JPWO2020214644A5 - - Google Patents
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- Publication number
- JPWO2020214644A5 JPWO2020214644A5 JP2021560961A JP2021560961A JPWO2020214644A5 JP WO2020214644 A5 JPWO2020214644 A5 JP WO2020214644A5 JP 2021560961 A JP2021560961 A JP 2021560961A JP 2021560961 A JP2021560961 A JP 2021560961A JP WO2020214644 A5 JPWO2020214644 A5 JP WO2020214644A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- mitochondria
- aerosolized
- subject
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 59
- 210000003470 mitochondria Anatomy 0.000 claims 27
- 239000003814 drug Substances 0.000 claims 9
- 239000000032 diagnostic agent Substances 0.000 claims 8
- 229940039227 diagnostic agent Drugs 0.000 claims 8
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 230000001225 therapeutic effect Effects 0.000 claims 7
- 239000000443 aerosol Substances 0.000 claims 6
- 239000006199 nebulizer Substances 0.000 claims 6
- 210000002345 respiratory system Anatomy 0.000 claims 5
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 4
- 230000002438 mitochondrial effect Effects 0.000 claims 4
- 239000002953 phosphate buffered saline Substances 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 239000007995 HEPES buffer Substances 0.000 claims 2
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000007922 nasal spray Substances 0.000 claims 2
- 229940097496 nasal spray Drugs 0.000 claims 2
- 230000000241 respiratory effect Effects 0.000 claims 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 108700011259 MicroRNAs Proteins 0.000 claims 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108020003217 Nuclear RNA Proteins 0.000 claims 1
- 102000043141 Nuclear RNA Human genes 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 206010038678 Respiratory depression Diseases 0.000 claims 1
- 108010077895 Sarcosine Proteins 0.000 claims 1
- 206010040954 Skin wrinkling Diseases 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- 206010069351 acute lung injury Diseases 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229960003237 betaine Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 230000000065 osmolyte Effects 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 201000004193 respiratory failure Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 229940043230 sarcosine Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 239000006200 vaporizer Substances 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962834020P | 2019-04-15 | 2019-04-15 | |
| US62/834,020 | 2019-04-15 | ||
| PCT/US2020/028219 WO2020214644A1 (en) | 2019-04-15 | 2020-04-15 | Aerosolized compositions comprising mitochondria and methods of use thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022529262A JP2022529262A (ja) | 2022-06-20 |
| JPWO2020214644A5 true JPWO2020214644A5 (https=) | 2023-04-25 |
| JP2022529262A5 JP2022529262A5 (https=) | 2023-04-25 |
| JP7590341B2 JP7590341B2 (ja) | 2024-11-26 |
Family
ID=72837565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021560961A Active JP7590341B2 (ja) | 2019-04-15 | 2020-04-15 | ミトコンドリアを含むエアロゾル化組成物及びその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220395531A1 (https=) |
| EP (2) | EP3955902B1 (https=) |
| JP (1) | JP7590341B2 (https=) |
| CN (1) | CN113905724A (https=) |
| ES (1) | ES2988040T3 (https=) |
| WO (1) | WO2020214644A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI4272834T1 (sl) | 2016-01-15 | 2026-03-31 | Beth Israel Deaconess Medical Center, Inc. | Terapevtska uporaba mitohondrijev in kombiniranih mitohondrijskih sredstev |
