JPWO2021067484A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021067484A5 JPWO2021067484A5 JP2022519473A JP2022519473A JPWO2021067484A5 JP WO2021067484 A5 JPWO2021067484 A5 JP WO2021067484A5 JP 2022519473 A JP2022519473 A JP 2022519473A JP 2022519473 A JP2022519473 A JP 2022519473A JP WO2021067484 A5 JPWO2021067484 A5 JP WO2021067484A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleobase
- subsample
- item
- cfdna
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025122521A JP2025148581A (ja) | 2019-09-30 | 2025-07-22 | メチル化分配アッセイにおいて無細胞ｄｎａを解析するための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962908569P | 2019-09-30 | 2019-09-30 | |
| US62/908,569 | 2019-09-30 | ||
| PCT/US2020/053610 WO2021067484A1 (en) | 2019-09-30 | 2020-09-30 | Compositions and methods for analyzing cell-free dna in methylation partitioning assays |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025122521A Division JP2025148581A (ja) | 2019-09-30 | 2025-07-22 | メチル化分配アッセイにおいて無細胞ｄｎａを解析するための組成物および方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022550131A JP2022550131A (ja) | 2022-11-30 |
| JPWO2021067484A5 true JPWO2021067484A5 (https=) | 2023-10-02 |
| JP2022550131A5 JP2022550131A5 (https=) | 2023-10-02 |
| JP7717057B2 JP7717057B2 (ja) | 2025-08-01 |
Family
ID=72896163
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022519473A Active JP7717057B2 (ja) | 2019-09-30 | 2020-09-30 | メチル化分配アッセイにおいて無細胞ｄｎａを解析するための組成物および方法 |
| JP2025122521A Pending JP2025148581A (ja) | 2019-09-30 | 2025-07-22 | メチル化分配アッセイにおいて無細胞ｄｎａを解析するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025122521A Pending JP2025148581A (ja) | 2019-09-30 | 2025-07-22 | メチル化分配アッセイにおいて無細胞ｄｎａを解析するための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11891653B2 (https=) |
| EP (1) | EP4041919A1 (https=) |
| JP (2) | JP7717057B2 (https=) |
| CN (1) | CN114616343A (https=) |
| CA (1) | CA3151538A1 (https=) |
| WO (1) | WO2021067484A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4567131A3 (en) * | 2019-01-31 | 2025-09-03 | Guardant Health, Inc. | Compositions and methods for isolating cell-free dna |
| GB202012433D0 (en) * | 2020-08-10 | 2020-09-23 | Univ Manchester | Nanoparticle-enabled analysis of cell-free nucleic acid in complex biological fluids |
| US12234518B2 (en) | 2020-10-23 | 2025-02-25 | Guardant Health, Inc. | Compositions and methods for analyzing DNA using partitioning and base conversion |
| JP2024523401A (ja) * | 2021-06-21 | 2024-06-28 | ガーダント ヘルス， インコーポレイテッド | コピー数情報に基づく組織起源分析のための方法および組成物 |
| WO2023086967A1 (en) * | 2021-11-12 | 2023-05-19 | Guardant Health, Inc. | Method of analysis of methylated dna-binding proteins |
| EP4453241A1 (en) * | 2021-12-21 | 2024-10-30 | Guardant Health, Inc. | Methods and systems for combinatorial chromatin-ip sequencing |
| EP4453240A1 (en) * | 2021-12-23 | 2024-10-30 | Guardant Health, Inc. | Compositions and methods for detection of metastasis |
| EP4634403A1 (en) * | 2022-12-16 | 2025-10-22 | Illumina, Inc. | Boranes on solid supports |
| AU2023409008A1 (en) * | 2022-12-21 | 2025-06-26 | Guardant Health, Inc. | Detecting homologous recombination deficiences based on methylation status of cell-free nucleic acid molecules |
| JP2025542261A (ja) * | 2022-12-22 | 2025-12-25 | ガーダント ヘルス， インコーポレイテッド | 統合された対象および全ゲノム体細胞およびｄｎａメチル化シーケンシングワークフロー |
| WO2025038399A1 (en) * | 2023-08-11 | 2025-02-20 | Guardant Health, Inc. | Methylated enrichment methods for single-molecule genetic and epigenetic sequencing |
| WO2025155895A1 (en) * | 2024-01-19 | 2025-07-24 | Guardant Health, Inc. | Nucleic acid modification profiling method |
| WO2026015607A1 (en) * | 2024-07-09 | 2026-01-15 | Guardant Health, Inc. | Methods for partitioning hyper-, hypo-, and non-methylated dna |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US20030017081A1 (en) | 1994-02-10 | 2003-01-23 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| AU2002359522A1 (en) | 2001-11-28 | 2003-06-10 | Applera Corporation | Compositions and methods of selective nucleic acid isolation |
