JPWO2021141041A5 - - Google Patents
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- JPWO2021141041A5 JPWO2021141041A5 JP2021570066A JP2021570066A JPWO2021141041A5 JP WO2021141041 A5 JPWO2021141041 A5 JP WO2021141041A5 JP 2021570066 A JP2021570066 A JP 2021570066A JP 2021570066 A JP2021570066 A JP 2021570066A JP WO2021141041 A5 JPWO2021141041 A5 JP WO2021141041A5
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- 125000005843 halogen group Chemical group 0.000 claims 188
- 125000000217 alkyl group Chemical group 0.000 claims 159
- 125000003545 alkoxy group Chemical group 0.000 claims 130
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 81
- 229920006395 saturated elastomer Polymers 0.000 claims 64
- 125000004093 cyano group Chemical group *C#N 0.000 claims 51
- 125000000623 heterocyclic group Chemical group 0.000 claims 41
- 125000002837 carbocyclic group Chemical group 0.000 claims 39
- 239000003795 chemical substances by application Substances 0.000 claims 35
- 230000000069 prophylactic effect Effects 0.000 claims 33
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 31
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 30
- 229910052799 carbon Inorganic materials 0.000 claims 29
- 230000001225 therapeutic effect Effects 0.000 claims 25
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 20
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 19
- 229910052757 nitrogen Inorganic materials 0.000 claims 16
- 125000004432 carbon atom Chemical group C* 0.000 claims 15
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 11
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 10
- 229940124597 therapeutic agent Drugs 0.000 claims 10
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 9
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000001153 fluoro group Chemical group F* 0.000 claims 8
- 206010012289 Dementia Diseases 0.000 claims 7
- 229910052731 fluorine Inorganic materials 0.000 claims 7
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 6
- 208000034799 Tauopathies Diseases 0.000 claims 6
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 239000012190 activator Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 4
- -1 phenyloxy Chemical group 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 101000631760 Homo sapiens Sodium channel protein type 1 subunit alpha Proteins 0.000 claims 3
- 102100028910 Sodium channel protein type 1 subunit alpha Human genes 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 3
- 208000023697 ABri amyloidosis Diseases 0.000 claims 2
- 208000017227 ADan amyloidosis Diseases 0.000 claims 2
- 208000024806 Brain atrophy Diseases 0.000 claims 2
- 208000014644 Brain disease Diseases 0.000 claims 2
