JPWO2021195536A5 - - Google Patents
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- JPWO2021195536A5 JPWO2021195536A5 JP2022558042A JP2022558042A JPWO2021195536A5 JP WO2021195536 A5 JPWO2021195536 A5 JP WO2021195536A5 JP 2022558042 A JP2022558042 A JP 2022558042A JP 2022558042 A JP2022558042 A JP 2022558042A JP WO2021195536 A5 JPWO2021195536 A5 JP WO2021195536A5
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- 239000000427 antigen Substances 0.000 claims description 47
- 102000036639 antigens Human genes 0.000 claims description 47
- 108091007433 antigens Proteins 0.000 claims description 47
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 38
- 108090000623 proteins and genes Proteins 0.000 claims description 33
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 27
- 210000004027 cell Anatomy 0.000 claims description 27
- 102000004169 proteins and genes Human genes 0.000 claims description 27
- 208000034578 Multiple myelomas Diseases 0.000 claims description 25
- 229920001184 polypeptide Polymers 0.000 claims description 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 22
- 239000012634 fragment Substances 0.000 claims description 20
- 102000005962 receptors Human genes 0.000 claims description 14
- 108020003175 receptors Proteins 0.000 claims description 14
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 12
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 claims description 11
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 claims description 11
- 101001003142 Homo sapiens Interleukin-12 receptor subunit beta-1 Proteins 0.000 claims description 11
- 101000984186 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 4 Proteins 0.000 claims description 11
- 101000633786 Homo sapiens SLAM family member 6 Proteins 0.000 claims description 11
- 102100020790 Interleukin-12 receptor subunit beta-1 Human genes 0.000 claims description 11
- 102100025578 Leukocyte immunoglobulin-like receptor subfamily B member 4 Human genes 0.000 claims description 11
- 102100029197 SLAM family member 6 Human genes 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 10
- 102100031512 Fc receptor-like protein 3 Human genes 0.000 claims description 9
- 101000846910 Homo sapiens Fc receptor-like protein 3 Proteins 0.000 claims description 9
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 claims description 9
- 101001001420 Homo sapiens Interferon gamma receptor 1 Proteins 0.000 claims description 9
- 101000650820 Homo sapiens Semaphorin-4A Proteins 0.000 claims description 9
- 101000965705 Homo sapiens Volume-regulated anion channel subunit LRRC8D Proteins 0.000 claims description 9
- 102100032818 Integrin alpha-4 Human genes 0.000 claims description 9
- 102100035678 Interferon gamma receptor 1 Human genes 0.000 claims description 9
- 102100027718 Semaphorin-4A Human genes 0.000 claims description 9
- 102100040987 Volume-regulated anion channel subunit LRRC8D Human genes 0.000 claims description 9
- 108091008874 T cell receptors Proteins 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 210000002865 immune cell Anatomy 0.000 claims description 5
- 108010083359 Antigen Receptors Proteins 0.000 claims description 4
- 102000006306 Antigen Receptors Human genes 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 4
- 210000002540 macrophage Anatomy 0.000 claims description 4
- 210000000066 myeloid cell Anatomy 0.000 claims description 4
- 210000000822 natural killer cell Anatomy 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 102100026423 Adhesion G protein-coupled receptor E5 Human genes 0.000 claims description 2
- 102100027207 CD27 antigen Human genes 0.000 claims description 2
- 102100032937 CD40 ligand Human genes 0.000 claims description 2
- 101000718243 Homo sapiens Adhesion G protein-coupled receptor E5 Proteins 0.000 claims description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 2
- 101000868215 Homo sapiens CD40 ligand Proteins 0.000 claims description 2
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims description 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 2
- 102000018697 Membrane Proteins Human genes 0.000 claims description 2
- 108010052285 Membrane Proteins Proteins 0.000 claims description 2
- 108010092262 T-Cell Antigen Receptors Proteins 0.000 claims description 2
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims description 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
- 239000002254 cytotoxic agent Substances 0.000 claims description 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 2
- 210000000936 intestine Anatomy 0.000 claims description 2
- 230000004068 intracellular signaling Effects 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 210000000265 leukocyte Anatomy 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 210000004698 lymphocyte Anatomy 0.000 claims description 2
- 238000004949 mass spectrometry Methods 0.000 claims description 2
- 108020004999 messenger RNA Proteins 0.000 claims description 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 2
- 210000000581 natural killer T-cell Anatomy 0.000 claims description 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 2
- 210000003289 regulatory T cell Anatomy 0.000 claims description 2
- 230000011664 signaling Effects 0.000 claims description 2
- 210000000278 spinal cord Anatomy 0.000 claims description 2
- 101000980827 Homo sapiens T-cell surface glycoprotein CD1a Proteins 0.000 claims 1
