JPWO2020072428A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020072428A5 JPWO2020072428A5 JP2021542077A JP2021542077A JPWO2020072428A5 JP WO2020072428 A5 JPWO2020072428 A5 JP WO2020072428A5 JP 2021542077 A JP2021542077 A JP 2021542077A JP 2021542077 A JP2021542077 A JP 2021542077A JP WO2020072428 A5 JPWO2020072428 A5 JP WO2020072428A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- lys
- dpr
- poly
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002163 immunogen Effects 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 4
- 125000006850 spacer group Chemical group 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 2
- 229910052782 aluminium Inorganic materials 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862739794P | 2018-10-01 | 2018-10-01 | |
| US62/739,794 | 2018-10-01 | ||
| PCT/US2019/053967 WO2020072428A1 (en) | 2018-10-01 | 2019-10-01 | Peptide immunogen constructs directed against dipeptide repeat proteins from c9orf72 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022511995A JP2022511995A (ja) | 2022-02-01 |
| JPWO2020072428A5 true JPWO2020072428A5 (https=) | 2022-10-05 |
| JP2022511995A5 JP2022511995A5 (https=) | 2022-10-05 |
| JP7505788B2 JP7505788B2 (ja) | 2024-06-25 |
Family
ID=70055826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021542077A Active JP7505788B2 (ja) | 2018-10-01 | 2019-10-01 | Ｃ９ｏｒｆ７２に由来するジペプチドリピートタンパク質に対して指向化されたペプチド免疫原コンストラクト |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20210347866A1 (https=) |
| EP (1) | EP3861007A4 (https=) |
| JP (1) | JP7505788B2 (https=) |
| CN (1) | CN113227116A (https=) |
| AU (1) | AU2019354291A1 (https=) |
| CA (1) | CA3114657A1 (https=) |
| TW (1) | TWI781347B (https=) |
| WO (1) | WO2020072428A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021061537A1 (en) * | 2019-09-23 | 2021-04-01 | University Of Florida Research Foundation, Incorporated | Vaccine therapy for ran protein diseases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025468A (en) * | 1998-06-20 | 2000-02-15 | United Biomedical, Inc. | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
| US6906169B2 (en) * | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
| GB0510763D0 (en) * | 2005-05-27 | 2005-06-29 | London School Hygiene & Tropical Medicine | Malaria vaccines |
| PT2948777T (pt) * | 2013-01-22 | 2019-09-26 | Deutsches Zentrum Fuer Neurodegenerative Erkrankungen E V | Proteínas de repetição por dipeptídeos como alvo terapêutico em doenças neurodegenerativas com expansão de hexanucleotídico repetido |
| EP2948471A4 (en) | 2013-01-24 | 2016-08-10 | Mayo Foundation | METHOD AND MATERIALS FOR DETECTING POSITIVE FRONTOTEMPORAL PAPER DEGENERATION BY C9ORF72 HEXANUCLEOTIDE REPEAT EXPANSION OR AMYOTROPHATE LATERAL SCLEROSIS BY C9ORF72 HEXANUCLEOTIDE REPEAT EXPANSION |
| US9102752B2 (en) | 2013-03-15 | 2015-08-11 | United Biomedical, Inc. | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
| EP4166667A3 (en) * | 2013-10-11 | 2023-08-02 | Ionis Pharmaceuticals, Inc. | Compositions for modulating c9orf72 expression |
| KR20230104759A (ko) | 2014-09-30 | 2023-07-10 | 뉴리뮨 홀딩 아게 | 인간-유래의 항-디펩티드 반복체(dpr) 항체 |
-
2019
- 2019-10-01 CN CN201980079206.9A patent/CN113227116A/zh active Pending
- 2019-10-01 JP JP2021542077A patent/JP7505788B2/ja active Active
- 2019-10-01 TW TW108135458A patent/TWI781347B/zh active
- 2019-10-01 CA CA3114657A patent/CA3114657A1/en active Pending
- 2019-10-01 WO PCT/US2019/053967 patent/WO2020072428A1/en not_active Ceased
- 2019-10-01 AU AU2019354291A patent/AU2019354291A1/en not_active Abandoned
- 2019-10-01 EP EP19869951.4A patent/EP3861007A4/en not_active Withdrawn
- 2019-10-01 US US17/282,336 patent/US20210347866A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021508672A5 (https=) | ||
| JP5276598B2 (ja) | コイルドコイル構造を有するリポペプチドビルディングブロック、リポペプチドヘリックスバンドル、合成ウイルス様粒子、および医薬製剤 | |
| JP2006504653A5 (https=) | ||
| RU2005104565A (ru) | Конъюгаты грелин-носитель | |
| JP2003529319A (ja) | ＨＩＶ−１ｇｐ４１を標的化する広範に中和する抗体を誘発する方法 | |
| JP2010512792A5 (https=) | ||
| FR2718452A1 (fr) | Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation. | |
| CN107098974B (zh) | 一种融合蛋白及其应用 | |
| RU2007119319A (ru) | Наборы антигенов полипептида, угнетающего секрецию желудка (gip), и их применение | |
| JPH05262667A (ja) | ウイルス抗原を用いるワクチン | |
| JP2002524031A (ja) | アレルギーの予防および／または治療のための化合物と方法 | |
| JPH10503494A (ja) | インフルエンザウイルスのサブユニット複合体 | |
| TWI507413B (zh) | 脂質化多抗原表位疫苗 | |
| US20140112943A1 (en) | Method of developing a vaccine using peptide-poly ic complexes | |
| JPWO2020011972A5 (https=) | ||
| JP2006519160A5 (https=) | ||
| JPWO2020072428A5 (https=) | ||
| JP2022511995A5 (https=) | ||
| AU732085B2 (en) | Vaccine comprising antigens bound to carriers through labile bonds | |
| CN117797252B (zh) | 一种基于dna纳米技术的病毒多肽-蛋白亚单位组合疫苗及其制备方法和应用 | |
| CN1482916A (zh) | 含有转化生长因子α的疫苗组合物 | |
| CN118178632A (zh) | 针对猫FIPV的M和N抗原构建mRNA和疫苗的方法 | |
| TWI781347B (zh) | 針對源自c9orf72二肽重複蛋白的胜肽免疫原結構 | |
| CN102775478A (zh) | 口蹄疫病毒抗原多肽及疫苗 | |
| KR900004313B1 (ko) | 합성 펩티드를 함유하는 복합 면역원 |