| CA2519860C (en) | 2003-03-21 | 2018-01-16 | Santaris Pharma A/S | Short interfering rna (sirna) analogues |
| EP1817430B1 (en) | 2004-11-29 | 2009-09-16 | Klinikum der Universität Regensburg | Means and methods for detecting methylated dna |
| EP1693468A1 (en) | 2005-02-16 | 2006-08-23 | Epigenomics AG | Method for determining the methylation pattern of a polynucleic acid |
| DE102005034628B4 (de) | 2005-07-19 | 2007-08-23 | Epigenomics Ag | Verfahren zur Untersuchung von Cytosin-Methylierungen in DNA |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| WO2010037001A2 (en) | 2008-09-26 | 2010-04-01 | Immune Disease Institute, Inc. | Selective oxidation of 5-methylcytosine by tet-family proteins |
| US8486630B2 (en) | 2008-11-07 | 2013-07-16 | Industrial Technology Research Institute | Methods for accurate sequence data and modified base position determination |
| US20130157266A1 (en) | 2009-03-15 | 2013-06-20 | Ribomed Biotechnologies, Inc. | Abscription based molecular detection of dna methylation |
| US20110237444A1 (en) * | 2009-11-20 | 2011-09-29 | Life Technologies Corporation | Methods of mapping genomic methylation patterns |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| CN102971434B (zh) * | 2010-08-11 | 2014-04-09 | 中国科学院心理研究所 | 一种甲基化dna的高通量测序方法及其应用 |
| EP2675913B1 (en) | 2011-02-15 | 2016-12-14 | Bio-Rad Laboratories, Inc. | Detecting methylation in a subpopulation of genomic dna |
| EP2694686B2 (en) * | 2011-04-06 | 2023-07-19 | The University of Chicago | COMPOSITION AND METHODS RELATED TO MODIFICATION OF 5-METHYLCYTOSINE (5mC) |
| ES3018861T3 (en) | 2011-12-13 | 2025-05-19 | Univ Oslo Hf | Method for detection of hydroxymethylation status |
| EP3744857A1 (en) | 2012-03-20 | 2020-12-02 | University Of Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing |
| EP2698436A1 (en) | 2012-08-14 | 2014-02-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Colorectal cancer markers |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| GB2533006B (en) | 2012-09-04 | 2017-06-07 | Guardant Health Inc | Systems and methods to detect copy number variation |
| US10612088B2 (en) | 2013-03-14 | 2020-04-07 | The Broad Institute, Inc. | Massively multiplexed RNA sequencing |
| EP2983693A4 (en) | 2013-04-08 | 2016-10-26 | Univ Carmel Haifa Economic Cor | SEPT4 / ARTS AS TUMOR SUPPRESSOR IN THE DIAGNOSIS, FORECASTING AND TREATMENT OF LIVER DISEASES |
| EP2805769A1 (en) | 2013-05-24 | 2014-11-26 | European Molecular Biology Laboratory | Methods for nano-scale single cell analysis |
| KR102429186B1 (ko) | 2013-10-21 | 2022-08-03 | 베리나타 헬스, 인코포레이티드 | 사본수 변동을 결정함에 있어서 검출의 감수성을 향상시키기 위한 방법 |
| EP3132055A2 (en) | 2014-04-14 | 2017-02-22 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | A method and kit for determining the tissue or cell origin of dna |
| CN107002122B (zh) | 2014-07-25 | 2023-09-19 | 华盛顿大学 | 确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法 |
| EP3191628B1 (en) | 2014-09-12 | 2022-05-25 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acids |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| US9984201B2 (en) | 2015-01-18 | 2018-05-29 | Youhealth Biotech, Limited | Method and system for determining cancer status |
| CA2978616A1 (en) * | 2015-03-16 | 2016-09-22 | Cedars-Sinai Medical Center | Methods of treating inflammatory bowel disease with ifn-gamma therapy |
| US11384382B2 (en) | 2016-04-14 | 2022-07-12 | Guardant Health, Inc. | Methods of attaching adapters to sample nucleic acids |
| EP4488686A3 (en) * | 2016-04-14 | 2025-04-30 | Guardant Health, Inc. | Methods for early detection of cancer |
| US11702702B2 (en) | 2016-04-15 | 2023-07-18 | Predicine, Inc. | Systems and methods for detecting genetic alterations |
| JP2019515674A (ja) | 2016-04-19 | 2019-06-13 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝的解析および他の適用のための固定化ベースのシステムおよび方法 |
