JPWO2020132232A5 - - Google Patents
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- Publication number
- JPWO2020132232A5 JPWO2020132232A5 JP2021536253A JP2021536253A JPWO2020132232A5 JP WO2020132232 A5 JPWO2020132232 A5 JP WO2020132232A5 JP 2021536253 A JP2021536253 A JP 2021536253A JP 2021536253 A JP2021536253 A JP 2021536253A JP WO2020132232 A5 JPWO2020132232 A5 JP WO2020132232A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cdr2
- cdr3
- cdr1
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090001123 antibodies Proteins 0.000 claims 32
- 102000004965 antibodies Human genes 0.000 claims 32
- 125000005647 linker group Chemical group 0.000 claims 13
- 102100006043 MCAM Human genes 0.000 claims 9
- 101710034704 MCAM Proteins 0.000 claims 9
- 125000000539 amino acid group Chemical group 0.000 claims 7
- 239000000611 antibody drug conjugate Substances 0.000 claims 7
- 108091008116 antibody drug conjugates Proteins 0.000 claims 7
- 210000004027 cells Anatomy 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- 102000033147 ERVK-25 Human genes 0.000 claims 2
- 108091005771 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007172 antigens Proteins 0.000 claims 2
- 102000038129 antigens Human genes 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 1
- 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N Glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- 229960003180 Glutathione Drugs 0.000 claims 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N Iodoacetamide Chemical group NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 claims 1
- DASWEROEPLKSEI-UIJRFTGLSA-N Monomethyl auristatin E Chemical group CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1 DASWEROEPLKSEI-UIJRFTGLSA-N 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 101700029485 UC18 Proteins 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate group Chemical group C(C=C)(=O)[O-] NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N acrylonitrile Chemical group C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 108091006028 chimera Proteins 0.000 claims 1
- 210000004748 cultured cells Anatomy 0.000 claims 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical group C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 1
- 239000001963 growth media Substances 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate group Chemical group C(C(=C)C)(=O)[O-] CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 108010093470 monomethyl auristatin E Proteins 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003568 thioethers Chemical class 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018122572 | 2018-12-21 | ||
| CNPCT/CN2018/122572 | 2018-12-21 | ||
| PCT/US2019/067457 WO2020132232A2 (en) | 2018-12-21 | 2019-12-19 | Antibodies specific to muc18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022514786A JP2022514786A (ja) | 2022-02-15 |
| JPWO2020132232A5 true JPWO2020132232A5 (es) | 2022-12-16 |
Family
ID=71101906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021536253A Pending JP2022514786A (ja) | 2018-12-21 | 2019-12-19 | Ｍｕｃ１８に特異的な抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220041749A1 (es) |
| EP (1) | EP3898964A4 (es) |
| JP (1) | JP2022514786A (es) |
| CN (2) | CN117343187A (es) |
| AU (1) | AU2019401657A1 (es) |
| TW (1) | TW202039571A (es) |
| WO (1) | WO2020132232A2 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2024081820A1 (en) | 2022-10-13 | 2024-04-18 | Sana Biotechnology, Inc. | Viral particles targeting hematopoietic stem cells |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2471849A1 (en) * | 2001-12-28 | 2003-07-17 | Abgenix, Inc. | Antibodies against the muc18 antigen |
| JP2005516965A (ja) * | 2001-12-28 | 2005-06-09 | アブジェニックス・インコーポレーテッド | 抗ｍｕｃ１８抗体を使用する方法 |
| CN101918448A (zh) * | 2007-12-18 | 2010-12-15 | 生物联合公司 | 识别癌细胞上表达的cd-43和cea的含糖表位的抗体及其使用方法 |
| CN102936283B (zh) * | 2008-01-31 | 2014-11-05 | 中国科学院生物物理研究所 | 抗人cd146的单克隆抗体，包含其的组合物，检测可溶性cd146的方法 |
| EP3049118B1 (en) * | 2013-09-24 | 2018-05-30 | Oncoinvent AS | Anti-cd146 monoclonal antibody |
| CN104650231A (zh) * | 2015-02-13 | 2015-05-27 | 南京任诺药业有限公司 | 一种具备高效中和活性的人源化抗人cd146单克隆抗体 |
| WO2017149513A1 (en) * | 2016-03-03 | 2017-09-08 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
-
2019
- 2019-12-19 JP JP2021536253A patent/JP2022514786A/ja active Pending
- 2019-12-19 AU AU2019401657A patent/AU2019401657A1/en active Pending
- 2019-12-19 EP EP19900282.5A patent/EP3898964A4/en active Pending
- 2019-12-19 CN CN202311007127.1A patent/CN117343187A/zh active Pending
- 2019-12-19 CN CN201980092138.XA patent/CN113423830B/zh active Active
- 2019-12-19 WO PCT/US2019/067457 patent/WO2020132232A2/en unknown
- 2019-12-19 TW TW108146802A patent/TW202039571A/zh unknown
-
2021
- 2021-06-17 US US17/351,014 patent/US20220041749A1/en active Pending
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