JPWO2020106891A5 - - Google Patents

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JPWO2020106891A5
JPWO2020106891A5 JP2021528452A JP2021528452A JPWO2020106891A5 JP WO2020106891 A5 JPWO2020106891 A5 JP WO2020106891A5 JP 2021528452 A JP2021528452 A JP 2021528452A JP 2021528452 A JP2021528452 A JP 2021528452A JP WO2020106891 A5 JPWO2020106891 A5 JP WO2020106891A5
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sample collection
collection container
sealing cap
sample
connecting member
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JP7413381B2 (en
JP2022507875A (en
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一つの態様では、接続部材及び、相補的な接続部材は、ねじ山を備える。相補的な接続部材のねじ山は、シーリングキャップの内側表面上に配置されてもよい。 In one aspect, the connecting member and the complementary connecting member include threads . A complementary connecting member thread may be arranged on the inner surface of the sealing cap.

一つの態様では、シーリングキャップを試料収集容器に連結させることは、試料収集容器の外側表面に配置された接続部材とシーリングキャップの内側表面に配置された相補的な接続部材とをねじ山を通して係合させることを含む。 In one embodiment, coupling the sealing cap to the sample collection container includes threaded engagement between a connecting member disposed on the outer surface of the sample collection container and a complementary connecting member disposed on the inner surface of the sealing cap. including matching.

以下により詳細に記載するように、バルブは、開いて試薬チャンバから試料収集チャンバ中へ試薬を放出させることが出来る。いくつかの実施形態で、選択的に移動可能なバルブの近位部分は、シーリングキャップと機械的に（例えば、摩擦フィットを介して）かみ合ってポストがシーリングキャップと調和して動くようになる。バルブヘッドは、それらの間に流体タイト接続を形成するポストの遠位部分に固定される。バルブヘッドは、試料収集容器の開口内にフィットするように形成及び成型され、そして、試料収集容器（又はそれらに連結した構造）の内側壁と係合するように形成及び成型されて配置されたカラーを備える。シーリングキャップを試料収集容器に連結させることで、バルブキャップは試料収集チャンバに入り、そして、それらの内側壁と係合する。シーリングキャップは、更に、試料収集容器（例えば、ねじ山を通した係合により）に固定されるので、ポストはシーリングキャップとかみ合って動き、そして、バルブキャップは動かないままである。このように、ポストはバルブヘッドに対して移動（例えば、回転）し、（例えば、物理的再構成を受けることにより）選択的に移動可能なバルブを開かせる。バルブキャップに対するポストの独立した動きは、例えば、バルブヘッドと試料収集チャンバとの間の力よりも小さいポストとバルブヘッドとの間（流体タイト接続を形成する）の力（例えば、摩擦力又は機械的にかみ合って克服するために必要とされる力）により可能になり得る。開いた配置に移動するとき、その前はポストにより形成され妨害されていた流体ベントは、バルブヘッドの本体中に形成されたアパーチャと少なくとも部分的に整合し、それにより、シーリングキャップの試薬チャンバから試料収集チャンバ中に試料保存溶液を連通するための溝を作成する。 As described in more detail below, the valve can be opened to release reagent from the reagent chamber into the sample collection chamber. In some embodiments, the selectively movable proximal portion of the valve mechanically engages the sealing cap (eg, via a friction fit) such that the post moves in unison with the sealing cap. The valve head is secured to the distal portion of the post forming a fluid tight connection therebetween. The valve head is shaped and shaped to fit within the opening of the sample collection container and is shaped and shaped and positioned to engage the interior wall of the sample collection container (or structure coupled thereto). Equipped with color. By connecting the sealing cap to the sample collection container, the valve cap enters the sample collection chamber and engages their inner wall. The sealing cap is further secured to the sample collection container (eg, by threaded engagement) so that the post moves in engagement with the sealing cap and the valve cap remains stationary. In this manner, the post moves (e.g., rotates) relative to the valve head to selectively open the movable valve (e.g., by undergoing physical reconfiguration). Independent movement of the post relative to the valve cap is caused by forces between the post and the valve head (forming a fluid-tight connection) (e.g., frictional forces or mechanical This can be made possible by the force required to engage and overcome the When moved to the open configuration, the fluid vent previously formed and obstructed by the post becomes at least partially aligned with the aperture formed in the body of the valve head, thereby removing the fluid from the reagent chamber of the sealing cap. Create a groove to communicate the sample storage solution into the sample collection chamber.

