JPWO2023154900A5 - - Google Patents

Info

Publication number
JPWO2023154900A5
JPWO2023154900A5 JP2024547599A JP2024547599A JPWO2023154900A5 JP WO2023154900 A5 JPWO2023154900 A5 JP WO2023154900A5 JP 2024547599 A JP2024547599 A JP 2024547599A JP 2024547599 A JP2024547599 A JP 2024547599A JP WO2023154900 A5 JPWO2023154900 A5 JP WO2023154900A5
Authority
JP
Japan
Prior art keywords
dsrna agent
nucleotide
nucleotides
tau
antisense strand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024547599A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025507372A5 (https=
JP2025507372A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2023/062440 external-priority patent/WO2023154900A2/en
Publication of JP2025507372A publication Critical patent/JP2025507372A/ja
Publication of JP2025507372A5 publication Critical patent/JP2025507372A5/ja
Publication of JPWO2023154900A5 publication Critical patent/JPWO2023154900A5/ja
Pending legal-status Critical Current

Links

JP2024547599A 2022-02-11 2023-02-10 微小管関連タンパク質タウ（ＭＡＰＴ）ｉＲＮＡ剤組成物およびその使用方法 Pending JP2025507372A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263309399P 2022-02-11 2022-02-11
US63/309,399 2022-02-11
US202263322618P 2022-03-22 2022-03-22
US63/322,618 2022-03-22
PCT/US2023/062440 WO2023154900A2 (en) 2022-02-11 2023-02-10 Microtubule associated protein tau (mapt) irna agent compositions and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2025507372A JP2025507372A (ja) 2025-03-18
JP2025507372A5 JP2025507372A5 (https=) 2026-02-17
JPWO2023154900A5 true JPWO2023154900A5 (https=) 2026-02-17

Family

ID=87565165

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024547599A Pending JP2025507372A (ja) 2022-02-11 2023-02-10 微小管関連タンパク質タウ（ＭＡＰＴ）ｉＲＮＡ剤組成物およびその使用方法

Country Status (4)

Country Link
US (1) US20250171777A1 (https=)
EP (1) EP4476338A2 (https=)
JP (1) JP2025507372A (https=)
WO (1) WO2023154900A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12551569B2 (en) 2024-03-31 2026-02-17 Arrowhead Pharmaceuticals, Inc. RNAi agents for inhibiting expression of microtubule associated protein tau (MAPT), compositions thereof, and methods of use
WO2026048822A1 (ja) * 2024-08-30 2026-03-05 東亞合成株式会社 Ｍａｐｔ ｒｎａ配列に基づく新規二本鎖ｒｎａ及びその利用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008124066A1 (en) 2007-04-05 2008-10-16 The J. David Gladstone Institutes Agents that reduce neuronal overexcitation
EP3274456B1 (en) 2015-03-25 2020-06-24 Università Degli Studi Di Trento Rna interference mediated therapy for neurodegenerative diseases
AU2021246024A1 (en) * 2020-03-30 2022-10-27 Alnylam Pharmaceuticals, Inc. Microtubule associated protein Tau (MAPT) iRNA agent compositions and methods of use thereof

Similar Documents

Publication Publication Date Title
CN115397436B (zh) 用于抑制PNPLA3表达的RNAi剂、其药物组合物和使用方法
CN113748208A (zh) 用于抑制中枢神经系统中的基因表达的组合物和方法
TR201816256T4 (tr) Bir süjede smn2 uç birleştirmesinin modülasyonu için bileşimler ve yöntemler.
CN105637090A (zh) 用于调节c9orf72表达的组合物
JPWO2021202511A5 (https=)
AU2006243218B2 (en) Use of low doses of oligonucleotides antisense to TGF-beta, VEGF, interleukin-10, c-jun, c-fos or prostaglandin E2 genes in the treatment of tumors
JPWO2020132227A5 (https=)
JP2023538284A (ja) Ｐｌｐ１発現を阻害するための組成物及び方法
IL294728A (en) lrrk2 RNA material preparations and methods of using them
BR112021012516A2 (pt) Composições e métodos para inibir a expressão de hmgb1
JP2024071571A (ja) ミトコンドリアアミドキシム還元成分１（ｍａｒｃ１）発現を阻害するための組成物および方法
CN119403927A (zh) 用于抑制跨膜丝氨酸蛋白酶6（tmprss6）表达的组合物和方法
JPWO2023049871A5 (https=)
US11634715B2 (en) Methods and compositions for treating bile duct paucity-associated conditions
JPWO2023154900A5 (https=)
JPWO2021222065A5 (https=)
CN118202053A (zh) 一种调节补体C3表达的siRNA、其缀合物和药物组合物及用途
CN121240865A (zh) 用于调节亨廷顿蛋白表达的等位基因选择性化合物和方法
RU2024111073A (ru) КОМПОЗИЦИИ АГЕНТА иРНК ПРОТИВ АССОЦИИРОВАННОГО С МИКРОТРУБОЧКАМИ ТАУ-БЕЛКА (MAPT) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
US20220186229A1 (en) Methods and compositions for inhibiting expression of cyp27a1
JPWO2021150969A5 (https=)
JP7536187B2 (ja) 核内受容体サブファミリー１グループｈメンバー３（ｎｒ１ｈ３）発現を阻害するための組成物および方法
JPWO2022245583A5 (https=)
WO2026067818A1 (zh) 一种用于调控SCN1A基因mRNA和蛋白表达的方法和化合物
JPWO2022271972A5 (https=)