JPWO2023278589A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2023278589A5 JPWO2023278589A5 JP2023580484A JP2023580484A JPWO2023278589A5 JP WO2023278589 A5 JPWO2023278589 A5 JP WO2023278589A5 JP 2023580484 A JP2023580484 A JP 2023580484A JP 2023580484 A JP2023580484 A JP 2023580484A JP WO2023278589 A5 JPWO2023278589 A5 JP WO2023278589A5
- Authority
- JP
- Japan
- Prior art keywords
- stabilizer
- modified oligonucleotide
- sulfonyl
- substituted
- sugar moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163217137P | 2021-06-30 | 2021-06-30 | |
| US63/217,137 | 2021-06-30 | ||
| PCT/US2022/035539 WO2023278589A1 (en) | 2021-06-30 | 2022-06-29 | Method for synthesis of linkage modified oligomeric compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024527542A JP2024527542A (ja) | 2024-07-25 |
| JP2024527542A5 JP2024527542A5 (https=) | 2025-07-08 |
| JPWO2023278589A5 true JPWO2023278589A5 (https=) | 2025-07-08 |
Family
ID=84691597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023580484A Pending JP2024527542A (ja) | 2021-06-30 | 2022-06-29 | 結合修飾オリゴマー化合物の合成のための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240287520A1 (https=) |
| EP (1) | EP4363572A4 (https=) |
| JP (1) | JP2024527542A (https=) |
| KR (1) | KR20240027745A (https=) |
| CN (1) | CN117480254A (https=) |
| WO (1) | WO2023278589A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4013767A4 (en) | 2019-08-15 | 2023-10-25 | Ionis Pharmaceuticals, Inc. | Linkage modified oligomeric compounds and uses thereof |
| EP4669753A1 (en) | 2023-02-20 | 2025-12-31 | ProQR Therapeutics II B.V. | Antisense oligonucleotides for the treatment of atherosclerotic cardiovascular disease |
| WO2024206175A1 (en) | 2023-03-24 | 2024-10-03 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurological disorders |
| GB202304363D0 (en) | 2023-03-24 | 2023-05-10 | Proqr Therapeutics Ii Bv | Chemically modified antisense oligonucleotides for use in RNA editing |
| AU2024246572A1 (en) | 2023-03-27 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of liver disease |
| WO2024220934A1 (en) | 2023-04-21 | 2024-10-24 | University Of Rochester | Nucleic acid molecules for pseudouridylation |
| WO2024256620A1 (en) | 2023-06-16 | 2024-12-19 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurodegenerative disease |
| WO2025051946A1 (en) | 2023-09-07 | 2025-03-13 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| WO2025072672A2 (en) | 2023-09-27 | 2025-04-03 | Judo Bio, Inc. | Slc6a19-targeting modulatory nucleic acid agents |
| WO2025072699A1 (en) | 2023-09-27 | 2025-04-03 | Judo Bio, Inc. | Aminoglycosides for delivery of agents to the kidney |
| WO2025072713A1 (en) | 2023-09-27 | 2025-04-03 | Judo Bio, Inc. | Polymyxins for delivery of agents to the kidney |
| WO2025104239A1 (en) | 2023-11-16 | 2025-05-22 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of classic galactosemia |
| WO2025132708A1 (en) | 2023-12-20 | 2025-06-26 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of huntington's disease |
| WO2025141016A1 (en) * | 2023-12-27 | 2025-07-03 | F. Hoffmann-La Roche Ag | A method for the synthesis of oligonucleotides with modfied internucleoside linkages |
| GB202404661D0 (en) | 2024-04-02 | 2024-05-15 | Proqr Therapeutics Ii Bv | Antisense oligoncleotides for the treatment of liver disease |
| GB202405143D0 (en) | 2024-04-11 | 2024-05-29 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of poly-q disease |
| WO2025224230A1 (en) | 2024-04-25 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of fatty liver disease |