続けて、図１を参照しつつ、シーリングキャップ１１０及び、唾液漏斗（図示せず）は、接続機構を使用して試料収集容器１０２にそれぞれ独立して付けることが出来る。この接続機構は、例えば、ねじ山、スナップ又はプレスフィット接続、タング及びグラブ部材、差し込み接続若しくは、他のかみ合った又は機械的カップリング機構を備えることが出来る。例えば、漏斗は、相補的接続機構（例えば、相補的なねじ山、図示せず）を介して試料収集容器１０２に最初に付けることが出来る。使用者からの生体試料の受領を促進させた後、漏斗は、相補的な接続機構（例えば、漏斗を回して緩める、図示せず）を逆転させることにより除去することが出来、そして、シーリングキャップ１１０は、同様又は類似の相補的な接続機構を使用して試料収集容器１０２に固定することが出来る。例えば、図１に示すように、シーリングキャップ１１０は、相補的であり且つ試料収集容器１０２の外側表面上に配置された接続部材１１４（例えば、相補的なねじ山）とかみ合って働くシーリングキャップ１１０の内側円周壁上に配置された接続部材１１２（例えば、ねじ山）を備えることが出来る。 Continuing to refer to FIG. 1, the sealing cap 110 and saliva funnel (not shown) can each be independently attached to the sample collection container 102 using a connecting mechanism. The connection mechanism can include, for example, threads , snap or press-fit connections, tongue and grab members, bayonet connections, or other interlocking or mechanical coupling mechanisms. For example, the funnel can be initially attached to the sample collection container 102 via a complementary connection mechanism (eg, complementary threads , not shown). After facilitating receipt of the biological sample from the user, the funnel can be removed by reversing the complementary connection mechanism (e.g., unscrewing the funnel, not shown) and removing the sealing cap. 110 can be secured to sample collection container 102 using similar or similar complementary attachment mechanisms. For example, as shown in FIG. 1, the sealing cap 110 is complementary and operates in engagement with a connecting member 114 (e.g., complementary threads ) disposed on the outer surface of the sample collection container 102. A connecting member 112 (eg, a thread ) disposed on the inner circumferential wall of the connecting member 112 may be provided.

いくつかの実施形態で、漏斗と収集容器の間の接続機構は、溶液キャップと収集容器の間の接続機構とは異なる。例えば、漏斗は、収集容器上にプレスフィット又はスナップフィットされてもよく、一方、溶液キャップは、収集容器の外側部分上及び、溶液キャッの内側部分上に又はその逆に配置された相補的なねじ山の係合を通して回転して固定される。使用する付ける機構にかかわらず、試料保存流体は、試料収集チャンバ１０３中に導入されることが出来、そして、シーリングキャップ１１０が試料収集容器１０２に付けられた結果として、預けられた生体試料と混合される。先に提供されたように、これは、選択的に移動可能なバルブ１０４が開いたことによるものであり得、そして、試薬を開口バルブにより規定される流体ベント１１６を通って試料収集チャンバ１０３中に放出させる。 In some embodiments, the connection mechanism between the funnel and the collection container is different than the connection mechanism between the solution cap and the collection container. For example, the funnel may be press-fit or snap-fit onto the collection container, while the solution cap may be fitted with a complementary Rotationally fixed through engagement of threads . Regardless of the application mechanism used, sample storage fluid can be introduced into the sample collection chamber 103 and mixed with the deposited biological sample as a result of the sealing cap 110 being applied to the sample collection container 102. be done. As previously provided, this may be due to the selectively movable valve 104 opening and allowing reagents to flow into the sample collection chamber 103 through the fluid vent 116 defined by the open valve. to be released.