- ZEWLROGMAUKXJB-UHFFFAOYSA-N CC1CCC(=CC1)C2=CN=C3C=NN(C3=N2)CC(=O)NC4=CC5=NC=NN5C=C4 Chemical compound CC1CCC(=CC1)C2=CN=C3C=NN(C3=N2)CC(=O)NC4=CC5=NC=NN5C=C4 ZEWLROGMAUKXJB-UHFFFAOYSA-N 0.000 claims 2
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims 2
- 208000011990 Corticobasal Degeneration Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 208000032274 Encephalopathy Diseases 0.000 claims 2
- 208000002339 Frontotemporal Lobar Degeneration Diseases 0.000 claims 2
- 201000000162 ITM2B-related cerebral amyloid angiopathy 1 Diseases 0.000 claims 2
- 201000000194 ITM2B-related cerebral amyloid angiopathy 2 Diseases 0.000 claims 2
- 208000036626 Mental retardation Diseases 0.000 claims 2
- 206010068871 Myotonic dystrophy Diseases 0.000 claims 2
- 208000010577 Niemann-Pick disease type C Diseases 0.000 claims 2
- 208000027089 Parkinsonian disease Diseases 0.000 claims 2
- 206010034010 Parkinsonism Diseases 0.000 claims 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 2
- 208000036757 Postencephalitic parkinsonism Diseases 0.000 claims 2
- 108091006657 SLC9A6 Proteins 0.000 claims 2
- 206010039966 Senile dementia Diseases 0.000 claims 2
- 102100029972 Sodium/hydrogen exchanger 6 Human genes 0.000 claims 2
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 claims 2
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 claims 2
- 208000007930 Type C Niemann-Pick Disease Diseases 0.000 claims 2
- 125000000033 alkoxyamino group Chemical group 0.000 claims 2
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 230000002308 calcification Effects 0.000 claims 2
- 210000000349 chromosome Anatomy 0.000 claims 2
- 208000017004 dementia pugilistica Diseases 0.000 claims 2
- 210000002682 neurofibrillary tangle Anatomy 0.000 claims 2
- 208000000170 postencephalitic Parkinson disease Diseases 0.000 claims 2
- 230000003449 preventive effect Effects 0.000 claims 2
- 230000000750 progressive effect Effects 0.000 claims 2
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 2
- WTCWHVGXMDKSLM-UHFFFAOYSA-N 2-(6-oxo-3-spiro[2.5]oct-6-en-6-ylpyridazin-1-yl)-N-([1,2,4]triazolo[1,5-a]pyridin-7-yl)acetamide Chemical compound O=C1C=CC(=NN1CC(=O)NC1=CC=2N(C=C1)N=CN=2)C1=CCC2(CC2)CC1 WTCWHVGXMDKSLM-UHFFFAOYSA-N 0.000 claims 1
- JNPQNXCZVIFNMZ-UHFFFAOYSA-N 2-[2-oxo-2-(4-pyridazin-4-yl-2,3-dihydroindol-1-yl)ethyl]-6-spiro[2.5]oct-6-en-6-ylpyridazin-3-one Chemical compound O=C(CN1N=C(C=CC1=O)C1=CCC2(CC2)CC1)N1CCC2=C(C=CC=C12)C1=CN=NC=C1 JNPQNXCZVIFNMZ-UHFFFAOYSA-N 0.000 claims 1
- ADICAMULCAGLDQ-UHFFFAOYSA-N 2-[3-(4,4-dimethylcyclohexen-1-yl)-6-oxopyridazin-1-yl]-N-([1,2,4]triazolo[1,5-a]pyridin-6-yl)acetamide Chemical compound CC1(CC=C(CC1)C1=NN(C(C=C1)=O)CC(=O)NC=1C=CC=2N(C=1)N=CN=2)C ADICAMULCAGLDQ-UHFFFAOYSA-N 0.000 claims 1
