JPWO2022046809A5 - - Google Patents

Info

Publication number

JPWO2022046809A5

JPWO2022046809A5 JP2023513299A JP2023513299A JPWO2022046809A5 JP WO2022046809 A5 JPWO2022046809 A5 JP WO2022046809A5 JP 2023513299 A JP2023513299 A JP 2023513299A JP 2023513299 A JP2023513299 A JP 2023513299A JP WO2022046809 A5 JPWO2022046809 A5 JP WO2022046809A5

Authority

JP

Japan

Prior art keywords

seq

sequence

feline

fusion protein

raav vector

Prior art date

2024-09-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 241000282324 Felis Species 0.000 claims 15
• 239000013608 rAAV vector Substances 0.000 claims 13
• 108020001507 fusion proteins Proteins 0.000 claims 11
• 102000037865 fusion proteins Human genes 0.000 claims 11
• 150000001413 amino acids Chemical group 0.000 claims 6
• 238000006467 substitution reaction Methods 0.000 claims 6
• 229940089838 Glucagon-like peptide 1 receptor agonist Drugs 0.000 claims 5
• 108090000190 Thrombin Proteins 0.000 claims 5
• 229960004072 thrombin Drugs 0.000 claims 5
• 241000702421 Dependoparvovirus Species 0.000 claims 4
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
• 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 claims 4
• 101800004266 Glucagon-like peptide 1(7-37) Proteins 0.000 claims 3
• 230000004927 fusion Effects 0.000 claims 3
• 102000040430 polynucleotide Human genes 0.000 claims 3
• 108091033319 polynucleotide Proteins 0.000 claims 3
• 239000002157 polynucleotide Substances 0.000 claims 3
• 229920001184 polypeptide Polymers 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 239000013598 vector Substances 0.000 claims 3
• 102000009027 Albumins Human genes 0.000 claims 2
• 108010088751 Albumins Proteins 0.000 claims 2
• 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 claims 2
• 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims 2
• 102400000324 Glucagon-like peptide 1(7-37) Human genes 0.000 claims 2
• 210000000234 capsid Anatomy 0.000 claims 2
• 230000001105 regulatory effect Effects 0.000 claims 2
• 230000003248 secreting effect Effects 0.000 claims 2
• 241001164825 Adeno-associated virus - 8 Species 0.000 claims 1
• 241000958487 Adeno-associated virus 3B Species 0.000 claims 1
• 108010002350 Interleukin-2 Proteins 0.000 claims 1
• 230000037396 body weight Effects 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 208000016097 disease of metabolism Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000037431 insertion Effects 0.000 claims 1
• 238000003780 insertion Methods 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims 1