JPWO2020120983A5 - - Google Patents

Info

Publication number

JPWO2020120983A5

JPWO2020120983A5 JP2021534213A JP2021534213A JPWO2020120983A5 JP WO2020120983 A5 JPWO2020120983 A5 JP WO2020120983A5 JP 2021534213 A JP2021534213 A JP 2021534213A JP 2021534213 A JP2021534213 A JP 2021534213A JP WO2020120983 A5 JPWO2020120983 A5 JP WO2020120983A5

Authority

JP

Japan

Prior art keywords

seq

peptide ligand

mmp

ligand according

drug conjugate

Prior art date

2022-12-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 description 18
• 239000003446 ligand Substances 0.000 description 14
• 239000003814 drug Substances 0.000 description 6
• 229940079593 drug Drugs 0.000 description 5
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 4
• 102000004196 processed proteins & peptides Human genes 0.000 description 4
• 102000011716 Matrix Metalloproteinase 14 Human genes 0.000 description 3
• 108010076557 Matrix Metalloproteinase 14 Proteins 0.000 description 3
• 235000001014 amino acid Nutrition 0.000 description 3
• 150000001413 amino acids Chemical class 0.000 description 3
• 239000002062 molecular scaffold Substances 0.000 description 3
• 229920001184 polypeptide Polymers 0.000 description 3
• 229910052717 sulfur Inorganic materials 0.000 description 3
• 101001011906 Homo sapiens Matrix metalloproteinase-14 Proteins 0.000 description 2
• WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 description 2
• 229940127089 cytotoxic agent Drugs 0.000 description 2
• 239000002254 cytotoxic agent Substances 0.000 description 2
• 231100000599 cytotoxic agent Toxicity 0.000 description 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
• 238000002875 fluorescence polarization Methods 0.000 description 2
• 102000056429 human MMP14 Human genes 0.000 description 2
• 229910052757 nitrogen Inorganic materials 0.000 description 2
• 239000008194 pharmaceutical composition Substances 0.000 description 2
• 229910052700 potassium Inorganic materials 0.000 description 2
• 150000003839 salts Chemical class 0.000 description 2
• 239000000126 substance Substances 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• 102000008186 Collagen Human genes 0.000 description 1
• 108010035532 Collagen Proteins 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical group CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 150000003863 ammonium salts Chemical class 0.000 description 1
• 125000003118 aryl group Chemical group 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 229920001436 collagen Polymers 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000035475 disorder Diseases 0.000 description 1
• 239000012636 effector Substances 0.000 description 1
• 125000000524 functional group Chemical group 0.000 description 1
• 230000001404 mediated effect Effects 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1
• 229910052698 phosphorus Inorganic materials 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 238000000159 protein binding assay Methods 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1