JPWO2020022437A1 - Antiviral compositions, antinorovirus compositions, sprays, wipers, compounds - Google Patents

Abstract

The subject of the present invention is an antiviral composition having excellent antiviral properties, an antinorovirus composition comprising the antiviral composition, a spray and wiper using the antiviral composition, and a novel compound. To provide. The antiviral composition of the present invention contains a compound having a hydroxyl group bonded to sp3 carbon and having a pKa of 9 to 15, and a solvent, and has a pH of 9 to 14.

Description

The present invention relates to antiviral compositions, antinorovirus compositions, sprays, wipers, and compounds.

A virus is a structure that does not have a cell structure and has a genome in an outer shell protein called a capsid, unlike microorganisms such as bacteria and fungi that have a cell structure. Viruses are roughly divided into two types depending on whether the genome is DNA (deoxyribonucleic acid) or RNA (ribonucleic acid), and capsids are enveloped with a lipid bilayer envelope and not enveloped. It is further classified according to whether it is a membrane virus. Specifically, the DNA type membrane virus includes human herpes virus and hepatitis B virus, the DNA type membraneless virus includes adenovirus, and the B19 virus, and the RNA type membrane virus. , Influenza virus, SARS (severe acute respiratory syndrome) coronavirus, and other RNA-type membraneless viruses include norovirus, poliovirus, enterovirus, and the like.

In recent years, there has been a demand for a drug capable of inactivating a virus (particularly norovirus) by a simpler means. For example, Patent Document 1 discloses an antiviral agent composition containing benzyl alcohol as an antiviral agent composition capable of inactivating a virus.

Japanese Unexamined Patent Publication No. 2013-040167

The present inventors prepared the antiviral agent composition described in the Example column of Patent Document 1, and prepared cat calicivirus (a closely related species of norovirus, a genome composition similar to that of norovirus, a capsid structure, and biochemistry). As a result of examining the antiviral activity against (which is the most widely used substitute virus at present because of its characteristics), it was clarified that there is room for further improvement of the antiviral activity.

Therefore, an object of the present invention is to provide an antiviral composition having excellent antiviral activity.
Another object of the present invention is to provide an antinorovirus composition comprising the above antiviral composition.
Another object of the present invention is to provide a spray and a wiper using the above antiviral composition.
Another object of the present invention is to provide a novel compound.

As a result of diligent studies to solve the above problems, the present inventors have found that the above problems can be solved by an antiviral composition having a predetermined composition, and have completed the present invention.
That is, it was found that the above problem can be solved by the following configuration.

[1] ^{A compound having a hydroxyl group bonded to sp 3} carbon and having a pKa of 9 to 15 and
Containing with solvent,
An antiviral composition having a pH of 9.0 to 14.0.
[2] The antiviral composition according to [1], wherein the compound is a compound represented by the formula (1) described later.
[3] The monovalent substituents represented by ^{R X1 to} R ^X3 are groups represented by -C (= O) -OR ^{X4 and -C (= O) -NR X5-} R ^X6. Represents a group represented by, an aliphatic hydrocarbon group, an aryl group, a heteroaryl group, an aralkyl group, a carboxylic acid group, a sulfonic acid group, a phosphoric acid group, a sulfonimide group, or a cyano group, and ^{RX4 and RX6} are. The antiviral composition according to [2], wherein each of them independently represents a monovalent substituent, and ^{RX5 represents a hydrogen atom or a monovalent substituent.}
[4] Two of R ^X1 to R ^X3 represents a -CF ₃ or cyano group, [2] or antiviral composition according to [3].
[5] The monovalent substituent represented by ^{R X1 to} R ^X3 is a group represented by -C (= O) -OR ^{X4 , -C (= O) -NR X5-} R ^X6. The group represented by, -CF ₃ , or cyano group, and ^RX4 and ^RX6 are independently linear or branched aliphatic hydrocarbon groups, aryl groups, or heteroaryl groups. , The antiviral composition according to any one of [2] to [4].
[6] The monovalent substituent represented by ^{R X1 to} R ^X3 is a group represented by -C (= O) -OR ^{X4 , -C (= O) -NR X5-} R ^X6. a group represented by, -CF _3, or a cyano group, R ^X4 and R ^X6 are each a linear or branched aliphatic hydrocarbon group having 8 or more carbon atoms, (2) - The antiviral composition according to any one of [5].
[7] The antiviral composition according to any one of [1] to [6], wherein the pKa is 10 to 14.
[8] The antiviral composition according to any one of [1] to [7], wherein the ClogP of the above compound is 5.00 or more.
[9] The antiviral composition according to any one of [1] to [8], wherein the ClogP of the above compound is 7.00 or more.
[10] The antiviral composition according to any one of [1] to [9], wherein the solvent contains alcohol.
[11] The antiviral composition according to [10], wherein the content of the alcohol is 25 to 100% by volume based on the total volume of the solvent.
[12] The antiviral composition according to [10] or [11], wherein the alcohol comprises an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms.
[13] The antiviral composition according to [12], wherein the alcohol having 2 or less carbon atoms contains ethanol, and the alcohol having 3 or more carbon atoms contains isopropanol.
[14] The antiviral composition according to any one of [1] to [13], which further contains a surfactant.
[15] The antiviral composition according to any one of [1] to [14], which further contains a quaternary ammonium salt.
[16] The antiviral composition according to any one of [1] to [15], wherein the pH is 10.0 to 12.0.
[17] The antiviral composition according to any one of [1] to [16], which is a liquid preparation.
[18] The antiviral composition according to any one of [1] to [16], which is a gel agent.
[19] An anti-norovirus composition comprising the anti-virus composition according to any one of [1] to [18].
[20] A spray containing a spray container and the antiviral composition according to any one of [1] to [18] contained in the spray container.
[21] A wiper containing the base cloth and the antiviral composition according to any one of [1] to [18] impregnated in the base cloth.
[22] A compound represented by the formula (1A) described later or the formula (1B) described later.

According to the present invention, it is possible to provide an antiviral composition having excellent antiviral activity.
Further, according to the present invention, it is possible to provide an antinorovirus composition comprising the above antiviral composition.
Further, according to the present invention, it is possible to provide a spray and a wiper using the above-mentioned antiviral composition.
Moreover, according to this invention, a novel compound can be provided.

Hereinafter, the present invention will be described in detail.
The description of the constituent elements described below may be based on typical embodiments of the present invention, but the present invention is not limited to such embodiments.
In the present specification, the numerical range represented by using "~" means a range including the numerical values before and after "~" as the lower limit value and the upper limit value.
In the present specification, when there are a plurality of substituents, linking groups, etc. (hereinafter referred to as substituents, etc.) indicated by specific reference numerals, or when a plurality of substituents, etc. are specified at the same time, the respective substituents, etc. are used. It means that they may be the same or different from each other. This also applies to the regulation of the number of substituents and the like.
Further, in the present specification, in the notation of a group (atomic group), the notation that does not describe substitution or non-substitution includes those having no substituent as well as those having a substituent. For example, the "alkyl group" includes not only an alkyl group having no substituent (unsubstituted alkyl group) but also an alkyl group having a substituent (substituted alkyl group).

[Antiviral composition]
The antiviral composition of the present invention (hereinafter, also referred to as "composition of the present invention") is
A compound having a hydroxyl group bonded to sp ³ carbon and having a pKa of 9 to 15 (hereinafter, also referred to as “specific compound”) and
Containing with solvent,
The pH is 9.0 to 14.0.
Due to the above composition, the composition of the present invention is remarkably excellent in antiviral activity (particularly, antiviral activity against feline calicivirus (a closely related species of norovirus)).
In addition, the composition of the present invention is also excellent in antibacterial activity against microorganisms such as bacteria and fungi (for example, Escherichia coli, staphylococcus, etc.) due to the above composition.
The antiviral compositions of the present invention can be used in applications used to act on a virus to reduce the activity of the virus. In particular, it is preferably used as a composition for anti-norovirus. The antiviral composition of the present invention can also be used for applications used to reduce the activity of microorganisms by acting on microorganisms such as bacteria and fungi.

Although the mechanism of action of the present invention is not clear in detail, the present inventors speculate as follows.
In the composition of the present invention, the specific compound functions as an active ingredient.
If the pH of the composition is in the range of 9.0 to 14.0, a hydroxyl group in a particular compound, a proton receptor by hydrogen ions dissociate ^- a (-O). It is speculated that this proton receptor deprotonates the acid groups present on the surface of the virus, thereby inactivating the virus. At this time, when the pKa of the specific compound is 9 or more, the deprotonation reaction of the virus surface acid group is more likely to occur. On the other hand, when the pKa of the specific compound exceeds 15, hydrogen ions are less likely to dissociate from the hydroxyl groups in the specific compound. That is, when the pKa of the specific compound is 9 to 15, hydrogen ions are easily dissociated from the hydroxyl groups in the specific compound and the deprotonation reaction is more likely to occur, so that the specific compound exhibits excellent antiviral activity.
The pKa of the specific compound is preferably a value derived from the acid dissociation of the hydroxyl group in the specific compound.

Further, as will be described later, when the specific compound is more hydrophobic (in other words, when the ClogP value of the specific compound is 5.00 or more), the antiviral activity is more excellent. Viruses generally have hydrophilic and hydrophobic sites. Therefore, when the specific compound is more hydrophobic, it is considered that the specific compound is easily adsorbed by the virus. As a result, the specific compound has better antiviral activity.

Further, as will be described later, when the pH of the composition of the present invention is 12.0 or less, metal corrosion is unlikely to occur, and the range of application of the object that can be disinfected by the composition of the present invention is wide. For example, corrosion is less likely to occur on metals such as aluminum, copper, and brass.
The composition of the present invention is particularly excellent in antiviral activity against feline calicivirus (a closely related species of norovirus), and is therefore preferably used as a composition for antinorovirus.

Hereinafter, each component contained in the composition of the present invention will be described in detail.
[Specific compound]
The composition of the present invention contains a compound (specific compound) having a hydroxyl group bonded to ^{sp 3 carbon and having a pKa of 9 to 15.}
The pKa of the specific compound is preferably 10 to 14 in that it has more excellent antiviral activity.

As the specific compound, a compound represented by the following formula (1) is preferable.

In formula (1), R ^{X1 to} R ^X3 each independently represent a hydrogen atom or a monovalent substituent.
The monovalent substituent is not particularly limited, but is, for example, ^{a group represented by -C (= O) -OR X4} (hereinafter, also referred to as "formula (1-1)") or-. Group represented by C (= O) -NR ^X5- R ^X6 (hereinafter, also referred to as "formula (1-2)"), aliphatic hydrocarbon group, aryl group, heteroaryl group, aralkyl group, carboxylic acid Examples thereof include a group, a sulfonic acid group, a phosphoric acid group, a sulfonimide group, a cyano group and the like.

However, the pKa of the specific compound from the viewpoint of a 9 to 15, in the formula (1), at least one of R ^X1 to R ^X3 represents -CF ₃ or a cyano group. Of these, two of R ^{X1 to} R ^{X 3} _{preferably represent -CF 3} or a cyano group.

^{R X4} and R ^{X 6} in the formulas (1-1) and (1-2) each independently represent a monovalent substituent.
^{Examples of the monovalent substituents represented by RX4} and ^RX6 in the formulas (1-1) and (1-2) include those exemplified in the substituent group W described later, which are fats. Group hydrocarbon groups, aryl groups, or heteroaryl groups are preferred.

Examples of the aliphatic hydrocarbon group represented by R ^X4 and ^RX6 include linear, branched and cyclic aliphatic hydrocarbon groups. In the aliphatic hydrocarbon group represented by ^{R X4} and ^RX6 _{, −CH 2} − may be substituted with a hetero atom.
Among them, ^{as the aliphatic hydrocarbon group represented by RX4} and ^RX6 , a linear or branched aliphatic hydrocarbon group is preferable in that the antiviral activity is more excellent. Further, the above-mentioned aliphatic hydrocarbon group preferably has 8 or more carbon atoms in that it has more excellent antiviral activity. The upper limit of the number of carbon atoms is not particularly limited, but is, for example, 30 or less.