| EP3962365A4 (en) * | 2019-05-02 | 2023-02-01 | Children's Medical Center Corporation | PROPHYLACTIC AND THERAPEUTIC USE OF MITOCHONDRIA AND COMBINED MITOCHONDRIA |
| KR102665782B1 (ko) * | 2022-03-29 | 2024-05-14 | 주식회사 파이안바이오테크놀로지 | 동결 및 동결건조된 미토콘드리아 및 이의 용도 |
| CA3257638A1 (en) * | 2022-06-10 | 2023-12-14 | Cellvie Ag | COMPOSITION AND CRYOCONSERVATION PROCESS OF MITOCHONDRIA |
| CN115634178A (zh) * | 2022-10-13 | 2023-01-24 | 广州华茜药业科技有限公司 | 补充机体细胞能量的线粒体组合物及其制备方法 |
| CN115624515A (zh) * | 2022-10-13 | 2023-01-20 | 广州华茜药业科技有限公司 | 一种抗皱抗衰的线粒体组合物及其应用 |
| WO2025184537A1 (en) * | 2024-03-01 | 2025-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Bio-engineered mitochondria for targeted delivery to cells |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3826255A (en) | 1972-06-22 | 1974-07-30 | Hudson Oxygen Therapy Sales Co | Intermittent positive pressure breathing manifold |
| YU41046B (en) | 1974-08-22 | 1986-10-31 | Schering Ag | Medicine inholating device |
| US4268460A (en) | 1977-12-12 | 1981-05-19 | Warner-Lambert Company | Nebulizer |
| US4253468A (en) | 1978-08-14 | 1981-03-03 | Steven Lehmbeck | Nebulizer attachment |
| DE3151275C2 (de) | 1981-12-24 | 1986-07-10 | SKF GmbH, 8720 Schweinfurt | Befestigungsvorrichtung für Werkzeuge |
| US4649911A (en) | 1983-09-08 | 1987-03-17 | Baylor College Of Medicine | Small particle aerosol generator for treatment of respiratory disease including the lungs |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| WO2000041949A1 (en) | 1999-01-18 | 2000-07-20 | Earth Chemical Co., Ltd. | Aerosol injection device |
| KR20100117148A (ko) * | 2002-04-01 | 2010-11-02 | 지티씨바이오쎄라퓨틱스,인크. | 폐 질환의 치료 방법 |
| US8616195B2 (en) * | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
| CA2560415A1 (en) | 2004-03-29 | 2005-10-13 | The Procter & Gamble Company | Aerosol |
| US7431222B2 (en) | 2005-06-03 | 2008-10-07 | Monterrosa Christopher H | Aerosol spray masking device |
| IL183818A0 (en) | 2007-06-10 | 2007-10-31 | Shimon Harpaz | Uniformly abrasive confectionery product and process therefor |
| EP2654865B1 (en) * | 2010-12-22 | 2015-02-25 | Koninklijke Philips N.V. | Nebulizer device |
| WO2014113638A1 (en) * | 2013-01-17 | 2014-07-24 | Aer Devices, Inc. | Multi-use albuterol maintenance therapy formulations and devices therefor |
| US20160113887A1 (en) * | 2014-06-05 | 2016-04-28 | The Regents Of The University Of California | Halogenated ether compounds and methods of inducing anesthesia |
| CN107249600A (zh) * | 2014-12-31 | 2017-10-13 | 台湾粒线体应用技术股份有限公司 | 新颖医药组合物及其用于治疗肺损伤的用途 |
| SI4272834T1 (sl) * | 2016-01-15 | 2026-03-31 | Beth Israel Deaconess Medical Center, Inc. | Terapevtska uporaba mitohondrijev in kombiniranih mitohondrijskih sredstev |
| CN112243372A (zh) * | 2018-05-31 | 2021-01-19 | 克里蒂泰克公司 | 从受试者分离肿瘤特异性免疫细胞用于过继性细胞疗法的方法和癌症疫苗 |
| JP2022500059A (ja) * | 2018-09-17 | 2022-01-04 | エラスムス ユニバーシティ メディカルセンター ロッテルダムErasmus University Medical Center Rotterdam | アデノソーム |
| JP2022542495A (ja) * | 2019-07-24 | 2022-10-03 | ルカ・サイエンス株式会社 | 細胞からミトコンドリアを得る方法および得られたミトコンドリア |
-
2020
- 2020-04-15 CN CN202080039304.2A patent/CN113905724A/zh active Pending
- 2020-04-15 ES ES20790601T patent/ES2988040T3/es active Active
- 2020-04-15 JP JP2021560961A patent/JP7590341B2/ja active Active
- 2020-04-15 EP EP20790601.7A patent/EP3955902B1/en active Active
- 2020-04-15 WO PCT/US2020/028219 patent/WO2020214644A1/en not_active Ceased
- 2020-04-15 US US17/603,646 patent/US20220395531A1/en active Pending
- 2020-04-15 EP EP24188510.2A patent/EP4461369B1/en active Active
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