JPWO2020056232A5 - - Google Patents
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- Publication number
- JPWO2020056232A5 JPWO2020056232A5 JP2021514070A JP2021514070A JPWO2020056232A5 JP WO2020056232 A5 JPWO2020056232 A5 JP WO2020056232A5 JP 2021514070 A JP2021514070 A JP 2021514070A JP 2021514070 A JP2021514070 A JP 2021514070A JP WO2020056232 A5 JPWO2020056232 A5 JP WO2020056232A5
- Authority
- JP
- Japan
- Prior art keywords
- etv1
- erg
- combination
- pharmaceutical composition
- etv4
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 206010060862 Prostate cancer Diseases 0.000 claims 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 6
- 238000009167 androgen deprivation therapy Methods 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- GZOSMCIZMLWJML-VJLLXTKPSA-N abiraterone Chemical group C([C@H]1[C@H]2[C@@H]([C@]3(CC[C@H](O)CC3=CC2)C)CC[C@@]11C)C=C1C1=CC=CN=C1 GZOSMCIZMLWJML-VJLLXTKPSA-N 0.000 claims 3
- 229960000853 abiraterone Drugs 0.000 claims 3
- HJBWBFZLDZWPHF-UHFFFAOYSA-N apalutamide Chemical group C1=C(F)C(C(=O)NC)=CC=C1N1C2(CCC2)C(=O)N(C=2C=C(C(C#N)=NC=2)C(F)(F)F)C1=S HJBWBFZLDZWPHF-UHFFFAOYSA-N 0.000 claims 3
- 229950007511 apalutamide Drugs 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- WXCXUHSOUPDCQV-UHFFFAOYSA-N enzalutamide Chemical group C1=C(F)C(C(=O)NC)=CC=C1N1C(C)(C)C(=O)N(C=2C=C(C(C#N)=CC=2)C(F)(F)F)C1=S WXCXUHSOUPDCQV-UHFFFAOYSA-N 0.000 claims 3
- 229960004671 enzalutamide Drugs 0.000 claims 3
- 229940125763 bromodomain inhibitor Drugs 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 238000011275 oncology therapy Methods 0.000 claims 2
- VUFGOHIETLJZRG-UHFFFAOYSA-N 1-benzyl-6-(3,5-dimethyl-1,2-oxazol-4-yl)-N-methylimidazo[4,5-b]pyridin-2-amine Chemical compound C(C1=CC=CC=C1)N1C(=NC2=NC=C(C=C21)C=1C(=NOC=1C)C)NC VUFGOHIETLJZRG-UHFFFAOYSA-N 0.000 claims 1
- OEPMGQATBAQVFK-UHFFFAOYSA-N 1-benzyl-6-(3,5-dimethyl-1,2-oxazol-4-yl)imidazo[4,5-b]pyridin-2-amine Chemical compound C(C1=CC=CC=C1)N1C(=NC2=NC=C(C=C21)C=1C(=NOC=1C)C)N OEPMGQATBAQVFK-UHFFFAOYSA-N 0.000 claims 1
- 102100032959 Alpha-actinin-4 Human genes 0.000 claims 1
- 229940123407 Androgen receptor antagonist Drugs 0.000 claims 1
- 206010061818 Disease progression Diseases 0.000 claims 1
- 102100039563 ETS translocation variant 1 Human genes 0.000 claims 1
- 102100039577 ETS translocation variant 5 Human genes 0.000 claims 1
- 101000797282 Homo sapiens Alpha-actinin-4 Proteins 0.000 claims 1
- 101000813729 Homo sapiens ETS translocation variant 1 Proteins 0.000 claims 1
- 101000813745 Homo sapiens ETS translocation variant 5 Proteins 0.000 claims 1
- 101000910249 Homo sapiens Soluble calcium-activated nucleotidase 1 Proteins 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 108010018070 Proto-Oncogene Proteins c-ets Proteins 0.000 claims 1
- 102000004053 Proto-Oncogene Proteins c-ets Human genes 0.000 claims 1
- 102100024397 Soluble calcium-activated nucleotidase 1 Human genes 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000003098 androgen Substances 0.000 claims 1
- 239000003936 androgen receptor antagonist Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229950001379 darolutamide Drugs 0.000 claims 1
- 230000005750 disease progression Effects 0.000 claims 1
- 231100000371 dose-limiting toxicity Toxicity 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- BLIJXOOIHRSQRB-PXYINDEMSA-N n-[(2s)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-5-(1-hydroxyethyl)-1h-pyrazole-3-carboxamide Chemical compound C([C@H](C)NC(=O)C=1NN=C(C=1)C(C)O)N(N=1)C=CC=1C1=CC=C(C#N)C(Cl)=C1 BLIJXOOIHRSQRB-PXYINDEMSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 206010043554 thrombocytopenia Diseases 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862730869P | 2018-09-13 | 2018-09-13 | |