Specific examples of the aliphatic hydrocarbon groups represented by R ^X4 and R ^{X 6} are linear and branched alkyl groups having 1 to 30 carbon atoms in which _{−CH 2 − may be substituted with a heteroatom.} , -CH ₂ − may be substituted with a heteroatom linear and branched alkenyl groups having 2 to 30 carbon atoms, −CH ₂ − may be substituted with a heteroatom linear and Examples thereof include a branched alkynyl group having 2 to 30 carbon atoms and an alicyclic hydrocarbon group having 3 to 30 carbon atoms in which _{−CH 2 − may be substituted with a heteroatom.} However, in the above-mentioned aliphatic hydrocarbon group, it is preferable that the connection position with the oxygen atom specified in the formulas (1-1) and (1-2) is not replaced by a hetero atom (in other words, the above-mentioned fat. In the group hydrocarbon group, the connection position with the oxygen atom specified in the formulas (1-1) and (1-2) is preferably a carbon atom).
The type of the hetero atom is not particularly limited, and examples thereof include an oxygen atom, a nitrogen atom, a sulfur atom, a selenium atom, and a tellurium atom. ^{Among them, heteroatoms are -Y 1-} , -N (Ra)-, -C (= Y ² )-, -CON (Rb)-, -C (= Y ³ ) in that they have better antiviral activity. ^{) Y 4 -, - SOt -} , - SO 2 N (Rc) -, or be included in an embodiment of the group comprising a combination thereof.
Y ^{1 to Y 4} are independently selected from the group consisting of an oxygen atom, a sulfur atom, a selenium atom, and a tellurium atom. Of these, an oxygen atom is preferable because it is easier to handle. t represents an integer of 1 to 3. The Ra, Rb, and Rc independently represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, an aryl group, or a heteroaryl group.

The _{linear and branched alkyl groups having 1 to 30 carbon atoms in which −CH 2} − may be substituted with a hetero atom are preferably 1 to 20 carbon atoms, and more preferably 8 to 20 carbon atoms. , 12 to 20 carbon atoms are more preferable. Specifically, methyl group, ethyl group, n-propyl group, isopropyl group, n-butyl group, isobutyl group, sec-butyl group, tert-butyl group, n-pentyl group, isopentyl group, neopentyl group, 1, 1-Dimethylpropyl group, n-hexyl group, 2-ethylhexyl group, isohexyl group, heptyl group, octyl group, 3,7-dimethyloctyl group, nonyl group, decyl group, undecyl group, dodecyl group, tridecyl group, tetradecyl group , Pentadecyl group, hexadecyl group, heptadecyl group, octadecyl group, nonadesyl group, icosyl group, eicosyl, henicosyl group, heneicosyl group, docosyl group, tricosyl group, tetracosyl group, pentacosyl group, hexacosyl group, heptacosyl group, octacosyl group, nonacosyl group. , And a toriacontyl group and the like.

The _{linear or branched alkenyl group having 2 to 30 carbon atoms in which −CH 2} − may be substituted with a heteroatom is preferably 2 to 20 carbon atoms, more preferably 8 to 20 carbon atoms. , 12 to 20 carbon atoms are more preferable. Specifically, vinyl group, propenyl group, butenyl group, pentenyl group, hexenyl group, heptenyl group, octenyl group, nonenyl group, decenyl group, undecenyl group, dodecenyl group, tridecenyl group, tetradecenyl group, pentadecenyl group, hexadecenyl group, Octadesenyl group, nonadesenyl group, icosenyl group, eicosenyl group, henicosenyl group, heneicosenyl group, docosenyl group, tricosenyl group, detracosenyl group, pentacosenyl group, hexacosenyl group, hexacosenyl group, heptacosenyl group, octacosenyl group, nonacocenyl group Examples thereof include an octadecadienyl group, an octadecatrienyl group, a butadienyl group, a pentadienyl group, a hexadienyl group, an octadienyl group and the like.
In the _{linear and branched chain alkenyl groups in which −CH 2} − may be substituted with a hetero atom, the position of the unsaturated bond is not limited, and the cis and trans isomers are not limited. It may be either. For example, the octadecenyl group is an oleyl group (cis-9-octadecenyl group) and an eleidyl group (trans-9-octadecenyl group), and the octadecadienyl group is a linoleyl group (cis, cis-9,12-octadecadi). The enyl group) and the elelide linoleyl group (trans, trans-9,12-octadecazienyl group), and the octadecatrienyl group is the linolenic group (cis, cis, cis-9,12,15-octadeca). The trienyl group) and the elelideenorenyl group (trans, trans, trans-9,12,15-octadecatrienyl group), and the hexadecene group contains a palmitrail group (cis-9-hexadecene group).

The _{linear or branched alkynyl group having 2 to 30 carbon atoms in which −CH 2} − may be substituted with a heteroatom is preferably 2 to 20 carbon atoms, and more preferably 8 to 20 carbon atoms. , 12 to 20 carbon atoms are more preferable. Specifically, ethynyl group, propynyl group, butynyl group, pentynyl group, hexynyl group, heptynyl group, octynyl group, nonynyl group, decynyl group, undecynyl group, dodecynyl group, tridecynyl group, tetradecynyl group, pentadecynyl group, hexadecynyl group, Heptadecynyl group, octadecynyl group, nonadecinyl group, icocinyl group, exocinyl group, henicocinyl group, heneicosynyl group, docosinyl group, tricosinyl group, tetracosynyl group, pentacocinyl group, hexacosynyl group, heptacosynyl group, octacosynyl group, octacosynyl group, octacosynyl group Examples thereof include a continyl group.

The _{alicyclic hydrocarbon group having 3 to 30 carbon atoms in which −CH 2} − may be substituted with a heteroatom may be any of a monocyclic type, a polycyclic type, and a crosslinked ring type. Specific examples of the ring constituting the alicyclic hydrocarbon group include cyclopropane, cyclobutane, cyclopentane, cyclopentene, cyclopentadiene, cyclohexane, 2-isopropyl-5-methylcyclohexane, cyclohexene, cyclohexadiene, cycloheptane, cycloheptene, and the like. Cycloheptadiene, cyclooctane, cyclooctene, cyclooctadiene, cyclooctane, cyclononane, cyclononene, cyclodecane, cyclodecene, cyclodecadien, cyclodecatorien, cycloundecane, cyclododecan, bicycloheptane, bicyclohexane, bicyclohexene, tri Cyclohexene, norcalan, norpinan, norbornan, norbornen, norbornadien, tricycloheptane, tricycloheptene, decalin, adamantan and the like can be mentioned.

Examples of the aryl group represented by R ^X4 and R ^{X 6} include an aryl group having 6 to 18 carbon atoms.
The aryl group may have a monocyclic structure or a condensed ring structure in which two or more rings are fused (condensed ring structure).
Examples of the aryl group include a phenyl group, a tolyl group, a xsilyl group, a naphthyl group, an anthracenyl group, a phenanthryl group, a pyrenyl group and the like, and a phenyl group or a naphthyl group is preferable, and a phenyl group is more preferable.

^Examples of the heteroaryl group represented by R ^X4 and RX6 include a heteroaryl group having a monocyclic or polycyclic ring structure containing a hetero atom such as a sulfur atom, an oxygen atom, and a nitrogen atom.

The number of carbon atoms in the heteroaryl group is not particularly limited, but is preferably 3 to 18, and more preferably 3 to 5.
The number of heteroatoms contained in the heteroaryl group is not particularly limited, but is preferably 1 to 10, more preferably 1 to 4, and even more preferably 1 to 2.
The number of ring members of the heteroaryl group is not particularly limited, but is preferably 3 to 8, more preferably 5 to 7, and even more preferably 5 to 6.
Examples of the heteroaryl group include a fryl group, a pyridyl group, a quinolyl group, an isoquinolyl group, an acridinyl group, a phenanthridinyl group, a pteridinyl group, a pyrazinyl group, a quinoxalinyl group, a pyrimidinyl group, a quinazolyl group, a pyridadinyl group, a cinnolinyl group and a phthalazinyl group. Group, triazinyl group, oxazolyl group, benzoxazolyl group, thiazolyl group, benzothiazolyl group, imidazolyl group, benzoimidazolyl group, pyrazolyl group, indazolyl group, isooxazolyl group, benzoisoxazolyl group, isothiazolyl group, benzoisothiazolyl group. , Oxaziazolyl group, thiadiazolyl group, triazolyl group, tetrazolyl group, benzofuryl group, thienyl group, benzothienyl group, dibenzofuryl group, dibenzothienyl group, pyrrolyl group, indolyl group, imidazolypyridinyl group, carbazolyl group and the like. ..

^{Among the RX4} and ^{RX6 in the} formulas (1-1) and (1-2), linear or branched aliphatic hydrocarbon groups, aryl, are particularly excellent in antiviral activity. A group or a heteroaryl group is more preferable, a linear or branched aliphatic hydrocarbon group is further preferable, and a linear or branched aliphatic hydrocarbon group having 8 or more carbon atoms is particularly preferable.

The aliphatic hydrocarbon group, aryl group, and heteroaryl group represented by ^RX4 and ^RX6 in the formulas (1-1) and (1-2) may further have a substituent. The above-mentioned substituent is not particularly limited, and examples thereof include those exemplified in the Substituent Group W described later.

^RX5 in the formula (1-2) represents a hydrogen atom or a monovalent substituent.
The ^{monovalent substituent represented by R X5} is not particularly limited, and examples thereof include an alkyl group (preferably having 1 to 10 carbon atoms) which may have a substituent.
A hydrogen atom is preferable as ^{R X5.}

In the formula (1), the aliphatic hydrocarbon groups represented by R ^X1 to R ^X3, it is synonymous with the aliphatic hydrocarbon group represented by R ^X4 and R ^X6.
As the aliphatic hydrocarbon group represented by ^{R X1 to} R ^X3 _{, a linear or branched alkyl group in which −CH 2} − may be substituted with a hetero atom is preferable. The alkyl group preferably has 1 to 30 carbon atoms, more preferably 1 to 20 carbon atoms, and even more preferably 1 to 10 carbon atoms. However, the aliphatic hydrocarbon groups represented by R ^X1 to R ^X3, the connecting position of the sp ³ carbon is manifested in the formula (1), when it is preferable (in other words that are not substituted with a heteroatom, the fat ^{In the group hydrocarbon group, the connection position with the sp 3} carbon specified in the formula (1) is preferably a carbon atom).
Incidentally, aliphatic hydrocarbon groups represented by R ^X1 to R ^X3 is, -CH ₂ - it is preferred that is not substituted with a heteroatom.

The aryl group represented by ^{R X1 to} R ^X3 has the same meaning as the aryl group represented by ^{R X4} and ^{RX6, and the preferred embodiment is also the same.}

The heteroaryl group represented by ^{R X1 to} R ^X3 has the same meaning as the heteroaryl group represented by ^{R X4} and ^{RX6, and the preferred embodiment is also the same.}

The aralkyl group represented by R ^X1 to R ^X3, above one of linear and branched-chain hydrogen atom of the alkyl group having 1 to 30 carbon atoms represented by R ^X1 to R ^X3 described above It includes the group is replaced with a heteroaryl group represented by R ^X1 R aryl group or above represented by ~R ^{X3 X1} ~R ^X3. Specific examples of the aralkyl group include a benzyl group, a phenethyl group, a naphthylmethyl group and the like.

