JPWO2020175660A5 - - Google Patents

Info

Publication number

JPWO2020175660A5

JPWO2020175660A5 JP2021502389A JP2021502389A JPWO2020175660A5 JP WO2020175660 A5 JPWO2020175660 A5 JP WO2020175660A5 JP 2021502389 A JP2021502389 A JP 2021502389A JP 2021502389 A JP2021502389 A JP 2021502389A JP WO2020175660 A5 JPWO2020175660 A5 JP WO2020175660A5

Authority

JP

Japan

Prior art keywords

protein

rsv

positions

seq

sequence

Prior art date

2020-02-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims description 32
• 102000037865 fusion proteins Human genes 0.000 claims description 30
• 108020001507 fusion proteins Proteins 0.000 claims description 30
• 108091006027 G proteins Proteins 0.000 claims description 21
• 102000030782 GTP binding Human genes 0.000 claims description 21
• 108091000058 GTP-Binding Proteins 0.000 claims description 21
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 20
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
• 239000012634 fragment Substances 0.000 claims description 6
• 239000013604 expression vector Substances 0.000 claims description 4
• 238000000034 method Methods 0.000 claims description 2
• 241000725643 Respiratory syncytial virus Species 0.000 claims 39
• 150000001413 amino acids Chemical class 0.000 claims 7
• 230000013595 glycosylation Effects 0.000 claims 5
• 238000006206 glycosylation reaction Methods 0.000 claims 5
• 230000004048 modification Effects 0.000 claims 4
• 238000012986 modification Methods 0.000 claims 4
• 229940124679 RSV vaccine Drugs 0.000 claims 3
• 230000004075 alteration Effects 0.000 claims 2
• 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 230000001419 dependent effect Effects 0.000 claims 1
• 230000003472 neutralizing effect Effects 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 description 4
• 238000010367 cloning Methods 0.000 description 3
• 239000013612 plasmid Substances 0.000 description 2
• 108010011170 Ala-Trp-Arg-His-Pro-Gln-Phe-Gly-Gly Proteins 0.000 description 1
• 101150074155 DHFR gene Proteins 0.000 description 1
• 241000588724 Escherichia coli Species 0.000 description 1
• 210000004102 animal cell Anatomy 0.000 description 1
• 238000007845 assembly PCR Methods 0.000 description 1
• 229960000074 biopharmaceutical Drugs 0.000 description 1
• 210000004027 cell Anatomy 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 108700023453 human respiratory syncytial virus F Proteins 0.000 description 1
• 239000000463 material Substances 0.000 description 1
• 238000002703 mutagenesis Methods 0.000 description 1
• 231100000350 mutagenesis Toxicity 0.000 description 1
• 238000005829 trimerization reaction Methods 0.000 description 1
• 239000013598 vector Substances 0.000 description 1