JPWO2021224261A5 - - Google Patents
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- Publication number
- JPWO2021224261A5 JPWO2021224261A5 JP2022567414A JP2022567414A JPWO2021224261A5 JP WO2021224261 A5 JPWO2021224261 A5 JP WO2021224261A5 JP 2022567414 A JP2022567414 A JP 2022567414A JP 2022567414 A JP2022567414 A JP 2022567414A JP WO2021224261 A5 JPWO2021224261 A5 JP WO2021224261A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain
- specific binding
- amino acid
- binding molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000009870 specific binding Effects 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 12
- 230000035772 mutation Effects 0.000 claims 8
- 230000004927 fusion Effects 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 5
- 230000027455 binding Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 108700026244 Open Reading Frames Proteins 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102220573536 C-C motif chemokine 5_T31A_mutation Human genes 0.000 claims 1
- 102220546739 Coiled-coil domain-containing protein 24_Y95V_mutation Human genes 0.000 claims 1
- 102220553651 Cyclic GMP-AMP synthase_S98D_mutation Human genes 0.000 claims 1
- 101000662909 Homo sapiens T cell receptor beta constant 1 Proteins 0.000 claims 1
- 101000662902 Homo sapiens T cell receptor beta constant 2 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100037272 T cell receptor beta constant 1 Human genes 0.000 claims 1
- 102100037298 T cell receptor beta constant 2 Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102220368314 c.295G>A Human genes 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102200012577 rs111033648 Human genes 0.000 claims 1
- 102200156911 rs121964886 Human genes 0.000 claims 1
- 102220319450 rs1554378297 Human genes 0.000 claims 1
- 102220040213 rs587778234 Human genes 0.000 claims 1
- 102220032019 rs72554317 Human genes 0.000 claims 1
- 102200115849 rs79977247 Human genes 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2006629.6A GB202006629D0 (en) | 2020-05-05 | 2020-05-05 | Specific binding molecules |
| GB2006629.6 | 2020-05-05 | ||
| PCT/EP2021/061731 WO2021224261A1 (fr) | 2020-05-05 | 2021-05-04 | Tor solubles et fusions à kras de reconnaissance anti-cd3 g12d permettant le traitement du cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023524788A JP2023524788A (ja) | 2023-06-13 |
| JPWO2021224261A5 true JPWO2021224261A5 (fr) | 2024-01-30 |
Family
ID=71080372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022567414A Pending JP2023524788A (ja) | 2020-05-05 | 2021-05-04 | 特異的結合性分子 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230348595A1 (fr) |
| EP (1) | EP4146257A1 (fr) |
| JP (1) | JP2023524788A (fr) |
| CN (1) | CN115867310A (fr) |
| AU (1) | AU2021267361A1 (fr) |
| CA (1) | CA3181362A1 (fr) |
| GB (1) | GB202006629D0 (fr) |
| WO (1) | WO2021224261A1 (fr) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6685698A (en) | 1997-03-07 | 1998-09-22 | Sunol Molecular Corporation | Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor |
| WO1999018129A1 (fr) | 1997-10-02 | 1999-04-15 | Sunol Molecular Corporation | Proteines solubles du recepteur des lymphocytes t a chaine unique |
| EP2287185A3 (fr) | 1999-12-06 | 2012-10-10 | Board Of Trustees Of The University Of Illinois | Protéines TCR haute affinité et procédés |
| EP1259601A2 (fr) | 2000-02-22 | 2002-11-27 | Ahuva Nissim | Banques d'affichage de phages chimeriques et tcr, reactifs chimeriques et tcr et methodes d'utilisation correspondantes |
| AU2002321581C1 (en) | 2001-08-31 | 2008-09-18 | Adaptimmune Limited | Soluble T cell receptor |
| AU2003271904B2 (en) | 2002-10-09 | 2009-03-05 | Adaptimmune Limited | Single chain recombinant T cell receptors |
| CA2505558C (fr) | 2002-11-09 | 2013-07-02 | Avidex Limited | Presentation de recepteurs pour l'antigene des lymphocytes t |
| GB0908613D0 (en) | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
| GB201223172D0 (en) | 2012-12-21 | 2013-02-06 | Immunocore Ltd | Method |
| CA3025894A1 (fr) | 2016-06-02 | 2017-12-07 | Immunocore Limited | Schema de traitement pour proteine de fusion scfv tcr-anti-cd3 gp100 specifique |
| DK3428194T3 (da) | 2017-07-14 | 2021-11-15 | Immatics Biotechnologies Gmbh | Forbedret polypeptidmolekyle med dobbelt specificitet |
-
2020
- 2020-05-05 GB GBGB2006629.6A patent/GB202006629D0/en not_active Ceased
-
2021
- 2021-05-04 CN CN202180042266.0A patent/CN115867310A/zh active Pending
- 2021-05-04 CA CA3181362A patent/CA3181362A1/fr active Pending
- 2021-05-04 US US17/998,032 patent/US20230348595A1/en active Pending
- 2021-05-04 EP EP21723720.5A patent/EP4146257A1/fr active Pending
- 2021-05-04 AU AU2021267361A patent/AU2021267361A1/en active Pending
- 2021-05-04 JP JP2022567414A patent/JP2023524788A/ja active Pending
- 2021-05-04 WO PCT/EP2021/061731 patent/WO2021224261A1/fr unknown
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