シーリングキャップ１１０は、試薬チャンバ１１１中に試薬の測定物を受容するように配置されており、そして、図１中の組立てられた試料収集システム１００の断面図により示されるように、選択的に移動可能なバルブ１０４は、シーリングキャップ１１０と連結されている。ポスト１０６は、シーリングキャップ１１０中にスナップフィットで受容され得、その間に流体タイト接続を形成する。上記に示すように、ポストは、その中にシーリングキャップ１１０の内側側壁の突出部１２０が入り、ポスト１０６を安定化させる保持リング１１８を備える。いくつかの実施形態で、突出部１２０と保持リング１１８との間の相互作用により、シーリングキャップ１１０とポスト１０６との間の流体タイト接続を生じる。追加的に又は代替的に、ポストの上部カラー１２２は、シーリングキャップ１１０の本体中又は、試薬チャンバ１１１中に延び、そして、締まりばめを介して固定され、それにより、試薬チャンバ１１１とポスト１０６との間の流体タイト接続を生じさせる。保持リング１１８は、いくつかの実施形態で、ポスト１０６をキャップ１１０で固定し、そして、ねじ山を通した係合部材により固定された熱可塑性成分に一般的である変形を防止する。 Sealing cap 110 is positioned to receive a measurement of reagent in reagent chamber 111 and is selectively moved, as shown by the cross-sectional view of assembled sample collection system 100 in FIG. A possible valve 104 is connected with a sealing cap 110. Post 106 may be received in a sealing cap 110 with a snap fit to form a fluid tight connection therebetween. As shown above, the post includes a retaining ring 118 into which a protrusion 120 of the inner sidewall of the sealing cap 110 enters to stabilize the post 106. In some embodiments, the interaction between protrusion 120 and retaining ring 118 creates a fluid tight connection between sealing cap 110 and post 106. Additionally or alternatively, the post top collar 122 extends into the body of the sealing cap 110 or into the reagent chamber 111 and is secured via an interference fit, thereby connecting the reagent chamber 111 and the post 106. creating a fluid tight connection between the Retaining ring 118, in some embodiments, secures post 106 with cap 110 and prevents deformation that is common with thermoplastic components secured by threaded engagement members.

シーリングキャップ１１０と試料収集容器１０２との間の相補的なねじ山１１４，１１２は、相互に係合し、そして、シーリングキャップ１１０は、試料収集容器１０２の方向に進み、バルブヘッド１０８及び、ポスト１０６の連結された遠位部分は、試料収集チャンバ１０３の開口部に導入されるか又は、更に開口部中に延びる。バルブヘッド１０８のカラー１２６は、開口１２４を備えたバルブヘッドの遠位部分よりも大きい直径を有し、そして、この大きい直径のカラー１２６は、試料収集チャンバ１０３の開口部内にフィットするように形成又は成型されて、そこで、それらの側壁に係合する。バルブヘッド１０８とチャンバ側壁の係合に由来する反発力は、ポスト１０６とバルブヘッド１０８との間の力よりも大きい。トルク（又は他の力）が溶液キャップ１１０に適用されて、更に、溶液キャップ１１０を試料収集容器１０２に連結させ、ポスト１０６とバルブヘッド１０８との間の力は克服され、バルブヘッド１０８がそれぞれ動かない間、－シーリングキャップと直接結合している－ポスト１０６を、シーリングキャップに沿って回転させる。したがって、選択的に移動可能なバルブ１０４は、（図２中に示すように）閉じた配置から、ポスト１０６をバルブヘッド１０８内で回転させて、少なくとも部分的に流体ベント１１６を開口１２４と整合させる、（図１及び図３中に示すように）開いた配置に配置変換させる。 Complementary threads 114, 112 between sealing cap 110 and sample collection container 102 engage each other, and sealing cap 110 is advanced toward sample collection container 102 and threads 114, 112 between valve head 108 and post. The connected distal portion of 106 is introduced into or extends further into the opening of the sample collection chamber 103. Collar 126 of valve head 108 has a larger diameter than the distal portion of the valve head with opening 124 and this larger diameter collar 126 is shaped to fit within the opening of sample collection chamber 103. or molded therein to engage their side walls. The repulsive force resulting from the engagement of the valve head 108 with the chamber sidewall is greater than the force between the post 106 and the valve head 108. A torque (or other force) is applied to the solution cap 110 to further couple the solution cap 110 to the sample collection container 102 such that the force between the post 106 and the valve head 108 is overcome so that the valve heads 108 each While stationary, the post 106 - which is directly connected to the sealing cap - is rotated along the sealing cap. Accordingly, the selectively movable valve 104 rotates the post 106 within the valve head 108 from a closed configuration (as shown in FIG. 2) to at least partially align the fluid vent 116 with the opening 124. 1 and 3, and then repositioned to an open configuration (as shown in FIGS. 1 and 3).

