JPWO2022190018A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022190018A5 JPWO2022190018A5 JP2023554813A JP2023554813A JPWO2022190018A5 JP WO2022190018 A5 JPWO2022190018 A5 JP WO2022190018A5 JP 2023554813 A JP2023554813 A JP 2023554813A JP 2023554813 A JP2023554813 A JP 2023554813A JP WO2022190018 A5 JPWO2022190018 A5 JP WO2022190018A5
- Authority
- JP
- Japan
- Prior art keywords
- repeat domain
- ankyrin repeat
- human
- binding
- binding protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000008102 Ankyrins Human genes 0.000 claims 13
- 108010049777 Ankyrins Proteins 0.000 claims 13
- 108091008324 binding proteins Proteins 0.000 claims 13
- 102000023732 binding proteins Human genes 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 210000002865 immune cell Anatomy 0.000 claims 6
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 102000052088 human IL3RA Human genes 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000008100 Human Serum Albumin Human genes 0.000 claims 3
- 108091006905 Human Serum Albumin Proteins 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163158539P | 2021-03-09 | 2021-03-09 | |
| US63/158,539 | 2021-03-09 | ||
| US202163173227P | 2021-04-09 | 2021-04-09 | |
| US63/173,227 | 2021-04-09 | ||
| US202163265187P | 2021-12-09 | 2021-12-09 | |
| US63/265,187 | 2021-12-09 | ||
| PCT/IB2022/052128 WO2022190018A1 (en) | 2021-03-09 | 2022-03-09 | Novel darpin based cd123 engagers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024509241A JP2024509241A (ja) | 2024-02-29 |
| JPWO2022190018A5 true JPWO2022190018A5 (enExample) | 2025-03-18 |
Family
ID=80820043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023554813A Pending JP2024509241A (ja) | 2021-03-09 | 2022-03-09 | 新規のＤＡＲＰｉｎに基づくＣＤ１２３エンゲージャ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240150475A1 (enExample) |
| EP (1) | EP4304729A1 (enExample) |
| JP (1) | JP2024509241A (enExample) |
| AU (1) | AU2022233791A1 (enExample) |
| CA (1) | CA3211368A1 (enExample) |
| WO (1) | WO2022190018A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112022023049A2 (pt) | 2020-05-14 | 2022-12-20 | Molecular Partners Ag | Proteínas multiespecíficas |
| JP2024509904A (ja) | 2021-03-09 | 2024-03-05 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規なＤＡＲＰｉｎに基づく多重特異性Ｔ細胞エンゲージャ |
| WO2024179981A1 (en) * | 2023-02-27 | 2024-09-06 | Molecular Partners Ag | Darpins for use in reducing renal accumulation of drugs |
| WO2024251628A1 (en) * | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd16a binding proteins and their use |
| US20250332297A1 (en) * | 2024-01-31 | 2025-10-30 | Molecular Partners Ag | Dll3-specific binding constructs and their use in radiotherapy |
| WO2025181039A1 (en) | 2024-03-01 | 2025-09-04 | Molecular Partners Ag | Therapeutic combinations comprising a multi-specific t cell engager |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| JP5291279B2 (ja) | 2000-09-08 | 2013-09-18 | ウニヴェルジテート・チューリッヒ | 反復モジュールを含む反復タンパク質の集合体 |
| US20040175756A1 (en) | 2001-04-26 | 2004-09-09 | Avidia Research Institute | Methods for using combinatorial libraries of monomer domains |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| US20050048512A1 (en) | 2001-04-26 | 2005-03-03 | Avidia Research Institute | Combinatorial libraries of monomer domains |
| WO2005063815A2 (en) | 2003-11-12 | 2005-07-14 | Biogen Idec Ma Inc. | Fcϝ receptor-binding polypeptide variants and methods related thereto |
| US20060008844A1 (en) | 2004-06-17 | 2006-01-12 | Avidia Research Institute | c-Met kinase binding proteins |
| WO2009040338A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zürich | Designed armadillo repeat proteins |
| WO2010060748A1 (en) | 2008-11-03 | 2010-06-03 | Molecular Partners Ag | Binding proteins inhibiting the vegf-a receptor interaction |
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| CN103459415B (zh) | 2010-11-26 | 2021-04-09 | 分子组合公司 | 设计的与血清白蛋白结合的重复蛋白 |
| BR112014032316A2 (pt) | 2012-06-28 | 2017-06-27 | Molecular Partners Ag | proteínas de repetição de anquirina projetadas que se ligam ao fator de crescimento derivado de plaqueta |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| EP2789630A1 (en) | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
| US11453708B2 (en) | 2013-05-31 | 2022-09-27 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
| EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| AU2016240220B2 (en) | 2015-04-02 | 2019-11-21 | Molecular Partners Ag | Designed ankyrin repeat domains with binding specificity for serum albumin |
| ES2953516T3 (es) | 2016-09-22 | 2023-11-14 | Molecular Partners Ag | Proteínas de unión recombinantes y su uso |
-
2022
- 2022-03-09 US US18/281,161 patent/US20240150475A1/en active Pending
- 2022-03-09 WO PCT/IB2022/052128 patent/WO2022190018A1/en not_active Ceased
- 2022-03-09 AU AU2022233791A patent/AU2022233791A1/en active Pending
- 2022-03-09 EP EP22711618.3A patent/EP4304729A1/en active Pending
- 2022-03-09 CA CA3211368A patent/CA3211368A1/en active Pending
- 2022-03-09 JP JP2023554813A patent/JP2024509241A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021502810A5 (enExample) | ||
| JPWO2020069028A5 (enExample) | ||
| JP2019531093A5 (enExample) | ||
| WO2021092075A1 (en) | IL-2RβγC BINDING COMPOUNDS | |
| JP2023123649A5 (enExample) | ||
| JP2016052315A5 (enExample) | ||
| TW200531979A (en) | Inhibitors of type 2 vascular endothelial growth factor receptors | |
| JP2012520059A5 (enExample) | ||
| JP2019511201A5 (enExample) | ||
| JP2015520172A5 (enExample) | ||
| JPWO2021116182A5 (enExample) | ||
| JPWO2022190018A5 (enExample) | ||
| JP7028557B2 (ja) | 新規ポリペプチド | |
| JPWO2022094299A5 (enExample) | ||
| JPWO2022190010A5 (enExample) | ||
| JPWO2022215032A5 (enExample) | ||
| CN111499762A (zh) | 一种包含PDGFRβ特异性亲和体和TNFα的融合蛋白及其用途 | |
| CN114929745B (zh) | Clec12a抗体片段序列和方法 | |
| JPWO2022129560A5 (enExample) | ||
| RU2004114878A (ru) | Агенты, увеличивающие аффинность | |
| JPWO2021229076A5 (enExample) | ||
| JP2023550191A (ja) | Ｄｒ４および／またはｄｒ５を標的とするポリペプチドならびに関連する組成物および方法 | |
| JPWO2022190016A5 (enExample) | ||
| CN101210048A (zh) | 用于靶向结合髓系白血病细胞的抗cd33的工程抗体及其表达载体和用途 | |
| JPWO2022129428A5 (enExample) |