| WO2025240884A1 (en) * | 2024-05-17 | 2025-11-20 | Ionis Pharmaceuticals, Inc. | Patterned modified oligonucleotides |
| WO2025250953A1 (en) * | 2024-05-31 | 2025-12-04 | Ionis Pharmaceuticals, Inc. | Linkage modified oligomeric agents and uses thereof |
| GB202410081D0 (en) | 2024-07-11 | 2024-08-28 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for the treatment of cardiovascular disease |
| WO2026022136A1 (en) | 2024-07-23 | 2026-01-29 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of metabolic disorders |
| WO2026060374A2 (en) | 2024-09-16 | 2026-03-19 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of neurological disorders |
| WO2026068781A1 (en) | 2024-09-30 | 2026-04-02 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of liver disease |
| WO2026080897A1 (en) | 2024-10-11 | 2026-04-16 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of chronic pain |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2740501C2 (ru) * | 2017-02-21 | 2021-01-14 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | МОДИФИЦИРОВАННЫЕ ОЛИГОНУКЛЕОТИДЫ, АКТИВИРУЮЩИЕ РНКазу Н |
| EP4013767A4 (en) * | 2019-08-15 | 2023-10-25 | Ionis Pharmaceuticals, Inc. | Linkage modified oligomeric compounds and uses thereof |
-
2022
- 2022-06-29 CN CN202280041577.XA patent/CN117480254A/zh active Pending
- 2022-06-29 US US18/571,631 patent/US20240287520A1/en active Pending
- 2022-06-29 WO PCT/US2022/035539 patent/WO2023278589A1/en not_active Ceased
- 2022-06-29 KR KR1020247002976A patent/KR20240027745A/ko active Pending
- 2022-06-29 JP JP2023580484A patent/JP2024527542A/ja active Pending
- 2022-06-29 EP EP22834149.1A patent/EP4363572A4/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2023278589A5 (https=) | ||
| AU739468B2 (en) | Activators for oligonucleotide synthesis | |
| US6693187B1 (en) | Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge | |
| EP2160396B1 (en) | Thiocarbon-protecting groups for rna synthesis | |
| US6630581B2 (en) | Monomers for solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection | |
| WO2010034024A2 (en) | Protected monomers and methods of deprotection for rna synthesis | |
| WO1997019092A1 (en) | Improved process for the synthesis of oligomeric compounds | |
| EP3004131B1 (en) | Phosphoramidite building blocks for sugar-conjugated oligonucleotides | |
| JPH07103150B2 (ja) | ２’―０―アルキルヌクレオチド並びにこのようなヌクレオチドを含むポリマー | |
| JP2001515086A (ja) | オリゴヌクレオチドの溶液相合成 | |
| JPWO2021195533A5 (https=) | ||
| EP1317466B1 (en) | Synthons for oligonucleotide synthesis | |
| WO2006066260A9 (en) | Compositions of and methods for producing phosphorus-chiral monomers and oligomers | |
| WO2004085454A1 (en) | Silylated oligonucleotide compounds | |
| US6340749B1 (en) | Preparation of nucleoside phosphoramidites and oligonucleotide synthesis | |
| EP3372610A1 (en) | Novel phosphorylation reagents and uses thereof | |
| EP0901500B1 (en) | In situ preparation of nucleoside phosphoramidites and their use in synthesis of oligonucleotides | |
| WO2015191303A2 (en) | Protecting groups for "z nucleotide" and methods thereof | |
| JP7657736B2 (ja) | セグメント型アミダイトを用いた核酸合成法 | |
| JP2022177332A (ja) | オリゴヌクレオチドを製造する方法 | |
| KR20130143675A (ko) | 올리고뉴클레오티드의 정제 | |
| Tsukamoto et al. | Strategies useful for the chemical synthesis of oligonucleotides and related compounds | |
| EP1828218B1 (en) | Synthesis of phosphitylated compounds using a quaternary heterocyclic activator | |
| Weetman | A new route to oligonucleotides |