使用者により獲得されたとき、上記に記載のキットは、組立てられ、そして、生体試料を保存するために使用することが出来る。具体的な実施で、生体試料は、生体試料収集容器１０２中に受容される。受容された生体試料は、生体試料チャンバ１０３中に直接入るか、又は、任意選択的に付属の漏斗の内側側壁にそって、重力の流れを介して導入されても良い。漏斗が使用されるとき、生体試料の受領をさせた後、生体試料収集容器１０２から漏斗は除かれる。シーリングキャップ１１０及び連結され閉じられたバルブは、バルブ１０４の遠位部分を生体試料チャンバ１０３により規定された開口部へ挿入し、そして、シーリングキャップ１１０を（例えば、キャップ１１０と容器１０２の間に相補的なねじ山１１２，１１４に沿ってシーリングキャップ１１０を回転させることにより）生体試料収集容器１０２上部の上に固定することにより、生体試料収集容器１０２と連結されて運ばれる。選択的に移動可能なバルブ１０４は、シーリングキャップ１１０が収集容器１０２上に固定され、バルブ１０４を閉じた配置から開いた配置へ転換させるとき、配置変換を受ける。シーリングキャップ１１０内に貯蔵された試薬は、試料収集チャンバ１０３と連通して、そして、いくつかの実施形態で、収集容器１０２は振られ又は、そうでなければ、かき回して、保存試薬の全部又は少なくとも一部が収集試料を覆い、そして混合されるようにさせる。試料は、シーリングキャップ１１０と容器１０２の間で形成された流体及び／又は空気タイトシールにより、化学的及び生物学的に外側の雰囲気から有益的に保存される。これは、試料汚染の機会を減少させ、そして、プロセシング施設への移動及び／又は保存中に証拠となる成分の完全性を維持することを助ける。 When obtained by a user, the kit described above can be assembled and used to store biological samples. In a particular implementation, a biological sample is received in biological sample collection container 102. The received biological sample may be introduced directly into the biological sample chamber 103 or via gravity flow, optionally along the inner sidewall of an attached funnel. When the funnel is used, it is removed from the biological sample collection container 102 after receiving the biological sample. The sealing cap 110 and the coupled closed valve may be inserted into the opening defined by the biological sample chamber 103 by inserting the distal portion of the valve 104 into the opening defined by the biological sample chamber 103 and inserting the sealing cap 110 (e.g., between the cap 110 and the container 102) into the opening defined by the biological sample chamber 103. The sealing cap 110 is secured onto the top of the biological sample collection container 102 (by rotating the sealing cap 110 along complementary threads 112, 114) and transported in conjunction with the biological sample collection container 102. Selectively movable valve 104 undergoes a positional transformation when sealing cap 110 is secured onto collection container 102, converting valve 104 from a closed configuration to an open configuration. Reagents stored within sealing cap 110 are in communication with sample collection chamber 103 and, in some embodiments, collection container 102 may be shaken or otherwise agitated to remove all or any of the stored reagents. Allow at least a portion to cover the collected sample and mix. The sample is advantageously preserved chemically and biologically from the outside atmosphere by the fluid and/or air tight seal formed between the sealing cap 110 and the container 102. This reduces the chance of sample contamination and helps maintain the integrity of the evidentiary components during transfer to a processing facility and/or storage.

