JPWO2021110805A5 - - Google Patents
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- Publication number
- JPWO2021110805A5 JPWO2021110805A5 JP2022531534A JP2022531534A JPWO2021110805A5 JP WO2021110805 A5 JPWO2021110805 A5 JP WO2021110805A5 JP 2022531534 A JP2022531534 A JP 2022531534A JP 2022531534 A JP2022531534 A JP 2022531534A JP WO2021110805 A5 JPWO2021110805 A5 JP WO2021110805A5
- Authority
- JP
- Japan
- Prior art keywords
- isopropylphenyl
- pulmonary fibrosis
- fibrosis
- azetidin
- carbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 25
- 150000003839 salts Chemical class 0.000 claims 14
- 230000003510 anti-fibrotic effect Effects 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 208000019425 cirrhosis of liver Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 6
- 229960003073 pirfenidone Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 208000027866 inflammatory disease Diseases 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 230000009885 systemic effect Effects 0.000 claims 5
- 208000025721 COVID-19 Diseases 0.000 claims 4
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 4
- 201000010001 Silicosis Diseases 0.000 claims 4
- 239000010425 asbestos Substances 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 4
- 201000002793 renal fibrosis Diseases 0.000 claims 4
- 229910052895 riebeckite Inorganic materials 0.000 claims 4
- 201000000306 sarcoidosis Diseases 0.000 claims 4
- 208000032056 Radiation Fibrosis Syndrome Diseases 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- XZXHXSATPCNXJR-ZIADKAODSA-N nintedanib Chemical compound O=C1NC2=CC(C(=O)OC)=CC=C2\C1=C(C=1C=CC=CC=1)\NC(C=C1)=CC=C1N(C)C(=O)CN1CCN(C)CC1 XZXHXSATPCNXJR-ZIADKAODSA-N 0.000 claims 3
- 229960004378 nintedanib Drugs 0.000 claims 3
- -1 4-(3-((2-(difluoromethoxy)-6-methylpyridin-3-yl)carbamoyl)-3-(2-isopropylphenyl)azetidin-1-yl)-2,2-dimethyl-4-oxobutane Chemical compound 0.000 claims 2
- AHMHQDZHVSRILS-UHFFFAOYSA-N 4-[3-[[2-(difluoromethoxy)-6-methylpyridin-3-yl]carbamoyl]-3-(2-propan-2-ylphenyl)azetidin-1-yl]-2,2-dimethylbutanoic acid Chemical compound FC(OC1=NC(=CC=C1NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)C)F AHMHQDZHVSRILS-UHFFFAOYSA-N 0.000 claims 2
- UHFBJBPMIVQTBG-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OC Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OC UHFBJBPMIVQTBG-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 208000020832 chronic kidney disease Diseases 0.000 claims 2
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- UXHGYVHOQNAHDR-UHFFFAOYSA-N 4-[3-[(6-chloro-4-ethoxypyridin-3-yl)carbamoyl]-3-(2-propan-2-ylphenyl)azetidin-1-yl]-2,2-dimethyl-4-oxobutanoic acid Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)C(CC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)OCC UXHGYVHOQNAHDR-UHFFFAOYSA-N 0.000 claims 1
- IXZVCNYCFLJWLQ-UHFFFAOYSA-N 5-[3-[(6-chloro-4-ethoxypyridin-3-yl)carbamoyl]-3-(2-propan-2-ylphenyl)azetidin-1-yl]-2,2-dimethylpentanoic acid Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OCC IXZVCNYCFLJWLQ-UHFFFAOYSA-N 0.000 claims 1
- AEVSKFPVHQEJGE-UHFFFAOYSA-N 5-[3-[[2-(difluoromethoxy)-6-methylpyridin-3-yl]carbamoyl]-3-(2-propan-2-ylphenyl)azetidin-1-yl]-2,2-dimethylpentanoic acid Chemical compound FC(OC1=NC(=CC=C1NC(=O)C1(CN(C1)CCCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)C)F AEVSKFPVHQEJGE-UHFFFAOYSA-N 0.000 claims 1
