JPWO2020123827A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2020123827A5
JPWO2020123827A5 JP2021533640A JP2021533640A JPWO2020123827A5 JP WO2020123827 A5 JPWO2020123827 A5 JP WO2020123827A5 JP 2021533640 A JP2021533640 A JP 2021533640A JP 2021533640 A JP2021533640 A JP 2021533640A JP WO2020123827 A5 JPWO2020123827 A5 JP WO2020123827A5
Authority
JP
Japan
Prior art keywords
group
alkyl
pharmaceutically acceptable
acceptable salt
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021533640A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022512482A (ja
Publication date
Priority claimed from CN201811527414.4A external-priority patent/CN111320609A/zh
Application filed filed Critical
Publication of JP2022512482A publication Critical patent/JP2022512482A/ja
Publication of JPWO2020123827A5 publication Critical patent/JPWO2020123827A5/ja
Pending legal-status Critical Current

Links

JP2021533640A 2018-12-13 2019-12-12 Thrβ受容体アゴニスト化合物、およびその製造方法および使用 Pending JP2022512482A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201811527414.4A CN111320609A (zh) 2018-12-13 2018-12-13 一种THRβ受体激动剂化合物及其制备方法和用途
CN201811527414.4 2018-12-13
PCT/US2019/066013 WO2020123827A1 (en) 2018-12-13 2019-12-12 Thrβ receptor agonist compound and preparation method and use thereof

Publications (2)

Publication Number Publication Date
JP2022512482A JP2022512482A (ja) 2022-02-04
JPWO2020123827A5 true JPWO2020123827A5 (US20080131398A1-20080605-C00009.png) 2022-12-16

Family

ID=71071432

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021533640A Pending JP2022512482A (ja) 2018-12-13 2019-12-12 Thrβ受容体アゴニスト化合物、およびその製造方法および使用

Country Status (17)

