JPWO2020026212A5 - - Google Patents

Info

Publication number

JPWO2020026212A5

JPWO2020026212A5 JP2021529544A JP2021529544A JPWO2020026212A5 JP WO2020026212 A5 JPWO2020026212 A5 JP WO2020026212A5 JP 2021529544 A JP2021529544 A JP 2021529544A JP 2021529544 A JP2021529544 A JP 2021529544A JP WO2020026212 A5 JPWO2020026212 A5 JP WO2020026212A5

Authority

JP

Japan

Prior art keywords

whole blood

blood sample

fgf

growth factor

tubular scaffold

Prior art date

2022-08-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000004369 Blood Anatomy 0.000 claims 14
• 239000008280 blood Substances 0.000 claims 14
• 239000000725 suspension Substances 0.000 claims 10
• 239000003146 anticoagulant agent Substances 0.000 claims 6
• 102000018233 Fibroblast growth factor family Human genes 0.000 claims 4
• 108050007372 Fibroblast growth factor family Proteins 0.000 claims 4
• 229920002307 Dextran Polymers 0.000 claims 3
• 229960002897 Heparin Drugs 0.000 claims 3
• ZFGMDIBRIDKWMY-PASTXAENSA-N Heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims 3
• 108050003490 Insulin-like growth factor Proteins 0.000 claims 3
• 102000014429 Insulin-like growth factor Human genes 0.000 claims 3
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Vitamin C Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 3
• 229960001138 acetylsalicylic acid Drugs 0.000 claims 3
• 229960005070 ascorbic acid Drugs 0.000 claims 3
• 235000010323 ascorbic acid Nutrition 0.000 claims 3
• 239000011668 ascorbic acid Substances 0.000 claims 3
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 3
• 239000003102 growth factor Substances 0.000 claims 3
• 229920000669 heparin Polymers 0.000 claims 3
• 101700052211 BDNF Proteins 0.000 claims 2
• 102100015985 BDNF Human genes 0.000 claims 2
• 210000004204 Blood Vessels Anatomy 0.000 claims 2
• 102100008428 CCL2 Human genes 0.000 claims 2
• 102100006400 CSF2 Human genes 0.000 claims 2
• 108010055292 Chemokine CCL2 Proteins 0.000 claims 2
• 108010055166 Chemokine CCL5 Proteins 0.000 claims 2
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
• 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 2
• 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 2
• 108010063738 Interleukins Proteins 0.000 claims 2
• 102000015696 Interleukins Human genes 0.000 claims 2
• 102100012750 MDK Human genes 0.000 claims 2
• 108010092801 Midkine Proteins 0.000 claims 2
• 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 2
• 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 2
• 102000009618 Transforming Growth Factors Human genes 0.000 claims 2
• 108010009583 Transforming Growth Factors Proteins 0.000 claims 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
• 108010001801 Tumor Necrosis Factor-alpha Proteins 0.000 claims 2
• 230000002429 anti-coagulation Effects 0.000 claims 2
• 230000002785 anti-thrombosis Effects 0.000 claims 2
• 102000005162 pleiotrophin Human genes 0.000 claims 2
• 108010056011 pleiotrophin Proteins 0.000 claims 2
• 230000002792 vascular Effects 0.000 claims 2
• DPFYBZWSVVKNPZ-AQWIXGDGSA-N (3S,4S,6R)-2-[[(2R,4R,5R)-3,5-dihydroxy-4-methoxy-6-(methoxymethyl)oxan-2-yl]methoxymethyl]-6-ethyloxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)C(O)[C@@H](CC)OC1COC[C@@H]1C(O)[C@H](OC)[C@H](O)C(COC)O1 DPFYBZWSVVKNPZ-AQWIXGDGSA-N 0.000 claims 1
• 210000001772 Blood Platelets Anatomy 0.000 claims 1
• 102100016449 CCL5 Human genes 0.000 claims 1
• 102000001327 Chemokine CCL5 Human genes 0.000 claims 1
• 108010008978 Chemokine CXCL10 Proteins 0.000 claims 1
• 102000006579 Chemokine CXCL10 Human genes 0.000 claims 1
• 229940119744 Dextran 40 Drugs 0.000 claims 1
• 102100008645 FGF3 Human genes 0.000 claims 1
• 102100007406 FGF4 Human genes 0.000 claims 1
• 101700036125 FGF4 Proteins 0.000 claims 1
• 102100007408 FGF5 Human genes 0.000 claims 1
• 101700010264 FGF5 Proteins 0.000 claims 1
• 102100007407 FGF6 Human genes 0.000 claims 1
• 101700012851 FGF6 Proteins 0.000 claims 1
• 102100007405 FGF7 Human genes 0.000 claims 1
• 101700033323 FGF7 Proteins 0.000 claims 1
• 102100015613 FGF8 Human genes 0.000 claims 1
• 101700012405 FGF8 Proteins 0.000 claims 1
• 102100015612 FGF9 Human genes 0.000 claims 1
• 101700084870 FGF9 Proteins 0.000 claims 1
• 102000003974 Fibroblast Growth Factor 2 Human genes 0.000 claims 1
• 108090000379 Fibroblast Growth Factor 2 Proteins 0.000 claims 1
• 102000018710 Heparin-binding EGF-like growth factor Human genes 0.000 claims 1
• 101800001649 Heparin-binding EGF-like growth factor Proteins 0.000 claims 1
• 101710004181 INTS2 Proteins 0.000 claims 1
• 108090000978 Interleukin-4 Proteins 0.000 claims 1
• 108090001007 Interleukin-8 Proteins 0.000 claims 1
• 102000004890 Interleukin-8 Human genes 0.000 claims 1
• 102100015249 VEGFA Human genes 0.000 claims 1
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 1
• 230000027455 binding Effects 0.000 claims 1
• 210000004027 cells Anatomy 0.000 claims 1
• 230000001413 cellular Effects 0.000 claims 1
• 101700023228 fgf8a Proteins 0.000 claims 1
• 230000000977 initiatory Effects 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 230000001737 promoting Effects 0.000 claims 1
• 238000002054 transplantation Methods 0.000 claims 1