- ZYRYTCOACGPHEV-UHFFFAOYSA-N 2-[3-(4,4-dimethylcyclohexen-1-yl)-6-oxopyridazin-1-yl]-N-([1,2,4]triazolo[1,5-a]pyridin-7-yl)acetamide Chemical compound CC1(CC=C(CC1)C1=NN(C(C=C1)=O)CC(=O)NC1=CC=2N(C=C1)N=CN=2)C ZYRYTCOACGPHEV-UHFFFAOYSA-N 0.000 claims 1
- GPDYSOJPVLEOCW-UHFFFAOYSA-N 2-[3-(6-azaspiro[3.4]octan-6-yl)-6-oxopyridazin-1-yl]-N-quinazolin-7-ylacetamide Chemical compound C1CCC11CN(CC1)C1=NN(C(C=C1)=O)CC(=O)NC1=CC=C2C=NC=NC2=C1 GPDYSOJPVLEOCW-UHFFFAOYSA-N 0.000 claims 1
- MCQIGXDZBMRMHH-ZDUSSCGKSA-N 2-[3-[(4R)-4-methylcyclohexen-1-yl]-6-oxopyridazin-1-yl]-N-([1,2,4]triazolo[1,5-a]pyridin-6-yl)acetamide Chemical compound C[C@H]1CC=C(CC1)C1=NN(C(C=C1)=O)CC(=O)NC=1C=CC=2N(C=1)N=CN=2 MCQIGXDZBMRMHH-ZDUSSCGKSA-N 0.000 claims 1
- JUXVHCWFAGDRPD-ZDUSSCGKSA-N 2-[3-[(4R)-4-methylcyclohexen-1-yl]-6-oxopyridazin-1-yl]-N-([1,2,4]triazolo[1,5-a]pyridin-7-yl)acetamide Chemical compound C[C@H]1CC=C(CC1)C1=NN(C(C=C1)=O)CC(=O)NC1=CC=2N(C=C1)N=CN=2 JUXVHCWFAGDRPD-ZDUSSCGKSA-N 0.000 claims 1
- MCQIGXDZBMRMHH-CYBMUJFWSA-N 2-[3-[(4S)-4-methylcyclohexen-1-yl]-6-oxopyridazin-1-yl]-N-([1,2,4]triazolo[1,5-a]pyridin-6-yl)acetamide Chemical compound C[C@@H]1CC=C(CC1)C1=NN(C(C=C1)=O)CC(=O)NC=1C=CC=2N(C=1)N=CN=2 MCQIGXDZBMRMHH-CYBMUJFWSA-N 0.000 claims 1
- JUXVHCWFAGDRPD-CYBMUJFWSA-N 2-[3-[(4S)-4-methylcyclohexen-1-yl]-6-oxopyridazin-1-yl]-N-([1,2,4]triazolo[1,5-a]pyridin-7-yl)acetamide Chemical compound C[C@@H]1CC=C(CC1)C1=NN(C(C=C1)=O)CC(=O)NC1=CC=2N(C=C1)N=CN=2 JUXVHCWFAGDRPD-CYBMUJFWSA-N 0.000 claims 1
- VJFVTXFAQYGLHH-UHFFFAOYSA-N 2-[6-[(3,3-dimethylcyclobutyl)-methylamino]pyrazolo[3,4-d]pyrimidin-1-yl]-N-([1,2,4]triazolo[1,5-a]pyridin-6-yl)acetamide Chemical compound CC(C)(C1)CC1N(C)C1=NC=C(C=NN2CC(NC3=CN4N=CN=C4C=C3)=O)C2=N1 VJFVTXFAQYGLHH-UHFFFAOYSA-N 0.000 claims 1
- OSAWDIPPGAEFAI-UHFFFAOYSA-N 2-[6-[cyclobutylmethyl(methyl)amino]pyrazolo[3,4-d]pyrimidin-1-yl]-N-([1,2,4]triazolo[1,5-a]pyridin-6-yl)acetamide Chemical compound CN(CC1CCC1)C1=NC=C(C=NN2CC(NC3=CN4N=CN=C4C=C3)=O)C2=N1 OSAWDIPPGAEFAI-UHFFFAOYSA-N 0.000 claims 1
- KXTOUPCATIPTGU-UHFFFAOYSA-N 2-[6-[cyclopentyl(methyl)amino]pyrazolo[3,4-d]pyrimidin-1-yl]-N-([1,2,4]triazolo[1,5-a]pyridin-7-yl)acetamide Chemical compound CN(C1CCCC1)C1=NC=C(C=NN2CC(NC3=CC4=NC=NN4C=C3)=O)C2=N1 KXTOUPCATIPTGU-UHFFFAOYSA-N 0.000 claims 1
- NFFJLPZLLVKCRR-UHFFFAOYSA-N 2-[6-[methyl(spiro[2.3]hexan-5-yl)amino]pyrazolo[3,4-b]pyrazin-1-yl]-N-([1,2,4]triazolo[1,5-a]pyridin-7-yl)acetamide Chemical compound CN(C1CC2(CC2)C1)C1=CN=C(C=NN2CC(NC3=CC4=NC=NN4C=C3)=O)C2=N1 NFFJLPZLLVKCRR-UHFFFAOYSA-N 0.000 claims 1
