glycidyl groups as a crosslinking agent. It is characterized in that it is manufactured using.

Description

[Name of invention]

Cosmetic Collagen Capsule

[Detailed Description of Onset]

The present invention relates to a cosmetic capsule, and more particularly to a collagen capsule for cosmetics, characterized in that it contains collagen and derivatives thereof as a coating material, and a compound having 2 to 4 glycidyl groups as a crosslinking agent. .

Currently, commercially available cosmetic capsules include hard capsules, soft capsules, and seamless capsules. The encapsulating materials mainly used in these capsules include gelatin, alginic acid, or agar, and when the capsule is manufactured using gelatin as the encapsulating material, it is difficult to rupture due to the thick film and must be broken using a device. The encapsulant remains on the skin, which causes poor usability and irritates the skin. In addition, since gelatin is water-soluble, it is impossible to disperse it in the cosmetics of the water phase when formulating a capsule made of the coating material in the cosmetics, and thus its use range is limited. In other words, when the capsule is made of water-soluble gelatin and dispersed in the cosmetic of the aqueous phase, the coating material gelatin begins to swell after about 1 hour, and after a long time it dissolves in the cosmetic of the aqueous phase and the contents of the capsule are eluted, which functions as a capsule. Also, since gelatin has a melting temperature of 37 ° C., the gelatin has a problem in that it dissolves easily when the temperature is 40 ° C. or higher when it is added to the cosmetic of the aqueous phase. The seamless capsule uses sodium alginate, gelatin, or agar as the coating material.If sodium alginate cured with polyvalent metal ions is used as the coating material, it must be ruptured using an instrument because of its poor pressure collapse. And, there is a problem that remains after peeling irritate the skin. In order to solve these problems, the proposed capsule is a seamless capsule made of agar, which is stable and attracting attention to the dispersion medium of the water phase in the temperature range of the actual distribution conditions, but the agar itself has a moisturizing effect on the skin when the skin is applied. There is a problem that cannot be granted.

Accordingly, the present inventors have solved the problems of the prior art as described above, and as a result of earnestly research to provide a cosmetic capsule having excellent pressure disintegration property and stable dispersibility even in the dispersion medium of the aqueous phase, collagen or derivatives thereof as a coating material When the compound obtained by using a compound having 2 to 4 glycidyl groups as a crosslinking agent was added to the cosmetic, it was found that the above object can be achieved and the present invention has been completed.

Accordingly, it is an object of the present invention to provide a cosmetic collagen capsule excellent in pressure disintegration and excellent in dispersibility. That is, the cosmetic collagen capsule of the present invention is characterized in that the collagen and its derivatives are prepared as a coating material, and the compound having 2 to 4 glycidyl groups is used as a crosslinking agent.

Hereinafter, the collagen capsule for cosmetics of the present invention will be described in detail.

In the capsule according to the present invention, collagen used as a coating material is a kind of protein constituting the human body and is present in the form of fibers in the living body, and is mainly used for food, cosmetic raw materials, surgical sutures, artificial skin, and the like. As it has degradability, it is expected to play a role in anti-aging of skin when used in cosmetics.

In the present invention, one or two or more selected from the group consisting of atelocollagen, myristylated atelocollagen, succinylated atelocollagen, millyl succinylated atelocollagen, and phthalated atelocollagen may be used as collagen. have. Collagen is used in the form of an aqueous solution, the concentration of 0.5 ~ 4% (w / v) is suitable, preferably 1% (w / v).

The preparation of the capsule can be carried out by mixing a hydrophilic active ingredient solution in a collagen aqueous solution or dispersing a hydrophobic active ingredient, adding it to an organic dispersion medium and dispersing it under stirring, and then adding and crosslinking it with an organic solvent solution of a crosslinking agent. The capsules thus prepared are washed several times to remove the solvent and unreacted materials.

A crosslinking agent that can be used in the manufacture of capsules is a compound having 2 to 4 glycidyl groups. Specific examples include trimethylolpropane polyglycidyl ether, neopentyl glycol diglycidyl ether, glycerol polyglycidyl ether, polypropylene glycol diglycidyl ether, ethylene glycol diglycidyl ether, polyethylene glycol digly Cylyl ether, sorbitol polyglycidyl ether, etc. are mentioned, A crosslinking agent is melt | dissolved in the same solvent as a dispersion medium, or a solvent compatible with a dispersion medium, and is used in the form of a solution. The concentration is preferably 3 to 15% (w / v). If the concentration is 15% (w / v) or more, the capsules used in combination with the cosmetics are poor in pressure decay and 3% (w). / v), there is a problem that the capsule is collapsed by the operation of washing with water or the like during the preparation of the capsule during the preparation of the capsule.

