JPWO2021133748A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021133748A5 JPWO2021133748A5 JP2022538818A JP2022538818A JPWO2021133748A5 JP WO2021133748 A5 JPWO2021133748 A5 JP WO2021133748A5 JP 2022538818 A JP2022538818 A JP 2022538818A JP 2022538818 A JP2022538818 A JP 2022538818A JP WO2021133748 A5 JPWO2021133748 A5 JP WO2021133748A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- cycloalkyl
- och
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 51
- 229910052799 carbon Inorganic materials 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 14
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 13
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 13
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 11
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 9
- -1 cyanocyclopropyl Chemical group 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- COXKNKHXVAHVPA-UHFFFAOYSA-N 6-fluoro-4-[4-[(3-fluoro-5-methylphenyl)methyl]piperazin-1-yl]-1-methyl-3-pyridin-4-ylquinolin-2-one Chemical compound FC=1C=C2C(=C(C(N(C2=CC=1)C)=O)C1=CC=NC=C1)N1CCN(CC1)CC1=CC(=CC(=C1)C)F COXKNKHXVAHVPA-UHFFFAOYSA-N 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000002757 morpholinyl group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- PBZCKZMEAGILKI-UHFFFAOYSA-N 4-(4-benzyl-3-oxopiperazin-1-yl)-6-fluoro-1-methyl-3-nitroquinolin-2-one Chemical compound C(C1=CC=CC=C1)N1C(CN(CC1)C1=C(C(N(C2=CC=C(C=C12)F)C)=O)[N+](=O)[O-])=O PBZCKZMEAGILKI-UHFFFAOYSA-N 0.000 claims 2
- ZILATJQHQQWRGD-UHFFFAOYSA-N 4-[4-[(1-ethylindol-4-yl)methyl]piperazin-1-yl]-6-fluoro-1-methyl-3-nitroquinolin-2-one Chemical compound C(C)N1C=CC2=C(C=CC=C12)CN1CCN(CC1)C1=C(C(N(C2=CC=C(C=C12)F)C)=O)[N+](=O)[O-] ZILATJQHQQWRGD-UHFFFAOYSA-N 0.000 claims 2
- LCHWEYIQKVIGRW-UHFFFAOYSA-N 6-fluoro-4-[4-(1H-indol-4-ylmethyl)piperazin-1-yl]-1-methyl-3-nitroquinolin-2-one Chemical compound N1C=CC2=C(C=CC=C12)CN1CCN(CC1)C1=C(C(N(C2=CC=C(C=C12)F)C)=O)[N+](=O)[O-] LCHWEYIQKVIGRW-UHFFFAOYSA-N 0.000 claims 2
- VVHHHEXDEZQKLX-UHFFFAOYSA-N 6-fluoro-4-[4-[(3-fluorophenyl)methyl]piperazin-1-yl]-1-methyl-3-nitroquinolin-2-one Chemical compound FC=1C=C2C(=C(C(N(C2=CC=1)C)=O)[N+](=O)[O-])N1CCN(CC1)CC1=CC(=CC=C1)F VVHHHEXDEZQKLX-UHFFFAOYSA-N 0.000 claims 2
- HDBNFDAZVBIFPD-UHFFFAOYSA-N 6-methoxy-1-methyl-4-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]-3-nitroquinolin-2-one Chemical compound COC=1C=C2C(=C(C(N(C2=CC=1)C)=O)[N+](=O)[O-])N1CCN(CC1)CC1=CC=CC2=CC=CC=C12 HDBNFDAZVBIFPD-UHFFFAOYSA-N 0.000 claims 2
- INJUAESEVFTURL-UXHICEINSA-N FC1=CC=C(C=C1)C(N1C[C@@H](N(C[C@H]1C)C1=C(C(N(C2=CC=CC=C12)C)=O)C#N)C)C1=CC=C(C=C1)F Chemical compound FC1=CC=C(C=C1)C(N1C[C@@H](N(C[C@H]1C)C1=C(C(N(C2=CC=CC=C12)C)=O)C#N)C)C1=CC=C(C=C1)F INJUAESEVFTURL-UXHICEINSA-N 0.000 claims 2
- MODTVAKVRSSEKI-VQTJNVASSA-N FC1=CC=C(C=C1)C(N1C[C@@H](N(C[C@H]1C)C1=CC(N(C2=CC=C(C=C12)C#N)C)=O)C)C1=CC=C(C=C1)F Chemical compound FC1=CC=C(C=C1)C(N1C[C@@H](N(C[C@H]1C)C1=CC(N(C2=CC=C(C=C12)C#N)C)=O)C)C1=CC=C(C=C1)F MODTVAKVRSSEKI-VQTJNVASSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102000011107 Diacylglycerol Kinase Human genes 0.000 claims 1