- 208000024985 Alport syndrome Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- MMDMEZKSWCAEQP-UHFFFAOYSA-N BrC1=CC(=C(C=N1)NC(=O)C1(CN(C1)C(CC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)OC Chemical compound BrC1=CC(=C(C=N1)NC(=O)C1(CN(C1)C(CC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)OC MMDMEZKSWCAEQP-UHFFFAOYSA-N 0.000 claims 1
- PJBXDRPYGIEXTR-UHFFFAOYSA-N BrC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC Chemical compound BrC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC PJBXDRPYGIEXTR-UHFFFAOYSA-N 0.000 claims 1
- LYUHUWVPOGPQBN-UHFFFAOYSA-N C(C)(C)C1=C(C=CC=C1)C1(CN(C1)S(N)(=O)=O)C(=O)NC=1C(=NC(=CC=1)C)OC Chemical compound C(C)(C)C1=C(C=CC=C1)C1(CN(C1)S(N)(=O)=O)C(=O)NC=1C(=NC(=CC=1)C)OC LYUHUWVPOGPQBN-UHFFFAOYSA-N 0.000 claims 1
- NFTLCPKJANELJF-UHFFFAOYSA-N C(C)(C)OC1=NC(=CC=C1NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)C Chemical compound C(C)(C)OC1=NC(=CC=C1NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)C NFTLCPKJANELJF-UHFFFAOYSA-N 0.000 claims 1
- PHADFUHHMQVNHT-UHFFFAOYSA-N C(C)OC1=NC(=CC=C1NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)C Chemical compound C(C)OC1=NC(=CC=C1NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)C PHADFUHHMQVNHT-UHFFFAOYSA-N 0.000 claims 1
- RJQHNYDFUBUQBS-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)C(CC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)OC Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)C(CC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)OC RJQHNYDFUBUQBS-UHFFFAOYSA-N 0.000 claims 1
- NTWIQNLJVMFOEB-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC NTWIQNLJVMFOEB-UHFFFAOYSA-N 0.000 claims 1
- PPFFNHUJOGQXML-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC(C)C Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC(C)C PPFFNHUJOGQXML-UHFFFAOYSA-N 0.000 claims 1
- RXPPIFRABBTGPL-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OCC Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OCC RXPPIFRABBTGPL-UHFFFAOYSA-N 0.000 claims 1
- OXCMUISOAICMMJ-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)CCCC(C(=O)O)(C)C)C1=C(C=CC=C1)C(C)C)OC OXCMUISOAICMMJ-UHFFFAOYSA-N 0.000 claims 1
- XNSGSFYMSSWMDL-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OC(C)C Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OC(C)C XNSGSFYMSSWMDL-UHFFFAOYSA-N 0.000 claims 1
- ICOPNXVMXLFUCM-UHFFFAOYSA-N ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OCC Chemical compound ClC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OCC ICOPNXVMXLFUCM-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- WMPVNQNVSISYDP-UHFFFAOYSA-N FC(OC1=NC(=CC=C1NC(=O)C1(CN(C1)C(CCC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)C)F Chemical compound FC(OC1=NC(=CC=C1NC(=O)C1(CN(C1)C(CCC(C(=O)O)(C)C)=O)C1=C(C=CC=C1)C(C)C)C)F WMPVNQNVSISYDP-UHFFFAOYSA-N 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims 1
- 206010021263 IgA nephropathy Diseases 0.000 claims 1
- SBWVREBFWCRYRB-UHFFFAOYSA-N N-(4-methoxy-6-methylpyridin-3-yl)-3-(2-propan-2-ylphenyl)-1-sulfamoylazetidine-3-carboxamide Chemical compound C(C)(C)C1=C(C=CC=C1)C1(CN(C1)S(N)(=O)=O)C(=O)NC=1C=NC(=CC=1OC)C SBWVREBFWCRYRB-UHFFFAOYSA-N 0.000 claims 1