- IDNHOCVSAXTVBR-UHFFFAOYSA-N 6-[cyclopentyl(methyl)amino]-2-[2-(4-morpholin-4-yl-2,3-dihydroindol-1-yl)-2-oxoethyl]pyridazin-3-one Chemical compound C1(N(C=2C=CC(=O)N(N=2)CC(=O)N2C3=CC=CC(=C3CC2)N2CCOCC2)C)CCCC1 IDNHOCVSAXTVBR-UHFFFAOYSA-N 0.000 claims 1
- 102100037991 85/88 kDa calcium-independent phospholipase A2 Human genes 0.000 claims 1
- GICCPPNHUJSISX-UHFFFAOYSA-N C1C2(C(F)(F)CN(CC2)C=2C=CC(=O)N(N=2)CC(=O)NC2=CN=C(C=C2)C#N)C1 Chemical compound C1C2(C(F)(F)CN(CC2)C=2C=CC(=O)N(N=2)CC(=O)NC2=CN=C(C=C2)C#N)C1 GICCPPNHUJSISX-UHFFFAOYSA-N 0.000 claims 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- ZHXNQRHKBJDYMY-UHFFFAOYSA-N CC(CC1)CC=C1C(C=C1)=NN(CC(N(CC2)CCN2C2=CC=CN=C2C)=O)C1=O Chemical compound CC(CC1)CC=C1C(C=C1)=NN(CC(N(CC2)CCN2C2=CC=CN=C2C)=O)C1=O ZHXNQRHKBJDYMY-UHFFFAOYSA-N 0.000 claims 1
- HYCZAZUMFXAUHB-UHFFFAOYSA-N CC(CC1)CC=C1C(C=C1)=NN(CC(NC2=CC(C)=NC(C)=C2)=O)C1=O Chemical compound CC(CC1)CC=C1C(C=C1)=NN(CC(NC2=CC(C)=NC(C)=C2)=O)C1=O HYCZAZUMFXAUHB-UHFFFAOYSA-N 0.000 claims 1
- AVQBEZCICOJDSB-UHFFFAOYSA-N CN(C1CCCC1)C1=CN=C(C=NN2CC(NC3=CC4=NC=NN4C=C3)=O)C2=N1 Chemical compound CN(C1CCCC1)C1=CN=C(C=NN2CC(NC3=CC4=NC=NN4C=C3)=O)C2=N1 AVQBEZCICOJDSB-UHFFFAOYSA-N 0.000 claims 1
- KYGDWRZSRCNCFH-UHFFFAOYSA-N N-(1,3-benzoxazol-5-yl)-2-[3-(4-methylcyclohexen-1-yl)-6-oxopyridazin-1-yl]acetamide Chemical compound O1C=NC2=C1C=CC(=C2)NC(CN1N=C(C=CC1=O)C1=CCC(CC1)C)=O KYGDWRZSRCNCFH-UHFFFAOYSA-N 0.000 claims 1
- OEJLJABPNGZFIR-UHFFFAOYSA-N N-(1,3-benzoxazol-5-yl)-2-[3-(4-methylpiperidin-1-yl)-6-oxopyridazin-1-yl]acetamide Chemical compound O1C=NC2=C1C=CC(=C2)NC(CN1N=C(C=CC1=O)N1CCC(CC1)C)=O OEJLJABPNGZFIR-UHFFFAOYSA-N 0.000 claims 1
- SRFRUCXPJOBWHA-UHFFFAOYSA-N N-(4-cyanophenyl)-2-[3-(4-methylpiperidin-1-yl)-6-oxopyridazin-1-yl]acetamide Chemical compound C(#N)C1=CC=C(C=C1)NC(CN1N=C(C=CC1=O)N1CCC(CC1)C)=O SRFRUCXPJOBWHA-UHFFFAOYSA-N 0.000 claims 1
- IJSPYCCNEVNGBY-UHFFFAOYSA-N N-(6-cyanopyridin-3-yl)-2-[6-(8,8-difluoro-6-azaspiro[2.5]octan-6-yl)pyrazolo[3,4-b]pyrazin-1-yl]acetamide Chemical compound N#CC(N=C1)=CC=C1NC(CN1N=CC2=NC=C(N(CCC34CC3)CC4(F)F)N=C12)=O IJSPYCCNEVNGBY-UHFFFAOYSA-N 0.000 claims 1
- ZMIGEVDGLZPBEI-UHFFFAOYSA-N N-(6-cyanopyridin-3-yl)-2-[6-[methyl(spiro[2.3]hexan-5-yl)amino]pyrazolo[3,4-b]pyrazin-1-yl]acetamide Chemical compound CN(C1CC2(CC2)C1)C1=CN=C(C=NN2CC(NC(C=C3)=CN=C3C#N)=O)C2=N1 ZMIGEVDGLZPBEI-UHFFFAOYSA-N 0.000 claims 1
- GLBDTOTZRPJTLB-UHFFFAOYSA-N O=C(CN1N=CC2=NC=C(N(CCC34CC3)CC4(F)F)N=C12)NC1=CC2=NC=NN2C=C1 Chemical compound O=C(CN1N=CC2=NC=C(N(CCC34CC3)CC4(F)F)N=C12)NC1=CC2=NC=NN2C=C1 GLBDTOTZRPJTLB-UHFFFAOYSA-N 0.000 claims 1
- 101710125553 PLA2G6 Proteins 0.000 claims 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 230000002518 glial effect Effects 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 201000007599 neurodegeneration with brain iron accumulation 2a Diseases 0.000 claims 1
