JPWO2020041741A5 - - Google Patents
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- Publication number
- JPWO2020041741A5 JPWO2020041741A5 JP2021533405A JP2021533405A JPWO2020041741A5 JP WO2020041741 A5 JPWO2020041741 A5 JP WO2020041741A5 JP 2021533405 A JP2021533405 A JP 2021533405A JP 2021533405 A JP2021533405 A JP 2021533405A JP WO2020041741 A5 JPWO2020041741 A5 JP WO2020041741A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- alkyl
- compound
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000004429 atom Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000000468 ketone group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 101100509371 Arabidopsis thaliana CHR11 gene Proteins 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- -1 C 1 -C 4 alkyl Chemical group 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 102100033451 Thyroid hormone receptor beta Human genes 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 108091008762 thyroid hormone receptors ß Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024187991A JP2025020206A (ja) | 2018-08-24 | 2024-10-25 | 甲状腺ホルモン受容体ベータアゴニスト化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862722312P | 2018-08-24 | 2018-08-24 | |
| US62/722,312 | 2018-08-24 | ||
| US201962867117P | 2019-06-26 | 2019-06-26 | |
| US62/867,117 | 2019-06-26 | ||
| PCT/US2019/047968 WO2020041741A1 (en) | 2018-08-24 | 2019-08-23 | Thyroid hormone receptor beta agonist compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024187991A Division JP2025020206A (ja) | 2018-08-24 | 2024-10-25 | 甲状腺ホルモン受容体ベータアゴニスト化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021535207A JP2021535207A (ja) | 2021-12-16 |
| JPWO2020041741A5 true JPWO2020041741A5 (enExample) | 2022-08-30 |
| JP7579253B2 JP7579253B2 (ja) | 2024-11-07 |
Family
ID=69584321
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021533405A Active JP7579253B2 (ja) | 2018-08-24 | 2019-08-23 | 甲状腺ホルモン受容体ベータアゴニスト化合物 |
| JP2024187991A Pending JP2025020206A (ja) | 2018-08-24 | 2024-10-25 | 甲状腺ホルモン受容体ベータアゴニスト化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024187991A Pending JP2025020206A (ja) | 2018-08-24 | 2024-10-25 | 甲状腺ホルモン受容体ベータアゴニスト化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10800767B2 (enExample) |
| EP (1) | EP3840755A4 (enExample) |
| JP (2) | JP7579253B2 (enExample) |
| CN (1) | CN112805005A (enExample) |
| AU (2) | AU2019325656B2 (enExample) |
| CA (1) | CA3110520A1 (enExample) |
| MA (1) | MA53448A (enExample) |
| TW (1) | TWI837169B (enExample) |
| WO (1) | WO2020041741A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI884745B (zh) | 2018-10-12 | 2025-05-21 | 美商拓臻股份有限公司 | 甲狀腺素受體β促效劑化合物 |
| CN111320609A (zh) | 2018-12-13 | 2020-06-23 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
| FI3965884T3 (fi) | 2019-05-08 | 2025-04-02 | Aligos Therapeutics Inc | Thr-beetan modulaattoreita, joissa on diokso-1,2,4-triatsyylipääryhmä |
| WO2020228577A1 (zh) * | 2019-05-10 | 2020-11-19 | 深圳微芯生物科技股份有限公司 | 一种哒嗪酮衍生物及其应用 |
| US12398127B2 (en) | 2019-09-12 | 2025-08-26 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| CN114437034A (zh) * | 2020-11-06 | 2022-05-06 | 深圳微芯生物科技股份有限公司 | 一种酞嗪类化合物的可药用盐、晶型及其制备方法 |
| AU2021377248A1 (en) | 2020-11-13 | 2023-06-22 | Inipharm, Inc. | Dichlorophenol hsd17b13 inhibitors and uses thereof |
| CN114621207B (zh) * | 2020-12-11 | 2025-02-11 | 广东东阳光药业股份有限公司 | 一种作为甲状腺激素β受体激动剂的化合物及其用途 |
| EP4301357A4 (en) * | 2021-03-03 | 2025-01-22 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| CN117624073A (zh) * | 2021-03-19 | 2024-03-01 | 南京明德新药研发有限公司 | 双环苯酚类化合物及其应用 |
| CN117624154A (zh) * | 2021-03-19 | 2024-03-01 | 南京明德新药研发有限公司 | 双环吡啶酮类化合物及其应用 |
| EP4568664A1 (en) | 2023-04-07 | 2025-06-18 | Terns Pharmaceuticals, Inc. | Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating a liver disorder or a cardiometabolic disease |
| CN116554063B (zh) * | 2023-05-23 | 2025-03-07 | 江苏省农用激素工程技术研究中心有限公司 | 氟胺磺隆中间体的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7230031B2 (en) * | 2002-01-30 | 2007-06-12 | Kissei Pharmaceutical Co., Ltd. | Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof |
| US7572799B2 (en) * | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| GB0327319D0 (en) * | 2003-11-24 | 2003-12-24 | Pfizer Ltd | Novel pharmaceuticals |
| HRP20100633T1 (hr) | 2005-07-21 | 2011-01-31 | F. Hoffmann - La Roche Ag | Derivati piridazinona kao agonisti receptora tiroidnih hormona |
| WO2007132475A1 (en) * | 2006-05-15 | 2007-11-22 | Cadila Healthcare Limited | Selective tr-beta 1 agonist |
| WO2008130637A1 (en) * | 2007-04-18 | 2008-10-30 | New York University | Hydrazide compounds as thyroid hormone receptor modulators and uses thereof |
| EP3725779A4 (en) | 2018-01-23 | 2021-02-24 | Shenzhen TargetRx, Inc. | SUBSTITUTED PYRIDAZINONE COMPOUND |
| CN113683597A (zh) | 2018-06-12 | 2021-11-23 | 四川海思科制药有限公司 | 甲状腺激素受体激动剂及其用途 |
| EP3864013A4 (en) | 2018-10-12 | 2022-09-28 | InventisBio Co., Ltd. | Thyroid hormone receptor agonists |
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2019
- 2019-08-23 US US16/549,979 patent/US10800767B2/en active Active
- 2019-08-23 JP JP2021533405A patent/JP7579253B2/ja active Active
- 2019-08-23 AU AU2019325656A patent/AU2019325656B2/en active Active
- 2019-08-23 MA MA053448A patent/MA53448A/fr unknown
- 2019-08-23 EP EP19852050.4A patent/EP3840755A4/en active Pending
- 2019-08-23 WO PCT/US2019/047968 patent/WO2020041741A1/en not_active Ceased
- 2019-08-23 CA CA3110520A patent/CA3110520A1/en active Pending
- 2019-08-23 TW TW108130298A patent/TWI837169B/zh active
- 2019-08-23 CN CN201980066702.0A patent/CN112805005A/zh active Pending
-
2024
- 2024-08-29 US US18/818,705 patent/US20250236615A1/en active Pending
- 2024-10-25 JP JP2024187991A patent/JP2025020206A/ja active Pending
-
2025
- 2025-07-22 AU AU2025206402A patent/AU2025206402A1/en active Pending