US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
CU22545A1
(es)
|
1994-11-18 |
1999-03-31 |
Centro Inmunologia Molecular |
Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
WO1985003357A1
(fr)
|
1984-01-30 |
1985-08-01 |
Icrf Patents Ltd. |
Ameliorations relatives aux facteurs de croissance
|
US4943533A
(en)
|
1984-03-01 |
1990-07-24 |
The Regents Of The University Of California |
Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
US5401638A
(en)
|
1986-06-04 |
1995-03-28 |
Oncogene Science, Inc. |
Detection and quantification of neu related proteins in the biological fluids of humans
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
US4994560A
(en)
|
1987-06-24 |
1991-02-19 |
The Dow Chemical Company |
Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
|
US5489425A
(en)
|
1987-06-24 |
1996-02-06 |
The Dow Chemical Company |
Functionalized polyamine chelants
|
ZA894792B
(en)
|
1988-06-24 |
1991-04-24 |
Dow Chemical Co |
Macrocyclic bifunctional chelants,complexes thereof and their antibody conjugates
|
WO1989012631A1
(fr)
|
1988-06-24 |
1989-12-28 |
The Dow Chemical Company |
Agents de chelation bifonctionnels macrocycliques, leurs complexes et leurs conjugues anticorps
|
US5756065A
(en)
|
1988-06-24 |
1998-05-26 |
The Dow Chemical Company |
Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
|
US5274119A
(en)
|
1988-07-01 |
1993-12-28 |
The Dow Chemical Company |
Vicinal diols
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
US5342604A
(en)
|
1988-10-31 |
1994-08-30 |
The Dow Chemical Company |
Complexes possessing ortho ligating functionality
|
US5696239A
(en)
|
1988-10-31 |
1997-12-09 |
The Dow Chemical Company |
Conjugates possessing ortho ligating functionality and complexes thereof
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
US5808003A
(en)
|
1989-05-26 |
1998-09-15 |
Perimmune Holdings, Inc. |
Polyaminocarboxylate chelators
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
WO1991003489A1
(fr)
|
1989-09-08 |
1991-03-21 |
The Johns Hopkins University |
Modifications structurelles du gene recepteur du facteur de croissance epidermique dans les gliomes humains
|
JP3208427B2
(ja)
|
1989-09-29 |
2001-09-10 |
オー・エス・アイ・ファーマシューテイカルズ・インコーポレイテッド |
ヒトの生物学的流体中のneu関連タンパク質の検出及び定量
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
DE69133476T2
(de)
|
1990-08-29 |
2006-01-05 |
GenPharm International, Inc., Palo Alto |
Transgene Mäuse fähig zur Produktion heterologer Antikörper
|
DK0590058T3
(da)
|
1991-06-14 |
2004-03-29 |
Genentech Inc |
Humaniseret heregulin-antistof
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
WO1993008829A1
(fr)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions induisant la destruction de cellules infectees par l'hiv
|
JPH07501451A
(ja)
|
1991-11-25 |
1995-02-16 |
エンゾン・インコーポレイテッド |
多価抗原結合タンパク質
|
US5428139A
(en)
|
1991-12-10 |
1995-06-27 |
The Dow Chemical Company |
Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
|
AU661533B2
(en)
|
1992-01-20 |
1995-07-27 |
Astrazeneca Ab |
Quinazoline derivatives
|
US5573905A
(en)
|
1992-03-30 |
1996-11-12 |
The Scripps Research Institute |
Encoded combinatorial chemical libraries
|
US5505931A
(en)
|
1993-03-04 |
1996-04-09 |
The Dow Chemical Company |
Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents
|
JP3095175B2
(ja)
|
1992-11-13 |
2000-10-03 |
アイデック ファーマシューティカルズ コーポレイション |
B細胞リンパ腫の治療のためのヒトbリンパ球限定分化抗原に対するキメラ抗体と放射能標識抗体の療法利用
|
GB9314893D0
(en)
|
1993-07-19 |
1993-09-01 |
Zeneca Ltd |
Quinazoline derivatives
|
EP0659439B1
(fr)
|
1993-12-24 |
2001-10-24 |
MERCK PATENT GmbH |
Immunoconjugués
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
IL112249A
(en)
|
1994-01-25 |
2001-11-25 |
Warner Lambert Co |
Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
|
US5654307A
(en)
|
1994-01-25 |
1997-08-05 |
Warner-Lambert Company |
Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
|
AU686466B2
(en)
|
1994-07-21 |
1998-02-05 |
Akzo Nobel N.V. |
Cyclic ketone peroxide formulations
|
US5804396A
(en)
|
1994-10-12 |
1998-09-08 |
Sugen, Inc. |
Assay for agents active in proliferative disorders
|
EP2295415A1
(fr)
|
1995-03-30 |
2011-03-16 |
OSI Pharmaceuticals, Inc. |
Derives de quinazoline
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
GB9508565D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quiazoline derivative
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
CA2222231A1
(fr)
|
1995-06-07 |
1996-12-19 |
Imclone Systems Incorporated |
Anticorps et fragments d'anticorps inhibant la croissance des tumeurs
|
HUP9900330A3
(en)
|
1995-07-06 |
2001-08-28 |
Novartis Ag |
Pyrrolopyrimidines and processes for the preparation thereof
|
EP1516628B1
(fr)
|
1995-07-27 |
2013-08-21 |
Genentech, Inc. |
Formulation de protéine stabile, lyophilisée et isotonique
|
DE19544393A1
(de)
|
1995-11-15 |
1997-05-22 |
Hoechst Schering Agrevo Gmbh |
Synergistische herbizide Mischungen
|
US5760041A
(en)
|
1996-02-05 |
1998-06-02 |
American Cyanamid Company |
4-aminoquinazoline EGFR Inhibitors
|
GB9603095D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
ES2174250T5
(es)
|
1996-04-12 |
2010-04-21 |
Warner-Lambert Company Llc |
Inhibidores irreversibles de tirosina quinasas.