- AWIANFVBUOGQAV-UHFFFAOYSA-N N-(6-bromo-4-methoxypyridin-3-yl)-3-(2-propan-2-ylphenyl)-1-sulfamoylazetidine-3-carboxamide Chemical compound BrC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OC AWIANFVBUOGQAV-UHFFFAOYSA-N 0.000 claims 1
- DGFUVKOGJQTWAI-UHFFFAOYSA-N N-(6-fluoro-4-methoxypyridin-3-yl)-3-(2-propan-2-ylphenyl)-1-sulfamoylazetidine-3-carboxamide Chemical compound FC1=CC(=C(C=N1)NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)OC DGFUVKOGJQTWAI-UHFFFAOYSA-N 0.000 claims 1
- YXRNQUBUJDLVPK-UHFFFAOYSA-N N-[2-(difluoromethoxy)-6-methylpyridin-3-yl]-3-(2-propan-2-ylphenyl)-1-sulfamoylazetidine-3-carboxamide Chemical compound FC(OC1=NC(=CC=C1NC(=O)C1(CN(C1)S(N)(=O)=O)C1=C(C=CC=C1)C(C)C)C)F YXRNQUBUJDLVPK-UHFFFAOYSA-N 0.000 claims 1
- 206010035600 Pleural fibrosis Diseases 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 206010048302 Tubulointerstitial nephritis Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 210000000013 bile duct Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 claims 1
- 231100000854 focal segmental glomerulosclerosis Toxicity 0.000 claims 1
- 230000001434 glomerular Effects 0.000 claims 1
- 208000003215 hereditary nephritis Diseases 0.000 claims 1
- 230000000642 iatrogenic effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 201000006334 interstitial nephritis Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2019083757 | 2019-12-04 | ||
EPPCT/EP2019/083757 | 2019-12-04 | ||
PCT/EP2020/084401 WO2021110805A1 (en) | 2019-12-04 | 2020-12-03 | Combination of an azetidine lpa1 receptor antagonist with pirfenidone and/or nintedanib for use in the treatment of fibrotic diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2023504415A JP2023504415A (ja) | 2023-02-03 |
JPWO2021110805A5 true JPWO2021110805A5 (es) | 2023-12-12 |
Family
ID=76221504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022531534A Pending JP2023504415A (ja) | 2019-12-04 | 2020-12-03 | 線維性疾患の治療に使用するためのアゼチジンlpa1受容体アンタゴニストのピルフェニドン及び/又はニンテダニブとの合剤 |
Country Status (13)
Country | Link |
---|---|
US (1) | US20230000846A1 (es) |
EP (1) | EP4069227A1 (es) |
JP (1) | JP2023504415A (es) |
KR (1) | KR20220109439A (es) |
CN (1) | CN114761001A (es) |
AU (1) | AU2020397207A1 (es) |
BR (1) | BR112022010891A2 (es) |
CA (1) | CA3160410A1 (es) |
CL (1) | CL2022001439A1 (es) |
IL (1) | IL293474A (es) |
MX (1) | MX2022006736A (es) |
TW (1) | TW202133844A (es) |
WO (1) | WO2021110805A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114728168B (zh) | 2019-11-15 | 2024-04-09 | 吉利德科学公司 | 三唑氨基甲酸酯吡啶基磺酰胺作为lpa受体拮抗剂及其用途 |
EP4161936A1 (en) | 2020-06-03 | 2023-04-12 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
TWI838626B (zh) | 2020-06-03 | 2024-04-11 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
EP4337641A1 (en) | 2021-05-11 | 2024-03-20 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
AU2022405082A1 (en) | 2021-12-08 | 2024-07-11 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
WO2023192648A1 (en) * | 2022-03-31 | 2023-10-05 | Puretech Lyt 100, Inc. | Methods of treating interstitial lung diseases and other fibrotic-mediated pulmonary diseases and disorders with deupirfenidone |
WO2024138185A1 (en) * | 2022-12-23 | 2024-06-27 | Bristol-Myers Squibb Company | Lpa1 antagonists for treating interstitial lung disease |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
