JPWO2021216891A5 - - Google Patents

Info

Publication number

JPWO2021216891A5

JPWO2021216891A5 JP2023509461A JP2023509461A JPWO2021216891A5 JP WO2021216891 A5 JPWO2021216891 A5 JP WO2021216891A5 JP 2023509461 A JP2023509461 A JP 2023509461A JP 2023509461 A JP2023509461 A JP 2023509461A JP WO2021216891 A5 JPWO2021216891 A5 JP WO2021216891A5

Authority

JP

Japan

Prior art keywords

seq

peptide

fusion inhibitor

amino acid

acid sequence

Prior art date

2024-05-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 28
• 229940125777 fusion inhibitor Drugs 0.000 claims description 22
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 20
• 150000002632 lipids Chemical class 0.000 claims description 19
• 239000008194 pharmaceutical composition Substances 0.000 claims description 19
• 125000006850 spacer group Chemical group 0.000 claims description 15
• 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 claims description 12
• 235000012000 cholesterol Nutrition 0.000 claims description 10
• 239000002202 Polyethylene glycol Substances 0.000 claims description 9
• 229920001223 polyethylene glycol Polymers 0.000 claims description 9
• GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
• IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims description 8
• 229960001295 tocopherol Drugs 0.000 claims description 8
• 229930003799 tocopherol Natural products 0.000 claims description 8
• 235000010384 tocopherol Nutrition 0.000 claims description 8
• 239000011732 tocopherol Substances 0.000 claims description 8
• GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 8
• 208000025721 COVID-19 Diseases 0.000 claims description 6
• 210000002345 respiratory system Anatomy 0.000 claims description 3
• 239000007923 nasal drop Substances 0.000 claims description 2
• 239000007922 nasal spray Substances 0.000 claims description 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 14
• 230000002265 prevention Effects 0.000 claims 2
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 230000000840 anti-viral effect Effects 0.000 description 10
• 230000004927 fusion Effects 0.000 description 4
• 239000000203 mixture Substances 0.000 description 4
• 239000000546 pharmaceutical excipient Substances 0.000 description 4
• 239000000654 additive Substances 0.000 description 3
• 230000000996 additive effect Effects 0.000 description 3
• 108010088468 Ebola virus envelope glycoprotein Proteins 0.000 description 2
• 210000000170 cell membrane Anatomy 0.000 description 2
• 239000003112 inhibitor Substances 0.000 description 2
• 230000000149 penetrating effect Effects 0.000 description 2
• VZQHRKZCAZCACO-PYJNHQTQSA-N (2s)-2-[[(2s)-2-[2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]prop-2-enoylamino]-3-methylbutanoyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCNC(N)=N VZQHRKZCAZCACO-PYJNHQTQSA-N 0.000 description 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 description 1
• 101710176384 Peptide 1 Proteins 0.000 description 1