JPWO2020113213A5 - - Google Patents
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- Publication number
- JPWO2020113213A5 JPWO2020113213A5 JP2021531391A JP2021531391A JPWO2020113213A5 JP WO2020113213 A5 JPWO2020113213 A5 JP WO2020113213A5 JP 2021531391 A JP2021531391 A JP 2021531391A JP 2021531391 A JP2021531391 A JP 2021531391A JP WO2020113213 A5 JPWO2020113213 A5 JP WO2020113213A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- deficiency
- coa
- cycloalkyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 18
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 claims 17
- 125000000753 cycloalkyl group Chemical group 0.000 claims 17
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 16
- 125000000304 alkynyl group Chemical group 0.000 claims 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 229910004759 OSi Inorganic materials 0.000 claims 3
- 125000004429 atoms Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862773952P | 2018-11-30 | 2018-11-30 | |
| US62/773,952 | 2018-11-30 | ||
| US201862774759P | 2018-12-03 | 2018-12-03 | |
| US62/774,759 | 2018-12-03 | ||
| US201962794503P | 2019-01-18 | 2019-01-18 | |
| US62/794,503 | 2019-01-18 | ||
| US201962795490P | 2019-01-22 | 2019-01-22 | |
| US62/795,490 | 2019-01-22 | ||
| US201962941643P | 2019-11-27 | 2019-11-27 | |
| US201962941644P | 2019-11-27 | 2019-11-27 | |
| US62/941,643 | 2019-11-27 | ||
| US62/941,644 | 2019-11-27 | ||
| PCT/US2019/063986 WO2020113213A2 (fr) | 2018-11-30 | 2019-12-02 | Dérivés de pantéthéine cyclique et utilisations de ceux-ci |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022511469A JP2022511469A (ja) | 2022-01-31 |
| JPWO2020113213A5 true JPWO2020113213A5 (fr) | 2023-01-30 |
Family
ID=70853524
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021531391A Pending JP2022511469A (ja) | 2018-11-30 | 2019-12-02 | 環状パンテテイン誘導体及びその使用 |
| JP2021531392A Pending JP2022520518A (ja) | 2018-11-30 | 2019-12-02 | パンテテイン誘導体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021531392A Pending JP2022520518A (ja) | 2018-11-30 | 2019-12-02 | パンテテイン誘導体及びその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20230072313A1 (fr) |
| EP (2) | EP3887353A1 (fr) |
| JP (2) | JP2022511469A (fr) |
| KR (2) | KR20210113184A (fr) |
| CN (2) | CN113727986A (fr) |
| AU (2) | AU2019389169A1 (fr) |
| CA (2) | CA3121504A1 (fr) |
| CL (2) | CL2021001395A1 (fr) |
| IL (2) | IL283525A (fr) |
| MX (2) | MX2021006274A (fr) |
| PH (2) | PH12021551256A1 (fr) |
| TW (2) | TW202039426A (fr) |
| WO (2) | WO2020113213A2 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| WO2017210134A1 (fr) | 2016-05-31 | 2017-12-07 | Board Of Regents, University Of Texas System | Inhibiteurs hétérocycliques de ptpn11 |
| KR102611661B1 (ko) | 2018-05-02 | 2023-12-08 | 나비레 파르마, 인코퍼레이티드 | Ptpn11의 치환된 헤테로사이클릭 억제제 |
| JP2021534124A (ja) | 2018-08-10 | 2021-12-09 | ナビール ファーマ，インコーポレイティド | 癌治療用ｐｔｐｎ１１（ｓｈｐ２）阻害剤としての６−（４−アミノ−３−メチル−２−オキサ−８−アザスピロ［４．５］デカン−８−イル）−３−（２，３−ジクロロフェニル）−２−メチルピリミジン−４（３ｈ）−オン誘導体及び関連化合物 |
| AU2020245580A1 (en) * | 2019-03-27 | 2021-10-28 | Comet Therapeutics, Inc. | Pantethenoylcysteine derivatives and uses thereof |
| US20230301953A1 (en) * | 2020-08-10 | 2023-09-28 | Oncocross Co.,Ltd. | Composition for prevention and treatment of myopathy |
| CN112876436B (zh) * | 2021-03-01 | 2022-06-21 | 安徽金轩科技有限公司 | 一种高选择性制备呋喃铵盐的方法 |
| WO2023081775A1 (fr) * | 2021-11-03 | 2023-05-11 | Memorial Sloan-Kettering Cancer Center | Inhibiteurs de combinaison en vue du traitement de la fibrose |
| WO2023081832A1 (fr) * | 2021-11-04 | 2023-05-11 | The Johns Hopkins University | Méthodes destinées à prévenir et à traiter une lésion rénale aiguë |
| CN114107426B (zh) * | 2021-11-10 | 2023-01-06 | 苏州大学 | 一种筛选谷氨酰胺转运蛋白抑制剂的方法、采用该方法筛选出的抑制剂及其应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH333732A (de) * | 1955-06-15 | 1958-10-31 | Bracco Fulvio Dr | Verfahren zur Herstellung von S-Acyl-pantetheinen |
| JPS52144618A (en) * | 1976-05-25 | 1977-12-02 | Sogo Yatsuko Kk | Method of manufacturing panthethine or panthetheine |
| JPS577405A (en) * | 1980-06-17 | 1982-01-14 | Pola Chem Ind Inc | Whitening cosmetic |
| GB8319457D0 (en) * | 1983-07-19 | 1983-08-17 | Maggioni Farma | Compounds with hypolipemic activity |
| US5143831A (en) * | 1988-08-30 | 1992-09-01 | G. D. Searle & Co. | Fructose 1,6-diphosphate aldolase catalyzed steroselective synthesis of sugars |