DE10233500A1 (de) | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
NZ591443A (en) | 2005-09-22 | 2013-04-26 | Intermune Inc | Granule formation of pirfenidone and pharmaceutically acceptable excipients |
DK2124945T3 (da) | 2006-12-18 | 2011-08-01 | Intermune Inc | Fremgangsmåde til at give pirfenidonterapi til en patient |
US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
US20110301177A1 (en) | 2008-06-06 | 2011-12-08 | Boehringer Ingelheim International Gmbh | Capsule pharmaceutical dosage form comprising a suspension formulation of an indolinone derivative |
US7566729B1 (en) | 2008-11-10 | 2009-07-28 | Intermune, Inc. | Modifying pirfenidone treatment for patients with atypical liver function |
US7635707B1 (en) | 2008-11-10 | 2009-12-22 | Intermune, Inc. | Pirfenidone treatment for patients with atypical liver function |
GB2470833B (en) | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
US7816383B1 (en) | 2009-12-04 | 2010-10-19 | Intermune, Inc. | Methods of administering pirfenidone therapy |
US8084475B2 (en) | 2009-12-04 | 2011-12-27 | Intermune, Inc. | Pirfenidone therapy and inducers of cytochrome P450 |
PL2648726T3 (pl) | 2010-12-07 | 2018-10-31 | Amira Pharmaceuticals, Inc. | Policykliczny antagonista lpa1 i jego zastosowania |
US20150164874A1 (en) | 2011-05-25 | 2015-06-18 | Intermune, Inc. | Pirfenidone and anti-fibrotic therapy in selected patients |
WO2013025733A1 (en) * | 2011-08-15 | 2013-02-21 | Intermune, Inc. | Lysophosphatidic acid receptor antagonists |
CA2819967C (en) | 2012-08-31 | 2016-03-22 | Intermune, Inc. | Use of pirfenidone concomitantly with ciprofloxacin |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
CN106459042B (zh) | 2014-04-02 | 2019-06-28 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
JP2019523225A (ja) * | 2016-06-01 | 2019-08-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ニンテダニブおよびピルフェニドンによる治療開始を決定するためのecmバイオマーカーの使用 |
HRP20230645T1 (hr) | 2018-02-02 | 2023-09-29 | Genentech, Inc. | Farmaceutski spoj, njegove soli, njegove formulacije i postupci izrade i upotrebe istih |
FI3802517T3 (fi) | 2018-06-07 | 2023-03-23 | Idorsia Pharmaceuticals Ltd | Alkoksisubstituoituja pyridinyylijohdannaisia LPA1-reseptoriantagonisteina ja niiden käyttö fibroosin hoidossa |
AR119162A1 (es) * | 2019-06-18 | 2021-12-01 | Idorsia Pharmaceuticals Ltd | Derivados de piridin-3-ilo |
-
2020
- 2020-12-03 TW TW109142607A patent/TW202133844A/zh unknown
- 2020-12-03 WO PCT/EP2020/084401 patent/WO2021110805A1/en unknown
- 2020-12-03 CN CN202080083930.1A patent/CN114761001A/zh active Pending
- 2020-12-03 KR KR1020227022458A patent/KR20220109439A/ko unknown
- 2020-12-03 IL IL293474A patent/IL293474A/en unknown
- 2020-12-03 BR BR112022010891A patent/BR112022010891A2/pt unknown
- 2020-12-03 MX MX2022006736A patent/MX2022006736A/es unknown
- 2020-12-03 CA CA3160410A patent/CA3160410A1/en active Pending
- 2020-12-03 AU AU2020397207A patent/AU2020397207A1/en active Pending
- 2020-12-03 EP EP20816188.5A patent/EP4069227A1/en active Pending
- 2020-12-03 US US17/782,530 patent/US20230000846A1/en active Pending
- 2020-12-03 JP JP2022531534A patent/JP2023504415A/ja active Pending
-
2022
- 2022-06-01 CL CL2022001439A patent/CL2022001439A1/es unknown
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