| US62/730,869 | 2018-09-13 | ||
| US201862737612P | 2018-09-27 | 2018-09-27 | |
| US62/737,612 | 2018-09-27 | ||
| US201862778185P | 2018-12-11 | 2018-12-11 | |
| US62/778,185 | 2018-12-11 | ||
| PCT/US2019/050970 WO2020056232A1 (en) | 2018-09-13 | 2019-09-13 | Combination therapy for the treatment of prostate cancer |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022500431A JP2022500431A (ja) | 2022-01-04 |
| JPWO2020056232A5 true JPWO2020056232A5 (https=) | 2022-09-22 |
| JP2022500431A5 JP2022500431A5 (https=) | 2022-09-22 |
| JP7441214B2 JP7441214B2 (ja) | 2024-02-29 |
Family
ID=69778254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021514070A Active JP7441214B2 (ja) | 2018-09-13 | 2019-09-13 | 前立腺がんの治療のための併用療法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220117942A1 (https=) |
| EP (1) | EP3849544A4 (https=) |
| JP (1) | JP7441214B2 (https=) |
| KR (1) | KR102844523B1 (https=) |
| CN (1) | CN112912075B (https=) |
| AU (1) | AU2019338483B2 (https=) |
| CA (1) | CA3112396A1 (https=) |
| IL (1) | IL281281B2 (https=) |
| MX (1) | MX2021002884A (https=) |
| SG (1) | SG11202102492PA (https=) |
| TW (1) | TWI816880B (https=) |
| WO (1) | WO2020056232A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI882964B (zh) | 2018-09-13 | 2025-05-11 | 大陸商恒翼生物醫藥（上海）股份有限公司 | Bet 溴結構域(bromodomain)抑制劑之固體形式之製備方法 |
| US20220265618A1 (en) * | 2021-02-22 | 2022-08-25 | Celgene Quanticel Research, Inc. | Methods of treating prostate cancer |
| CN114644687B (zh) * | 2022-04-07 | 2023-06-27 | 华中科技大学同济医学院附属协和医院 | 一种可拮抗rbm25蛋白rna结合活性的多肽rbip-21及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0919434D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| EP2621483A1 (en) * | 2010-09-27 | 2013-08-07 | Exelixis, Inc. | Dual inhibitors of met and vegf for the treatment of castration resistant prostate cancer and osteoblastic bone metastases |
| CA2915838C (en) * | 2013-06-21 | 2023-04-18 | Zenith Epigenetics Corp. | Bicyclic bromodomain inhibitors |
| WO2015065919A1 (en) * | 2013-10-28 | 2015-05-07 | The Regents Of The University Of California | Treatment of metastatic prostate cancer |
| NO2719005T3 (https=) * | 2014-07-28 | 2018-01-20 | ||
| WO2016171470A1 (en) * | 2015-04-21 | 2016-10-27 | Kainos Medicine, Inc. | Bromodomain-inhibiting compounds and methods to prevent or treat a cancer |
| WO2017216772A2 (en) * | 2016-06-16 | 2017-12-21 | The University Of Chicago | Methods and compositions for treating breast and prostate cancer |
| WO2018097977A1 (en) * | 2016-11-22 | 2018-05-31 | Gilead Sciences, Inc. | Crystalline forms of a phosphate complex of a bet inhibitor |
| WO2018106433A1 (en) * | 2016-12-06 | 2018-06-14 | Gilead Sciences, Inc. | Treatment of prostate cancer by concomitant administration of a bromodomain inhibitor and a second agent |
-
2019
- 2019-09-12 TW TW108133128A patent/TWI816880B/zh active
- 2019-09-13 EP EP19860912.5A patent/EP3849544A4/en active Pending
- 2019-09-13 WO PCT/US2019/050970 patent/WO2020056232A1/en not_active Ceased
- 2019-09-13 JP JP2021514070A patent/JP7441214B2/ja active Active
- 2019-09-13 MX MX2021002884A patent/MX2021002884A/es unknown
- 2019-09-13 IL IL281281A patent/IL281281B2/en unknown
- 2019-09-13 AU AU2019338483A patent/AU2019338483B2/en active Active
- 2019-09-13 CA CA3112396A patent/CA3112396A1/en active Pending
- 2019-09-13 CN CN201980059904.2A patent/CN112912075B/zh active Active
- 2019-09-13 KR KR1020217010491A patent/KR102844523B1/ko active Active
- 2019-09-13 SG SG11202102492PA patent/SG11202102492PA/en unknown
- 2019-09-13 US US17/275,473 patent/US20220117942A1/en active Pending
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