| CN109415763A (zh) | 2016-05-03 | 2019-03-01 | 大学健康网络 | 捕获无细胞的甲基化dna的方法及其用途 |
| EP4257701A3 (en) | 2016-06-30 | 2023-12-20 | Grail, LLC | Differential tagging of rna for preparation of a cell-free dna/rna sequencing library |
| KR102610098B1 (ko) | 2016-07-06 | 2023-12-04 | 가던트 헬쓰, 인크. | 무세포 핵산의 프래그멘톰 프로파일링을 위한 방법 |
| CN116445593A (zh) * | 2016-08-10 | 2023-07-18 | 格里尔公司 | 测定一生物样品的一甲基化图谱的方法 |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| CA3046007A1 (en) | 2016-12-22 | 2018-06-28 | Guardant Health, Inc. | Methods and systems for analyzing nucleic acid molecules |
| EP3366780B1 (en) * | 2017-02-23 | 2020-05-06 | Siemens Healthcare GmbH | Single-molecule sequence and high sensitivity methylation analysis for tissue-specific analysis |
| EP4134444B1 (en) * | 2017-03-23 | 2024-10-02 | University of Washington | Methods for targeted nucleic acid sequence enrichment with applications to error corrected nucleic acid sequencing |
| ES2868074T3 (es) * | 2017-04-14 | 2021-10-21 | Guardant Health Inc | Métodos para unir adaptadores a ácidos nucleicos de muestra |
| JP2020537487A (ja) | 2017-07-12 | 2020-12-24 | ユニバーシティー ヘルス ネットワーク | メチローム解析を用いる癌の検出及び分類 |
| EP4567131A3 (en) | 2019-01-31 | 2025-09-03 | Guardant Health, Inc. | Compositions and methods for isolating cell-free dna |
| EP4041888A4 (en) | 2019-10-11 | 2023-11-01 | Guardant Health, Inc. | USE OF CELLULAR BACTERIAL NUCLEIC ACIDS FOR CANCER DETECTION |
-
2020
- 2020-09-30 US US17/039,642 patent/US11891653B2/en active Active
- 2020-09-30 JP JP2022519473A patent/JP7717057B2/ja active Active
- 2020-09-30 WO PCT/US2020/053610 patent/WO2021067484A1/en not_active Ceased
- 2020-09-30 EP EP20792882.1A patent/EP4041919A1/en active Pending
- 2020-09-30 CN CN202080076649.5A patent/CN114616343A/zh active Pending
- 2020-09-30 CA CA3151538A patent/CA3151538A1/en active Pending
-
2024
- 2024-02-05 US US18/433,345 patent/US20240229112A1/en active Pending
-
2025
- 2025-07-22 JP JP2025122521A patent/JP2025148581A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN113661249B (zh) | 用于分离无细胞dna的组合物和方法 | |
| AU2021232750B2 (en) | Methods for labeling DNA fragments to reconstruct physical linkage and phase | |
| Davies et al. | Multiplexed analysis of chromosome conformation at vastly improved sensitivity | |
| US20250179554A1 (en) | Recovering Long-Range Linkage Information From Preserved Samples | |
| Hirst et al. | Next generation sequencing based approaches to epigenomics | |
| CN103233072B (zh) | 一种高通量全基因组dna甲基化检测技术 | |
| Wen et al. | Single cell epigenome sequencing technologies | |
| JP2020504606A (ja) | 核酸分子を解析するための方法およびシステム | |
| CN103476946A (zh) | 基于配对末端随机序列的基因分型 | |
| Tost | Current and emerging technologies for the analysis of the genome-wide and locus-specific DNA methylation patterns | |
| JPWO2021067484A5 (https=) | ||
| CN117568492A (zh) | 一种沙子岭猪snp分子标记及其制备的芯片和应用 | |
| Tost | Current and emerging technologies for the analysis of the genome-wide and locus-specific DNA methylation patterns | |
| CN115125624A (zh) | 一组条码接头以及中通量多重单细胞代表性dna甲基化建库和测序方法 | |
| EP4215619A1 (en) | Methods for sensitive and accurate parallel quantification of nucleic acids | |
| WO2019212138A1 (ko) | 차세대 염기서열 분석을 위한 시료 간 교차 오염 탐색용 내부 검정 물질 | |
| CN114206895A (zh) | 用于检测dna中n-4-乙酰基脱氧胞苷的方法和试剂盒 | |
| JPWO2022115810A5 (https=) | ||
| CN117625763A (zh) | 准确地平行定量变体核酸的高灵敏度方法 | |
| EP3924511B1 (en) | Methods for noninvasive prenatal testing of fetal abnormalities | |
| WO2026043702A1 (en) | Methods and approaches for personalized identification and monitoring of extrachromosomal circular dna | |
| WO2026024956A1 (en) | Selecting low technical noise biomarkers for sensitive molecular diagnostics | |
| WO2026024692A1 (en) | Direct methylation single-base resolution sequencing of enriched unmethylated dna | |
| JPWO2022087309A5 (https=) | ||
| WO2017176971A1 (en) | Methods of genome sequencing and epigenetic analysis |