Represented by R ^X1 to R ^X3, the aliphatic hydrocarbon group, the aryl group, the heteroaryl group, and the aralkyl group may further have a substituent. The above-mentioned substituent is not particularly limited, and examples thereof include those exemplified in the substituent group W described later, and examples thereof include a halogen atom (for example, a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom, and among them, among them. Fluorine atom is preferable), hydroxyl group, or hexafluoroisopropanol group is preferable.
Examples of the aliphatic hydrocarbon group having a substituent include an alkyl halide group, and specifically, -CF ₃ .

Among them, R ^{X1 to} R ^X3 are more excellent in antiviral properties, and are represented by a ^{hydrocarbon atom, -C (= O) -OR X4 (as R X4} , linear or branched. Chain-like aliphatic hydrocarbon groups, aryl groups, or heteroaryl groups are preferable, linear or branched aliphatic hydrocarbon groups are more preferable, and linear or branched aliphatic hydrocarbon groups having 8 or more carbon atoms are preferable. Group hydrocarbon groups are more preferred.), -C (= O) -NR ^X5- R ^X6 (R ^X6 includes linear or branched aliphatic hydrocarbon groups, aryl groups, or heteroaryl groups. Preferably, a linear or branched aliphatic hydrocarbon group is more preferable, and a linear or branched aliphatic hydrocarbon group having 8 or more carbon atoms is further preferable), halogenated. May be aliphatic hydrocarbon groups (eg, alkyl halides, specifically -CF ₃ ), aryl groups, heteroaryl groups, aralkyl groups, or cyano groups, preferably hydrogen. More preferred are an atom, a group represented by ^{-C (= O) -OR X4} , a group represented by -C (= O) -NR ^X5 -R ^X6 _{, -CF 3} or a cyano group.

As the specific compound, a compound represented by the following formula (1A) or the following formula (1B) is preferable.

Wherein (1A), X ¹ represents an oxygen atom or NR ^{A. RA} represents a hydrogen atom or a monovalent substituent. As ^RA , a hydrogen atom is particularly preferable.
The ^{monovalent substituent represented by RA} is not particularly limited, and examples thereof include an alkyl group (preferably having 1 to 10 carbon atoms) which may have a substituent.
When X ¹ represents an oxygen atom, R ¹ represents a linear or branched aliphatic hydrocarbon group having 6 or more carbon atoms.
Examples of the linear or branched aliphatic hydrocarbon group having 6 or more carbon atoms include a linear and branched alkyl group having 6 to 30 carbon atoms, and a linear and branched chain having 6 carbon atoms. Examples include ~ 30 alkenyl groups and linear and branched chain alkynyl groups having 6 to 30 carbon atoms.

The linear and branched alkyl groups having 6 to 30 carbon atoms are preferably 8 to 20 carbon atoms, and more preferably 12 to 20 carbon atoms. Specifically, n-hexyl group, 2-hexylhexyl group, isohexyl group, heptyl group, octyl group, 3,7-dimethyloctyl group, nonyl group, decyl group, undecylic group, dodecyl group, tridecylic group, tetradecyl group. , Pentadecyl group, hexadecyl group, heptadecyl group, octadecyl group, nonadecil group, icosanyl group, eikosanyl group, henicosanyl group, heneicosanyl group, docosanyl group, tricosanyl group, tridecylic group, tetracosanyl group, pentacosanyl group, hexacosanyl group, heptacosanyl group. Examples include a group, a nonacosanyl group, a tridecontanyl group and the like. Of these, a dodecyl group, a tridecylic group, a tetradecyl group, a pentadecyl group, a hexadecyl group, a heptadecyl group, an octadecyl group, a nonadecylic group, or an icosanyl group is preferable.

The linear and branched alkenyl groups having 6 to 30 carbon atoms are preferably 8 to 20 carbon atoms, and more preferably 12 to 20 carbon atoms. Specifically, hexenyl group, heptenyl group, octenyl group, nonenyl group, decenyl group, undecenyl group, dodecenyl group, tridecenyl group, tetradecenyl group, pentadecenyl group, hexadecenyl group, heptadecenyl group, octadecenyl group, nonadesenyl group, icosenyl group, Eicosenyl group, henicosenyl group, heneicosenyl group, docosenyl group, tricosenyl group, detracosenyl group, pentacosenyl group, hexacosenyl group, hexacosenyl group, heptacosenyl group, octacosenyl group, nonacosinel group, triacocenyl group, octadecadienyl group, octadecatrienyl group Examples thereof include an enyl group, an eicosenyl group, a docosenyl group, a butadienyl group, a pentadienyl group, a hexadienyl group, an octadienyl group and the like. Of these, a dodecenyl group, a tridecenyl group, a tetradecenyl group, a pentadecenyl group, a hexadecenyl group, a heptadecenyl group, an octadecenyl group, a nonadesenyl group, or an icosenyl group is preferable.

The linear and branched alkynyl groups having 6 to 30 carbon atoms are preferably 8 to 20 carbon atoms, and more preferably 12 to 20 carbon atoms. Specifically, hexynyl group, heptynyl group, octynyl group, nonynyl group, decynyl group, undecynyl group, dodecynyl group, tridecynyl group, tetradecynyl group, pentadecynyl group, hexadecynyl group, heptadecynyl group, octadecynyl group, nonadecinyl group, icocinyl group, Examples thereof include an exocinyl group, a henicosynyl group, a heneicosynyl group, a docosynyl group, a tricosynyl group, a tetracosynyl group, a pentacocinyl group, a hexacocinyl group, a heptacosynyl group, an octacocinyl group, an octacocinyl group, a nonacocynyl group, and a triacontinyl group. Of these, a dodecynyl group, a tridecynyl group, a tetradecynyl group, a pentadecynyl group, a hexadecynyl group, a heptadecynyl group, an octadecynyl group, a nonadecinyl group, or an icocinyl group is preferable.

If the X ¹ represents NR ^A, R ¹ represents a linear or branched aliphatic hydrocarbon group having 5 or more carbon atoms.
The linear or branched aliphatic hydrocarbon group having 5 or more carbon atoms is a linear or branched alkyl group having 5 to 30 carbon atoms (preferably 8 to 20 carbon atoms, 12 carbon atoms). ~ 20 is more preferable), linear and branched alkenyl groups having 5 to 30 carbon atoms (preferably 8 to 20 carbon atoms, more preferably 12 to 20 carbon atoms), and linear and branched alkenyl groups. Examples thereof include a branched alkynyl group having 5 to 30 carbon atoms (preferably 8 to 20 carbon atoms, more preferably 12 to 20 carbon atoms).
The linear and branched chain alkyl groups having 5 to 30 carbon atoms, the linear and branched chain alkenyl groups having 5 to 30 carbon atoms, and the linear and branched chain carbon atoms 5 specific examples of the 30 alkynyl group, a linear or branched alkyl group having 6 to 30 carbon atoms represented by R ^1, linear or branched represented by R ¹ Examples thereof include alkenyl groups having 6 to 30 carbon atoms and linear and branched alkynyl groups represented by ^{R 1 having 6 to 30 carbon atoms.}

In formula (1B), X ² represents an oxygen atom or NR ^B. R ^B represents a hydrogen atom or a monovalent substituent. The R ^B, among them a hydrogen atom is preferable.
Examples of the monovalent substituent represented by R ^B, has the same meaning as R ^A in formula (1A), preferred embodiments are also the same.
When X ² represents an oxygen atom, R ² represents a linear or branched aliphatic hydrocarbon group having 12 or more carbon atoms.
Examples of the linear or branched aliphatic hydrocarbon group having 12 or more carbon atoms include a linear and branched alkyl group having 12 to 30 carbon atoms, and a linear and branched chain having 12 carbon atoms. Examples include ~ 30 alkenyl groups and linear and branched chain alkynyl groups having 12 to 30 carbon atoms.
The linear and branched chain alkyl groups having 12 to 30 carbon atoms, the linear and branched chain alkenyl groups having 12 to 30 carbon atoms, and the linear and branched chain carbon atoms 12 Specifically the 30 alkynyl group, a linear or branched alkyl group having 6 to 30 carbon atoms represented by R ^1, linear or branched represented by R ¹ Among the alkenyl groups having 6 to 30 carbon atoms and the ^{linear and branched alkynyl groups represented by R 1} having 6 to 30 carbon atoms, those having 12 or more carbon atoms can be mentioned.

When X ² is NR ^B , R ² represents a linear or branched aliphatic hydrocarbon group having 6 or more carbon atoms. The linear or branched aliphatic hydrocarbon group having 6 or more carbon atoms represented by R ^1, the number 6 or more linear or branched aliphatic carbon represented by R ¹ It has the same meaning as a hydrocarbon group, and the preferred embodiment is also the same.
In the above formula (1B), R ³ represents a hydrogen atom or a cyano group.

The compound represented by the above formula (1) can be synthesized according to a known method.

The molecular weight of the specific compound is not particularly limited, but is, for example, 150 or more. The upper limit is not particularly limited, but is, for example, 1000 or less. The molecular weight of the specific compound is preferably 150 to 800.

The ClogP of the specific compound is not particularly limited, but is preferably 0.70 or more, preferably 5.00 or more, and more preferably 7.00 or more in that the antiviral activity is more excellent. The upper limit is not particularly limited, but is, for example, 15.00 or less, preferably 12.00 or less from the viewpoint of solubility.
The ClogP of the specific compound can be determined by ChemBioDrow Ultra Ver13.

(Substituent group W)
For example, halogen atom (fluorine atom, chlorine atom, bromine atom, iodine atom, etc.), alkyl group (including cycloalkyl group, bicycloalkyl group, and tricycloalkyl group), alkenyl group (cycloalkenyl group, and bicycloalkenyl group). ), Alkinyl group, aryl group, heterocyclic group (may be called heterocyclic group, including heteroaryl group), cyano group, hydroxyl group, nitro group, alkoxy group, aryloxy group, silyloxy group, heterocycle Oxy group, acyloxy group, carbamoyloxy group, alkoxycarbonyloxy group, aryloxycarbonyloxy group, amino group (including anilino group), ammonio group, acylamino group, aminocarbonylamino group, alkoxycarbonylamino group, aryloxycarbonylamino Group, sulfamoylamino group, alkyl or arylsulfonylamino group, mercapto group, alkylthio group, arylthio group, heterocyclic thio group, acylthio group, sulfamoyl group, alkyl or arylsulfinyl group, alkyl or arylsulfonyl group, acyl group, Aryloxycarbonyl group, alkoxycarbonyl group, carbamoyl group, aryl or heterocyclic azo group, imide group, phosphino group, phosphinyl group, phosphinyloxy group, phosphinylamino group, phosphono group, silyl group, hydrazino group, ureido Examples include groups, boronic acid groups (-B (OH) ₂ ), sulfonic acid groups, carboxy groups, phosphoric acid groups and other known substituents.
Further, each group listed in these substituent group W may be further substituted with the group exemplified in the above-mentioned substituent group W. For example, the alkyl group may be substituted with a halogen atom.

Hereinafter, the compound represented by the formula (1) will be illustrated, but the present invention is not limited thereto.

The specific compound may be used alone or in combination of two or more.
In the composition of the present invention, the content of the specific compound (the total of a plurality of types, if present) is preferably 0.01% by mass or more, more preferably 0.10% by mass or more, based on the total mass of the composition. It is preferable, and 0.30% by mass or more is more preferable. The upper limit thereof is preferably 10% by mass or less, more preferably 5% by mass or less.