| US5053426A (en) * | 1990-03-29 | 1991-10-01 | American Cyanamid Company | Simplified thioester and isostere analogs of oleoyl coenzyme a as hypocholesterolemic agents |
| AU7104694A (en) * | 1993-10-27 | 1995-05-22 | Oculon Corporation | Compounds and methods for treating sickle cell anemia |
| WO2001077366A1 (fr) * | 2000-04-10 | 2001-10-18 | Cubist Pharmaceuticals, Inc. | Procede de selection positive, composes, cellules hotes et leur utilisation |
| US7045547B2 (en) * | 2002-08-20 | 2006-05-16 | University Of Delaware | Acyl-CoA dehydrogenase allenic inhibitors |
| US7745163B2 (en) * | 2003-10-03 | 2010-06-29 | Albert Einstein College Of Medicine Of Yeshiva University | Method for identifying acetyltransferase substrates |
| SG124419A1 (en) * | 2005-02-03 | 2006-08-30 | Agency Science Tech & Res | Polycations capable of forming complexes with nucleic acids |
| US7626005B2 (en) * | 2005-02-18 | 2009-12-01 | Mcgill University | Inhibitors of aminoglycoside 6′-N-acetyltransferases, compositions and uses thereof |
| US20120189566A1 (en) * | 2009-09-11 | 2012-07-26 | Daiichi Fine Chemical Co., Ltd. | External preparation containing pantethine phosphate ester |
| WO2012017400A1 (fr) * | 2010-08-03 | 2012-02-09 | North-West University | Synthèse de dérivés d'acyl-pantéthéine et utilisation de ceux-ci dans la synthèse de dérivés d'acyl-coenzyme a |
| WO2014037834A2 (fr) * | 2012-09-08 | 2014-03-13 | Mahesh Kandula | Compositions et méthodes de traitement d'une inflammation et de troubles lipidiques |
| WO2014080307A2 (fr) * | 2012-11-21 | 2014-05-30 | Mahesh Kandula | Compositions et procédés pour le traitement du diabète et du pré-diabète |
| CN104513235B (zh) * | 2013-09-02 | 2017-12-05 | 广东东阳光药业有限公司 | 取代的氨基嘧啶类化合物及其使用方法和用途 |
| EP2868662A1 (fr) * | 2013-11-04 | 2015-05-06 | Acies Bio d.o.o. | Dérivés de la pantéthéine stable pour le traitement de la neurodégénérescence associée de pantothénate kinase (pkan) et procédés pour la synthèse de ces composés |
| SI24899A (sl) * | 2014-12-23 | 2016-06-30 | Acies Bio D.O.O. | Fosfopanteteinske spojine,same ali v kombinaciji z inhibitorji HMG-COA reduktaze za zniževanje serumskega holesterola in serumskih trigliceridov |
| US20190337971A1 (en) * | 2016-07-25 | 2019-11-07 | Retrophin, Inc. | Pantetheine derivatives for the treatment of neurologic disorders |
| EP3549574B1 (fr) * | 2016-11-30 | 2024-02-14 | Korea Institute of Ocean Science & Technology | Composition pour favoriser la pousse des cheveux ou la restauration des cheveux, contenant une substance nouvelle à base de pantothéine |
-
2019
- 2019-12-02 WO PCT/US2019/063986 patent/WO2020113213A2/fr active Application Filing
- 2019-12-02 JP JP2021531391A patent/JP2022511469A/ja active Pending
- 2019-12-02 KR KR1020217018746A patent/KR20210113184A/ko unknown
- 2019-12-02 WO PCT/US2019/063955 patent/WO2020113209A1/fr active Application Filing
- 2019-12-02 EP EP19827992.9A patent/EP3887353A1/fr active Pending
- 2019-12-02 CN CN201980090790.8A patent/CN113727986A/zh active Pending
- 2019-12-02 CN CN201980090697.7A patent/CN113727966A/zh active Pending
- 2019-12-02 AU AU2019389169A patent/AU2019389169A1/en active Pending
- 2019-12-02 MX MX2021006274A patent/MX2021006274A/es unknown
- 2019-12-02 JP JP2021531392A patent/JP2022520518A/ja active Pending
- 2019-12-02 TW TW108143944A patent/TW202039426A/zh unknown
- 2019-12-02 KR KR1020217020541A patent/KR20210113196A/ko unknown
- 2019-12-02 US US17/298,658 patent/US20230072313A1/en active Pending
- 2019-12-02 US US17/298,652 patent/US20230107216A1/en active Pending
- 2019-12-02 EP EP19835330.2A patent/EP3887381A2/fr active Pending
- 2019-12-02 CA CA3121504A patent/CA3121504A1/fr active Pending
- 2019-12-02 AU AU2019389168A patent/AU2019389168A1/en active Pending
- 2019-12-02 CA CA3121500A patent/CA3121500A1/fr active Pending
- 2019-12-02 MX MX2021006265A patent/MX2021006265A/es unknown
- 2019-12-02 TW TW108143945A patent/TW202039522A/zh unknown
-
2021
- 2021-05-27 CL CL2021001395A patent/CL2021001395A1/es unknown
- 2021-05-27 IL IL283525A patent/IL283525A/en unknown
- 2021-05-27 CL CL2021001396A patent/CL2021001396A1/es unknown
- 2021-05-28 IL IL283533A patent/IL283533A/en unknown
- 2021-05-29 PH PH12021551256A patent/PH12021551256A1/en unknown
- 2021-05-29 PH PH12021551257A patent/PH12021551257A1/en unknown
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