JPWO2020086635A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020086635A5 JPWO2020086635A5 JP2021521530A JP2021521530A JPWO2020086635A5 JP WO2020086635 A5 JPWO2020086635 A5 JP WO2020086635A5 JP 2021521530 A JP2021521530 A JP 2021521530A JP 2021521530 A JP2021521530 A JP 2021521530A JP WO2020086635 A5 JPWO2020086635 A5 JP WO2020086635A5
- Authority
- JP
- Japan
- Prior art keywords
- biopharmaceutical process
- biopharmaceutical
- processors
- analytical
- query
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 56
- 238000011087 biopharmaceutical technology Methods 0.000 claims 50
- 230000003595 spectral Effects 0.000 claims 27
- 238000004458 analytical method Methods 0.000 claims 20
- 238000005259 measurement Methods 0.000 claims 11
- 238000004611 spectroscopical analysis Methods 0.000 claims 5
- 230000001276 controlling effect Effects 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 3
- 230000005670 electromagnetic radiation Effects 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 229960002989 Glutamic Acid Drugs 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 2
- 238000001069 Raman spectroscopy Methods 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 230000000875 corresponding Effects 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 235000013922 glutamic acid Nutrition 0.000 claims 2
- 239000004220 glutamic acid Substances 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 2
- 238000010801 machine learning Methods 0.000 claims 2
- 239000012092 media component Substances 0.000 claims 2
- 230000015654 memory Effects 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
- 102000007312 Recombinant Proteins Human genes 0.000 claims 1
- 108010033725 Recombinant Proteins Proteins 0.000 claims 1
- 230000001131 transforming Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862749359P | 2018-10-23 | 2018-10-23 | |
| US62/749,359 | 2018-10-23 | ||
| US201962833044P | 2019-04-12 | 2019-04-12 | |
| US62/833,044 | 2019-04-12 | ||
| US201962864565P | 2019-06-21 | 2019-06-21 | |
| US62/864,565 | 2019-06-21 | ||
| PCT/US2019/057513 WO2020086635A1 (fr) | 2018-10-23 | 2019-10-23 | Étalonnage automatique et maintenance automatique de modèles de spectroscopie raman pour des prédictions en temps réel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022512775A JP2022512775A (ja) | 2022-02-07 |
| JPWO2020086635A5 true JPWO2020086635A5 (fr) | 2022-10-26 |
Family
ID=70331744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021521530A Pending JP2022512775A (ja) | 2018-10-23 | 2019-10-23 | リアルタイム予測のためのラマン分光モデルの自動校正及び自動保守 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220128474A1 (fr) |
| EP (1) | EP3870957A1 (fr) |
| JP (1) | JP2022512775A (fr) |
| KR (1) | KR20210078531A (fr) |
| CN (1) | CN112912716A (fr) |
| AU (1) | AU2019365102A1 (fr) |
| BR (1) | BR112021007611A2 (fr) |
| CA (1) | CA3115296A1 (fr) |
| CL (1) | CL2021001024A1 (fr) |
| IL (1) | IL281977A (fr) |
| MX (1) | MX2021004510A (fr) |
| SG (1) | SG11202103232WA (fr) |
| WO (1) | WO2020086635A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020024296A2 (pt) | 2018-08-27 | 2021-03-09 | Regeneron Pharmaceuticals, Inc. | Métodos para produção de um intermediário de purificação de proteína concentrado, para monitoramento e controle dos atributos de qualidade críticos em um intermediário de purificação de proteína e para monitorar e controlar os níveis de excipientes no fluido de cultura de células colhido e/ou intermediário de purificação de proteína, e, intermediário de purificação de proteína |
