JPWO2020236524A5 - - Google Patents
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- Publication number
- JPWO2020236524A5 JPWO2020236524A5 JP2021567059A JP2021567059A JPWO2020236524A5 JP WO2020236524 A5 JPWO2020236524 A5 JP WO2020236524A5 JP 2021567059 A JP2021567059 A JP 2021567059A JP 2021567059 A JP2021567059 A JP 2021567059A JP WO2020236524 A5 JPWO2020236524 A5 JP WO2020236524A5
- Authority
- JP
- Japan
- Prior art keywords
- solvate
- compound
- pharmaceutically acceptable
- acceptable salt
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 37
- 150000003839 salts Chemical class 0.000 claims 37
- 239000012453 solvate Substances 0.000 claims 37
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000004452 carbocyclyl group Chemical group 0.000 claims 3
- 125000005884 carbocyclylalkyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962849534P | 2019-05-17 | 2019-05-17 | |
| US62/849,534 | 2019-05-17 | ||
| US201962907491P | 2019-09-27 | 2019-09-27 | |
| US62/907,491 | 2019-09-27 | ||
| PCT/US2020/032939 WO2020236524A1 (en) | 2019-05-17 | 2020-05-14 | Inhibitors of fibroblast growth factor receptor kinases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022533939A JP2022533939A (ja) | 2022-07-27 |
| JPWO2020236524A5 true JPWO2020236524A5 (https=) | 2023-05-08 |
| JP2022533939A5 JP2022533939A5 (https=) | 2023-05-08 |
Family
ID=73458745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021567059A Pending JP2022533939A (ja) | 2019-05-17 | 2020-05-14 | 線維芽細胞増殖因子受容体キナーゼの阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230174535A1 (https=) |
| EP (1) | EP3969442A4 (https=) |
| JP (1) | JP2022533939A (https=) |
| CN (1) | CN114127051A (https=) |
| AU (1) | AU2020278566A1 (https=) |
| CA (1) | CA3139161A1 (https=) |
| WO (1) | WO2020236524A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021138391A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
| EP4161657A1 (en) * | 2020-06-05 | 2023-04-12 | Kinnate Biopharma Inc. | Inhibitors of fibroblast growth factor receptor kinases |
| IL298760A (en) | 2020-06-05 | 2023-02-01 | Kinnate Biopharma Inc | Fibroblast growth factor receptor kinase inhibitors |
| WO2023107870A1 (en) * | 2021-12-08 | 2023-06-15 | Kinnate Biopharma Inc. | Inhibitors of fibroblast growth factor receptor kinases |
| AU2022407440A1 (en) * | 2021-12-08 | 2024-06-20 | Kinnate Biopharma Inc. | Solid state forms of an fgfr inhibitor |
| WO2024109799A1 (zh) * | 2022-11-22 | 2024-05-30 | 西藏海思科制药有限公司 | 一种嘧啶衍生物及其在医药上的应用 |
| WO2025024665A1 (en) * | 2023-07-26 | 2025-01-30 | Kinnate Biopharma Inc. | Treatment of cancer with a cdk inhibitor |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI378934B (en) * | 2004-04-02 | 2012-12-11 | Osi Pharm Inc | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
| GB0428082D0 (en) * | 2004-12-22 | 2005-01-26 | Welcome Trust The Ltd | Therapeutic compounds |
| US7723336B2 (en) * | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| US20070078136A1 (en) * | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| KR101461680B1 (ko) * | 2005-12-02 | 2014-11-19 | 바이엘 헬스케어 엘엘씨 | 과다-증식성 장애 및 맥관형성과 관련된 질환의 치료에유용한 치환된 4-아미노-피롤로트리아진 유도체 |
| DK2657233T3 (da) * | 2012-01-19 | 2014-09-22 | Taiho Pharmaceutical Co Ltd | 3,5-disubstitueret alkynylbenzenforbindelse og salt deraf |
| GB201503590D0 (en) * | 2015-03-03 | 2015-04-15 | Davis Adrian | Topical formulation |
| MY196077A (en) * | 2015-03-31 | 2023-03-13 | Taiho Pharmaceutical Co Ltd | Crystal Of 3,5-Disubstituted Benzene Alkynyl Compound |
| WO2017139509A1 (en) * | 2016-02-12 | 2017-08-17 | Purdue Research Foundation | Manipulating 3d virtual objects using hand-held controllers |
| CN107698593A (zh) * | 2016-08-09 | 2018-02-16 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
| US10685111B2 (en) * | 2016-10-31 | 2020-06-16 | Crowdstrike, Inc. | File-modifying malware detection |
| CN110139865B (zh) * | 2016-12-29 | 2022-02-18 | 石药集团中奇制药技术（石家庄）有限公司 | Fgfr抑制剂 |
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2020
- 2020-05-14 EP EP20810387.9A patent/EP3969442A4/en not_active Withdrawn
- 2020-05-14 US US17/605,127 patent/US20230174535A1/en not_active Abandoned
- 2020-05-14 WO PCT/US2020/032939 patent/WO2020236524A1/en not_active Ceased
- 2020-05-14 CN CN202080051864.XA patent/CN114127051A/zh active Pending
- 2020-05-14 CA CA3139161A patent/CA3139161A1/en active Pending
- 2020-05-14 AU AU2020278566A patent/AU2020278566A1/en not_active Abandoned
- 2020-05-14 JP JP2021567059A patent/JP2022533939A/ja active Pending