- 101000716149 Homo sapiens T-cell surface glycoprotein CD1b Proteins 0.000 claims 1
- 101000716124 Homo sapiens T-cell surface glycoprotein CD1c Proteins 0.000 claims 1
- 101500021084 Locusta migratoria 5 kDa peptide Proteins 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000000523 sample Substances 0.000 description 10
- -1 CD1laCD18 Proteins 0.000 description 3
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 description 2
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 description 2
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 238000010200 validation analysis Methods 0.000 description 2
- 101001015037 Homo sapiens Integrin beta-7 Proteins 0.000 description 1
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 description 1
- 101001018021 Homo sapiens T-lymphocyte surface antigen Ly-9 Proteins 0.000 description 1
- 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 description 1
- 102100033016 Integrin beta-7 Human genes 0.000 description 1
- 102100029198 SLAM family member 7 Human genes 0.000 description 1
- 102100033447 T-lymphocyte surface antigen Ly-9 Human genes 0.000 description 1
- 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063000694P | 2020-03-27 | 2020-03-27 | |
| US63/000,694 | 2020-03-27 | ||
| PCT/US2021/024431 WO2021195536A1 (en) | 2020-03-27 | 2021-03-26 | Immunotherapeutic targets in multiple myeloma and methods for their identification |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023519304A JP2023519304A (ja) | 2023-05-10 |
| JPWO2021195536A5 true JPWO2021195536A5 (de) | 2024-02-27 |
Family
ID=77890610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022558042A Pending JP2023519304A (ja) | 2020-03-27 | 2021-03-26 | 多発性骨髄腫における免疫療法の標的およびその同定方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230137672A1 (de) |
| EP (1) | EP4126243A4 (de) |
| JP (1) | JP2023519304A (de) |
| KR (1) | KR20220160053A (de) |
| CN (1) | CN116097096A (de) |
| CA (1) | CA3175860A1 (de) |
| IL (1) | IL296714A (de) |
| WO (1) | WO2021195536A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230065254A (ko) * | 2020-08-05 | 2023-05-11 | 신테카인, 인크. | IL27Rα 결합 분자 및 사용 방법 |
| CN114031690B (zh) * | 2021-12-03 | 2022-07-15 | 广州百暨基因科技有限公司 | 靶向ccr1和nkg2d配体的嵌合抗原受体及其应用 |
| GB202117928D0 (en) | 2021-12-11 | 2022-01-26 | Cancer Research Tech Ltd | Immunotherapy for cancer |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6046012A (en) * | 1993-07-19 | 2000-04-04 | Hoffmann-La Roche Inc. | Antibody to IL-12 receptor |
| US20030092002A1 (en) * | 1997-09-17 | 2003-05-15 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP2363403B1 (de) * | 1999-11-29 | 2016-04-20 | The Trustees of Columbia University in the City of New York | Isolierung von fünf neuen Genen für das neue Fc-Rezeptor-Melanom, das die Pathogenese von Lymphomen bzw. Melanomen beeinflusst |
| WO2008092030A2 (en) * | 2007-01-25 | 2008-07-31 | The Regents Of The University Of California | Specific n-terminal labeling of peptides and proteins in complex mixtures |
| US20150301058A1 (en) * | 2012-11-26 | 2015-10-22 | Caris Science, Inc. | Biomarker compositions and methods |
| DK3105317T3 (en) * | 2014-02-14 | 2019-01-14 | Cellectis | Immunotherapy cells that are genetically engineered to target antigen on both immune cells and pathological cells |
| EA036975B1 (ru) * | 2015-08-03 | 2021-01-21 | Энгмаб Сарл | Моноклональные антитела против bcma |
| US10746739B2 (en) * | 2015-09-14 | 2020-08-18 | Leukemia Therapeutics, LLC | Identification of novel diagnostics and therapeutics by modulating RhoH |
| US20170234874A1 (en) * | 2015-10-07 | 2017-08-17 | Clearbridge Biophotonics Pte Ltd. | Integrated visual morphology and cell protein expression using resonance-light scattering |
| FR3051555B1 (fr) * | 2016-05-20 | 2018-05-11 | Horiba Abx Sas | Detection de la maladie residuelle du myelome multiple |
| CA3000514A1 (en) * | 2016-08-04 | 2018-02-08 | Memorial Sloan-Kettering Cancer Center | Cancer antigen targets and uses thereof |
| KR20240043810A (ko) * | 2016-11-02 | 2024-04-03 | 유니버시타트 바셀 | 세포 치료에 사용하기 위한 면역학적으로 식별 가능한 세포 표면 변이체 |
| JP7339944B2 (ja) * | 2017-11-07 | 2023-09-06 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | がんの処置におけるｃａｒ－ｔ細胞またはｃａｒ－ｎｋ細胞を用いるｌｉｌｒｂ４のターゲティング法 |
| CA3082410A1 (en) * | 2017-11-14 | 2019-05-23 | Arcellx, Inc. | Multifunctional immune cell therapies |
| CA3082611A1 (en) * | 2017-11-17 | 2019-05-23 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for alleviating cytokine release syndrome |
| SG11202004806SA (en) * | 2017-12-22 | 2020-06-29 | Jounce Therapeutics Inc | Antibodies to lilrb2 |
| US20210308171A1 (en) * | 2018-08-07 | 2021-10-07 | The Broad Institute, Inc. | Methods for combinatorial screening and use of therapeutic targets thereof |
-
2021
- 2021-03-26 WO PCT/US2021/024431 patent/WO2021195536A1/en active Application Filing
- 2021-03-26 EP EP21775630.3A patent/EP4126243A4/de active Pending
- 2021-03-26 US US17/913,189 patent/US20230137672A1/en active Pending
- 2021-03-26 IL IL296714A patent/IL296714A/en unknown
- 2021-03-26 CN CN202180024834.4A patent/CN116097096A/zh active Pending
- 2021-03-26 JP JP2022558042A patent/JP2023519304A/ja active Pending
- 2021-03-26 KR KR1020227037268A patent/KR20220160053A/ko active Search and Examination
- 2021-03-26 CA CA3175860A patent/CA3175860A1/en active Pending
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