〔solvent〕
The composition of the present invention contains a solvent.
The solvent is not particularly limited, but alcohol is preferably contained because it has more excellent antiviral activity. The alcohol referred to here does not contain a specific compound.
Hereinafter, the solvent that can be used in the composition of the present invention will be described.
<Alcohol>
The alcohol is not particularly limited, but for example, linear, branched, and cyclic alcohols having 1 to 20 carbon atoms (including ether alcohol) are preferable. Specifically, methanol, ethanol, n-propanol, isopropanol, polyethylene glycol, propylene glycol, propylene glycol acetate monoester, glycerin, n-butanol, 2-butanol, i-butanol, t-butanol, butane-1,3 -Dioyl, diethylene glycol, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, dipropylene glycol, n-pentanol, 2-pentanol, 3-pentanol, t-amyl alcohol, isoamyl alcohol, 2-methylbutanol, 3-methyl -2-butanol, 3-methyl-2-butenol, 3-methyl-3-butanol, 1-penten-3-ol, n-hexanol, capryl alcohol, 2-ethyl-1-hexanol, decanol, linalol, geraniol, Lauryl alcohol, myristyl alcohol, benzyl alcohol, phenylethyl alcohol, cinnamyl alcohol, 3-methoxypropanol, methoxymethoxyethanol, ethylene glycol, ethylene glycol mono-n-butyl ether, diethylene glycol mono-n-butyl ether, triethylene glycol mono-n -Butyl ether, tetraethylene glycol mono-n-butyl ether, dipropylene glycol monobutyl ether, citronellol, terpineol, hydroxycitroneral, hydroxycitronell dimethyl acetal, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol monomethyl ether, Examples thereof include propylene glycol monoethyl ether, diacetone alcohol, ethylene glycol monoisopropyl ether, and diethylene glycol monomethyl ether.

The alcohol is preferably a food additive from the viewpoint of safety, and among them, methanol, ethanol, propanol, isopropanol, polyethylene glycol, propylene glycol, propylene glycol acetic acid monoester, n-butanol, 2-butanol, butane. -1,3-diol, diethylene glycol, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, dipropylene glycol, 2-methyl-1-butanol, 1-decanol, 1-penten-3-ol, 2-ethyl1-hexanol, 2-Pentanol, 3-Pentanol, 3-Methyl-2-butanol, 3-Methyl-2-butanol, 3-Methyl-3-butanol, isoamyl alcohol, i-butanol, benzyl alcohol, citronellol, terpineol, hydroxycitro Neral or hydroxycitronellal dimethyl acetal is preferred.

The alcohol preferably contains one or more selected from the group consisting of ethanol and isopropanol because of its excellent antiviral activity.

The composition of the present invention preferably contains an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms as alcohols in that the variation in antiviral activity value becomes smaller. Alcohols having 3 or more carbon atoms are more lipophilic than alcohols having 2 or less carbon atoms, and it is considered that viruses and stains lurking in the viruses can be easily physically removed. Therefore, when the wiper is impregnated with a composition containing an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms and used for wiping, it is considered that the variation in the antiviral activity value becomes smaller. Further, since it is assumed that an alcohol having 3 or more carbon atoms has a higher surface active function than an alcohol having 2 or less carbon atoms, a synergistic effect with a proton receptor formed by dissociating hydrogen from a specific compound is obtained. It may be further strengthened and the antiviral activity may be improved.
When an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms are used in combination, the volume ratio of the alcohol having 3 or more carbon atoms to the alcohol having 2 or less carbon atoms (the volume of the alcohol having 3 or more carbon atoms / the volume of 2 or less carbon atoms) The volume of alcohol) is preferably 0.01 or more in that the antiviral activity is more excellent and / or the variation in the antiviral activity is smaller. The upper limit thereof is not particularly limited, but is, for example, 5 or less, preferably 1.5 or less.

<Solvents other than alcohol>
Examples of the solvent other than alcohol include water and organic solvents (excluding alcohol).
The organic solvent is not particularly limited, but for example, acetone, methyl ethyl ketone, cyclohexane, ethyl acetate, isoamyl acetate, isopropyl acetate, geranyl acetate, cyclohexyl acetate, citronellyl acetate, cinnamyl acetate, terpinyl acetate, phenylethyl acetate, butyl acetate, acetic acid. Benzyl, menthyl acetate, linaryl acetate, butyric acid, ethyl butyrate, butyl butyrate, isoamyl butyrate, cyclohexyl butyrate, ethylene dichloride, tetrahydrofuran, toluene, ethylene glycol dimethyl ether, acetylacetone, cyclohexanone, ethylene glycol monomethyl ether acetate, ethylene glycol ethyl ether acetate, ethylene Glycol monobutyl ether acetate, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, propylene glycol monomethyl ether acetate, 2-methylpropanol, 2-methylbutyl aldehyde, 3-methyl-2-butenal, 3-methylbutanal, L-perylaldehyde, acetaldehyde , Ethyl acetoacetate, isoamyl acetate, isoamyl butyrate, isobarrelaldehyde, isobutanal, isopropyl acetate, isopropyl myrysterate, isoamyl isovalerate, ethyl isovalerate, ethyl lactate, ethyl heptate, octanal, ethyl octanate, octanal, Octanoic acid, ethyl octanate, octylaldehyde, formic acid, isoamyl formate, geranyl formate, citronellyl formate, silicate aldehyde, ethyl silicate, methyl silicate, citral, citroneral, diisopropyl ether, diisopropyl disulfide, diisopropyl disulfide, diethyl Ether, diethyl tartrate, diethyl pyrocarbonate, decanal, ethyl decanoate, triacetin, triethyl citrate, toluene, nonalactone, barrel aldehyde, paramethylacetophenone, paramethoxybenzaldehyde, castor oil, isoamyl phenylacetate, isobutyl phenylacetate, phenylacetic acid Ethyl, butanal, propionaldehyde, propionic acid, isoamyl propionate, ethyl propionate, benzyl propionate, hexane, heptane, benzaldehyde, eucalyptol, ionone, terpinyl acetate, α-amylcinnamaldehyde, brominated vegetable oil, acetic acid, di Diethyl carbonate, ethyl lactate, large thermal oxidation Examples thereof include soybean oil, esters of thermally oxidized soybean oil and glycerin, and liquid paraffin.

The organic solvent is preferably a food additive from the viewpoint of safety, and is preferably an acetone, methyl ethyl ketone, ethyl acetate, isoamyl acetate, isopropyl acetate, geranyl acetate, cyclohexyl acetate, citronellyl acetate, cinnamyl acetate, terpinyl acetate, phenyl acetate. Ethyl, butyl acetate, benzyl acetate, menthyl acetate, linaryl acetate, butyric acid, ethyl butyrate, butyl butyrate, isoamyl acetate, cyclohexyl butyrate, 2-methylpropanol, 2-methylbutylaldehyde, 3-methyl-2-butenal 3-methyl Butanal, l-perylaldehyde, acetaldehyde, ethyl acetoacetate, isoamyl acetate, isoamyl butyrate, isobarraldehyde, isobutanal, isopropyl acetate, isopropyl myrysterate, isoamyl isovalerate, ethyl isovalerate, ethyl lactate, ethyl heptate , Octanal, octanoic acid, ethyl octanoate, octylaldehyde, formic acid, isoamyl acetate, geranyl formate, citronellyl formate, silicate aldehyde, ethyl silicate, methyl silicate, citral, citroneral, diisopropyl ether, diisopropyldisulfide, diisopropyl Disulfide, diethyl ether, diethyl tartrate, diethyl pyrocarbonate, decanal, ethyl decanoate, triacetin, triethyl citrate, toluene, nonalactone, barrelaldehyde, paramethylacetophenone, paramethoxybenzaldehyde, castor oil, isoamyl phenylacetate, isobutyl phenylacetate , Ethylphenylacetate, butanal, propionaldehyde, propionic acid, isoamyl propionate, ethyl propionate, benzyl propionate, hexane, heptane, benzaldehyde, eucalyptol, ionone, terpinyl acetate, α-amyl cinnamaldehyde, brominated vegetable oil, Acetic acid, dimethyl dicarbonate, ethyl lactate, hot-oxidized soybean oil, ester of hot-oxidized soybean oil and glycerin, or liquid paraffin are preferable.

In the composition of the present invention, the content of the solvent (the total of a plurality of types, if present) is preferably 0.5 to 99.9% by mass, preferably 10 to 99.8% by mass, based on the total mass of the composition. % Is more preferable, 50 to 99.8% by mass is further preferable, and 80 to 99.8% by mass is particularly preferable.

In the composition of the present invention, the content of alcohol (the total of a plurality of alcohols if present) is preferably 25% by volume or more, preferably 40% by volume, based on the total volume of the solvent, in that the antiviral activity is more excellent. The above is more preferable, and 50% by volume or more is further preferable. The upper limit of the alcohol content is not particularly limited, but is, for example, 100% by volume or less.

[PH of composition]
The composition of the present invention has a pH of 9.0 to 14.0. If the pH is less than 9.0, the antiviral activity may be inferior. The pH is preferably 10.0 or higher, more preferably 11.0 or higher, in that it has more excellent antiviral activity. On the other hand, the pH is 14.0 or less, and 12.0 or less is preferable because the corrosiveness to metal can be further suppressed.
The pH can be measured using a desktop pH meter "F-72S" (manufactured by HORIBA, Ltd.) using a pH electrode "6337-10D" (manufactured by HORIBA, Ltd.). The specific measurement method will be described later.
In the present specification, the pH is intended to be a value at 25 ° C.

[Arbitrary component]
The composition of the present invention may contain components other than the above as long as the effects of the present invention are exhibited. The optional component is not particularly limited, but for example, a surfactant, a disinfectant, a disinfectant, a disinfectant, an antioxidant, a pH adjuster, an ultraviolet absorber, a chelating agent, a moisturizer, a thickener / gelling agent. , Preservatives, fragrances, pigments and the like. The composition of the present invention preferably contains a surfactant, a bactericidal agent, a disinfectant, a disinfectant, or an antioxidant in that the antiviral activity is more excellent, and the surfactant, quaternary ammonium. It is more preferable to contain a salt (for example, benzalkonium chloride, etc.) or an antioxidant, and it is further preferable to contain a surfactant or a quaternary ammonium salt (for example, benzalkonium chloride, etc.).

<Surfactants and emulsifiers>
The composition of the present invention preferably contains a surfactant and / or an emulsifier. When the composition of the present invention containing a surfactant and / or an emulsifier is impregnated into a base cloth and used as a wiper, there is little unwiped residue and the cleaning property is excellent.
The surfactant and the emulsifier are not particularly limited, but for example, an ionic surfactant such as an anionic surfactant and a cationic surfactant (however, the ionic surfactant referred to here is a quaternary ammonium salt. Does not include), and nonionic surfactants and the like.

Examples of the ionic surfactant include alkyl sulfate (sodium dodecyl sulfate, etc.), alkylbenzene sulfonate (sodium dodecylbenzene sulfonate, etc.), alkyl phosphate, and cholic acid salt (sodium deoxycholate, sodium lithocate). , And anionic surfactants such as sodium cholic acid; cationic surfactants such as alkyldiaminoethylglycine hydrochloride;

The nonionic surfactant is preferably a compound having more than 20 carbon atoms, for example, mono-, di-, or polyglycerin fatty acid esters, propylene glycol fatty acid monoesters, sorbitan fatty acid esters, sucrose fatty acid esters, and the like. Ester type; Ether type such as polyoxyethylene alkyl ether, polyalkylene alkyl ether, and polyoxyethylene polyoxypropylene glycol (manufactured by Kao Co., Ltd., Emargen series, etc.); Fatty polyethylene glycol, fatty acid polyoxyethylene sorbitan, etc. Ester ether type; Examples thereof include alkanolamide type such as fatty acid alkanolamide.
Specific examples of the nonionic surfactant include polyethylene glycol monolauryl ether, polyethylene glycol monostearyl ether, polyethylene glycol monocetyl ether, polyethylene glycol monolauryl ester, polyethylene glycol monostearyl ester, and the like.

