JPWO2022173006A5 - - Google Patents
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- Publication number
- JPWO2022173006A5 JPWO2022173006A5 JP2022580687A JP2022580687A JPWO2022173006A5 JP WO2022173006 A5 JPWO2022173006 A5 JP WO2022173006A5 JP 2022580687 A JP2022580687 A JP 2022580687A JP 2022580687 A JP2022580687 A JP 2022580687A JP WO2022173006 A5 JPWO2022173006 A5 JP WO2022173006A5
- Authority
- JP
- Japan
- Prior art keywords
- cation
- acid
- group
- composition
- anion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001768 cations Chemical class 0.000 claims 8
- 150000001450 anions Chemical class 0.000 claims 6
- 239000004475 Arginine Substances 0.000 claims 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 5
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 5
- 229960003121 arginine Drugs 0.000 claims 5
- 229960003194 meglumine Drugs 0.000 claims 5
- 150000007524 organic acids Chemical class 0.000 claims 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims 3
- 229940043237 diethanolamine Drugs 0.000 claims 3
- 235000002906 tartaric acid Nutrition 0.000 claims 3
- 239000011975 tartaric acid Substances 0.000 claims 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 3
- 229960000281 trometamol Drugs 0.000 claims 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000002608 ionic liquid Substances 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
- 235000011044 succinic acid Nutrition 0.000 claims 1
- 229920003169 water-soluble polymer Polymers 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021021288 | 2021-02-12 | ||
| PCT/JP2022/005412 WO2022173006A1 (ja) | 2021-02-12 | 2022-02-10 | 難吸収性薬物の吸収性が改善された組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2022173006A1 JPWO2022173006A1 (https=) | 2022-08-18 |
| JPWO2022173006A5 true JPWO2022173006A5 (https=) | 2025-02-21 |
Family
ID=82838345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022580687A Pending JPWO2022173006A1 (https=) | 2021-02-12 | 2022-02-10 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240108578A1 (https=) |
| EP (1) | EP4292583A4 (https=) |
| JP (1) | JPWO2022173006A1 (https=) |
| CN (1) | CN116887815A (https=) |
| WO (1) | WO2022173006A1 (https=) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| US6743771B2 (en) * | 1995-12-29 | 2004-06-01 | Novactyl, Inc. | Methods and compositions for controlling protein assembly or aggregation |
| JP5117732B2 (ja) * | 2007-01-29 | 2013-01-16 | 株式会社 メドレックス | 外用剤用の低刺激性溶解助剤 |
| US20100029704A1 (en) * | 2007-01-29 | 2010-02-04 | Medrx Co., Ltd. | Salt of nonsteroidal anti-inflammatory drug and organic amine compound and use thereof |
| CN102046208B (zh) * | 2008-03-28 | 2014-07-02 | 安琪士摩奇株式会社 | 包含转录因子诱饵作为活性成分的用于外部应用的组合物 |
| JP5681883B2 (ja) * | 2009-03-27 | 2015-03-11 | 株式会社 メドレックス | 核酸を有効成分とする外用剤組成物 |
| CN102363633B (zh) * | 2011-11-16 | 2013-11-20 | 天津拓飞生物科技有限公司 | 胰高血糖素样肽-1突变体多肽及其制备方法、药物组合物和其应用 |
| HUE045479T2 (hu) * | 2012-06-20 | 2019-12-30 | Medrx Co Ltd | Tapadó preparátum készítmény, amely elõállítható gyógyszerhatóanyag, szerves oldószer, lipofil kenõcsalap és por összekeverésével |
| WO2014024896A1 (ja) * | 2012-08-08 | 2014-02-13 | 株式会社メドレックス | アゴメラチンを含有する貼付剤組成物 |
| JP5550056B2 (ja) * | 2012-09-05 | 2014-07-16 | 株式会社 メドレックス | 外用剤用の低刺激性溶解助剤 |
| JP5816881B2 (ja) * | 2014-05-21 | 2015-11-18 | 株式会社 メドレックス | 核酸を有効成分とする外用剤組成物 |
| US10475457B2 (en) | 2017-07-03 | 2019-11-12 | Qualcomm Incorporated | Time-domain inter-channel prediction |
| US11446253B2 (en) * | 2017-11-17 | 2022-09-20 | President And Fellows Of Harvard College | Ionic liquids for internal delivery |
| JP2020169246A (ja) * | 2019-04-02 | 2020-10-15 | 旭化成株式会社 | 高分子組成物 |
-
2022
- 2022-02-10 EP EP22752828.8A patent/EP4292583A4/en active Pending
- 2022-02-10 WO PCT/JP2022/005412 patent/WO2022173006A1/ja not_active Ceased
- 2022-02-10 US US18/276,937 patent/US20240108578A1/en active Pending
- 2022-02-10 CN CN202280014688.1A patent/CN116887815A/zh active Pending
- 2022-02-10 JP JP2022580687A patent/JPWO2022173006A1/ja active Pending
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