- 108010062677 Diacylglycerol Kinase Proteins 0.000 claims 1
- 102100022735 Diacylglycerol kinase alpha Human genes 0.000 claims 1
- 101710181033 Diacylglycerol kinase alpha Proteins 0.000 claims 1
- 102100030220 Diacylglycerol kinase zeta Human genes 0.000 claims 1
- 101710192015 Diacylglycerol kinase zeta Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000005348 fluorocycloalkyl group Chemical group 0.000 claims 1
- 125000001207 fluorophenyl group Chemical group 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201911053557 | 2019-12-23 | ||
| IN201911053557 | 2019-12-23 | ||
| PCT/US2020/066503 WO2021133748A1 (en) | 2019-12-23 | 2020-12-22 | Substituted quinolinonyl piperazine compounds useful as t cell activators |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023508055A JP2023508055A (ja) | 2023-02-28 |
| JPWO2021133748A5 true JPWO2021133748A5 (https=) | 2023-12-07 |
| JP2023508055A5 JP2023508055A5 (https=) | 2023-12-07 |
| JP7653441B2 JP7653441B2 (ja) | 2025-03-28 |
Family
ID=74195153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022538818A Active JP7653441B2 (ja) | 2019-12-23 | 2020-12-22 | Ｔ細胞アクティベーターとして有用な置換キノリノニルピペラジン化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230061608A1 (https=) |
| EP (1) | EP4081513B1 (https=) |
| JP (1) | JP7653441B2 (https=) |
| KR (1) | KR20220119456A (https=) |
| CN (1) | CN115103841B (https=) |
| AU (1) | AU2020414688A1 (https=) |
| BR (1) | BR112022012220A2 (https=) |
| CA (1) | CA3162992A1 (https=) |
| ES (1) | ES2998500T3 (https=) |
| IL (1) | IL294269A (https=) |
| MX (1) | MX2022007369A (https=) |
| WO (1) | WO2021133748A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112022009631A2 (pt) * | 2019-12-19 | 2022-08-09 | Bristol Myers Squibb Co | Combinações de inibidores de dgk e antagonistas do ponto de checagem |
| LT4081305T (lt) | 2019-12-24 | 2024-11-25 | Carna Biosciences, Inc. | Diacilglicerolio kinazę moduliuojantys junginiai |
| WO2022271677A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| CA3222277A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| WO2022271659A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| WO2023122772A1 (en) * | 2021-12-22 | 2023-06-29 | Gossamer Bio Services, Inc. | Oxime derivatives useful as t cell activators |
| WO2023122777A1 (en) * | 2021-12-22 | 2023-06-29 | Gossamer Bio Services, Inc. | Oxime derivatives useful as t cell activators |
| EP4472963A1 (en) * | 2022-02-01 | 2024-12-11 | Arvinas Operations, Inc. | Dgk targeting compounds and uses thereof |
| KR20240156394A (ko) | 2022-03-01 | 2024-10-29 | 인실리코 메디신 아이피 리미티드 | 디아실글리세롤 키나아제 (dgk) 알파 억제제 및 이의 용도 |
| CN115124464B (zh) * | 2022-07-04 | 2023-06-06 | 新乡学院 | 一种喹啉二酮磺酰哌嗪杂合体及其制备方法和应用 |
