JPWO2022170280A5 - - Google Patents
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- JPWO2022170280A5 JPWO2022170280A5 JP2023547592A JP2023547592A JPWO2022170280A5 JP WO2022170280 A5 JPWO2022170280 A5 JP WO2022170280A5 JP 2023547592 A JP2023547592 A JP 2023547592A JP 2023547592 A JP2023547592 A JP 2023547592A JP WO2022170280 A5 JPWO2022170280 A5 JP WO2022170280A5
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- Prior art keywords
- seq
- variable region
- chain variable
- heavy chain
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- Prior art date
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- 102100024952 Protein CBFA2T1 Human genes 0.000 claims 50
- 239000000427 antigen Substances 0.000 claims 32
- 108091007433 antigens Proteins 0.000 claims 32
- 102000036639 antigens Human genes 0.000 claims 32
- 239000012634 fragment Substances 0.000 claims 24
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims 10
- 102100038081 Signal transducer CD24 Human genes 0.000 claims 10
- -1 CLTA-4 Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102100024263 CD160 antigen Human genes 0.000 claims 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- 102000001301 EGF receptor Human genes 0.000 claims 2
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- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 2
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims 2
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 2
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- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 2
- 102100030859 Tissue factor Human genes 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
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- 239000002157 polynucleotide Substances 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 1
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
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- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
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- 101710185679 CD276 antigen Proteins 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
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- 102100035139 Folate receptor alpha Human genes 0.000 claims 1
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- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
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- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 1
- 101001138062 Homo sapiens Leukocyte-associated immunoglobulin-like receptor 1 Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 1
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 1
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims 1
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- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 1
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 1
- 101000835984 Homo sapiens SLIT and NTRK-like protein 6 Proteins 0.000 claims 1
- 101000709472 Homo sapiens Sialic acid-binding Ig-like lectin 15 Proteins 0.000 claims 1
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 claims 1
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000795169 Homo sapiens Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 1
- 101001103033 Homo sapiens Tyrosine-protein kinase transmembrane receptor ROR2 Proteins 0.000 claims 1
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims 1
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 1
- 101000851030 Homo sapiens Vascular endothelial growth factor receptor 3 Proteins 0.000 claims 1
- 102000038455 IGF Type 1 Receptor Human genes 0.000 claims 1
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 1
- 102100039813 Inactive tyrosine-protein kinase 7 Human genes 0.000 claims 1
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 1
- 102100025390 Integrin beta-2 Human genes 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 102000003812 Interleukin-15 Human genes 0.000 claims 1
- 108090000172 Interleukin-15 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims 1
- 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 102100025583 Leukocyte immunoglobulin-like receptor subfamily B member 2 Human genes 0.000 claims 1
- 102100025578 Leukocyte immunoglobulin-like receptor subfamily B member 4 Human genes 0.000 claims 1
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 1
- 102100020943 Leukocyte-associated immunoglobulin-like receptor 1 Human genes 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 102100023123 Mucin-16 Human genes 0.000 claims 1
- 102000015728 Mucins Human genes 0.000 claims 1
- 108010063954 Mucins Proteins 0.000 claims 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 1
- 101100533516 Mus musculus Siglec10 gene Proteins 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 1
- 101710043865 Nectin-4 Proteins 0.000 claims 1
- 102100035486 Nectin-4 Human genes 0.000 claims 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 claims 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 claims 1
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 1
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
- 102100029198 SLAM family member 7 Human genes 0.000 claims 1
- 102100025504 SLIT and NTRK-like protein 6 Human genes 0.000 claims 1
- 102100027164 Sialic acid-binding Ig-like lectin 10 Human genes 0.000 claims 1
- 102100034361 Sialic acid-binding Ig-like lectin 15 Human genes 0.000 claims 1
- 102100027208 T-cell antigen CD7 Human genes 0.000 claims 1