Country Link
US (3) US11084802B2 (US20080131398A1-20080605-C00009.png)
EP (1) EP3893889A4 (US20080131398A1-20080605-C00009.png)
JP (1) JP2022512482A (US20080131398A1-20080605-C00009.png)
KR (1) KR20210102328A (US20080131398A1-20080605-C00009.png)
CN (3) CN111320609A (US20080131398A1-20080605-C00009.png)
AR (1) AR117694A1 (US20080131398A1-20080605-C00009.png)
AU (1) AU2019398339A1 (US20080131398A1-20080605-C00009.png)
BR (1) BR112021010871A2 (US20080131398A1-20080605-C00009.png)
CA (1) CA3120880A1 (US20080131398A1-20080605-C00009.png)
CL (1) CL2021001521A1 (US20080131398A1-20080605-C00009.png)
CO (1) CO2021008817A2 (US20080131398A1-20080605-C00009.png)
IL (2) IL310699A (US20080131398A1-20080605-C00009.png)
MA (1) MA54471A (US20080131398A1-20080605-C00009.png)
MX (1) MX2021006908A (US20080131398A1-20080605-C00009.png)
PE (1) PE20211788A1 (US20080131398A1-20080605-C00009.png)
SG (1) SG11202106194TA (US20080131398A1-20080605-C00009.png)
WO (1) WO2020123827A1 (US20080131398A1-20080605-C00009.png)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3111317C (en) 2012-09-17 2023-08-29 F. Hoffmann-La Roche Ltd. Method of synthesizing thyroid hormone analogs and polymorphs thereof
AU2019287679B2 (en) 2018-06-12 2022-04-21 Xizang Haisco Pharmaceutical Co., Ltd. Thyroid hormone receptor agonists and uses thereof
US11203587B2 (en) 2018-10-12 2021-12-21 Terns, Inc. Thyroid hormone receptor beta agonist compounds
CN111320609A (zh) 2018-12-13 2020-06-23 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
SG11202111552YA (en) 2019-05-08 2021-11-29 Aligos Therapeutics Inc MODULATORS OF THR-ß AND METHODS OF USE THEREOF
WO2020228577A1 (zh) * 2019-05-10 2020-11-19 深圳微芯生物科技股份有限公司 一种哒嗪酮衍生物及其应用
WO2020239076A1 (zh) * 2019-05-29 2020-12-03 南京明德新药研发有限公司 作为甲状腺素受体-β激动剂的哒嗪酮类衍生物及其应用
TW202128668A (zh) * 2019-12-16 2021-08-01 大陸商江蘇恆瑞醫藥股份有限公司 并環類衍生物、其製備方法及其在醫藥上的應用
CN115811972A (zh) * 2020-05-13 2023-03-17 拓臻制药公司 肝脏病症的组合治疗
AU2021332217A1 (en) 2020-08-25 2023-05-11 Eli Lilly And Company Polymorphs of an ssao inhibitor
WO2022053028A1 (zh) * 2020-09-10 2022-03-17 南京明德新药研发有限公司 1,2,4-三嗪-3,5(2h,4h)-二酮类化合物及其应用
CA3192169A1 (en) * 2020-09-17 2022-03-24 Sunshine Lake Pharma Co., Ltd. A compound as a thyroid hormone beta receptor agonist and use thereof
MX2023004658A (es) * 2020-10-23 2023-05-18 Madrigal Pharmaceuticals Inc Proceso para la preparacion de derivados de 6-(4-nitro-fenoxi)-2h- piridazin-3 -ona y 6-(4-amino-fenoxi)-2h-piridazin-3-ona como intermedios de analogos de hormona tiroidea.
CN116723844A (zh) * 2020-11-06 2023-09-08 阿利戈斯治疗公司 作为甲状腺激素受体β (TR-β)激动剂的双环哒嗪酮
CN116925045A (zh) * 2020-12-15 2023-10-24 中国科学院上海药物研究所 甲状腺素受体β选择性激动剂化合物、其药物组合物和用途
CN114685450A (zh) 2020-12-30 2022-07-01 昆药集团股份有限公司 2-吡啶酮类衍生物及其制备方法和在医药上的应用
AU2022228569A1 (en) * 2021-03-03 2023-10-12 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
AU2022388507A1 (en) * 2021-11-11 2024-06-20 Terns Pharmaceuticals, Inc. TREATMENT OF LIVER DISORDERS WITH A THR-β AGONIST
US20230241071A1 (en) * 2021-11-11 2023-08-03 Terns Pharmaceuticals, Inc. Combination treatment of liver disorders
WO2023154842A1 (en) * 2022-02-10 2023-08-17 Madrigal Pharmaceuticals, Inc. Thr beta analogs and uses thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0377903A3 (de) * 1989-01-09 1991-07-17 Bayer Ag Substituierte Hexahydro-1,2,4-triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
US6787652B1 (en) 1999-09-30 2004-09-07 Pfizer, Inc. 6-Azauracil derivatives as thyroid receptor ligands
CA2433100A1 (en) * 2000-12-27 2002-07-04 Helmut Haning Indole derivatives as ligands of thyroid receptors
CA2473162A1 (en) 2002-01-30 2003-08-07 Kissei Pharmaceutical Co., Ltd. Novel thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof
AU2003225305A1 (en) 2002-05-08 2003-11-11 Bristol-Myers Squibb Company Pyridine-based thyroid receptor ligands
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
FR2882750B1 (fr) 2005-03-03 2007-05-11 Pierre Fabre Medicament Sa Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine
GB0513692D0 (en) 2005-07-04 2005-08-10 Karobio Ab Novel pharmaceutical compositions
WO2007009913A1 (en) * 2005-07-21 2007-01-25 F. Hoffmann-La Roche Ag Pyridazinone derivatives as thyroid hormone receptor agonists
WO2010122980A1 (ja) 2009-04-20 2010-10-28 田辺三菱製薬株式会社 新規甲状腺ホルモンβ受容体作動薬
WO2011038207A1 (en) 2009-09-25 2011-03-31 Metabasis Therapeutics, Inc. Phosphorus-containing thyroid hormone receptor agonists and methods of use
EP3045453A1 (en) 2011-11-14 2016-07-20 Cephalon, Inc. Uracil derivatives as axl and c-met kinase inhibitors
CN103130723B (zh) 2011-11-30 2015-01-14 成都地奥制药集团有限公司 一种多聚(adp-核糖)聚合酶抑制剂
CN102898377B (zh) * 2012-02-14 2016-01-20 南京圣和药业股份有限公司 一类酞嗪酮衍生物及其用途
JP6814730B2 (ja) 2014-09-05 2021-01-20 ジェネンテック, インコーポレイテッド 治療用化合物およびその使用
EP4112056A1 (en) * 2016-10-18 2023-01-04 Madrigal Pharmaceuticals, Inc. Methods of treating liver disorders or lipid disorders with a thr-beta agonist
US11485729B2 (en) 2018-01-23 2022-11-01 Shenzhen Targetrx, Inc. Substituted pyridazinone compound
AU2019287679B2 (en) * 2018-06-12 2022-04-21 Xizang Haisco Pharmaceutical Co., Ltd. Thyroid hormone receptor agonists and uses thereof
US10800767B2 (en) 2018-08-24 2020-10-13 Terns, Inc. Thyroid hormone receptor beta agonist compounds
US11541745B2 (en) 2018-08-24 2023-01-03 Plastic Omnium Advanced Innovation And Research Assembly for a fluid tank comprising a baffle and a fluid transfer line passing through the baffle
US20210355110A1 (en) 2018-10-12 2021-11-18 InventisBio Co., Ltd. Thyroid hormone receptor agonists
US11203587B2 (en) 2018-10-12 2021-12-21 Terns, Inc. Thyroid hormone receptor beta agonist compounds
CN111320609A (zh) 2018-12-13 2020-06-23 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
CN111484481A (zh) 2019-01-26 2020-08-04 察略盛医药科技(上海)有限公司 哒嗪酮类衍生物、其制备方法及其在医药上的用途
CN113474335A (zh) 2019-02-21 2021-10-01 南京瑞捷医药科技有限公司 新型化合物及其作为甲状腺激素受体激动剂的用途
WO2020239076A1 (zh) 2019-05-29 2020-12-03 南京明德新药研发有限公司 作为甲状腺素受体-β激动剂的哒嗪酮类衍生物及其应用

