JPWO2022211052A5 - - Google Patents
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- Publication number
- JPWO2022211052A5 JPWO2022211052A5 JP2023511724A JP2023511724A JPWO2022211052A5 JP WO2022211052 A5 JPWO2022211052 A5 JP WO2022211052A5 JP 2023511724 A JP2023511724 A JP 2023511724A JP 2023511724 A JP2023511724 A JP 2023511724A JP WO2022211052 A5 JPWO2022211052 A5 JP WO2022211052A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- patient
- active ingredient
- gait
- diphenylpyrazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010017577 Gait disturbance Diseases 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 16
- 229940124597 therapeutic agent Drugs 0.000 claims description 16
- 239000004480 active ingredient Substances 0.000 claims description 9
- 208000023589 ischemic disease Diseases 0.000 claims description 8
- 208000000575 Arteriosclerosis Obliterans Diseases 0.000 claims description 5
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- QXWZQTURMXZVHJ-UHFFFAOYSA-N selexipag Chemical compound C=1C=CC=CC=1C1=NC(N(CCCCOCC(=O)NS(C)(=O)=O)C(C)C)=CN=C1C1=CC=CC=C1 QXWZQTURMXZVHJ-UHFFFAOYSA-N 0.000 claims description 4
- OJQMKCBWYCWFPU-UHFFFAOYSA-N ACT-333679 Chemical compound C=1C=CC=CC=1C1=NC(N(CCCCOCC(O)=O)C(C)C)=CN=C1C1=CC=CC=C1 OJQMKCBWYCWFPU-UHFFFAOYSA-N 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 208000031104 Arterial Occlusive disease Diseases 0.000 claims 1
- 208000021328 arterial occlusion Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 231100000682 maximum tolerated dose Toxicity 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 5
- 125000004663 dialkyl amino group Chemical group 0.000 description 5
- 125000005843 halogen group Chemical group 0.000 description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 5
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 125000000623 heterocyclic group Chemical group 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 3
- 125000004414 alkyl thio group Chemical group 0.000 description 3
- 125000003710 aryl alkyl group Chemical group 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 125000004093 cyano group Chemical group *C#N 0.000 description 3
- 125000001188 haloalkyl group Chemical group 0.000 description 3
- -1 monoalkylcarbamoyl Chemical group 0.000 description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
- 206010003210 Arteriosclerosis Diseases 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 208000011775 arteriosclerosis disease Diseases 0.000 description 2
- 125000004104 aryloxy group Chemical group 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000004450 alkenylene group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 125000005117 dialkylcarbamoyl group Chemical group 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021060178 | 2021-03-31 | ||
| PCT/JP2022/016648 WO2022211052A1 (ja) | 2021-03-31 | 2022-03-31 | 歩行障害治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2022211052A1 JPWO2022211052A1 (https=) | 2022-10-06 |
| JPWO2022211052A5 true JPWO2022211052A5 (https=) | 2025-04-07 |
Family
ID=83456587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023511724A Pending JPWO2022211052A1 (https=) | 2021-03-31 | 2022-03-31 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240197724A1 (https=) |
| EP (1) | EP4316489A4 (https=) |
| JP (1) | JPWO2022211052A1 (https=) |
| KR (1) | KR20230165247A (https=) |
| CN (1) | CN117157075A (https=) |
| AU (1) | AU2022248664A1 (https=) |
| BR (1) | BR112023019899A2 (https=) |
| CA (1) | CA3215414A1 (https=) |
| IL (1) | IL307277A (https=) |
| TW (1) | TW202304444A (https=) |
| WO (1) | WO2022211052A1 (https=) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI316055B (https=) | 2001-04-26 | 2009-10-21 | Nippon Shinyaku Co Ltd | |
| HRP20151443T1 (hr) * | 2008-06-23 | 2016-01-29 | Nippon Shinyaku Co., Ltd. | Terapijsko sredstvo protiv stenoze kralježniäśnog kanala |
| ES2762943T3 (es) * | 2015-09-03 | 2020-05-26 | Teva Pharmaceuticals Int Gmbh | Formas de Selexipag en estado sólido |
-
2022
- 2022-03-31 CA CA3215414A patent/CA3215414A1/en active Pending
- 2022-03-31 KR KR1020237034284A patent/KR20230165247A/ko active Pending
- 2022-03-31 IL IL307277A patent/IL307277A/en unknown
- 2022-03-31 TW TW111112395A patent/TW202304444A/zh unknown
- 2022-03-31 BR BR112023019899A patent/BR112023019899A2/pt unknown
- 2022-03-31 AU AU2022248664A patent/AU2022248664A1/en active Pending
- 2022-03-31 US US18/284,941 patent/US20240197724A1/en active Pending
- 2022-03-31 JP JP2023511724A patent/JPWO2022211052A1/ja active Pending
- 2022-03-31 CN CN202280023976.3A patent/CN117157075A/zh active Pending
- 2022-03-31 WO PCT/JP2022/016648 patent/WO2022211052A1/ja not_active Ceased
- 2022-03-31 EP EP22781262.5A patent/EP4316489A4/en active Pending
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