The emulsifier is not particularly limited, but in the case of a nonionic emulsifier, the number of carbon atoms is preferably more than 20. Specific examples of the emulsifier include oleate (salt forms include calcium salt, sodium salt, and potassium salt), capric acid salt (salt forms include calcium salt, sodium salt, and salt). Potassium salt can be mentioned), caprylate (salt forms include calcium salt, sodium salt, and potassium salt), laurate (salt forms include calcium salt, sodium salt, and potassium salt). Potassium salt.), Gumrosing lycerin ester, sodium octenyl succinate, stearyl citrate, citrate monoglyceride, glycerin lactic acid and fatty acid esters, mono-, di-, or polyglycerin fatty acid esters, stearic acid. Salts (forms of salts include calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt), myristate (forms of salt include calcium salt, magnesium salt, ammonium salt). , Aluminum salt, potassium salt, and sodium salt.), Palmitate (forms of the salt include calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt),. Calcium stearoyl lactate, sodium stearoyl lactate, sorbitan fatty acid ester, sodium dioctyl sulfosuccinate, lecithin, lecithin hydroxide, partially hydrolyzed lecithin, sunflower lecithin, enzyme-treated lecithin, propylene glycol fatty acid ester, polyoxyethylene sorbitan monolaurate, poly monostearate Oxyethylene sorbitan, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan oleate, Kiraya extract, vegetable sterol, sphingolipid, soybean saponin, bile powder, animal sterol, fractionated lecithin, yukkafoam extract, egg yolk lecithin , Thor oil, and rosinging lycerin ester.

The surfactant and emulsifier are preferably food additives from the viewpoint of safety, and colelate (the salt forms include calcium salt, sodium salt, and potassium salt). , Deoxycholate (forms of salt include calcium salt, sodium salt, and potassium salt), oleate (forms of salt include calcium salt, sodium salt, and potassium salt). ), Caprinate (forms of the salt include calcium salt, sodium salt, and potassium salt), caprylate (forms of the salt include calcium salt, sodium salt, and potassium salt). ), Laurate (forms of salt include calcium salt, sodium salt, and potassium salt), gum rosing lycerin ester, sodium octenyl succinate, triethyl citrate, stearyl citrate, monoglyceride citrate, Glycerin lactic acid and fatty acid esters, mono-, di-, or polyglycerin fatty acid esters, sucrose fatty acid esters, stearates (in the form of salts, calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium) Salts and sodium salts are included), myristate (salt forms include calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt), palmitate (salt). Examples include calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt), stearoyl calcium lactate, sodium stearoyl lactate, sorbitan fatty acid ester, sodium dioctyl sulfosuccinate, lecithin, hydroxylation. Lecithin, partially hydrolyzed lecithin, sunflower lecithin, enzyme-treated lecithin, propylene glycol fatty acid ester, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan oleate, Kiraya extraction Preferables are foods, vegetable stearic acid, sphingolipids, soybean saponin, bile powder, animal stearic acid, fractionated lecithin, yukkafoam extract, egg yolk lecithin, tall oil, or rosinglycerin ester.

The surfactant and emulsifier may be used alone or in combination of two or more.
When the composition of the present invention contains a surfactant and / or an emulsifier, the content of the surfactant and the emulsifier (the total of a plurality of kinds, if present) is 0.01 to the total mass of the composition. 2% by mass is preferable, 0.05 to 2% by mass is more preferable, and 0.05 to 1% by mass is further preferable.

<Fungicides, disinfectants, and disinfectants>
The disinfectant, disinfectant, and disinfectant are not particularly limited, and include, for example, a quaternary ammonium salt, an antibacterial agent containing a metal, a photocatalyst, an aldehyde compound, an iodo compound, a piganide compound, and an acrinol hydrate (for example). , Lactic acid 6,9-diamino-2-ethoxyacridin monohydrate) and the like. A quaternary ammonium salt is particularly preferable because it has more excellent antiviral activity when combined with the composition of the present invention.

(Quaternary ammonium salt)
The quaternary ammonium salt is not particularly limited, and examples thereof include compounds represented by the following formulas (2) to (5).

In formula (2), R ^{21 to} R ²⁴ each independently represent an aliphatic hydrocarbon group, an aryl group, an aralkyl group, or a heteroaryl group.
The ^{aliphatic hydrocarbon group represented by R 21 to} R ²⁴ may be linear, branched or cyclic.
Further, the ^{aliphatic hydrocarbon group represented by R 21 to} R ²⁴ may contain a hetero atom. The type of the hetero atom is not particularly limited, and examples thereof include an oxygen atom, a nitrogen atom, a sulfur atom, a selenium atom, and a tellurium atom. Among them, in terms of antiviral activity more ^{excellent, -Y 1 -, - N (} Ra) -, - C (= Y 2) -, - CON (Rb) -, - C (= Y 3) Y 4 - , -SOt-, -SO ₂ N (Rc)-, or a combination thereof.
Y ^{1 to Y 4} are independently selected from the group consisting of an oxygen atom, a sulfur atom, a selenium atom, and a tellurium atom. Of these, an oxygen atom or a sulfur atom is preferable because it is easier to handle. t represents an integer of 1 to 3. The Ra, Rb, and Rc independently represent a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.
When the aliphatic hydrocarbon group contains a hetero atom, −CH ₂ − is substituted with the hetero atom.

Specific examples of the aliphatic hydrocarbon group represented by R ^{21 to} R ²⁴ include an alkyl group (preferably 1 to 30 carbon atoms and more preferably 1 to 20 carbon atoms) and an alkenyl group (2 to 2 carbon atoms). 30 is preferable, and 2 to 20 carbon atoms are more preferable), or an alkynyl group (2 to 30 carbon atoms is preferable, and 2 to 20 carbon atoms are more preferable) and the like can be mentioned. Of these, an alkyl group is preferable.

The ^{aryl group represented by R 21 to} R ^{24 has the same meaning as the aryl group represented by R 1X to} R ^3X in the above-mentioned formula (1), and the same applies to the preferred embodiment.

The ^{aralkyl group represented by R 21 to} R ²⁴ is not particularly limited, but for example, an aralkyl group having 7 to 15 carbon atoms is preferable, and specifically, a benzyl group, a phenethyl group, a 1-naphthylmethyl group, 1-. Examples thereof include a (1-naphthyl) ethyl group, a triphenylmethyl group, and a pyrenylmethyl group.

As the ^{heteroaryl group represented by R 21 to} R ²⁴ , for example, a heteroaryl group having 3 to 12 carbon atoms is preferable, and for example, a frill group, a thiofryl group, a pyridyl group, a pyrazole group, an imidazolyl group, a benzoimidazolyl group and an indrill group. Examples thereof include a group, a quinolyl group, an isoquinolyl group, a purine group, a pyrimidyl group, a pyrazil group, an oxazolyl group, a thiazolyl group, a triazil group, a carbazolyl group, a quinoxalyl group, and a thiazine group.

The ^{aliphatic hydrocarbon group represented by R 21 to} R ²⁴ , an aryl group, an aralkyl group, and a heteroaryl group may further have a substituent. Examples of the substituent include those exemplified in the above-mentioned Substituent Group W.

X ⁻ represents a monovalent anion other than the hydroxide ion.
Specifically, as X ⁻ , halide ions (for example, F ⁻ , Cl ⁻ , Br ⁻ , I ⁻ , Br ₃ ⁻ , Br ₂ Cl ⁻ , I ₃ ⁻ , IBr ₂ ⁻ , Cl ₂ Br ⁻ , HF ₂ ⁻ , H ₂ F ₃ ⁻ , AuBr ₂ ⁻ , AuCl ₂ ⁻ , AuI ₂ ⁻ , and FeCl ₄ ⁻ ), carboxylate anion, cyanide anion, sulfonimide anion (N ⁻ (SO ₂ R) ) ₂ : R includes a fluorine atom, a hydrocarbon group (for example, an alkyl group having 1 to 20 carbon atoms), or a perfluoro hydrocarbon group (for example, a perfluoroalkyl group having 1 to 20 carbon atoms). .. for) a), borohydride anions, Jikuroroyou periodate anion, tetrafluoroborate anion, hexafluorophosphate anion, perchloric acid anion, sulfate anion, hydrogen anions sulfate, nitrate anions, dicyanamide anion [N ^- ( CN) ₂ ], azide anion (N ₃ ⁻ ), alkane or aryl sulfonic acid anion, perfluoroalkane or aryl sulfonic acid anion, alkyl or aryl sulfate anion (ROSO ₃ ⁻ : R has 1 to 20 carbon atoms. Alkyl group or aryl group having 6 to 18 carbon atoms.), Alkyl or aryl phosphate anion ((RO) ₂ PO ₂ ⁻ : R is an alkyl group having 1 to 20 carbon atoms or carbon, respectively. . the number represents the 6-18 aryl group), thiocyanide anion ^(S - CN), triacetoxyborohydride anion perruthenate anion ^{_{(RuO 4 -), Cu (}} CF 3) 4 -, C (CN) 3 ^{− And} CF ₃ BF ₃ ⁻ .

Hereinafter, the compound represented by the formula (2) will be illustrated, but the present invention is not limited thereto.

In the formula (3), X ^- is, X in the formula (2) ^- has the same meaning as, preferred embodiments are also the same.
Further, R ³¹ and R ³² have the same meanings ^{as R 21 to R 24} in the formula (2), and the preferred embodiments are also the same.
Y ³¹ and Y ³² are each _{^{independently, -C (R 33) 2 -}} , - NR 34 -, - O -, - CO -, - CO 2 -, - S -, - SO-, or -SO ₂ Represents-. ^{When there are a plurality of Y 32s} in the equation (2), the plurality of Y ^32s may be the same or different.
R ³³ represents a hydrogen atom or a monovalent organic group selected from the group consisting of an aliphatic hydrocarbon group, an aryl group, an aralkyl group, a heteroaryl group, and a halogen atom.
R ³⁴ represents a hydrogen atom or a monovalent organic group selected from the group consisting of an aliphatic hydrocarbon group, an aryl group, an aralkyl group, and a heteroaryl group.
The aliphatic hydrocarbon group, aryl group, aralkyl group, and heteroaryl group represented by ^{R 33} and R ³⁴ are the aliphatic hydrocarbon group and aryl group represented by ^{R 21 to} R ^{24 in the formula (2).} , Aralkyl group, or heteroaryl group, and preferred embodiments are also the same.
Examples of the halogen atom represented by R ³³ and R ³⁴ include a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom.

The ^{aliphatic hydrocarbon group represented by R 33} and R ³⁴ , an aryl group, an aralkyl group, or a heteroaryl group may further have a substituent. Examples of the substituent include those exemplified in the above-mentioned Substituent Group W.

When Y ³¹ or Y ³² represents −C (R ³³ ) ₂ − or −NR ³⁴ −, the monovalent organic group represented by ^{R 31} is linked to ^{R 33} or R ^34. Aromatic or non-aromatic rings may be formed.
In addition, R ³¹ and R ³² may be linked to each other to form an aromatic or non-aromatic ring.
n represents an integer of 1-18.

Hereinafter, the compound represented by the formula (3) will be illustrated, but the present invention is not limited thereto.

In the formula (4), X ^- is, X in the formula (2) ^- has the same meaning as, preferred embodiments are also the same.
Further, R ^{41 has the same meaning as R 21 to} R ²⁴ in the formula (2), and the preferred embodiment is also the same.
Y ^{41 to Y 45} each independently represent a nitrogen atom or = CR ⁴² −. R ⁴² represents a hydrogen atom or a monovalent substituent.
The ^{monovalent substituent represented by R 42} is not particularly limited, and examples thereof include those exemplified in the above-mentioned substituent group W.
When two or more of ^{Y 41 to Y 45 represent = CR 42 −, R 42s} substituted with adjacent carbon atoms are connected to each other to form an aromatic or non-aromatic ring. You may.
When Y ^{41 to Y 45} represent = CR ⁴² −, the monovalent substituent represented by ^{R 42 is linked to R 41} to form an aromatic or non-aromatic ring. May be good.

