JPWO2021003149A5 - - Google Patents

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Publication number
JPWO2021003149A5
JPWO2021003149A5 JP2021577915A JP2021577915A JPWO2021003149A5 JP WO2021003149 A5 JPWO2021003149 A5 JP WO2021003149A5 JP 2021577915 A JP2021577915 A JP 2021577915A JP 2021577915 A JP2021577915 A JP 2021577915A JP WO2021003149 A5 JPWO2021003149 A5 JP WO2021003149A5
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JP
Japan
Prior art keywords
rodent
immunoglobulin
canine
sequences
transgenic
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Granted
Application number
JP2021577915A
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English (en)
Japanese (ja)
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JP7744248B2 (ja
JP2022538886A (ja
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Priority claimed from PCT/US2020/040282 external-priority patent/WO2021003149A1/en
Publication of JP2022538886A publication Critical patent/JP2022538886A/ja
Publication of JPWO2021003149A5 publication Critical patent/JPWO2021003149A5/ja
Application granted granted Critical
Publication of JP7744248B2 publication Critical patent/JP7744248B2/ja
Active legal-status Critical Current
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JP2021577915A 2019-07-01 2020-06-30 トランスジェニック哺乳動物およびその使用法 Active JP7744248B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962869435P 2019-07-01 2019-07-01
US62/869,435 2019-07-01
PCT/US2020/040282 WO2021003149A1 (en) 2019-07-01 2020-06-30 Transgenic mammals and methods of use

Publications (3)

Publication Number Publication Date
JP2022538886A JP2022538886A (ja) 2022-09-06
JPWO2021003149A5 true JPWO2021003149A5 (enExample) 2023-07-07
JP7744248B2 JP7744248B2 (ja) 2025-09-25

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ID=71784658

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021577915A Active JP7744248B2 (ja) 2019-07-01 2020-06-30 トランスジェニック哺乳動物およびその使用法

Country Status (9)

Country Link
US (1) US20210000087A1 (enExample)
EP (1) EP3993622A1 (enExample)
JP (1) JP7744248B2 (enExample)
KR (1) KR20220025838A (enExample)
CN (1) CN114502725B (enExample)
AU (1) AU2020299569A1 (enExample)
CA (1) CA3144956A1 (enExample)
IL (1) IL289473A (enExample)
WO (1) WO2021003149A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024516996A (ja) * 2021-05-05 2024-04-18 トリアニ・インコーポレイテッド トランスジェニック哺乳動物およびその使用方法
GB202107372D0 (en) 2021-05-24 2021-07-07 Petmedix Ltd Animal models and therapeutics molecules
EP4408981A1 (en) 2021-10-01 2024-08-07 AbCellera Biologics Inc. Transgenic rodents for cell line identification and enrichment
WO2023086815A1 (en) * 2021-11-10 2023-05-19 Trianni, Inc. Transgenic mammals and methods of use thereof
GB202209247D0 (en) 2022-06-23 2022-08-10 Petmedix Ltd Animal models and therapeutic molecules
GB202217978D0 (en) * 2022-11-30 2023-01-11 Petmedix Ltd Rodents expressing a common light chain

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1293460C (en) 1985-10-07 1991-12-24 Brian Lee Sauer Site-specific recombination of dna in yeast
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
GB8904009D0 (en) 1989-02-22 1989-04-05 Celltech Ltd Vector
US6689610B1 (en) 1989-08-22 2004-02-10 University Of Utah Research Foundation Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
AU664976B2 (en) 1990-08-29 1995-12-14 Gene Pharming Europe Bv Homologous recombination in mammalian cells
WO1992015694A1 (en) 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor
DE4228162C1 (de) 1992-08-25 1994-01-13 Rajewsky Klaus Dr Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern
US5593598A (en) 1994-04-20 1997-01-14 Mcginness; Michael P. Method and apparatus for closed loop recycling of contaminated cleaning solution
US6130364A (en) 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6091001A (en) 1995-03-29 2000-07-18 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
EP1500329B1 (en) 1996-12-03 2012-03-21 Amgen Fremont Inc. Human antibodies that specifically bind human TNF alpha
US6774279B2 (en) 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7422889B2 (en) 2004-10-29 2008-09-09 Stowers Institute For Medical Research Dre recombinase and recombinase systems employing Dre recombinase
ES2445193T3 (es) * 2008-06-27 2014-02-28 Merus B.V. Mamíferos no humanos productores de anticuerpos
US9445581B2 (en) * 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
EP2597945B1 (en) * 2010-07-26 2020-07-22 Trianni, Inc. Transgenic animals and methods of use
US10662256B2 (en) * 2010-07-26 2020-05-26 Trianni, Inc. Transgenic mammals and methods of use thereof
US9253965B2 (en) * 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
GB2561352B (en) * 2017-04-10 2023-01-18 Genome Res Ltd Animal models and therapeutic molecules
SG11202003044SA (en) * 2017-12-05 2020-04-29 Regeneron Pharma Non-human animals having an engineered immunoglobulin lambda light chain and uses thereof
GB2578867A (en) * 2018-10-09 2020-06-03 Genome Res Ltd Animal models and therapeutic molecules

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