- 210000004498 neuroglial cell Anatomy 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020001010 | 2020-01-07 | ||
| JP2020094656 | 2020-05-29 | ||
| PCT/JP2021/000184 WO2021141041A1 (ja) | 2020-01-07 | 2021-01-06 | タウオパチーの治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2021141041A1 JPWO2021141041A1 (https=) | 2021-07-15 |
| JPWO2021141041A5 true JPWO2021141041A5 (https=) | 2024-01-15 |
Family
ID=76788006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021570066A Withdrawn JPWO2021141041A1 (https=) | 2020-01-07 | 2021-01-06 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230109839A1 (https=) |
| EP (1) | EP4104861A4 (https=) |
| JP (1) | JPWO2021141041A1 (https=) |
| CN (1) | CN115397467A (https=) |
| CA (1) | CA3166986A1 (https=) |
| WO (1) | WO2021141041A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12054486B2 (en) | 2021-09-24 | 2024-08-06 | Xenon Pharmaceuticals Inc. | Pyridine derivatives and their use as sodium channel activators |
| GB2640329A (en) * | 2024-04-09 | 2025-10-15 | Imperial College Innovations Ltd | Hedgehog acyltransferase inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0216224D0 (en) | 2002-07-12 | 2002-08-21 | Glaxo Group Ltd | Compounds |
| US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
| FR2889847B1 (fr) | 2005-08-18 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique. |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| CN109112126B (zh) * | 2010-06-23 | 2024-06-14 | 库尔纳公司 | 通过抑制电压门控钠通道α亚基(SCNA)的天然反义转录物而治疗SCNA相关疾病 |
| US20140073651A1 (en) | 2011-02-22 | 2014-03-13 | Actelion Pharmaceuticals Ltd. | Benzamide derivatives as p2x7 receptor antagonists |
| JP2018524372A (ja) | 2015-07-15 | 2018-08-30 | アウリジーン ディスカバリー テクノロジーズ リミテッド | Ｉｒａｋ−４阻害剤としてのインダゾール及びアザインダゾール化合物 |
| TW202500565A (zh) | 2016-10-24 | 2025-01-01 | 美商傳達治療有限公司 | Shp2磷酸酶抑制劑及其使用方法 |
| EP3717505A4 (en) * | 2017-12-01 | 2021-12-01 | Encoded Therapeutics, Inc. | GENENICALLY MODIFIED DNA-BINDING PROTEINS |
| EP3828174A4 (en) * | 2018-07-19 | 2022-08-17 | Sumitomo Pharma Co., Ltd. | PYRIDAZINONE DERIVATIVE |
-
2021
- 2021-01-06 WO PCT/JP2021/000184 patent/WO2021141041A1/ja not_active Ceased
- 2021-01-06 EP EP21738338.9A patent/EP4104861A4/en not_active Withdrawn
- 2021-01-06 CN CN202180019635.4A patent/CN115397467A/zh active Pending
- 2021-01-06 US US17/791,111 patent/US20230109839A1/en not_active Abandoned
- 2021-01-06 CA CA3166986A patent/CA3166986A1/en active Pending
- 2021-01-06 JP JP2021570066A patent/JPWO2021141041A1/ja not_active Withdrawn
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