Hereinafter, the compound represented by the formula (4) will be illustrated, but the present invention is not limited thereto.

In the formula (5), X ^- is, X in the formula (2) ^- has the same meaning as, preferred embodiments are also the same.
Y ^{51 to Y 53 are synonymous with Y 41 to Y 45} in the formula (4), and the preferred embodiments are also the same.
Y ⁵⁴ represents> NR ⁵¹ , a sulfur atom, or an oxygen atom.
R ⁵¹ and R ^{52 are synonymous with R 21 to} R ²⁴ in the formula (2), and the preferred embodiments are also the same.

Hereinafter, the compound represented by the formula (5) will be illustrated, but the present invention is not limited thereto.

(Antibacterial agent containing metal)
The antibacterial agent containing a metal is not particularly limited, and known ones can be used.
Examples of the metal include gold, silver, copper, mercury, zinc, iron, lead, bismuth, titanium, tin, nickel and the like. The mode of the metal contained in the antibacterial agent containing a metal is not particularly limited, and examples thereof include forms such as metal particles, metal ions, and metal salts (including metal complexes). Among them, the metal is preferably gold, silver or copper in that it has more excellent antibacterial properties.

Further, the antibacterial agent containing a metal may be a carrier and a metal-supported carrier containing the above-mentioned metal supported on the carrier.
The type of carrier is not particularly limited, and known carriers can be used. Examples of the carrier include inorganic oxides (for example, zeolite (crystalline aluminokeisan salt), silica gel, silicates such as clay minerals, glass (including water-soluble glass), zirconium phosphate, calcium phosphate, etc.) and activated carbon. , Metal carriers, organic metals and the like.

As the antibacterial agent containing a metal, an antibacterial agent containing silver is preferable because it is more excellent in antibacterial properties.
Specific examples of the antibacterial agent containing silver include silver salts such as silver nitrate, silver chloride, silver sulfate, silver lactate, and silver acetate; silver complexes such as silver ammonia complex, silver chloro complex, and silver thiosulfato complex; silver. Particles; silver ions; a silver-supporting carrier in which these are supported on the above carrier; and the like can be mentioned.

(photocatalyst)
The photocatalyst is not particularly limited as long as it is a substance known to exhibit a photocatalytic action, and examples thereof include TiO ₂ , SrTiO ₂ , ZnO, CdS, SnO ₂ , and WO ₃ .

(Aldehyde compound)
The aldehyde-based compound is not particularly limited, and examples thereof include glutaral, phthalal, and formalin.

(Iodine compound)
The iodine-based compound is not particularly limited, and examples thereof include povidone iodine and iodine tincture.

(Piguanide compound)
The piganide compound is not particularly limited, and examples thereof include chlorhexidine gluconate, chlorhexidine hydrochloride, and chlorhexidine acetate.

The disinfectant, disinfectant, and disinfectant may be used alone or in combination of two or more.
When the composition of the present invention contains a disinfectant, a disinfectant, and / or a disinfectant, the content of the disinfectant, the disinfectant, and the disinfectant (the total of the disinfectants if a plurality of types exist) is the composition. With respect to the total mass, 0.001 to 10% by mass is preferable, 0.01 to 3% by mass is more preferable, and 0.01 to 1% by mass is further preferable.

<Antioxidant>
The composition of the present invention preferably contains an antioxidant (excluding specific compounds). When the composition of the present invention contains an antioxidant, the antiviral activity is more excellent.
The antioxidant is not particularly limited, and is described in, for example, "Theory and Practice of Antioxidants" (Kajimoto, Sanshobo 1984) and "Handbook of Antioxidants" (Saruwatari, Nishino, Tabata, Taiseisha 1976). The various antioxidants described can be used.

Examples of the antioxidant include ascorbic acid, ascorbic acid derivatives, and salts thereof; erythorbic acid, erythorbic acid derivatives, and salts thereof; compounds having a phenolic hydroxyl group; amine compounds such as phenylenediamine.

Examples of the ascorbic acid, ascorbic acid derivative, and salts thereof include L-ascorbic acid, sodium L-ascorbic acid, potassium L-ascorbic acid, calcium L-ascorbic acid, L-ascorbic acid phosphate, and L-. Magnesium salt of ascorbic acid phosphate, L-ascorbic acid sulfate ester, L-ascorbic acid sulfate disodium salt, L-ascorbic acid stearate ester, L-ascorbic acid 2-glucoside, L-ascorbic acid palmitate, And L-ascorbic acid tetraisopalmitate and the like.

Examples of the above-mentioned erythorbic acid, erythorbic acid derivative, and salts thereof include erythorbic acid, sodium erythorbate, potassium erythorbate, calcium erythorbic acid, erythorbic acid phosphate, and erythorbic acid sulfate ester.

Examples of the compound having a phenolic hydroxyl group include polyphenols (for example, catechin contained in tea extract), nordihydroguayaletic acid (NDGA), gallate esters (for example, propyl gallate, butyl gallate, and butyl gallate). (Octyl gallate, etc.), BHT (dibutylhydroxytoluene), BHA (butylhydroxyanisole), carcinonic acids (rosemary extract, etc.), ferulic acid, vitamin Es, bisphenols, and the like.
Examples of the vitamin Es include tocopherol (vitamin E) and its derivatives, tocotrienols and their derivatives, and the like.
Examples of the tocopherol and its derivatives include dl-α-tocopherol, dl-β-tocopherol, dl-γ-tocopherol, dl-δ-tocopherol, dl-α-tocopherol acetate, and -dl-α-tocopherol nicotinate. Examples thereof include linoleic acid-dl-α-tocopherol, succinic acid dl-α-tocopherol, and acetates thereof.
Examples of the tocotrienol and its derivative include α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, and acetates thereof.

Examples of the amine compound include phenylenediamine, diphenyl-p-phenylenediamine, 4-amino-p-diphenylamine and the like.

The antioxidant is preferably a food additive from the viewpoint of safety, and is preferably 4-hexylresorcin, BHT, butylhydroxyanisole, ethylenediamine tetraacetate disodium, L-ascorbic acid, and L-ascorbic acid. Calcium acid, L-ascorbic acid stearic acid ester, L-ascorbic acid sodium, L-ascorbic acid palmitate, tert-butylhydroquinone, d-α-tocopherol concentrate, dl-α-tocopherol, anoxomer, isoascorbic acid, Elysorbic acid, sodium erythorbic acid, isopropyl citrate, guayaku fat, guayak resin, dilaurylthiodipropionate, thiodipropionic acid, thiodipropionic acid distearyl ester, sodium thiosulfate, nordihydroguayaletic acid, pyrosulfite Potassium, sodium pyrosulfate, ethyl protocatechuate, ferulic acid, propyl ascorbic acid, isoamyl ascorbic acid, dodecyl ascorbic acid, potassium sulfite, sodium sulfite, potassium hydrogen sulfite, sodium hydrogen sulfite, or stannous chloride are preferred.

The antioxidant may be used alone or in combination of two or more.
When the composition of the present invention contains an antioxidant, the content of the antioxidant (the total of a plurality of types, if present) is preferably 0.001 to 2% by mass with respect to the total mass of the composition. 0.01 to 1% by mass is more preferable, and 0.01 to 0.5% by mass is further preferable.

<pH adjuster>
The pH adjuster is not particularly limited, but is limited to metal alkoxides (eg, sodium methoxydo, sodium ethoxydo, etc.), metal oxides (eg, calcium oxide, magnesium oxide, etc.), and bicarbonates (ammonium hydrogencarbonate, carbonate, etc.). Sodium hydrogen hydrogen, potassium hydrogen carbonate, calcium hydrogen carbonate, etc.), metal hydroxides (calcium hydroxide, magnesium hydroxide, potassium hydroxide, sodium hydroxide, lithium hydroxide, aluminum hydroxide, rubidium hydroxide, cesium hydroxide , Strontium hydroxide, barium hydroxide, uropyrium hydroxide (II), and tarium hydroxide (I), etc.), carbonates (ammonium carbonate, potassium carbonate, calcium carbonate, sodium carbonate, magnesium carbonate, cesium carbonate, etc.), Examples thereof include quaternary ammonium hydroxide, organic bases (guanidine derivatives, diazabicycloundecene, diazabicyclononen, etc.), phosphazene bases, proazaphosphatlan bases, and the like.
As the pH adjuster, those used as food additives are preferable from the viewpoint of safety, and sodium methoxydo, calcium oxide, magnesium oxide, ammonium hydrogencarbonate, sodium hydrogencarbonate, potassium hydrogencarbonate, calcium hydrogencarbonate, and hydroxide are preferable. Calcium, magnesium hydroxide, potassium hydroxide, sodium hydroxide, ammonium carbonate, potassium carbonate, calcium carbonate, sodium carbonate, or magnesium carbonate are preferred.

The pH adjuster may be used alone or in combination of two or more.
When the composition of the present invention contains a pH adjuster, the content of the pH adjuster (the total of a plurality of types, if present) is appropriately changed depending on the content of a specific compound and the like, and thus cannot be limited. , 0.001 to 30% by mass, more preferably 0.005 to 20% by mass, 0.01 to 10% by mass, based on the total mass of the composition so that the pH of the composition exceeds 9.5. Mass% is more preferred.

<UV absorber>
The ultraviolet absorber is not particularly limited, and is, for example, a salicylic acid-based compound such as homomentyl salicylate, octyl salicylate, and triethanolamine salicylate; paraaminobenzoic acid, ethyldihydroxypropyl paraaminobenzoic acid, glyceryl paraaminobenzoic acid, octyldimethylparaaminobenzoic acid. , Paradimethylaminobenzoate amyl, and paraaminobenzoic acid compounds such as 2-ethylhexyl paradimethylaminobenzoate; 4- (2-β-glucopyranosyloxy) propoxy-2-hydroxybenzophenone, dihydroxydimethoxybenzophenone, Sodium dihydroxydimethoxybenzophenone disulfonate, 2-hydroxy-4-methoxybenzophenone, and hydroxymethoxybenzophenone sulfonic acid and its trihydrate, sodium hydroxymethoxybenzophenone sulfonate, 2-hydroxy-4-methoxybenzophenone-5-sulfate, 2, 2'-Dihydroxy-4-methoxybenzophenone, 2,4-dihydroxybenzophenone, 2,2'4,4'-tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, and 2-hydroxy- Benzophenone compounds such as 4-N-octoxybenzophenone; 2-ethylhexyl paramethoxycinerate (also known as octyl paramethoxykei dermatate), mono-2-ethylhexarate glyceryl diparamethoxycinerate, 2,5 -Methyl diisopropylsilicate, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, methylbis trimethoxysilicate (trimethylsiloxy) silylisopentyl , Paramethoxycinerate isopropyl-diisopropylsilicate ester mixture, and silicic acid compounds such as p-methoxyhydrosilicate diethanolamine salt; 2-phenyl-benzimidazole-5-sulfate, 4-isopropyldibenzoylmethane , And benzoylmethane compounds such as 4-tert-butyl-4'-methoxydibenzoylmethane; 2-cyano-3,3-diphenylprop-2-enoic acid-2-ethylhexyl ester (also known as octocrylene), dimethoxybenzylidene. 2-Ethylhexyl dioxoimidazolidine propionate, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentandione, synoxate, methyl -O-aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, 3- (4-methylbenzylidene) camphor, octylriazone, 4- (3,4-dimethoxyphenylmethylene) -2,5 Examples thereof include 2-ethylhexyl dioxo-1-imidazolidine propionate, high molecular weight derivatives thereof, and silane derivatives.

The ultraviolet absorber may be used alone or in combination of two or more.
When the composition of the present invention contains an ultraviolet absorber, the content of the ultraviolet absorber (the total of a plurality of types, if present) is preferably 0.001 to 3% by mass with respect to the total mass of the composition. 0.001 to 2% by mass is more preferable, and 0.001 to 1% by mass is further preferable.

