JPWO2022173033A5 - - Google Patents
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- Publication number
- JPWO2022173033A5 JPWO2022173033A5 JP2022580703A JP2022580703A JPWO2022173033A5 JP WO2022173033 A5 JPWO2022173033 A5 JP WO2022173033A5 JP 2022580703 A JP2022580703 A JP 2022580703A JP 2022580703 A JP2022580703 A JP 2022580703A JP WO2022173033 A5 JPWO2022173033 A5 JP WO2022173033A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- cyclopropyl
- oxy
- diazabicyclo
- indazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021021684 | 2021-02-15 | ||
| JP2021021684 | 2021-02-15 | ||
| PCT/JP2022/005583 WO2022173033A1 (ja) | 2021-02-15 | 2022-02-14 | ４－アミノキナゾリン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2022173033A1 JPWO2022173033A1 (https=) | 2022-08-18 |
| JPWO2022173033A5 true JPWO2022173033A5 (https=) | 2024-02-08 |
| JP7725511B2 JP7725511B2 (ja) | 2025-08-19 |
Family
ID=82838845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022580703A Active JP7725511B2 (ja) | 2021-02-15 | 2022-02-14 | ４－アミノキナゾリン化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20240150366A1 (https=) |
| EP (1) | EP4293025B1 (https=) |
| JP (1) | JP7725511B2 (https=) |
| KR (1) | KR20230145360A (https=) |
| CN (1) | CN116867788A (https=) |
| AU (1) | AU2022219651A1 (https=) |
| CA (1) | CA3211110A1 (https=) |
| ES (1) | ES3054794T3 (https=) |
| MX (1) | MX2023009520A (https=) |
| PL (1) | PL4293025T3 (https=) |
| SA (1) | SA523450286B1 (https=) |
| WO (1) | WO2022173033A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2024008849A (es) | 2022-01-21 | 2024-07-25 | Usynova Pharmaceuticals Ltd | Compuestos de benzopirimidina y uso de estos. |
| AU2023231912A1 (en) * | 2022-03-11 | 2024-08-15 | Astellas Pharma Inc. | Heterocyclic compound for inducing degradation of g12d mutant kras protein |
| JP7733274B1 (ja) * | 2022-08-12 | 2025-09-02 | アステラス製薬株式会社 | Ｇ１２ｄ変異ｋｒａｓ阻害活性を有する二官能性化合物を含む抗がん剤の組合せ |
| AR130192A1 (es) * | 2022-08-12 | 2024-11-13 | Astellas Pharma Inc | Combinaciones antineoplásicas que comprenden quimioterapia |
| WO2024188281A1 (zh) * | 2023-03-13 | 2024-09-19 | 南京明德新药研发有限公司 | 含喹唑啉结构的化合物及其应用 |
| AU2024337913A1 (en) | 2023-09-08 | 2026-03-26 | Gilead Sciences, Inc. | Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds |
| WO2025052649A1 (ja) * | 2023-09-08 | 2025-03-13 | アステラス製薬株式会社 | 単一の軸不斉化合物の選択的製造法 |
| US20250114339A1 (en) | 2023-10-09 | 2025-04-10 | Incyte Corporation | Combination therapy comprising a kras g12d inhibitor and an egfr inhibitor |
| AU2024357850A1 (en) | 2023-10-09 | 2026-04-23 | Incyte Corporation | Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10011600B2 (en) | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
| WO2016049565A1 (en) | 2014-09-25 | 2016-03-31 | Araxes Pharma Llc | Compositions and methods for inhibition of ras |
| WO2017172979A1 (en) * | 2016-03-30 | 2017-10-05 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
| JOP20190186A1 (ar) * | 2017-02-02 | 2019-08-01 | Astellas Pharma Inc | مركب كينازولين |
| US20220363681A1 (en) * | 2019-08-16 | 2022-11-17 | Genfleet Therapeutics (Shanghai) Inc. | Oxo six-membered cyclopyrimidine compound, preparation method and medical use thereof |
| WO2021041671A1 (en) | 2019-08-29 | 2021-03-04 | Mirati Therapeutics, Inc. | Kras g12d inhibitors |
| WO2021106231A1 (en) | 2019-11-29 | 2021-06-03 | Taiho Pharmaceutical Co., Ltd. | A compound having inhibitory activity against kras g12d mutation |
-
2022
- 2022-02-14 AU AU2022219651A patent/AU2022219651A1/en active Pending
- 2022-02-14 US US18/546,330 patent/US20240150366A1/en active Pending
- 2022-02-14 WO PCT/JP2022/005583 patent/WO2022173033A1/ja not_active Ceased
- 2022-02-14 JP JP2022580703A patent/JP7725511B2/ja active Active
- 2022-02-14 KR KR1020237027664A patent/KR20230145360A/ko active Pending
- 2022-02-14 CN CN202280014859.0A patent/CN116867788A/zh active Pending
- 2022-02-14 ES ES22752855T patent/ES3054794T3/es active Active
- 2022-02-14 EP EP22752855.1A patent/EP4293025B1/en active Active
- 2022-02-14 PL PL22752855.1T patent/PL4293025T3/pl unknown
- 2022-02-14 MX MX2023009520A patent/MX2023009520A/es unknown
- 2022-02-14 CA CA3211110A patent/CA3211110A1/en active Pending
-
2023
- 2023-08-14 SA SA523450286A patent/SA523450286B1/ar unknown
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