| US12600722B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| US12600723B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| AR131786A1 (es) | 2023-02-06 | 2025-04-30 | Bayer Ag | Combinación de anticuerpos ccr8 con inhibidores de dgk |
| WO2025030002A2 (en) * | 2023-08-02 | 2025-02-06 | Arvinas Operations, Inc. | Dgk targeting compounds and uses thereof |
| WO2025030163A1 (en) * | 2023-08-02 | 2025-02-06 | Horizon Therapeutics Ireland Dac | Heterocyclic inhibitors of igf-1r for treatment of disease |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4284768A (en) * | 1980-07-02 | 1981-08-18 | American Home Products Corporation | 1,2-Dihydro-4-amino-2-oxo-3-quinoline-carboxylic acid derivatives |
| MY140679A (en) | 2001-05-24 | 2010-01-15 | Avanir Pharmaceuticals | Inhibitors of macrohage migration inhibitory factor and methods for identifying the same |
| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| AU2006230099B2 (en) | 2005-03-25 | 2012-04-19 | Gitr, Inc. | GITR binding molecules and uses therefor |
| PL1879573T3 (pl) | 2005-05-10 | 2013-05-31 | Incyte Holdings Corp | Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| CA2634198C (en) | 2005-12-20 | 2014-06-03 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| GB0605689D0 (en) | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic compounds |
| WO2007114239A1 (ja) | 2006-03-30 | 2007-10-11 | Sapporo Medical University | DGKα阻害剤を含有する抗癌剤 |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| ES2444574T3 (es) | 2006-09-19 | 2014-02-25 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| ES2776406T3 (es) | 2007-07-12 | 2020-07-30 | Gitr Inc | Terapias de combinación que emplean moléculas de enlazamiento a GITR |
| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
| JP5583592B2 (ja) | 2007-11-30 | 2014-09-03 | ニューリンク ジェネティクス コーポレイション | Ｉｄｏ阻害剤 |
| US20110176972A1 (en) | 2008-05-29 | 2011-07-21 | Saint-Gobain Centre De Recherches et D'Etudes Eur | Cellular structure containing aluminium titanate |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| EP2473531A4 (en) | 2009-09-03 | 2013-05-01 | Merck Sharp & Dohme | Anti-gitr antibodies |
| US8722720B2 (en) | 2009-10-28 | 2014-05-13 | Newlink Genetics Corporation | Imidazole derivatives as IDO inhibitors |
| PH12012500881A1 (en) | 2009-12-10 | 2017-07-26 | Hoffmann La Roche | Antibodies binding preferentially human csf1r extracellular domain 4 and their use |
| JP5998060B2 (ja) | 2010-03-04 | 2016-09-28 | マクロジェニクス，インコーポレーテッド | Ｂ７−ｈ３と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用 |
| CA2789076C (en) | 2010-03-05 | 2017-11-21 | F. Hoffmann-La Roche Ag | Antibodies against human colony stimulating factor-1 receptor and uses thereof |
| CN102918061B (zh) | 2010-03-05 | 2016-06-08 | 霍夫曼-拉罗奇有限公司 | 针对人csf-1r的抗体及其用途 |
| MX378336B (es) | 2010-05-04 | 2025-03-10 | Five Prime Therapeutics Inc | Anticuerpos que se unen a factor estimulante de colonias 1 (csf1r). |
| PT2614082T (pt) | 2010-09-09 | 2018-12-03 | Pfizer | Moléculas de ligação a 4-1bb |