At this time, in order to ensure sufficient crosslinking of collagen in the preparation of the capsule, it is preferable to make the content of collagen to the crosslinking agent in the range of 1: 1.5 to 2.5 by weight ratio.

As the active ingredient contained in the collagen capsule in the present invention, both lipophilic cosmetics and hydrophilic cosmetics commonly used may be used, and organic or inorganic pigments and inorganic dyes for imparting color may also be contained in the collagen capsules.

According to the present invention, the preferred diameter of the capsule is 1 to 5,000 μm.

The cosmetic composition including the active ingredient-containing collagen capsule of the present invention can prevent the contents of the capsule from being deteriorated by ultraviolet light, and is also soft and smooth and evenly applied due to the role of collagen when applied to the skin.

Although an Example is given to the following and this invention is demonstrated in more detail, a ball invention is not limited to these Examples.

Example 1

1 g of magnesium ascorbic acid phosphate was dissolved in 500 g of myristylate fossilylated atelocollagen (Japanese Kobe Aterocollagen MS) 1% aqueous solution. The solution was added dropwise thereto while stirring 2,000 g of liquid paraffin LP # 70 at 6,000 rpm using a mixer, and then stirring was continued. 200 g of isopropyl myristate solution of polyethylene glycol diglycidyl ether as a crosslinking agent was added thereto, followed by crosslinking reaction for 2 hours while stirring at 6,000 rpm. After the reaction was completed, washed several times to remove the solvent and filtered. A capsule having an average diameter of 30 µm was obtained.

Example 2

50 g of ceramide was dissolved in 500 g of a succinylated atelocollagen (Japan Goya Aterocollagen SS) 2% aqueous solution. 2,000 g of cyclohexane was added dropwise thereto while stirring at 500 rpm using a mixer, followed by continued stirring. To this was added 300 g of a 5% isopropyl myristate solution of glycerol diglycidyl ether as a crosslinking agent, and then crosslinked for 2 hours with stirring at 500 rpm. After the reaction was rinsed several times to remove the solvent and filtered. A capsule having an average diameter of 150 µm was obtained.

Example 3

20 g of the capsule obtained in Example 2 was mixed with 100 g of the supernatant having the following composition to prepare a capsule cosmetic.

Comparative Example 1

A capsule having an average diameter of 150 µm was obtained in the same manner as in Example 2, except that gelatin was used as the coating material.

20 g of the obtained gelatin capsules were mixed with 100 g of the supernatant having the same composition as in Example 3 to obtain a capsule cosmetic.

[Test Example 1]

Pressure Collapse Test

In order to compare the degree of pressure collapse of the capsules, the capsules obtained in Examples 1 and 2 and the capsules obtained in Comparative Example 1 were used with a rheometer (SUN SCIENTIFIC, Model CR-200) to increase the speed of 45 mm / min and the diameter of 2.5 cm. The average value was measured 10 times with a rod. The results were shown in Table 1.

[Test Example 2]

Comparison of feelings

Average value of scores obtained by comparing the cosmetics obtained in Example 3 of the present invention with the cosmetics obtained in Comparative Example 1 by the three-point evaluation method by 50 men and women of professional inspection personnel aged 19-40 years Got it. The results were shown in Table 2.

1: Peel remaining, rough skin.

2: A small amount of skin remaining, feeling a slight physical irritation to the skin.

3: No remaining crust, applied to skin smoothly.

Claims (4)

In the collagen capsule for cosmetics, a compound having 2 to 4 glycidyl groups as a crosslinking agent and collagen or a derivative thereof is used, and the content of the crosslinking agent is in the range of 1: 1.5 to 2.5 in a weight ratio to collagen, Collagen capsules for cosmetics, characterized in that obtained by adjusting the concentration of the crosslinking agent in the range of 3 to 15% (w / v). The collagen or derivative thereof is one or more selected from the group consisting of atelocollagen, myristylated atelocollagen, succinylation atelocollagen, myristylosynylated atelocollagen, and phthalated atelocollagen. Cosmetic collagen capsules, characterized in that two or more. The compound having 2 to 4 glycidyl groups according to claim 1, wherein the compound having 2 to 4 glycidyl groups is trimethylolpropanepolyglycidyl ether, neopentyl glycol diglycidyl ether, gglycerol polyglycidyl ether, polypropylene glycol digly Cosmetic collagen capsules, characterized in that selected from the group consisting of cydyl ether, ethylene glycol diglycidyl ether, polyethylene glycol diglycidyl ether and sorbitol polyglycidyl ether. The cosmetic collagen capsule of claim 1, wherein the capsule has an average diameter of 1 to 5,000 μm.