Claims (15)

生体試料を収集するシステム（１００）であって、
生体試料を受容する開口部を備えた試料収集容器（１０２）、
少なくとも部分的に試料収集容器の開口部と連結して配置された選択的に移動可能なバルブ（１０４）、並びに、
選択的に移動可能なバルブ（１０４）及び試料収集容器（１０２）と連結して配置されたシーリングキャップ（１１０）を備え、
前記選択的に移動可能なバルブ（１０４）は、
中空本体及び、その側面部分により規定された流体ベント（１１６）を有するポスト（１０６）、並びに、
ポスト（１０６）の遠位部分と連結し且つ、流体ベント（１１６）と選択的に整合可能な開口（１２４）を有するバルブヘッド（１０８）を備え、
前記シーリングキャップ（１１０）は、試料保存試薬を保存する試薬チャンバ（１１１）を備え、前記試薬チャンバ（１１１）はポスト（１０６）の中空本体と流体連通し、
シーリングキャップ（１１０）と試料収集容器（１０２）とを連結させることは、ポスト（１０６）とバルブヘッド（１０８）とを物理的再構成させて、流体ベント（１１６）が、試薬チャンバ（１１１）と試料収集容器（１０２）の間を流体連通させるように、バルブヘッド（１０８）により規定される開口（１２４）と整合するようになる、
生体試料を収集するシステム。 A system (100) for collecting a biological sample, the system comprising:
a sample collection container (102) with an opening for receiving a biological sample;
a selectively movable valve (104) disposed at least partially in communication with the opening of the sample collection container; and
a sealing cap (110) disposed in conjunction with a selectively movable valve (104) and a sample collection container (102) ;
The selectively movable valve (104) comprises:
a post (106) having a hollow body and a fluid vent (116) defined by a side portion thereof; and
a valve head (108) coupled to the distal portion of the post (106) and having an opening (124) selectively alignable with the fluid vent ( 116) ;
said sealing cap (110) comprises a reagent chamber (111) for storing sample preservation reagents , said reagent chamber (111) being in fluid communication with the hollow body of the post (106) ;
Coupling the sealing cap (110) and the sample collection container (102) physically reconfigures the post (106) and valve head (108) so that the fluid vent (116) is connected to the reagent chamber (111). aligned with an opening (124) defined by the valve head (108) to provide fluid communication between the sample collection container (102) and the sample collection container (102);
A system for collecting biological samples. 物理的再構成は、バルブヘッドに対するポストの回転式再構成を含む、請求項１に記載の生体試料を収集するシステム。 2. The system of claim 1, wherein the physical reconfiguration includes rotational reconfiguration of the post relative to the valve head. 試料収集容器は、更に接続部材を備え、そして、シーリングキャップは、更に試料収集容器とシーリングキャップをつなぐために、試料収集容器の接続部材と連結するように配置された相補的な接続部材を備える請求項１又は２に記載の生体試料を収集するシステム。 The sample collection container further comprises a connecting member, and the sealing cap further comprises a complementary connecting member arranged to couple with the connecting member of the sample collection container to connect the sample collection container and the sealing cap. A system for collecting biological samples according to claim 1 or 2. 接続部材は、試料収集容器から離れて突出する隆起部又は、試料収集容器内に陥没部を備え、且つ、相補的な接続部材は、接続部材と係合するように形成若しくは成型されたフック又は隆起部を備える請求項３に記載の生体試料を収集するシステム。 The connecting member includes a raised portion projecting away from the sample collection container or a recessed portion within the sample collection container, and the complementary connecting member includes a hook or molded portion formed or molded to engage the connecting member. 4. The system for collecting a biological sample according to claim 3, comprising a ridge. 接続部材及び、相補的な接続部材はねじ山を備え、そして、相補的な接続部材のねじ山は、シーリングキャップの内側表面上に配置されている請求項３に記載の生体試料を収集するシステム。 