JPWO2021257262A5 - - Google Patents
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- Publication number
- JPWO2021257262A5 JPWO2021257262A5 JP2022578631A JP2022578631A JPWO2021257262A5 JP WO2021257262 A5 JPWO2021257262 A5 JP WO2021257262A5 JP 2022578631 A JP2022578631 A JP 2022578631A JP 2022578631 A JP2022578631 A JP 2022578631A JP WO2021257262 A5 JPWO2021257262 A5 JP WO2021257262A5
- Authority
- JP
- Japan
- Prior art keywords
- polyplex
- substituted
- amine
- unsubstituted
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000642 polymer Polymers 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 229920001477 hydrophilic polymer Polymers 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims 6
- 150000003512 tertiary amines Chemical group 0.000 claims 6
- -1 e.g. Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- FKUPPRZPSYCDRS-UHFFFAOYSA-N Cyclopentadecanolide Chemical compound O=C1CCCCCCCCCCCCCCO1 FKUPPRZPSYCDRS-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 150000005829 chemical entities Chemical class 0.000 claims 2
- 150000005690 diesters Chemical class 0.000 claims 2
- 150000002596 lactones Chemical class 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- CRVGTESFCCXCTH-UHFFFAOYSA-N methyl diethanolamine Chemical compound OCCN(C)CCO CRVGTESFCCXCTH-UHFFFAOYSA-N 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 229940089513 pentadecalactone Drugs 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 claims 2
- 125000003860 C1-C20 alkoxy group Chemical group 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000002676 chrysenyl group Chemical group C1(=CC=CC=2C3=CC=C4C=CC=CC4=C3C=CC12)* 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000005227 gel permeation chromatography Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005561 phenanthryl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 125000001725 pyrenyl group Chemical group 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
- 125000005023 xylyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063041739P | 2020-06-19 | 2020-06-19 | |
| US63/041,739 | 2020-06-19 | ||
| PCT/US2021/034462 WO2021257262A1 (fr) | 2020-06-19 | 2021-05-27 | Polymères de poly(amine-co-ester) présentant des groupes terminaux modifiés et administration pulmonaire améliorée |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023531444A JP2023531444A (ja) | 2023-07-24 |
| JPWO2021257262A5 true JPWO2021257262A5 (fr) | 2024-06-04 |
Family
ID=76859713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022578631A Pending JP2023531444A (ja) | 2020-06-19 | 2021-05-27 | 改変された末端基および増強された肺送達を有するポリ（アミン－ｃｏ－エステル）ポリマー |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230233693A1 (fr) |
| EP (1) | EP4168471A1 (fr) |
| JP (1) | JP2023531444A (fr) |
| KR (1) | KR20230042018A (fr) |
| CN (1) | CN116157444A (fr) |
| AU (1) | AU2021293780A1 (fr) |
| BR (1) | BR112022025855A2 (fr) |
| CA (1) | CA3183351A1 (fr) |
| MX (1) | MX2022016581A (fr) |
| WO (1) | WO2021257262A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11814464B2 (en) | 2019-04-29 | 2023-11-14 | Yale University | Poly(amine-co-ester) polymers and polyplexes with modified end groups and methods of use thereof |
| CA3240179A1 (fr) * | 2021-12-08 | 2023-06-15 | Alexandra Piotrowski-Daspit | Conjugaison de surface a des nanoparticules de poly(amine-co-ester) destinees a cibler des cellules et des tissus |
| WO2023159189A1 (fr) * | 2022-02-18 | 2023-08-24 | Yale University | Polymères de poly(amine-co-ester) ramifiés pour une expression nucléique plus efficace |
| CN114874422B (zh) * | 2022-06-16 | 2023-05-12 | 上海云沂生物医药科技有限公司 | 一种聚烷基胺、其合成方法、颗粒及用途 |
| EP4324485A1 (fr) * | 2022-08-15 | 2024-02-21 | Branca Banus Ltd | Procédé de production de poly( -amino esters) pégylés hyperramifiés, poly( -amino esters) pégylés hyperramifiés produits selon ces procédés et leur utilisation dans l'administration améliorée d'acide nucléique |
| WO2024103225A1 (fr) * | 2022-11-14 | 2024-05-23 | 林桂孜 | Polyester cationique, son procédé de préparation et son utilisation |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| AU5661386A (en) | 1985-03-15 | 1986-10-13 | Stirchak, E. | Stereoregular polynucleotide-binding polymers |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| GB9126677D0 (en) | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| GB9400411D0 (en) | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
| US5786571A (en) | 1997-05-09 | 1998-07-28 | Lexmark International, Inc. | Wrapped temperature sensing assembly |
| EP1305299A1 (fr) | 2000-08-02 | 2003-05-02 | SLIL Biomedical Corporation | Composes de polyamine cyclique pour la cancerotherapie |
| DK2813582T3 (en) | 2000-12-01 | 2017-07-31 | Max-Planck-Gesellschaft Zur Förderung Der Wss E V | Small RNA molecules that mediate RNA interference |
| WO2009114614A2 (fr) | 2008-03-11 | 2009-09-17 | Yale University | Compositions et procédés pour une administration contrôlée d'acides ribonucléiques inhibiteurs |
| US10465042B2 (en) | 2011-12-02 | 2019-11-05 | Yale University | Poly(amine-co-ester) nanoparticles and methods of use thereof |
| WO2013082529A1 (fr) | 2011-12-02 | 2013-06-06 | Yale University | Synthèse enzymatique de poly(amine-co-esters) et ses méthodes d'utilisation pour une libération de gènes |
| US9895451B2 (en) | 2011-12-02 | 2018-02-20 | Yale University | Formulations for targeted release of agents to low pH tissue environments or cellular compartments and methods of use thereof |
| US9272043B2 (en) | 2011-12-02 | 2016-03-01 | Yale University | Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery |
| WO2017151623A1 (fr) | 2016-03-01 | 2017-09-08 | Alexion Pharmaceuticals, Inc. | Polymères activés biodégradables pour administration thérapeutique |
| WO2017197128A1 (fr) | 2016-05-11 | 2017-11-16 | Yale University | Nanoparticules de poly(amine-co-ester) et leurs procédés d'utilisation |
-
2021
- 2021-05-27 MX MX2022016581A patent/MX2022016581A/es unknown
- 2021-05-27 CN CN202180059736.4A patent/CN116157444A/zh active Pending
- 2021-05-27 US US18/002,241 patent/US20230233693A1/en active Pending
- 2021-05-27 AU AU2021293780A patent/AU2021293780A1/en active Pending
- 2021-05-27 EP EP21740287.4A patent/EP4168471A1/fr active Pending
- 2021-05-27 KR KR1020237002394A patent/KR20230042018A/ko active Search and Examination
- 2021-05-27 BR BR112022025855A patent/BR112022025855A2/pt unknown
- 2021-05-27 CA CA3183351A patent/CA3183351A1/fr active Pending
- 2021-05-27 WO PCT/US2021/034462 patent/WO2021257262A1/fr unknown
- 2021-05-27 JP JP2022578631A patent/JP2023531444A/ja active Pending
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