JPWO2021189051A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021189051A5 JPWO2021189051A5 JP2022556587A JP2022556587A JPWO2021189051A5 JP WO2021189051 A5 JPWO2021189051 A5 JP WO2021189051A5 JP 2022556587 A JP2022556587 A JP 2022556587A JP 2022556587 A JP2022556587 A JP 2022556587A JP WO2021189051 A5 JPWO2021189051 A5 JP WO2021189051A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- heteroaryl
- cancer
- compound according
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 24
- 238000000034 method Methods 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 102000001307 androgen receptors Human genes 0.000 claims 3
- 108010080146 androgen receptors Proteins 0.000 claims 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 208000017701 Endocrine disease Diseases 0.000 claims 2
- 102000007399 Nuclear hormone receptor Human genes 0.000 claims 2
- 108020005497 Nuclear hormone receptor Proteins 0.000 claims 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 208000030172 endocrine system disease Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000005255 pyrrolopyridines Chemical class 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025139537A JP2025183239A (ja) | 2020-03-20 | 2025-08-25 | 小分子エナンチオマーによるアンドロゲン受容体調節 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062992668P | 2020-03-20 | 2020-03-20 | |
| US62/992,668 | 2020-03-20 | ||
| PCT/US2021/023512 WO2021189051A1 (en) | 2020-03-20 | 2021-03-22 | Androgen receptor regulation by small molecule enantiomers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025139537A Division JP2025183239A (ja) | 2020-03-20 | 2025-08-25 | 小分子エナンチオマーによるアンドロゲン受容体調節 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023518299A JP2023518299A (ja) | 2023-04-28 |
| JPWO2021189051A5 true JPWO2021189051A5 (https=) | 2024-04-03 |
| JP2023518299A5 JP2023518299A5 (https=) | 2024-04-03 |
Family
ID=77771673
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022556587A Pending JP2023518299A (ja) | 2020-03-20 | 2021-03-22 | 小分子エナンチオマーによるアンドロゲン受容体調節 |
| JP2025139537A Pending JP2025183239A (ja) | 2020-03-20 | 2025-08-25 | 小分子エナンチオマーによるアンドロゲン受容体調節 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025139537A Pending JP2025183239A (ja) | 2020-03-20 | 2025-08-25 | 小分子エナンチオマーによるアンドロゲン受容体調節 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20260103470A1 (https=) |
| EP (1) | EP4121044A4 (https=) |
| JP (2) | JP2023518299A (https=) |
| WO (1) | WO2021189051A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021189051A1 (en) * | 2020-03-20 | 2021-09-23 | University Of Southern California | Androgen receptor regulation by small molecule enantiomers |
| US12552806B2 (en) | 2020-03-20 | 2026-02-17 | University Of Southern California | Androgen receptor regulation by small molecule enantiomers |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077605A1 (en) * | 2001-06-20 | 2004-04-22 | Salvati Mark E. | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| TWI263640B (en) * | 2001-12-19 | 2006-10-11 | Bristol Myers Squibb Co | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| WO2008157291A2 (en) * | 2007-06-15 | 2008-12-24 | Bristol-Myers Squibb Company | CRYSTALLINE FORMS OF (3Aα, 4β, 5α, 7β, 7Aα)-4-(OCTAHYDRO-5-ETHYLSULFONAMIDO-4,7-DIMETHYL-1,3-DIOXO-4,7-EPOXY-2H-ISOINDOL-2-YL)-2-(TRIFLUOROMETHYL)BENZONITRILE AND METHOD OF PREPARATION |
| CN102481294A (zh) * | 2009-09-11 | 2012-05-30 | 拜耳医药股份有限公司 | 作为抗癌药物的取代(杂芳基甲基)乙内酰硫脲 |
| KR20220004100A (ko) * | 2019-04-18 | 2022-01-11 | 하이노바 파마슈티컬스 인코포레이티드 | 안드로겐 수용체를 표적 분해하는 이중 기능성의 키메라 헤테로 고리 화합물 및 이의 용도 |
| WO2021189051A1 (en) * | 2020-03-20 | 2021-09-23 | University Of Southern California | Androgen receptor regulation by small molecule enantiomers |
-
2021
- 2021-03-22 WO PCT/US2021/023512 patent/WO2021189051A1/en not_active Ceased
- 2021-03-22 JP JP2022556587A patent/JP2023518299A/ja active Pending
- 2021-03-22 EP EP21771481.5A patent/EP4121044A4/en active Pending
-
2025
- 2025-08-25 JP JP2025139537A patent/JP2025183239A/ja active Pending
- 2025-10-09 US US19/354,247 patent/US20260103470A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI765451B (zh) | 作為erk抑制劑的螺環類化合物及其應用 | |
| JP2024001048A5 (https=) | ||
| JP2025114555A5 (https=) | ||
| CN109790135B (zh) | 用于治疗或预防与痛风或高尿酸血症相关的症状的化合物、组合物和方法 | |
| JP2010506854A5 (https=) | ||
| WO2005102342A1 (en) | New pharmaceutical compositions for the treatment of sexual disorders ii | |
| JP2010540508A5 (https=) | ||
| HUP0103689A2 (hu) | In vivo radioszenzitizáló hatású farnezil-protein-transzferáz inhibitorok alkalmazása gyógyászati készítmények előállítására | |
| JP2011509309A5 (https=) | ||
| CN106458995B (zh) | 2－(3－吡啶基)－1h－苯并咪唑衍生物化合物及包含其的药物 | |
| JPWO2021030555A5 (https=) | ||
| JP2007505044A5 (https=) | ||
| TW202208363A (zh) | 製備具有經取代之苯基或吡啶基部分的ｓｅｒｄ三環化合物的方法 | |
| JPWO2021189051A5 (https=) | ||
| JPWO2020232274A5 (https=) | ||
| RU2004109517A (ru) | Применение прегнандионов или прегнандиолов в качестве невропатических анальгетических агентов | |
| CA2523253A1 (en) | Methyl indoles and methyl pyrrolopyridines as alpha-1 adrenergic agonists | |
| JPWO2021143706A5 (https=) | ||
| CA2540151A1 (en) | Chelerythrine, analogs thereof and their use in the treatment of bipolar disorder and other cognitive disorders | |
| JP2010528032A (ja) | 甲状腺癌の処置のためのｒａｆ阻害剤 | |
| JPWO2019131458A1 (ja) | ２−［５−（イミダゾール−１−イルメチル）ピリジン−３−イル］ベンズイミダゾール誘導体化合物、及び、これを含む医薬 | |
| CS277691A3 (en) | 3-/1h-indazol-3-yl/-4-pyridinamines, process and intermediates for their preparation and their application as medicaments | |
| JPWO2021139756A5 (https=) | ||
| WO2022022646A1 (zh) | 含硒五元杂芳环化合物 | |
| RU2007140788A (ru) | Монолизиновые соли производных азола |