<Chelating agent>
The chelating agent is not particularly limited, and for example, an aminopolycarboxylic acid chelating agent, an aromatic or aliphatic carboxylic acid chelating agent, an amino acid chelating agent, a phosphonic acid chelating agent, a phosphoric acid chelating agent, and a hydroxycarboxylic acid. Examples thereof include chelating agents based on polymers, polymer chelating agents (including oligomer electrolytes), dimethylglioxime, thioglycolic acid, phytic acid, glyoxylic acid, and glyoxal acid. Each of these chelating agents may be in the form of a free acid or in the form of a salt such as a sodium salt, a potassium salt, or an ammonium salt.

Examples of the aminopolycarboxylic acid-based chelating agent include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diethylenetriaminepentaacetic acid, and N- (2). -Hydroxyethyl) ethylenediaminetriacetic acid, glycol etherdiaminetetraacetic acid, glutamate diacetic acid, aspartate diacetic acid, salts thereof and the like can be mentioned.

Examples of aromatic or aliphatic carboxylic acid-based chelating agents include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvate, and salicylic acid. Examples thereof include acetylsalicylic acid, hydroxybenzoic acid, aminobenzoic acid (including anthranic acid), phthalic acid, fumaric acid, trimellitic acid, oxalic acid, hexahydrophthalic acid, and salts thereof.

Examples of the amino acid-based chelating agent include glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine, and salts thereof.

Examples of the phosphonic acid-based chelating agent include iminodimethylphosphonic acid, alkyldiphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, and salts thereof.

Examples of the phosphoric acid-based chelating agent include orthophosphoric acid, pyrophosphoric acid, triphosphoric acid, polyphosphoric acid and the like.

Examples of the hydroxycarboxylic acid-based chelating agent include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartrate acid, lactic acid, and salts thereof.

Examples of the polymer electrolyte (including oligomeric electrolyte) chelating agent include an acrylic acid polymer, a maleic anhydride polymer, an α-hydroxyacrylic acid polymer, an itaconic acid polymer, and a constituent monomer 2 of these polymers. Examples thereof include copolymers composed of more than one species, epoxy succinic acid polymers, and the like.

The chelating agent may be used alone or in combination of two or more.
When the composition of the present invention contains a chelating agent, the content of the chelating agent (the total of a plurality of types, if present) is preferably 0.001 to 3% by mass, based on the total mass of the composition. 001 to 2% by mass is more preferable, and 0.001 to 1% by mass is further preferable.

<Moisturizer>
The moisturizing agent is not particularly limited, and for example, deoxyribonucleic acid, mucopolysaccharide, hyaluronic acid, chondroitin sulfate, aloe extract, gelatin, elastin, chitin, chitosan, hydrolyzed eggshell membrane, polyoxyethylene methyl glucoside, polyoxypropylene methyl. Examples thereof include glucoside, sodium lactate, urea, sodium pyrrolidone carboxylate, betaine, whey and the like.

The moisturizer may be used alone or in combination of two or more.
When the composition of the present invention contains a moisturizer, the content of the moisturizer (the total of a plurality of types, if present) is preferably 0.001 to 3% by mass with respect to the total mass of the composition. 001 to 2% by mass is more preferable, and 0.001 to 1% by mass is further preferable.

<Thickener and gelling agent>
Examples of the thickener and gelling agent include maleic anhydride / methyl vinyl ether copolymer, dimethyldiallylammonium chloride / acrylamide copolymer, acrylamide / acrylic acid / dimethyldialylammonium chloride copolymer, cellulose or a derivative thereof. Keratin and collagen or derivatives thereof, calcium alginate, purulan, agar, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, starch gum, acacia gum, crystalline cellulose, arabinogalactan, Karaya gum, tragacant gum, carob bean gum, gati gum, alginic acid and salts thereof (forms of salts include ammonium salt, potassium salt, calcium salt, and sodium salt), propylene glycol alginate, albumin, casein, curdran, β Glucane and β-glucan derivatives, locust bean gum, gellan gum, cassia gum, mannan, tara gum, tragant gum, tamarind gum, dextran, polydextrose, α-glucose, ethylhydroxyethyl cellulose, carboxymethyl cellulose and salts thereof (calcium salt in the form of salt) , And sodium salts.), Enzymatically degraded sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl starch, hydroxypropyl methyl cellulose, methyl ethyl cellulose, methyl cellulose, hydroxypropylated epi-crosslinked starch, hydroxypropylated phosphoric acid cross-linked starch, amylopectin, Hydroxypropylated phosphoric acid cross-linked starch, acetylated adipic acid cross-linked starch, oxidized hydroxypropylated epi-crosslinked starch, acetylated phosphoric acid cross-linked starch, acetylated oxidized starch, alkali-treated starch, oxidized hydroxypropylated epi-crosslinked starch, glycerol cross-linked starch , Acid-treated starch, phosphoric acid monoesterified phosphoric acid cross-linked starch, phosphorylated starch, acetate starch, bleached starch, enzyme-treated starch, oxidized starch, sodium starch glycolate, sodium starch succinate, glucomannan, cyclodextrin, dextrin, Examples thereof include purulan, starch, sodium polyacrylate, eukema, β-1,3-glucan agar, and derivatives of α-glucose.

The thickener and the gelling agent may be used alone or in combination of two or more.
When the composition of the present invention contains a thickener and / or a gelling agent, the content of the thickening agent and the gelling agent (the total of a plurality of kinds, if present) is based on the total mass of the composition. 0.001 to 3% by mass is preferable, 0.001 to 2% by mass is more preferable, and 0.001 to 1% by mass is further preferable.

<Preservative>
The preservative is not particularly limited, but for example, sodium benzoate, sodium benzoate, potassium sorbate, sodium sorbate, sorbic acid, sodium dehydroacetate, hydrogen peroxide, formate, ethyl formate, sodium dichlorate, propionic acid. , Sodium propionate, calcium propionate, pectin degradation products, polylysine, phenoxyethanol, tiram, thiabendazole, imazalyl, diphenyl, natamycin, fludioxonyl, azoxystrone, and tea tree oil.

The preservative may be used alone or in combination of two or more.
When the composition of the present invention contains a preservative, the content of the preservative (the total of a plurality of types, if present) is preferably 0.001 to 3% by mass with respect to the total mass of the composition. 001 to 2% by mass is more preferable, and 0.001 to 1% by mass is further preferable.

<Fragrance>
The fragrance is not particularly limited, but for example, jako, acacia oil, anis oil, ylang ylang oil, jasmine oil, sweet orange oil, spare mint oil, geranium oil, neroli oil, peppermint oil, hinoki oil, fennel oil, peppermint oil, etc. Examples thereof include bergamot oil, lime oil, lavender oil, lemon oil, lemongrass oil, rose oil, rosewood oil, anisaldehyde, sibeton, muscon, and limonene.

The fragrance may be used alone or in combination of two or more.
When the composition of the present invention contains a fragrance, the content of the fragrance (the total of a plurality of types, if present) is preferably 0.001 to 3% by mass, preferably 0.001 to 1% by mass, based on the total mass of the composition. 2% by mass is more preferable, and 0.001 to 1% by mass is further preferable.

<Dye>
The pigment is not particularly limited, and examples thereof include krill pigment, orange pigment, kaolin, gunjo, chromium oxide, iron oxide, titanium dioxide, and chlorophyll.

The dye may be used alone or in combination of two or more.
When the composition of the present invention contains a dye, the content of the fragrance (the total of a plurality of types, if present) is preferably 0.001 to 3% by mass, preferably 0.001 to 1% by mass, based on the total mass of the composition. 2% by mass is more preferable, and 0.001 to 1% by mass is further preferable.

[Method for producing composition]
The composition of the present invention can be prepared by appropriately mixing the above-mentioned essential components and optional components. The order of mixing the above components is not particularly limited.

[Dosage form]
The dosage form of the composition of the present invention is not particularly limited, and examples thereof include liquid preparations, gel preparations, aerosol spray preparations, and non-aerosol spray preparations.

[Use]
The composition of the present invention is preferably used as an antiviral composition, and has an action of inactivating viruses belonging to, for example, Caliciviridae, Orthomixovirus, Coronavirus, Herpesvirus, etc. Therefore, it is preferable to use it by acting on the above virus to reduce the activity of the above virus. Examples of viruses belonging to the family Caliciviridae include viruses belonging to the genus Norovirus, Sapovirus, Lagovirus, Nebovirus, and Vesivirus. The composition of the present invention exerts a good inactivating effect on viruses belonging to the genus Norovirus and viruses belonging to the genus Vesivirus.
In addition, the composition of the present invention exerts a good inactivating effect on microorganisms such as bacteria and fungi (for example, Escherichia coli, staphylococcus, etc.).

The composition is preferably used as an anti-norovirus composition.
The method of using the above composition is not particularly limited, but it can be applied or pre-applied to a place where norovirus adheres or may adhere. The method of applying the composition is not particularly limited, but for example, a method of spraying the composition on the above-mentioned part, a method of wiping the above-mentioned part with a base cloth containing the composition, and a method of wiping the above-mentioned part with a composition which is a liquid cleaning agent are used. Examples include a cleaning method.

[spray]
The spray of the present invention includes a spray container and an antiviral composition contained in the spray container. The composition for antiviral is as described above.
The spray container may be an aerosol spray container or a non-aerosol spray container. As the spray container, a non-aerosol spray container is particularly preferable.
When the spray container is an aerosol spray container, for example, it is intended that the spray container contains a gas such as a liquid gas and a compressed gas in addition to the antiviral composition. Specific examples of the aerosol spray container include a spray container containing a gas such as liquefied petroleum gas (LPG), dimethyl ether (DME), carbon dioxide gas, nitrogen gas, and isopentan.
When the spray container is a non-aerosol spray container, the spray container does not substantially contain gas such as liquid gas and compressed gas, and the liquid contained in the container is in the form of mist or foam. It is intended to have a mechanism for ejecting the gas out of the container. Examples of the non-aerosol spray container include an accumulator type spray container such as a pump type and a trigger type.

[Wiper]
The wiper of the present invention includes a base cloth and an antiviral composition impregnated in the base cloth.
The composition for antiviral is as described above.
The base cloth is not particularly limited, and may be one made of natural fibers or one made of chemical fibers.
Examples of natural fibers include pulp, cotton, hemp, flax, wool, camel, cashmere, mohair, silk and the like.
Examples of chemical fibers include polyethylene terephthalate, rayon, polynosic, acetate, triacetate, nylon, polyester, polyacrylonitrile, polyvinyl alcohol, polyvinyl chloride, polyvinylidene chloride, polyethylene, polypropylene, polyurethane, polyalkylene paraoxybenzoate, and polyclaral. Be done.
Of these base fabrics, hydrophilic base fabrics are preferable because they are easily impregnated with the composition. The hydrophilic base cloth is a base cloth containing a fiber having a hydrophilic group such as a hydroxyl group, an amino group, a carboxy group, an amide group, and a sulfonyl group. Specific examples of the hydrophilic base fabric include vegetable fibers, cotton, pulp, animal fibers, rayon, nylon, polyester, polyacrylonitrile, polyvinyl alcohol and the like.
Further, as the base cloth, non-woven fabric, cloth, towel, gauze, absorbent cotton and the like can be used, and non-woven fabric is preferable.

The basis weight (mass per unit area) of the base cloth ^{is preferably 100 g / m 2} or less. The amount of impregnation when the base cloth is impregnated with the above composition is preferably 1 times or more the mass of the base cloth.

The present invention will be described in more detail below based on examples. The materials, amounts used, ratios, treatment contents, treatment procedures, etc. shown in the following examples can be appropriately changed as long as they do not deviate from the gist of the present invention. Therefore, the scope of the present invention should not be construed as limiting by the examples shown below.