| NO2694640T3 (https=) | 2011-04-15 | 2018-03-17 | ||
| KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | Ｂ7-ｈ1 및 ｐｄ-1과 결합하는 항체 및 다른 분자들 |
| HRP20201595T1 (hr) | 2011-11-28 | 2020-12-11 | Merck Patent Gmbh | Anti-pd-l1 protutijela i njihova uporaba |
| BR112014012624A2 (pt) | 2011-12-15 | 2018-10-09 | F Hoffmann-La Roche Ag | anticorpos, composição farmacêutica, ácido nucleico, vetores de expressão, célula hospedeira, método para a produção de um anticorpo recombinante e uso do anticorpo |
| RU2014136332A (ru) | 2012-02-06 | 2016-03-27 | Дженентек, Инк. | Композиции и способы применения ингибиторов csf1r |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| EP2847220A1 (en) | 2012-05-11 | 2015-03-18 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| CN107759690A (zh) | 2012-08-31 | 2018-03-06 | 戊瑞治疗有限公司 | 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法 |
| JP6464139B2 (ja) * | 2013-03-14 | 2019-02-06 | コンバージーン・リミテッド・ライアビリティ・カンパニーＣｏｎｖｅｒｇｅｎｅ Ｌｌｃ | ブロモドメイン含有タンパク質の阻害のための方法および組成物 |
| CN112654621B (zh) * | 2018-06-27 | 2024-05-14 | 百时美施贵宝公司 | 可作为t细胞活化剂的经取代萘啶酮化合物 |
-
2020
- 2020-12-22 KR KR1020227025288A patent/KR20220119456A/ko active Pending
- 2020-12-22 CN CN202080096443.9A patent/CN115103841B/zh active Active
- 2020-12-22 AU AU2020414688A patent/AU2020414688A1/en not_active Abandoned
- 2020-12-22 MX MX2022007369A patent/MX2022007369A/es unknown
- 2020-12-22 WO PCT/US2020/066503 patent/WO2021133748A1/en not_active Ceased
- 2020-12-22 IL IL294269A patent/IL294269A/en unknown
- 2020-12-22 JP JP2022538818A patent/JP7653441B2/ja active Active
- 2020-12-22 CA CA3162992A patent/CA3162992A1/en active Pending
- 2020-12-22 EP EP20845303.5A patent/EP4081513B1/en active Active
- 2020-12-22 ES ES20845303T patent/ES2998500T3/es active Active
- 2020-12-22 US US17/786,239 patent/US20230061608A1/en active Pending
- 2020-12-22 BR BR112022012220A patent/BR112022012220A2/pt not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2021133748A5 (https=) | ||
| JP7787063B2 (ja) | オーロラキナーゼ阻害剤およびその使用 | |
| JP5532366B2 (ja) | ピラジンカルボキサミド化合物 | |
| JP6644792B2 (ja) | ベンザゼピンスルホンアミド化合物 | |
| JP2020515574A5 (https=) | ||
| CN106458930B (zh) | 2-氨基嘧啶类化合物及其药物组合物和应用 | |
| CA2491632C (en) | Pyrimidinylaminobenzamide derivatives and their use as inhibitors of tyrosine kinases | |
| JP2016517417A5 (https=) | ||
| JP2016513660A5 (https=) | ||
| JP2016523973A5 (https=) | ||
| CN101426766A (zh) | 用作mek抑制剂的新颖的杂芳基取代的芳基氨基吡啶衍生物 | |
| JP2017522346A5 (https=) | ||
| JP2010043113A (ja) | 新規ピリミジンアミド誘導体およびその使用 | |
| JP2010539110A5 (https=) | ||
| JP2017537948A5 (https=) | ||
| JPWO2021133751A5 (https=) | ||
| JP2014527082A5 (https=) | ||
| JP6380777B2 (ja) | ＰＩ３Ｋ、ｍＴＯＲ阻害薬としての縮合キノリン化合物 | |
| CN110818641B (zh) | 哒嗪-3-甲酰胺类化合物、其制备方法及其在医药学上的应用 | |
| JP2020527173A5 (https=) | ||
| JP2017526720A (ja) | キナーゼ阻害剤としての化合物および組成物 | |
| RU2007130153A (ru) | Амидные производные | |
| JP2020512400A5 (https=) | ||
| JPWO2021133749A5 (https=) | ||
| JP2020517676A5 (https=) |