| CN114207593A (zh) * | 2019-06-10 | 2022-03-18 | 沃特世科技爱尔兰有限公司 | 用于分析仪器性能诊断的技术 |
| CN116457453A (zh) * | 2020-10-01 | 2023-07-18 | 美国安进公司 | 细胞培养的预测建模和控制 |
| US20220138557A1 (en) * | 2020-11-04 | 2022-05-05 | Adobe Inc. | Deep Hybrid Graph-Based Forecasting Systems |
| DE102021100531B3 (de) * | 2021-01-13 | 2022-03-31 | BioThera Institut GmbH | Apparatur zum Steuern eines Prozesses sowie zugehöriges Steuerungsverfahren |
| EP4352200A1 (fr) * | 2021-06-09 | 2024-04-17 | Amgen Inc. | Évaluation du volume cellulaire emballé pour cultures cellulaires |
| TW202326113A (zh) | 2021-10-27 | 2023-07-01 | 美商安進公司 | 使用光譜學進行的基於深度學習的預測 |
| WO2023167802A1 (fr) * | 2022-03-01 | 2023-09-07 | Amgen Inc. | Modélisation prédictive hybride pour la régulation d'une culture cellulaire |
| WO2024049725A1 (fr) * | 2022-08-29 | 2024-03-07 | Amgen Inc. | Modèle prédictif pour évaluer des impacts de temps de traitement |
| WO2024046603A1 (fr) * | 2022-08-29 | 2024-03-07 | Büchi Labortechnik AG | Procédés de fourniture de modèle prédictif pour spectroscopie et étalonnage d'un dispositif spectroscopique |
| US20240085864A1 (en) | 2022-09-14 | 2024-03-14 | Amgen Inc. | Just-In-Time Learning With Variational Autoencoder For Cell Culture Process Monitoring And/Or Control |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6319494B1 (en) | 1990-12-14 | 2001-11-20 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US5862060A (en) * | 1996-11-22 | 1999-01-19 | Uop Llc | Maintenance of process control by statistical analysis of product optical spectrum |
| CA2326389C (fr) | 1998-04-21 | 2007-01-23 | Micromet Gesellschaft Fur Biomedizinische Forschung Mbh | Polypeptides specifiques a cd19 et cd3 et leurs utilisations |
| US7398119B2 (en) * | 1998-07-13 | 2008-07-08 | Childrens Hospital Los Angeles | Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| WO2004058988A2 (fr) | 2002-12-20 | 2004-07-15 | Amgen, Inc. | Agents de liaison inhibant la myostatine |
| US8688384B2 (en) * | 2003-05-12 | 2014-04-01 | River Diagnostics B.V. | Automated characterization and classification of microorganisms |
| WO2005040220A1 (fr) | 2003-10-16 | 2005-05-06 | Micromet Ag | Element de liaison au cd3, desimmunise multispecifique |
| ES2695047T3 (es) | 2007-04-03 | 2018-12-28 | Amgen Research (Munich) Gmbh | Dominio de unión específico entre especies |
| US7961312B2 (en) * | 2007-08-13 | 2011-06-14 | C8 Medisensors Inc. | Calibrated analyte concentration measurements in mixtures |
| US8725667B2 (en) * | 2008-03-08 | 2014-05-13 | Tokyo Electron Limited | Method and system for detection of tool performance degradation and mismatch |
| GB2466442A (en) * | 2008-12-18 | 2010-06-23 | Dublin Inst Of Technology | A system to analyze a sample on a slide using Raman spectroscopy on an identified area of interest |
| CN101825567A (zh) * | 2010-04-02 | 2010-09-08 | 南开大学 | 一种近红外光谱和拉曼光谱波长的筛选方法 |
| EP2820047B1 (fr) | 2012-03-01 | 2018-04-25 | Amgen Research (Munich) GmbH | Molécules de liaison à un polypeptide à longue durée de vie |
| US20140114676A1 (en) * | 2012-10-23 | 2014-04-24 | Theranos, Inc. | Drug Monitoring and Regulation Systems and Methods |
| US20140308285A1 (en) | 2013-03-15 | 2014-10-16 | Amgen Inc. | Heterodimeric bispecific antibodies |
| US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| US11634502B2 (en) | 2013-03-15 | 2023-04-25 | Amgen Inc. | Heterodimeric bispecific antibodies |
| SI2970449T1 (sl) | 2013-03-15 | 2019-11-29 | Amgen Res Munich Gmbh | Enoverižne vezavne molekule, ki vsebujejo N-terminalni ABP |
