JPWO2022040798A5 - - Google Patents
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- JPWO2022040798A5 JPWO2022040798A5 JP2023513088A JP2023513088A JPWO2022040798A5 JP WO2022040798 A5 JPWO2022040798 A5 JP WO2022040798A5 JP 2023513088 A JP2023513088 A JP 2023513088A JP 2023513088 A JP2023513088 A JP 2023513088A JP WO2022040798 A5 JPWO2022040798 A5 JP WO2022040798A5
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- JP
- Japan
- Prior art keywords
- cells
- composition
- isolated
- optionally
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims 29
- 210000004027 cell Anatomy 0.000 claims 27
- 210000003716 mesoderm Anatomy 0.000 claims 13
- 239000000018 receptor agonist Substances 0.000 claims 11
- 229940044601 receptor agonist Drugs 0.000 claims 11
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 10
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 10
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 10
- 239000000654 additive Substances 0.000 claims 8
- 230000000996 additive effect Effects 0.000 claims 8
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims 7
- 102100039564 Leukosialin Human genes 0.000 claims 7
- 239000000556 agonist Substances 0.000 claims 7
- 210000003566 hemangioblast Anatomy 0.000 claims 7
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 7
- 238000012258 culturing Methods 0.000 claims 6
- 102000018918 Activin Receptors Human genes 0.000 claims 5
- 108010052946 Activin Receptors Proteins 0.000 claims 5
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 5
- 108091008794 FGF receptors Proteins 0.000 claims 5
- 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 claims 5
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 5
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 5
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 5
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 5
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 108010023082 activin A Proteins 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 102100035716 Glycophorin-A Human genes 0.000 claims 3
- 101001074244 Homo sapiens Glycophorin-A Proteins 0.000 claims 3
- 210000002242 embryoid body Anatomy 0.000 claims 3
- 210000003630 histaminocyte Anatomy 0.000 claims 3
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 210000002540 macrophage Anatomy 0.000 claims 3
- 239000011435 rock Substances 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 2
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 230000003394 haemopoietic effect Effects 0.000 claims 2
- 102000001893 Bone Morphogenetic Protein Receptors Human genes 0.000 claims 1
- 108010040422 Bone Morphogenetic Protein Receptors Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 239000007640 basal medium Substances 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 210000004413 cardiac myocyte Anatomy 0.000 claims 1
- 230000001143 conditioned effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 210000000267 erythroid cell Anatomy 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000001704 mesoblast Anatomy 0.000 claims 1
- 210000002996 primitive erythroblast Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063069904P | 2020-08-25 | 2020-08-25 | |
| US63/069,904 | 2020-08-25 | ||
| PCT/CA2021/051181 WO2022040798A1 (en) | 2020-08-25 | 2021-08-25 | Compositions and methods for generating human yolk sac-like hematopoietic cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023540212A JP2023540212A (ja) | 2023-09-22 |
| JPWO2022040798A5 true JPWO2022040798A5 (https=) | 2024-08-30 |
| JP2023540212A5 JP2023540212A5 (https=) | 2024-08-30 |
Family
ID=80354070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023513088A Pending JP2023540212A (ja) | 2020-08-25 | 2021-08-25 | ヒト卵黄嚢様造血細胞を生成するための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230374458A1 (https=) |
| EP (1) | EP4204544A4 (https=) |
| JP (1) | JP2023540212A (https=) |
| CA (1) | CA3190402A1 (https=) |
| WO (1) | WO2022040798A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202022002866U1 (de) | 2021-04-01 | 2024-03-20 | The Regents Of The University Of California | Genetische Modifikation von Säugetierzellen zur Verleihung von Resistenz gegen CSF1R-Antagonisten |
| US20260108560A1 (en) * | 2022-07-13 | 2026-04-23 | The Regents Of The University Of California | Transplanting stem cell-derived microglia to treat leukodystrophies |
| WO2024107010A1 (ko) * | 2022-11-17 | 2024-05-23 | 주식회사 씨티셀즈 | 미분화 줄기세포로부터 자연 살해 세포로의 분화 방법 및 이의 용도 |
| AU2023415203A1 (en) * | 2022-12-28 | 2025-08-07 | National University Corporation Chiba University | Method for regulating degree of cell differentiation |
| WO2024216379A1 (en) * | 2023-04-18 | 2024-10-24 | University Health Network | Use of macrophages for improved pancreatic cells |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6677631B2 (ja) * | 2013-03-13 | 2020-04-08 | ウイスコンシン アラムナイ リサーチ ファウンデーシヨンＷｉｓｃｏｎｓｉｎ Ａｌｕｍｎｉ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 定義された条件下におけるヒト多能性幹細胞の造血内皮分化のための方法及び材料 |
| WO2018031404A1 (en) * | 2016-08-10 | 2018-02-15 | Indiana University Research And Technology Corporation | Method for generating mesoderm and/or endothelial colony forming cell-like cells having in vivo blood vessel forming capacity |
-
2021
- 2021-08-25 EP EP21859460.4A patent/EP4204544A4/en active Pending
- 2021-08-25 JP JP2023513088A patent/JP2023540212A/ja active Pending
- 2021-08-25 US US18/023,289 patent/US20230374458A1/en active Pending
- 2021-08-25 WO PCT/CA2021/051181 patent/WO2022040798A1/en not_active Ceased
- 2021-08-25 CA CA3190402A patent/CA3190402A1/en active Pending
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