Similar Documents

Publication Publication Date Title
JPWO2020123827A5 (US20080131398A1-20080605-C00009.png)
JP2020531422A5 (US20080131398A1-20080605-C00009.png)
JP2019504898A5 (US20080131398A1-20080605-C00009.png)
RU2008106058A (ru) Производные пиридазинона в качестве агонистов рецептора тиреоидного гормона
JP2010530881A5 (US20080131398A1-20080605-C00009.png)
JP2020507589A5 (US20080131398A1-20080605-C00009.png)
JP2019500387A5 (US20080131398A1-20080605-C00009.png)
JP2020506951A5 (US20080131398A1-20080605-C00009.png)
JP2009530398A5 (US20080131398A1-20080605-C00009.png)
JP2011527334A5 (US20080131398A1-20080605-C00009.png)
JP2010532768A5 (US20080131398A1-20080605-C00009.png)
RU2010101611A (ru) Полициклические производные гуанина и способы их применения
JP2009501234A5 (US20080131398A1-20080605-C00009.png)
JP2009523841A5 (US20080131398A1-20080605-C00009.png)
JP2008530242A5 (US20080131398A1-20080605-C00009.png)
JP2011527345A5 (US20080131398A1-20080605-C00009.png)
JP2009502777A5 (US20080131398A1-20080605-C00009.png)
JP2012519691A5 (US20080131398A1-20080605-C00009.png)
WO2014129495A1 (ja) 眼疾患処置薬
RU2011133128A (ru) Противоопухолевые соединения дигидропиран-2-она
JP2009541224A5 (US20080131398A1-20080605-C00009.png)
JP2008542386A5 (US20080131398A1-20080605-C00009.png)
JP2007518798A5 (US20080131398A1-20080605-C00009.png)
JP2007525533A5 (US20080131398A1-20080605-C00009.png)
JP2005539014A5 (US20080131398A1-20080605-C00009.png)