4. The system for collecting a biological sample according to claim 3, wherein the connecting member and the complementary connecting member include threads , and the threads of the complementary connecting member are disposed on the inner surface of the sealing cap. . 流体ベントは、選択的に移動可能なバルブが閉じた配置であるとき、バルブヘッドにより妨害され、且つ流体ベントは、選択的に移動可能なバルブが開いた配置であるとき、少なくとも部分的にバルブヘッドに整合している請求項１～５の何れか一項に記載の生体試料を収集するシステム。 The fluid vent is obstructed by the valve head when the selectively movable valve is in the closed configuration, and the fluid vent is at least partially obstructed by the valve head when the selectively movable valve is in the open configuration. A system for collecting a biological sample according to any one of claims 1 to 5, wherein the system is aligned with a head. ポストは、シーリングキャップの内側部分内に突出部又は戻り止めを連結するように配置された保持リングを備える請求項１～６の何れか一項に記載の生体試料を収集するシステム。 A system for collecting a biological sample according to any one of claims 1 to 6, wherein the post comprises a retaining ring arranged to couple a protrusion or detent within the inner part of the sealing cap. 一つ以上のポスト又はバルブヘッドは、ポストとバルブヘッドの間のタイト連結を維持するために配置された環状保持部品を備える請求項１～７の何れか一項に記載の生体試料を収集するシステム。 Collecting a biological sample according to any one of claims 1 to 7, wherein the one or more posts or valve heads comprises an annular retaining piece arranged to maintain a tight connection between the posts and the valve head. system. バルブヘッドは、流体ベントを規定する側壁部分の近位に配置された上部カラーであって、流体ベントを規定する側壁部分よりも大きい直径を有し、且つ試料収集容器の内側側壁部分と接触するように配置された上部カラーを備える請求項１～８の何れか一項に記載の生体試料を収集するシステム。 The valve head is an upper collar disposed proximal to the sidewall portion defining the fluid vent, the valve head having a larger diameter than the sidewall portion defining the fluid vent and in contact with the inner sidewall portion of the sample collection container. System for collecting a biological sample according to any one of claims 1 to 8, comprising an upper collar arranged in such a manner. バルブヘッドとポストの間のシーリング力は、バルブの上部カラーと試料収集容器の内側側壁の間のグリッピング力よりも小さい請求項９に記載の生体試料を収集するシステム。 10. The system of claim 9, wherein the sealing force between the valve head and the post is less than the gripping force between the upper collar of the valve and the inner sidewall of the sample collection container. 生体試料を収集し且つ保存する方法であって、
請求項１に記載の試料収集システムの試料収集容器で生体試料を受容する工程、および、
請求項１に記載の試料収集システムのシーリングキャップを試料収集容器に連結させて、シーリングキャップに連結された選択的に移動可能なバルブを開けさせ、それにより、シーリングキャップ内に保持された試料保存試薬を、試料収集チャンバ中に放出させる工程を備える、方法。 A method of collecting and preserving a biological sample, the method comprising:
receiving a biological sample in a sample collection container of the sample collection system of claim 1, and
The sealing cap of the sample collection system of claim 1 is coupled to the sample collection container to open a selectively movable valve coupled to the sealing cap, thereby causing sample storage retained within the sealing cap. A method comprising releasing a reagent into a sample collection chamber. シーリングキャップを試料収集容器に連結させる工程は、試料収集容器の外側表面に配置された接続部材とシーリングキャップの内側表面に配置された相補的な接続部材とをねじ山を通して係合させることを含む請求項１１に記載の方法。 Coupling the sealing cap to the sample collection container includes threadingly engaging a connecting member disposed on the outer surface of the sample collection container and a complementary connecting member disposed on the inner surface of the sealing cap. The method according to claim 11. シーリングキャップを試料収集容器に連結させて、シーリングキャップに連結された選択的に移動可能なバルブを開けさせる工程は、連結されたバルブヘッド内でポストを回転させて、バルブヘッドにより規定される開口とポストの流体ベントを少なくとも部分的に整合させることを含む請求項１１又は１２に記載の方法。 