| CN104215623B (zh) * | 2013-05-31 | 2018-09-25 | 欧普图斯(苏州)光学纳米科技有限公司 | 面向多行业检测的激光拉曼光谱智能化辨识方法及系统 |
| EP3049440B1 (fr) | 2013-09-25 | 2020-03-25 | Amgen Inc. | Anticorps v-c-fc-v-c |
| EP3164481A4 (fr) * | 2014-07-02 | 2018-03-21 | Biogen MA Inc. | Modélisation inter-échelle de cultures de bioréacteur par spectroscopie raman |
| US20180291329A1 (en) * | 2015-05-29 | 2018-10-11 | Biogen Ma Inc. | Cell culture methods and systems |
| US20170127983A1 (en) * | 2015-11-10 | 2017-05-11 | Massachusetts Institute Of Technology | Systems and methods for sampling calibration of non-invasive analyte measurements |
| EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
-
2019
- 2019-10-23 JP JP2021521530A patent/JP2022512775A/ja active Pending
- 2019-10-23 CN CN201980068986.7A patent/CN112912716A/zh active Pending
- 2019-10-23 US US17/284,551 patent/US20220128474A1/en active Pending
- 2019-10-23 BR BR112021007611-5A patent/BR112021007611A2/pt unknown
- 2019-10-23 CA CA3115296A patent/CA3115296A1/fr active Pending
- 2019-10-23 KR KR1020217015045A patent/KR20210078531A/ko active Search and Examination
- 2019-10-23 EP EP19848831.4A patent/EP3870957A1/fr active Pending
- 2019-10-23 SG SG11202103232WA patent/SG11202103232WA/en unknown
- 2019-10-23 MX MX2021004510A patent/MX2021004510A/es unknown
- 2019-10-23 WO PCT/US2019/057513 patent/WO2020086635A1/fr unknown
- 2019-10-23 AU AU2019365102A patent/AU2019365102A1/en active Pending
-
2021
- 2021-04-01 IL IL281977A patent/IL281977A/en unknown
- 2021-04-22 CL CL2021001024A patent/CL2021001024A1/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7092879B2 (ja) | 細胞培養物の代謝状態の予測 | |
| Hamadeh et al. | An overview of toxicogenomics | |
| EP3963589A1 (fr) | Modélisation prédictive commandée par des données pour sélection de lignée cellulaire en production biopharmaceutique | |
| JPWO2020086635A5 (fr) | ||
| AU2012296458B2 (en) | Extrapolation of interpolated sensor data to increase sample throughput | |
| Mandenius | Quality by design (QbD) for biotechnology-related pharmaceuticals | |
| JP2014532187A (ja) | 時および／または空間系列ファイルの多成分回帰／多成分分析 | |
| US11561182B2 (en) | Method for detecting quality of cell culture fluid based on Raman spectral measurement | |
| Manninen et al. | Leukemia prediction using sparse logistic regression | |
| JP5854346B2 (ja) | トランスクリプトーム解析方法、疾病判定方法、コンピュータプログラム、記憶媒体、及び解析装置 | |
| JP6581975B2 (ja) | 細胞の特徴を判定または予測する方法 | |
| CN110997928B (zh) | 判定多能干细胞的未分化状态的方法、多能干细胞的传代培养方法及这些方法中使用的装置 | |
| Cadart et al. | Volume growth in animal cells is cell cycle dependent and shows additive fluctuations | |
| JP2017051162A (ja) | 検体表面の生菌数推定方法及び装置、その装置に搭載されるプログラム | |
| JP5945365B2 (ja) | Ｎｍｒスペクトルから物質を同定するための方法 | |
| Jimenez-Carretero et al. | Flow cytometry data preparation guidelines for improved automated phenotypic analysis | |
| CN110046377A (zh) | 一种基于异构相似度的选择性集成即时学习软测量建模方法 | |
| CN116052778A (zh) | 实时监测生物反应器中细胞培养液组分浓度的方法 | |
| Schimmel et al. | Standardization of protein biomarker measurements: is it feasible? | |
| Slavkov et al. | Finding explained groups of time-course gene expression profiles with predictive clustering trees | |
| US10626436B2 (en) | Method of determining a compositional or functional characteristic of a cell culture media | |
| US10591463B2 (en) | Method of predicting phenotypic instability in a cell | |
| JP6442538B2 (ja) | 核酸をリアルタイムで定量化する方法 | |
| CN115398552A (zh) | 遗传算法用于基于拉曼光谱识别样品特征的用途 | |
| Luan et al. | Quality control-based signal drift correction and interpretations of metabolomics/proteomics data using random forest regression |