JPWO2022101469A5 - - Google Patents
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- JPWO2022101469A5 JPWO2022101469A5 JP2023528665A JP2023528665A JPWO2022101469A5 JP WO2022101469 A5 JPWO2022101469 A5 JP WO2022101469A5 JP 2023528665 A JP2023528665 A JP 2023528665A JP 2023528665 A JP2023528665 A JP 2023528665A JP WO2022101469 A5 JPWO2022101469 A5 JP WO2022101469A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- concentration
- lnps
- sodium chloride
- buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063114478P | 2020-11-16 | 2020-11-16 | |
| US63/114,478 | 2020-11-16 | ||
| US202063115588P | 2020-11-18 | 2020-11-18 | |
| US63/115,588 | 2020-11-18 | ||
| PCT/EP2021/081674 WO2022101469A1 (en) | 2020-11-16 | 2021-11-15 | Compositions and methods for stabilization of lipid nanoparticle mrna vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023549265A JP2023549265A (ja) | 2023-11-22 |
| JPWO2022101469A5 true JPWO2022101469A5 (https=) | 2024-11-22 |
| JP2023549265A5 JP2023549265A5 (https=) | 2026-04-27 |
Family
ID=78770624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023528665A Pending JP2023549265A (ja) | 2020-11-16 | 2021-11-15 | 脂質ナノ粒子ｍＲＮＡワクチンの安定化のための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240041785A1 (https=) |
| EP (1) | EP4243789A1 (https=) |
| JP (1) | JP2023549265A (https=) |
| KR (1) | KR20230109689A (https=) |
| AU (1) | AU2021380033A1 (https=) |
| CA (1) | CA3198311A1 (https=) |
| IL (1) | IL302770A (https=) |
| MX (1) | MX2023005697A (https=) |
| WO (1) | WO2022101469A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017020026A1 (en) | 2015-07-30 | 2017-02-02 | Modernatx, Inc. | Concatemeric peptide epitopes rnas |
| TW201729835A (zh) | 2015-10-22 | 2017-09-01 | 現代公司 | 呼吸道病毒疫苗 |
| WO2018089851A2 (en) | 2016-11-11 | 2018-05-17 | Modernatx, Inc. | Influenza vaccine |
| WO2018170245A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| WO2018187590A1 (en) | 2017-04-05 | 2018-10-11 | Modernatx, Inc. | Reduction or elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins |
| WO2019148101A1 (en) | 2018-01-29 | 2019-08-01 | Modernatx, Inc. | Rsv rna vaccines |
| EP3901261A1 (en) | 2020-04-22 | 2021-10-27 | BioNTech RNA Pharmaceuticals GmbH | Coronavirus vaccine |
| CZ310613B6 (cs) | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| WO2022232585A1 (en) * | 2021-04-29 | 2022-11-03 | Modernatx, Inc. | Lyophilization methods for preparing lipid formulated therapeutics |
| CZ310443B6 (cs) | 2021-07-19 | 2025-06-25 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití |
| US12186387B2 (en) | 2021-11-29 | 2025-01-07 | BioNTech SE | Coronavirus vaccine |
| WO2024002985A1 (en) | 2022-06-26 | 2024-01-04 | BioNTech SE | Coronavirus vaccine |
| WO2024081639A1 (en) * | 2022-10-11 | 2024-04-18 | Seawolf Therapeutics, Inc. | Novel lipid nanoparticle compositions for the delivery of nucleic acids |
| WO2024089634A1 (en) * | 2022-10-27 | 2024-05-02 | Pfizer Inc. | Immunogenic compositions against influenza and rsv |
| IL320459A (en) * | 2022-10-27 | 2025-06-01 | Pfizer | Rna molecules encoding rsv-f and vaccines containing them |
| JP2026500218A (ja) * | 2022-12-11 | 2026-01-06 | ファイザー・インク | インフルエンザおよびｒｓｖに対する免疫原性組成物 |
| CN116139108B (zh) * | 2023-04-23 | 2023-08-01 | 威瑞生物科技(昆明)有限责任公司 | 一种脂质递送系统及其所构成的类病毒结构疫苗 |
| KR20260022409A (ko) * | 2023-06-09 | 2026-02-19 | 리누아진 바이오테크놀로지 씨오., 엘티디. | 발현 조절이 가능한 엔지니어링된 rna 분자 |
| WO2025038371A1 (en) * | 2023-08-11 | 2025-02-20 | Purdue Research Foundation | Salt-loaded solid lipid nanoparticles loaded with an active agent |
| WO2025077899A1 (zh) * | 2023-10-13 | 2025-04-17 | 北京先声祥瑞生物制品股份有限公司 | 一种核酸药物冻干制剂及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX342785B (es) * | 2009-06-10 | 2016-10-12 | Alnylam Pharmaceuticals Inc | Formulacion mejorada de lipido. |
| WO2016005004A1 (en) | 2014-07-11 | 2016-01-14 | Biontech Rna Pharmaceuticals Gmbh | Stabilization of poly(a) sequence encoding dna sequences |
| IL307179A (en) * | 2015-10-28 | 2023-11-01 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| WO2017218704A1 (en) * | 2016-06-14 | 2017-12-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| BR112019008481A2 (pt) * | 2016-10-26 | 2020-03-03 | Curevac Ag | Vacinas de mrna de nanopartículas lipídicas |
| WO2020072605A1 (en) * | 2018-10-02 | 2020-04-09 | Intellia Therapeutics, Inc. | Ionizable amine lipids |
| JP2023511633A (ja) * | 2020-01-28 | 2023-03-20 | モデルナティエックス インコーポレイテッド | コロナウイルスｒｎａワクチン |
-
2021
- 2021-11-14 US US18/036,679 patent/US20240041785A1/en active Pending
- 2021-11-15 MX MX2023005697A patent/MX2023005697A/es unknown
- 2021-11-15 WO PCT/EP2021/081674 patent/WO2022101469A1/en not_active Ceased
- 2021-11-15 AU AU2021380033A patent/AU2021380033A1/en active Pending
- 2021-11-15 JP JP2023528665A patent/JP2023549265A/ja active Pending
- 2021-11-15 IL IL302770A patent/IL302770A/en unknown
- 2021-11-15 KR KR1020237020260A patent/KR20230109689A/ko active Pending
- 2021-11-15 CA CA3198311A patent/CA3198311A1/en active Pending
- 2021-11-15 EP EP21814751.0A patent/EP4243789A1/en active Pending
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