CA3139161A1 - Inhibitors of fibroblast growth factor receptor kinases - Google Patents

Inhibitors of fibroblast growth factor receptor kinases Download PDF

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Publication number
CA3139161A1
CA3139161A1 CA3139161A CA3139161A CA3139161A1 CA 3139161 A1 CA3139161 A1 CA 3139161A1 CA 3139161 A CA3139161 A CA 3139161A CA 3139161 A CA3139161 A CA 3139161A CA 3139161 A1 CA3139161 A1 CA 3139161A1
Authority
CA
Canada
Prior art keywords
optionally substituted
pharmaceutically acceptable
compound
solvate
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3139161A
Other languages
English (en)
French (fr)
Inventor
Stephen W. Kaldor
John Tyhonas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kinnate Biopharma Inc
Original Assignee
Kinnate Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kinnate Biopharma Inc filed Critical Kinnate Biopharma Inc
Publication of CA3139161A1 publication Critical patent/CA3139161A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3139161A 2019-05-17 2020-05-14 Inhibitors of fibroblast growth factor receptor kinases Pending CA3139161A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962849534P 2019-05-17 2019-05-17
US62/849,534 2019-05-17
US201962907491P 2019-09-27 2019-09-27
US62/907,491 2019-09-27
PCT/US2020/032939 WO2020236524A1 (en) 2019-05-17 2020-05-14 Inhibitors of fibroblast growth factor receptor kinases

Publications (1)

Publication Number Publication Date
CA3139161A1 true CA3139161A1 (en) 2020-11-26

Family

ID=73458745

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3139161A Pending CA3139161A1 (en) 2019-05-17 2020-05-14 Inhibitors of fibroblast growth factor receptor kinases

Country Status (7)

Country Link
US (1) US20230174535A1 (https=)
EP (1) EP3969442A4 (https=)
JP (1) JP2022533939A (https=)
CN (1) CN114127051A (https=)
AU (1) AU2020278566A1 (https=)
CA (1) CA3139161A1 (https=)
WO (1) WO2020236524A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021138391A1 (en) 2019-12-30 2021-07-08 Tyra Biosciences, Inc. Indazole compounds
EP4161657A1 (en) * 2020-06-05 2023-04-12 Kinnate Biopharma Inc. Inhibitors of fibroblast growth factor receptor kinases
IL298760A (en) 2020-06-05 2023-02-01 Kinnate Biopharma Inc Fibroblast growth factor receptor kinase inhibitors
WO2023107870A1 (en) * 2021-12-08 2023-06-15 Kinnate Biopharma Inc. Inhibitors of fibroblast growth factor receptor kinases
AU2022407440A1 (en) * 2021-12-08 2024-06-20 Kinnate Biopharma Inc. Solid state forms of an fgfr inhibitor
WO2024109799A1 (zh) * 2022-11-22 2024-05-30 西藏海思科制药有限公司 一种嘧啶衍生物及其在医药上的应用
WO2025024665A1 (en) * 2023-07-26 2025-01-30 Kinnate Biopharma Inc. Treatment of cancer with a cdk inhibitor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI378934B (en) * 2004-04-02 2012-12-11 Osi Pharm Inc 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
GB0428082D0 (en) * 2004-12-22 2005-01-26 Welcome Trust The Ltd Therapeutic compounds
US7723336B2 (en) * 2005-09-22 2010-05-25 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
US20070078136A1 (en) * 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
KR101461680B1 (ko) * 2005-12-02 2014-11-19 바이엘 헬스케어 엘엘씨 과다-증식성 장애 및 맥관형성과 관련된 질환의 치료에유용한 치환된 4-아미노-피롤로트리아진 유도체
DK2657233T3 (da) * 2012-01-19 2014-09-22 Taiho Pharmaceutical Co Ltd 3,5-disubstitueret alkynylbenzenforbindelse og salt deraf
GB201503590D0 (en) * 2015-03-03 2015-04-15 Davis Adrian Topical formulation
MY196077A (en) * 2015-03-31 2023-03-13 Taiho Pharmaceutical Co Ltd Crystal Of 3,5-Disubstituted Benzene Alkynyl Compound
WO2017139509A1 (en) * 2016-02-12 2017-08-17 Purdue Research Foundation Manipulating 3d virtual objects using hand-held controllers
CN107698593A (zh) * 2016-08-09 2018-02-16 南京天印健华医药科技有限公司 作为fgfr抑制剂的杂环化合物
US10685111B2 (en) * 2016-10-31 2020-06-16 Crowdstrike, Inc. File-modifying malware detection
CN110139865B (zh) * 2016-12-29 2022-02-18 石药集团中奇制药技术（石家庄）有限公司 Fgfr抑制剂

Also Published As

Publication number Publication date
JP2022533939A (ja) 2022-07-27
WO2020236524A1 (en) 2020-11-26
AU2020278566A1 (en) 2021-12-23
EP3969442A1 (en) 2022-03-23
CN114127051A (zh) 2022-03-01
EP3969442A4 (en) 2023-08-02
US20230174535A1 (en) 2023-06-08

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