The step of coupling a sealing cap to a sample collection container to open a selectively movable valve coupled to the sealing cap includes rotating a post within the coupled valve head to open an opening defined by the valve head. 13. A method according to claim 11 or 12, comprising at least partially aligning the fluid vent of the post with the fluid vent of the post. 追加的に、試料収集容器からシーリングキャップを分離させることにより、試料収集容器内で、保存した試料にアクセスする工程を備え、試料収集容器からのシーリングキャップの分離が、シーリングキャップに連結された選択的に移動可能なバルブを開いた配置から閉じた配置に移動させる請求項１１～１３の何れか一項に記載の方法。 Additionally, the step of accessing the stored sample within the sample collection container by separating the sealing cap from the sample collection container, wherein separation of the sealing cap from the sample collection container includes a selection coupled to the sealing cap. 14. A method according to any one of claims 11 to 13, characterized in that the movable valve is moved from an open position to a closed position. 生体試料を収集し且つ保存するキットであって、
試料収集容器（１０２）、シーリングキャップ（１１０）及び、
任意選択的に、試料収集容器（１０２）と連結し且つ使用者から生体サンプルの受領を試料収集容器（１０２）の試料収集チャンバ（１０３）中に導くように配置された、漏斗を備え、
前記試料収集容器（１０２）は、
生体試料を試料収集チャンバ（１０３）中に受容するように配置されている開口を有する試料収集チャンバ（１０３）及び、試料収集容器の外側部分に配置された接続部材を備え、
前記シーリングキャップ（１１０）は、
試料保存試薬を保存する試薬チャンバ（１１１）及び、試料収集容器（１０３）の接続部材（１１２）と係合するよう配置された相補的な接続部材（１１４）並びに、シーリングキャップ（１１０）とつながれた選択的に移動可能なバルブ（１０４）を備え、
選択的に移動可能なバルブ（１０４）は、試料収集チャンバ（１０３）と連結するように配置され、
流体ベント（１１６）をその遠位部分で規定するポスト（１０６）及び、
ポスト（１０６）の遠位部分に連結され且つ開口（１２４）を規定するバルブヘッド（１０８）を備え、
選択的に移動可能なバルブ（１０４）は閉じた配置にあるとき、流体ベントはバルブヘッド（１０８）との流体タイト連結を形成し、
選択的に移動可能なバルブ（１０４）が開いた配置にあるとき、流体ベントは少なくとも部分的に開口（１２４）と整合している、キット。 A kit for collecting and storing biological samples, the kit comprising:
a sample collection container (102) , a sealing cap (110) , and
optionally comprising a funnel coupled to the sample collection container (102) and arranged to direct receipt of a biological sample from a user into a sample collection chamber ( 103) of the sample collection container (102);
The sample collection container (102) includes:
a sample collection chamber (103) having an opening arranged to receive a biological sample into the sample collection chamber (103) , and a connecting member arranged on an outer portion of the sample collection container;
The sealing cap (110) includes:
a reagent chamber (111) for storing sample storage reagents and a complementary connecting member (114) arranged to engage the connecting member (112) of the sample collection container (103) and a sealing cap (110) ; a selectively movable valve (104) ;
a selectively movable valve (104) arranged to communicate with the sample collection chamber (103) ;
a post ( 106 ) defining a fluid vent (116 ) at a distal portion thereof;
a valve head ( 108) coupled to a distal portion of the post (106) and defining an opening (124) ;
When the selectively movable valve (104) is in a closed configuration, the fluid vent forms a fluid tight connection with the valve head (108) ;
The kit, wherein the fluid vent is at least partially aligned with the opening (124 ) when the selectively movable valve (104) is in an open configuration.
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