JPWO2020099653A5 - - Google Patents
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- JPWO2020099653A5 JPWO2020099653A5 JP2021526658A JP2021526658A JPWO2020099653A5 JP WO2020099653 A5 JPWO2020099653 A5 JP WO2020099653A5 JP 2021526658 A JP2021526658 A JP 2021526658A JP 2021526658 A JP2021526658 A JP 2021526658A JP WO2020099653 A5 JPWO2020099653 A5 JP WO2020099653A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- amino acid
- antibody
- sirpα
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- QCQYVCMYGCHVMR-AAZUGDAUSA-N n-[(2r,3r,4s,5r)-4,5,6-trihydroxy-1-oxo-3-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexan-2-yl]acetamide Chemical compound CC(=O)N[C@@H](C=O)[C@H]([C@@H](O)[C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O QCQYVCMYGCHVMR-AAZUGDAUSA-N 0.000 claims 2
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- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18206594 | 2018-11-15 | ||
| EP18206594.6 | 2018-11-15 | ||
| PCT/EP2019/081523 WO2020099653A1 (en) | 2018-11-15 | 2019-11-15 | HUMANIZED ANTI-SIRPα ANTIBODIES |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022509065A JP2022509065A (ja) | 2022-01-20 |
| JP2022509065A5 JP2022509065A5 (https=) | 2022-11-02 |
| JPWO2020099653A5 true JPWO2020099653A5 (https=) | 2022-11-02 |
| JP7451520B2 JP7451520B2 (ja) | 2024-03-18 |
Family
ID=64331834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021526658A Active JP7451520B2 (ja) | 2018-11-15 | 2019-11-15 | ヒト化抗ＳＩＲＰα抗体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12180295B2 (https=) |
| EP (1) | EP3880707A1 (https=) |
| JP (1) | JP7451520B2 (https=) |
| CN (1) | CN113412279B (https=) |
| AU (1) | AU2019378101B2 (https=) |
| BR (1) | BR112021009275A2 (https=) |
| CA (1) | CA3118966A1 (https=) |
| CL (1) | CL2021001260A1 (https=) |
| IL (1) | IL282756A (https=) |
| MX (1) | MX2021005761A (https=) |
| MY (1) | MY204673A (https=) |
| SG (1) | SG11202104431PA (https=) |
| WO (1) | WO2020099653A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS66062B1 (sr) | 2016-04-14 | 2024-11-29 | Ose Immunotherapeutics | Nova anti-sirpa antitela i njihove terapijske primene |
| JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
| CN118027200A (zh) | 2016-12-09 | 2024-05-14 | 艾利妥 | 抗SIRPα抗体及其使用方法 |
| CN118267470A (zh) * | 2017-04-13 | 2024-07-02 | 赛罗帕私人有限公司 | 抗SIRPα抗体 |
| MX2020009774A (es) | 2018-03-21 | 2020-10-08 | Alx Oncology Inc | Anticuerpos contra proteína alfa reguladora de señal y métodos de uso. |
| EP3802602A1 (en) | 2018-05-25 | 2021-04-14 | Alector LLC | Anti-sirpa antibodies and methods of use thereof |
| AU2021378152A1 (en) * | 2020-11-11 | 2023-06-22 | Daiichi Sankyo Company, Limited | COMBINATION OF AN ANTIBODY-DRUG CONJUGATE WITH ANTI-SIRPα ANTIBODY |
| CN112574310B (zh) * | 2020-12-11 | 2023-05-05 | 浙江博锐生物制药有限公司 | 抗SIRPα抗体及其用途 |
| CN114790241B (zh) * | 2021-01-26 | 2024-12-13 | 北京免疫方舟医药科技有限公司 | 抗tigit抗体及其应用 |
| BR112023025194A2 (pt) * | 2021-06-04 | 2024-02-27 | Boehringer Ingelheim Int | Anticorpos anti-sirp-alfa |
| EP4619435A1 (en) | 2022-11-16 | 2025-09-24 | Boehringer Ingelheim International GmbH | Predictive efficacy biomarkers for anti-sirpa antibodies |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| AU1701001A (en) | 1999-11-30 | 2001-06-12 | Eberhard-Karls-Universitat Tubingen Universitatsklinikum | Antibodies against signal regulator proteins |
| CN103172731A (zh) | 2004-07-15 | 2013-06-26 | 赞科股份有限公司 | 优化的Fc变体 |
| DK2474557T3 (da) | 2007-07-16 | 2014-11-10 | Genentech Inc | Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse |
| EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
| CA2752373C (en) | 2009-02-20 | 2017-10-10 | To-Bbb Holding B.V. | Glutathione-based drug delivery system |
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| KR102878970B1 (ko) | 2016-08-03 | 2025-10-30 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항-SIRPalpha 항체 요법의 대식세포 증진 효능에서 Fc 수용체 참여의 붕괴 |
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-
2019
- 2019-11-15 CA CA3118966A patent/CA3118966A1/en active Pending
- 2019-11-15 EP EP19808550.8A patent/EP3880707A1/en active Pending
- 2019-11-15 CN CN201980088956.2A patent/CN113412279B/zh active Active
- 2019-11-15 MX MX2021005761A patent/MX2021005761A/es unknown
- 2019-11-15 JP JP2021526658A patent/JP7451520B2/ja active Active
- 2019-11-15 AU AU2019378101A patent/AU2019378101B2/en active Active
- 2019-11-15 WO PCT/EP2019/081523 patent/WO2020099653A1/en not_active Ceased
- 2019-11-15 MY MYPI2021002647A patent/MY204673A/en unknown
- 2019-11-15 US US17/292,182 patent/US12180295B2/en active Active
- 2019-11-15 SG SG11202104431PA patent/SG11202104431PA/en unknown
- 2019-11-15 BR BR112021009275A patent/BR112021009275A2/pt unknown
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2021
- 2021-04-28 IL IL282756A patent/IL282756A/en unknown
- 2021-05-13 CL CL2021001260A patent/CL2021001260A1/es unknown
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