|
WO1998002434A1
(fr)
|
1996-07-13 |
1998-01-22 |
Glaxo Group Limited |
Composes heterocycliques condenses en tant qu'inhibiteurs de la proteine tyrosine kinase
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
US6002008A
(en)
|
1997-04-03 |
1999-12-14 |
American Cyanamid Company |
Substituted 3-cyano quinolines
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
US5994071A
(en)
|
1997-04-04 |
1999-11-30 |
Albany Medical College |
Assessment of prostate cancer
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
CA2288705C
(fr)
|
1997-05-06 |
2008-03-18 |
American Cyanamid Company |
Utilisation de composes de quinazoline pour le traitement de la maladie polykystique des reins
|
DK0999853T3
(da)
|
1997-06-13 |
2003-04-22 |
Genentech Inc |
Stabiliseret antostofformulering
|
ZA986729B
(en)
|
1997-07-29 |
1999-02-02 |
Warner Lambert Co |
Irreversible inhibitors of tyrosine kinases
|
ZA986732B
(en)
|
1997-07-29 |
1999-02-02 |
Warner Lambert Co |
Irreversible inhibitiors of tyrosine kinases
|
TW436485B
(en)
|
1997-08-01 |
2001-05-28 |
American Cyanamid Co |
Substituted quinazoline derivatives
|
IL135622A0
(en)
|
1997-11-06 |
2001-05-20 |
American Cyanamid Co |
Use of quinazoline derivatives as tyrosine kinase inhibitors for treating colonic polyps
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
IL138608A0
(en)
|
1998-04-02 |
2001-10-31 |
Genentech Inc |
Antibody variants and fragments thereof
|
GEP20032997B
(en)
|
1998-11-19 |
2003-06-25 |
Warner Lambert Co |
N-[4-(3-Chloro-4-Fluoro-Phenylamino)-7-(3-Morpholin-4-Yl-Propoxy)-Quinazolin-6-Yl]-crylamide, as an Irreversible Inhibitor of Tyrosine Kinases
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
KR101077001B1
(ko)
|
1999-01-15 |
2011-10-26 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
JP6461800B2
(ja)
*
|
2012-10-04 |
2019-01-30 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
ヒトモノクローナル抗pd−l1抗体および使用方法
|
CA2953245A1
(fr)
*
|
2014-07-16 |
2016-01-21 |
Genentech, Inc. |
Methodes de traitement du cancer faisant appel a des inhibiteurs de tigit et a des agents anticancereux
|
PT3204417T
(pt)
*
|
2014-10-10 |
2020-10-08 |
Innate Pharma |
Bloqueio de cd73
|
WO2016131950A1
(fr)
*
|
2015-02-20 |
2016-08-25 |
Innate Pharma |
Blocage de cd73
|
PL3218406T3
(pl)
*
|
2014-11-10 |
2021-10-04 |
Medimmune Limited |
Cząsteczki wiążące specyficzne dla CD73 i ich zastosowania
|
UY36404A
(es)
*
|
2014-11-21 |
2016-06-01 |
Bristol Myers Squibb Company Una Corporación Del Estado De Delaware |
ANTICUERPOS MONOCLONALES (Ab) COMO DETECTORES DE CD73 E INHIBIDORES DE SU ACTIVIDAD ENZIMÁTICA, Y COMPOSICIONES QUE LOS CONTIENEN
|
EP3387442A4
(fr)
*
|
2015-12-09 |
2019-05-08 |
Corvus Pharmaceuticals, Inc. |
Anticorps anti-cd73 humanisés
|
CA3016187A1
(fr)
*
|
2016-03-04 |
2017-09-08 |
Bristol-Myers Squibb Company |
Polytherapie avec des anticorps anti-cd73
|
US10793636B2
(en)
*
|
2016-07-11 |
2020-10-06 |
Corvus Pharmaceuticals, Inc. |
Anti-CD73 antibodies
|
RU2752832C2
(ru)
*
|
2016-09-16 |
2021-08-09 |
Шанхай Хенлиус Байотек, Инк. |
Анти-pd-1 антитела
|
RU2770590C2
(ru)
*
|
2016-10-30 |
2022-04-18 |
Шанхай Хенлиус Байотек, Инк. |
Антитела против pd-l1 и их варианты
|
BR112019011988A2
(pt)
*
|
2016-12-13 |
2019-11-05 |
Astellas Pharma Inc |
anticorpo anti-cd73 humana
|
JP7206193B2
(ja)
*
|
2017-01-24 |
2023-01-17 |
アイ-エムエービー バイオファーマ ユーエス リミテッド |
抗cd73抗体およびその使用
|
CN110753703B
(zh)
*
|
2017-05-23 |
2024-04-09 |
德国亥姆霍兹慕尼黑中心健康与环境研究中心(有限公司) |
新的cd73抗体、其制备和用途
|
EP3642240A1
(fr)
*
|
2017-06-22 |
2020-04-29 |
Novartis AG |
Molécules d'anticorps dirigées contre cd73 et utilisations correspondantes
|
CU24606B1
(es)
*
|
2017-06-22 |
2022-06-06 |
Novartis Ag |
Moléculas de anticuerpo que se unen a cd73
|