JPWO2022011457A5 - - Google Patents
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- Publication number
- JPWO2022011457A5 JPWO2022011457A5 JP2023502801A JP2023502801A JPWO2022011457A5 JP WO2022011457 A5 JPWO2022011457 A5 JP WO2022011457A5 JP 2023502801 A JP2023502801 A JP 2023502801A JP 2023502801 A JP2023502801 A JP 2023502801A JP WO2022011457 A5 JPWO2022011457 A5 JP WO2022011457A5
- Authority
- JP
- Japan
- Prior art keywords
- gene segments
- camel
- human
- human animal
- transgenic non
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063051180P | 2020-07-13 | 2020-07-13 | |
| US63/051,180 | 2020-07-13 | ||
| US202063076096P | 2020-09-09 | 2020-09-09 | |
| US63/076,096 | 2020-09-09 | ||
| PCT/CA2021/050951 WO2022011457A1 (en) | 2020-07-13 | 2021-07-12 | Transgenic animals expressing heavy chain antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023535345A JP2023535345A (ja) | 2023-08-17 |
| JPWO2022011457A5 true JPWO2022011457A5 (https=) | 2024-07-24 |
| JP2023535345A5 JP2023535345A5 (https=) | 2024-07-24 |
Family
ID=79555903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023502801A Pending JP2023535345A (ja) | 2020-07-13 | 2021-07-12 | 重鎖抗体を発現するトランスジェニック動物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230270086A1 (https=) |
| EP (1) | EP4179095A4 (https=) |
| JP (1) | JP2023535345A (https=) |
| CN (1) | CN116193985A (https=) |
| CA (1) | CA3171186A1 (https=) |
| TW (1) | TWI908828B (https=) |
| WO (1) | WO2022011457A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025245358A1 (en) * | 2024-05-22 | 2025-11-27 | New York University | Genetically modified non-human animals producing heavy chain-only antibodies and methods of use |
| WO2025245494A1 (en) | 2024-05-24 | 2025-11-27 | Regeneron Pharmaceuticals, Inc. | Tumor-targeted split il12 receptor agonists |
| US20250376524A1 (en) | 2024-06-07 | 2025-12-11 | Regeneron Pharmaceuticals, Inc. | Tetravalent multispecific binding molecules and methods of use thereof |
| WO2025255452A2 (en) | 2024-06-07 | 2025-12-11 | Regeneron Pharmaceuticals, Inc. | Antigen-binding molecules that bind to aav particles and uses thereof |
| WO2026039791A1 (en) | 2024-08-16 | 2026-02-19 | Regeneron Pharmaceuticals, Inc. | Tumor-targeted split il2 receptor agonists |
| WO2026076013A1 (en) | 2024-10-01 | 2026-04-09 | Regeneron Pharmaceuticals, Inc. | Tumor-targeted il2 receptor agonists and multispecific t-cell engagers |
| WO2026075989A1 (en) | 2024-10-01 | 2026-04-09 | Regeneron Pharmaceuticals, Inc. | Engineered igg molecules and methods of use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0110029D0 (en) * | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| SI2311874T1 (sl) * | 2004-07-22 | 2017-12-29 | Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics | Vezavne molekule |
| TWI404727B (zh) * | 2006-01-25 | 2013-08-11 | 荷蘭鹿特丹Ｅｒａｓｍｕｓ大學醫學中心 | 對偶基因排除 |
| US8754287B2 (en) * | 2009-12-10 | 2014-06-17 | Regeneron Pharmaceuticals, Inc. | Mice that make heavy chain antibodies |
| RU2664181C2 (ru) * | 2011-12-20 | 2018-08-15 | Регенерон Фармасьютикалз, Инк. | Мыши с гуманизированной легкой цепью |
| KR102276752B1 (ko) * | 2014-03-21 | 2021-07-13 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
| WO2018144097A1 (en) * | 2016-11-04 | 2018-08-09 | Akeagen Llc | Genetically modified non-human animals and methods for producing heavy chain-only antibodies |
| EP3332637A1 (en) * | 2016-12-09 | 2018-06-13 | Universitätsklinikum Hamburg-Eppendorf | Vhh-containing heavy chain antibody and production thereof |
| CA3102122A1 (en) * | 2018-06-13 | 2019-12-19 | Crystal Bioscience Inc. | Transgenic chicken with functionally deleted igy ch1 coding sequence |
| CA3204101A1 (en) * | 2020-12-09 | 2022-06-16 | Trianni, Inc. | Heavy chain-only antibodies |
-
2021
- 2021-07-12 US US18/015,304 patent/US20230270086A1/en active Pending
- 2021-07-12 CN CN202180060845.8A patent/CN116193985A/zh active Pending
- 2021-07-12 JP JP2023502801A patent/JP2023535345A/ja active Pending
- 2021-07-12 CA CA3171186A patent/CA3171186A1/en active Pending
- 2021-07-12 EP EP21843204.5A patent/EP4179095A4/en active Pending
- 2021-07-12 WO PCT/CA2021/050951 patent/WO2022011457A1/en not_active Ceased
- 2021-07-13 TW TW110125742A patent/TWI908828B/zh active
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