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 1
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 1
- 101150117918 Tacstd2 gene Proteins 0.000 claims 1
- 108010033576 Transferrin Receptors Proteins 0.000 claims 1
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 1
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 1
- 102100027212 Tumor-associated calcium signal transducer 2 Human genes 0.000 claims 1
- 102100039616 Tyrosine-protein kinase transmembrane receptor ROR2 Human genes 0.000 claims 1
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 1
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 claims 1
- MXKCYTKUIDTFLY-ZNNSSXPHSA-N alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc-(1->3)-D-Galp Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](NC(C)=O)[C@H](O[C@H]3[C@H]([C@@H](CO)OC(O)[C@@H]3O)O)O[C@@H]2CO)O[C@H]2[C@H]([C@H](O)[C@H](O)[C@H](C)O2)O)O[C@H](CO)[C@H](O)[C@@H]1O MXKCYTKUIDTFLY-ZNNSSXPHSA-N 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 229940127276 delta-like ligand 3 Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 108010038795 estrogen receptors Proteins 0.000 claims 1
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
- 150000002270 gangliosides Chemical class 0.000 claims 1
- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2021/076075 | 2021-02-08 | ||
| CN2021076075 | 2021-02-08 | ||
| CN202210088172.3 | 2022-01-25 | ||
| CN202210088172 | 2022-01-25 | ||
| PCT/US2022/015711 WO2022170280A2 (en) | 2021-02-08 | 2022-02-08 | Novel anti-cd24 antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024508672A JP2024508672A (ja) | 2024-02-28 |
| JP2024508672A5 JP2024508672A5 (https=) | 2025-02-18 |
| JPWO2022170280A5 true JPWO2022170280A5 (https=) | 2025-02-18 |
Family
ID=82741874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023547592A Pending JP2024508672A (ja) | 2021-02-08 | 2022-02-08 | 新規抗ｃｄ２４抗体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20240052052A1 (https=) |
| EP (1) | EP4288099A4 (https=) |
| JP (1) | JP2024508672A (https=) |
| KR (1) | KR20230143177A (https=) |
| CN (1) | CN117412770A (https=) |
| AU (1) | AU2022217072A1 (https=) |
| CA (1) | CA3210934A1 (https=) |
| CO (1) | CO2023011463A2 (https=) |
| IL (1) | IL304898A (https=) |
| MX (1) | MX2023009238A (https=) |
| TW (1) | TW202241956A (https=) |
| WO (1) | WO2022170280A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024251257A1 (en) * | 2023-06-09 | 2024-12-12 | TJ Biopharma (Shanghai) Co., Ltd. | Anti-cd24 antibodies and uses thereof |
| GB202316777D0 (en) | 2023-11-01 | 2023-12-13 | Cambridge Entpr Ltd | New therapeutic use |
| WO2025101970A1 (en) * | 2023-11-08 | 2025-05-15 | Pheast Therapeutics, Inc. | Cd24 antibodies |
| WO2025128830A1 (en) * | 2023-12-12 | 2025-06-19 | The Methodist Hospital | Therapeutic lilrb regulation for treating neurological disorders |
| WO2025132836A1 (en) * | 2023-12-19 | 2025-06-26 | Pentixapharm Ag | Antibodies against cd24 |
| WO2025159754A1 (en) * | 2024-01-25 | 2025-07-31 | China Medical University | Therapeutic cd24 humanized monoclonal antibodies and anti-tumor translational use |
| WO2025218729A1 (en) * | 2024-04-17 | 2025-10-23 | TJ Biopharma (Shanghai) Co., Ltd. | Multifunctional molecules targeting cd24 |
| CN119161485B (zh) * | 2024-10-29 | 2026-03-24 | 上海中医药大学附属曙光医院 | 靶向GFRα3的抗体及其制备方法和在抗癌中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080002341A (ko) * | 2006-06-30 | 2008-01-04 | 재단법인서울대학교산학협력재단 | Ｃｄ２４를 표적으로 하는 암 억제방법 |
| WO2009063461A1 (en) * | 2007-11-14 | 2009-05-22 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | Methods of treating cancer using anti cd24 antibodies |
| ES3012974T3 (en) * | 2014-01-08 | 2025-04-10 | Univ Leland Stanford Junior | Targeted therapy for lung cancer |
| AU2015229448B2 (en) * | 2014-03-11 | 2020-09-03 | The Board Of Trustees Of The Leland Stanford Junior University | Anti SIRP-alpha antibodies and Bi-specific Macrophage Enhancing antibodies |
| AU2015254257B2 (en) * | 2014-04-28 | 2021-02-25 | Medicinal Chemistry Pharmaceuticals, Co., Ltd. | Anti-MUC1 antibody or antigen-binding fragment of same, and use thereof |
| US20170158753A1 (en) * | 2014-06-25 | 2017-06-08 | Integrated Biotherapeutics, Inc. | Monoclonal antibodies directed against envelope glycoproteins from multiple filovirus species |
| WO2019222082A1 (en) * | 2018-05-14 | 2019-11-21 | Oncoimmune, Inc. | Anti-cd24 compositions and uses thereof |
| KR20210143868A (ko) * | 2019-03-26 | 2021-11-29 | 포티 세븐, 인코포레이티드 | 암 치료용 다중특이성 제제 |
| BR112021026133A2 (pt) * | 2019-06-25 | 2022-02-08 | Ichilov Tech Ltd | Anticorpo anti-cd24 e usos do mesmo |
-
2022
- 2022-02-08 CN CN202280013601.9A patent/CN117412770A/zh active Pending
- 2022-02-08 CA CA3210934A patent/CA3210934A1/en active Pending
- 2022-02-08 TW TW111104626A patent/TW202241956A/zh unknown
- 2022-02-08 KR KR1020237030578A patent/KR20230143177A/ko active Pending
- 2022-02-08 EP EP22750598.9A patent/EP4288099A4/en active Pending
- 2022-02-08 US US18/264,436 patent/US20240052052A1/en active Pending
- 2022-02-08 AU AU2022217072A patent/AU2022217072A1/en active Pending
- 2022-02-08 JP JP2023547592A patent/JP2024508672A/ja active Pending
- 2022-02-08 IL IL304898A patent/IL304898A/en unknown
- 2022-02-08 WO PCT/US2022/015711 patent/WO2022170280A2/en not_active Ceased
- 2022-02-08 MX MX2023009238A patent/MX2023009238A/es unknown
-
2023
- 2023-08-29 CO CONC2023/0011463A patent/CO2023011463A2/es unknown
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