JPWO2020061498A5 - - Google Patents
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- JPWO2020061498A5 JPWO2020061498A5 JP2021515623A JP2021515623A JPWO2020061498A5 JP WO2020061498 A5 JPWO2020061498 A5 JP WO2020061498A5 JP 2021515623 A JP2021515623 A JP 2021515623A JP 2021515623 A JP2021515623 A JP 2021515623A JP WO2020061498 A5 JPWO2020061498 A5 JP WO2020061498A5
- Authority
- JP
- Japan
- Prior art keywords
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- lymphoma
- binding domain
- antigen binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010052781 Interleukin-3 Receptor alpha Subunit Proteins 0.000 claims 5
- 102000018883 Interleukin-3 Receptor alpha Subunit Human genes 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 230000004068 intracellular signaling Effects 0.000 claims 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 125000006850 spacer group Chemical group 0.000 claims 3
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 2
- 102100025390 Integrin beta-2 Human genes 0.000 claims 2
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
- 208000025321 B-lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 102100025221 CD70 antigen Human genes 0.000 claims 1
- 102100037904 CD9 antigen Human genes 0.000 claims 1
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims 1
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 1
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims 1
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims 1
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 1
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims 1
- 101000801227 Homo sapiens Tumor necrosis factor receptor superfamily member 19 Proteins 0.000 claims 1
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims 1
- 102100033760 Tumor necrosis factor receptor superfamily member 19 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 1
- 208000037832 acute lymphoblastic B-cell leukemia Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000002489 hematologic effect Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000017426 precursor B-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862734106P | 2018-09-20 | 2018-09-20 | |
US62/734,106 | 2018-09-20 | ||
PCT/US2019/052226 WO2020061498A1 (en) | 2018-09-20 | 2019-09-20 | Compositions and methods for treating cancer with anti-cd123 immunotherapy |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2022501043A JP2022501043A (ja) | 2022-01-06 |
JPWO2020061498A5 true JPWO2020061498A5 (zh) | 2022-09-28 |
JP7546553B2 JP7546553B2 (ja) | 2024-09-06 |
Family
ID=68240803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021515623A Active JP7546553B2 (ja) | 2018-09-20 | 2019-09-20 | 抗cd123免疫療法によりがんを処置するための組成物および方法 |
Country Status (7)
Country | Link |
---|---|
US (3) | US10844128B2 (zh) |
EP (1) | EP3853254A1 (zh) |
JP (1) | JP7546553B2 (zh) |
CN (2) | CN118291501A (zh) |
AU (1) | AU2019343184A1 (zh) |
CA (1) | CA3113058A1 (zh) |
WO (1) | WO2020061498A1 (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210252058A1 (en) * | 2018-05-17 | 2021-08-19 | St. Jude Children's Research Hospital, Inc. | Chimeric antigen receptors with myd88 and cd40 costimulatory domains |
AU2019343184A1 (en) | 2018-09-20 | 2021-04-15 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-CD123 immunotherapy |
CA3179911A1 (en) * | 2020-04-08 | 2021-10-14 | Janssen Biotech, Inc. | Compositions and methods for blood-brain barrier delivery |
ES2867373B2 (es) | 2020-04-17 | 2023-01-02 | Consejo Superior Investigacion | Tratamiento terapeutico de leucemias linfoblasticas agudas de celulas t con un anticuerpo monoclonal frente al receptor pre-tcr |
AU2022221633A1 (en) * | 2021-02-17 | 2023-08-10 | Igm Biosciences, Inc. | Anti-cd123 binding molecules and uses thereof |
WO2023017159A1 (en) * | 2021-08-13 | 2023-02-16 | Ludwig-Maximilians-Universität München | Anti-csf1r car expressing lymphocytes for targeted tumor therapy |
US11590169B1 (en) | 2022-03-02 | 2023-02-28 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-CD123 immunotherapy |
CN114591988B (zh) * | 2022-03-30 | 2023-01-13 | 北京贝来生物科技有限公司 | 一种激活肿瘤免疫的基因修饰干细胞制备方法 |
WO2024026107A2 (en) | 2022-07-28 | 2024-02-01 | Lentigen Technology, Inc. | Chimeric antigen receptor therapies for treating solid tumors |
WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
WO2024044743A1 (en) | 2022-08-26 | 2024-02-29 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with fully human anti-cd20/cd19 immunotherapy |
WO2024151737A2 (en) * | 2023-01-10 | 2024-07-18 | Sana Biotechnology, Inc. | Cd19-specific antibody constructs and compositions thereof |
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AU2019343184A1 (en) | 2018-09-20 | 2021-04-15 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-CD123 immunotherapy |
US11590169B1 (en) | 2022-03-02 | 2023-02-28 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-CD123 immunotherapy |
-
2019
- 2019-09-20 AU AU2019343184A patent/AU2019343184A1/en active Pending
- 2019-09-20 CN CN202410540321.4A patent/CN118291501A/zh active Pending
- 2019-09-20 WO PCT/US2019/052226 patent/WO2020061498A1/en unknown
- 2019-09-20 CA CA3113058A patent/CA3113058A1/en active Pending
- 2019-09-20 CN CN201980076357.9A patent/CN113260630B/zh active Active
- 2019-09-20 JP JP2021515623A patent/JP7546553B2/ja active Active
- 2019-09-20 US US16/578,063 patent/US10844128B2/en active Active
- 2019-09-20 EP EP19787123.9A patent/EP3853254A1/en active Pending
-
2020
- 2020-11-12 US US17/095,982 patent/US12037403B2/en active Active
-
2024
- 2024-06-05 US US18/733,957 patent/US20240309102A1/en active Pending
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