[Composition for antiviral of Example 1]
[Preparation method]
8.7 mL of ethanol was added to a glass container containing 90 mg of 1,1,1,3,3,3-hexafluoroisopropanol. Next, in the above glass container, water and a 1 mol / L sodium hydroxide aqueous solution were placed in a total amount of 20.4 mL of water (ethanol concentration 30% by volume based on the total volume of the solvent), and the resistance after preparation. An anti-viral composition was obtained by adding the composition for virus to a pH of 11.5.
The pH was measured by the following method.

[Measurement of pH]
A pH standard solution using a pH meter (product name "pH / water quality analyzer LAQUA F-72S", manufactured by HORIBA, Ltd.) and a pH electrode (product name "6377-10D", manufactured by HORIBA, Ltd.). The pH was calibrated and then measured. After preparing the sample solution at a solution temperature of 25 ° C., the electrode was immersed in the sample solution and left to stand for about 1 to 2 minutes, and the pH value when the numerical value became stable was read.

[Evaluation of pKa of antiviral agent]
The pKa of the antiviral agent was determined by the following equipment and procedure.
<Device>
Potential difference automatic titrator AT-610 (manufactured by Kyoto Denshi Kogyo Co., Ltd.)
<Procedure>
1 mmol of 1,1,1,3,3,3-hexafluoroisopropanol was dissolved in 40 mL of ethanol, and 10 mL of purified water was added. After adding 1 mL of 1 mol / L hydrochloric acid, pKa was calculated by titrating with 1 mol / L sodium hydroxide. The pKa of 1,1,1,3,3,3-hexafluoroisopropanol was 11.7.
Then, the obtained pKa was evaluated according to the following criteria.
In addition, the antiviral agents used in each Example and each Comparative Example were also evaluated according to the following criteria by calculating pKa by the method described above.

<Evaluation criteria>
"A": pKa is 10 or more and 14 or less "B": pKa is 9 or more and less than 10 or 14 or more and 15 or less "C": pKa is less than 9 or more than 15

[Evaluation of LogP value]
The ClogP value of the antiviral agent was determined by ChemBioDraw Ultra Ver13.
In addition, the ClogP value of the antiviral agent used in each Example and each Comparative Example was determined by the above-mentioned method.

[Antiviral compositions of Examples 2 to 25 and Comparative Examples 1 to 3]
[Preparation of antiviral compositions of Examples 2 to 25 and Comparative Examples 1 to 3]
According to the method for preparing the antiviral composition of Example 1, the antiviral compositions of Examples 2 to 25 and Comparative Examples 1 to 3 were prepared with the component formulations and pHs shown in Table 1.

[Evaluation of Antiviral Compositions of Examples 1 to 25 and Comparative Examples 1 to 3]
The prepared antiviral compositions of Examples 1 to 25 and Comparative Examples 1 to 3 were evaluated for antiviral activity by the methods shown below.

<Evaluation of anti-feline calicivirus activity>
A virus solution obtained by culturing feline calicivirus (ATCC VR-782) in a MEM (Minimum Essential Media) medium is inoculated into the antiviral composition prepared above, and then stirred for 10 seconds. , The mixture was allowed to stand at about 25 ° C. for 1 minute. Next, 0.1 mL of the antiviral composition solution after inoculation with the virus solution was collected, and 9.9 mL of SCDLP medium (Soybean. Casein Disease Agar with Lecithin and Polysorbate 80) was used so that the final concentration of serum was 10%. It was put into the added product) and mixed well to obtain a test solution. Next, 0.1 mL of the above test solution was inoculated into CRFK cells (cat kidney-derived cell lines, ATCC CCL-94) cultured on an agar medium, and the cells were adsorbed at 37 ° C. for 1 hour. Next, the test solution on the CRFK cells was washed away, an agar medium was layered, and the cells were cultured for 2 to 3 days. After culturing, the number of plaques formed was counted, the infectious titer was calculated, and this was used as the "infectious titer of the antiviral composition". In addition, the infectious titer was calculated for a sample prepared in the same manner as above except that sterilized purified water was used instead of the antiviral composition, and this was used as the "control infectious titer".
The antiviral activity (antiviral activity value) of the antiviral composition was calculated using the following formula 1, and the calculation result was evaluated using the following criteria. The results are shown in Table 1.

Equation 1: Antiviral activity value = AB
The above A represents a common logarithmic value of the control infectious titer.
B above represents a common logarithmic value of the infectious titer of the antiviral composition.

(Evaluation criteria)
"A": Antiviral activity value is 4.0 or more "B": Antiviral activity value is 3.5 or more and less than 4.0 "C": Antiviral activity value is 3.0 or more and less than 3.5 "D" : Antiviral activity value is 2.0 or more and less than 3.0 "E": Antiviral activity value is less than 2.0

In the table below, "oleyl" is intended an unsaturated alkyl group represented by _{C 18} H _35.

From the results in Table 1, it was confirmed that the antiviral composition of the example showed excellent antiviral activity against feline calicivirus.
Further, from the comparison of Examples 1 to 4, the antiviral composition is a feline when the alcohol content is 40 to 100% by volume (preferably 50 to 100% by volume) with respect to the total volume of the solvent. It was confirmed that it shows better antiviral activity against calicivirus.
Further, from the comparison of Examples 4 to 7, the antiviral composition shows more excellent antiviral activity against feline calicivirus when the pH is 10.0 or more (preferably 11.0 or more). Was confirmed.
Further, from the comparison of Examples 3 and 11 to 16, it was confirmed that when the pKa of the antiviral agent was 10 to 14, it showed more excellent antiviral activity against feline calicivirus.
Further, from the comparison of Examples 18 to 25, it was confirmed that when the ClogP value of the antiviral agent was 5.00 or more (preferably 7.00 or more), it showed better antiviral activity against feline calicivirus. Was done.
Further, from the comparison of Examples 18 to 25, the compound represented by the formula (1) is contained as an antiviral agent, and the above compound is a monovalent substituent of -C (= O) -OR ^X4. A linear or branched aliphatic hydrocarbon group having a group represented by (= O) -NR ^X5- R ^X6 and having 8 or more carbon atoms in the ^{above RX4} and the above ^{RX6 (} It was confirmed that when it is preferably a linear or branched aliphatic hydrocarbon group having 12 or more carbon atoms, it exhibits more excellent antiviral activity against cat calicivirus.
Further, from the results of Examples 18 to 25 and the results of Examples 32 to 33 described later, the ClogP value of the antiviral agent even in a relatively low pH range (pH is 9.0 or more and less than 11.0). It was confirmed that when the value is 5.00 or more (preferably 7.00 or more), the antiviral property based on the ClogP value works effectively to exhibit more excellent antiviral activity against feline calicivirus. ..
On the other hand, it is clear that the antiviral composition of the comparative example is inferior in antiviral activity against feline calicivirus.

[Antiviral compositions of Examples 26-33 and Comparative Example 4]
[Preparation of antiviral compositions of Examples 26 to 33 and Comparative Example 4]
According to the method for preparing the antiviral composition of Example 1, the antiviral compositions of Examples 26 to 33 were prepared with the component formulations and pHs shown in Table 2.
In addition, an aqueous sodium hypochlorite solution was prepared as the antiviral composition of Comparative Example 4 (not shown in the table).

[Evaluation of Antiviral Compositions of Examples 26-33 and Comparative Example 4]
<Evaluation of metal corrosiveness>
Approximately 100 mL of each antiviral composition shown in Table 2 was placed in a stainless steel vat, and aluminum, copper, and brass plates were immersed at room temperature under closed conditions. After one week, each plate was taken out, the surface of the plate was visually observed, and the evaluation was made according to the following criteria.

(Evaluation criteria)
"A": No change.
"B": A decrease in gloss and a slight change in color were confirmed.
"C": Rust has occurred.

In addition, the antiviral activity of each antiviral composition was evaluated by the same method as in Example 1.

From the results in Table 2, it was found that when the pH of the antiviral composition was 12.0 or less, almost no corrosion was observed on the aluminum plate, copper, and brass.
On the other hand, when sodium hypochlorite (Comparative Example 4), which is widely used as a norovirus disinfectant, is used as an antiviral agent, slight corrosion on aluminum (B evaluation) and severe corrosion on copper and brass (C evaluation) occur. confirmed.

[Antiviral compositions of Examples 34-40 and Comparative Example 5]
[Preparation of Antiviral Compositions of Examples 34-40 and Comparative Example 5]
According to the method for preparing the antiviral composition of Example 1, the antiviral compositions of Examples 34 to 40 and Comparative Example 5 were prepared with the component formulations and pHs shown in Table 3.

[Evaluation of Antiviral Compositions of Examples 34-40 and Comparative Example 5]
<Evaluation of antiviral activity in wet wiper form>
Antiviral compositions of Examples 34 to 40 and Comparative Example 5 with reference to "Test method for sterilization performance of wet wipers (revised on November 16, 2015)" established by the Japan Sanitary Materials Industry Association. Was wiped off.
As a specific procedure, MEM (Minimum Escential Media) is used as the test carrier in accordance with the "Wet wiper sterilization performance test method (revised on November 16, 2015)" established by the Japan Sanitary Materials Industry Association. A virus solution obtained by culturing feline calicivirus (ATCC VR-782) in a medium was inoculated, dried, and then wiped off with a weight wrapped with a test cloth impregnated with each antiviral composition. It was. Next, the test carrier (stainless steel plate) was placed in 20 mL of SCDLP medium, and the remaining virus was washed out from the test carrier to prepare a virus solution for sample preparation. Further, a virus solution for preparing a control sample was obtained in the same manner as in the above method except that a test cloth impregnated with sterilized purified water was used instead of the test cloth impregnated with the antiviral composition. Next, 0.1 mL of the virus solution for preparing the sample was inoculated into CRFK cells cultured on an agar medium and adsorbed at 37 ° C. for 1 hour. Next, the test solution on the CRFK cells was washed away, an agar medium was layered, and the cells were cultured for 2 to 3 days. After culturing, the number of plaques formed on the agar medium was counted, the infectious titer was calculated, and this was used as the "infectious titer of the antiviral composition". In addition, the infectious titer was calculated for the sample prepared in the same manner as the above method except that the virus solution for preparing the control sample was used instead of the virus solution for preparing the sample, and this was used as the "control infectious titer". ..

Equation 2: Antiviral activity value = AB
The above A represents a common logarithmic value of the control infectious titer.
B above represents a common logarithmic value of the infectious titer of the antiviral composition.

(Evaluation criteria)
"A": Antiviral activity value is 2.5 or more "B": Antiviral activity value is 2.0 or more and less than 2.5 "C": Antiviral activity value is less than 2.0

<Evaluation of wiping variation>
The antiviral compositions shown in Table 3 were prepared in 5 lots each using the antiviral agents of the same production lot, and the antiviral activity value in the wet wiper form was evaluated for each. The evaluation method is the same as the method shown in <Evaluation of antiviral activity in wet wiper form>. Then, based on the obtained virus activity value, it was evaluated according to the following evaluation criteria.

(Evaluation criteria)
"A": The difference between the maximum and minimum antiviral activity values is less than 0.3 "B": The difference between the maximum and minimum antiviral activity values is 0.3 or more and less than 0.5 "C" : The difference between the maximum and minimum antiviral activity values is 0.5 or more

In Table 3 below, the volume ratio of "A" to "B" ([B] / [A]) is intended to be the volume of alcohol of C3 or less / the volume of alcohol of C2 or less.

From the results in Table 3, when alcohols having 2 or less carbon atoms (for example, ethanol or methanol) and alcohols having 3 or more carbon atoms (for example, isopropanol, 1-butanol, or 2-pentanol) are used in combination as alcohols. It was found that the anti-feline calicivirus activity value was improved and the variation was small.
Alcohols having 3 or more carbon atoms (isopropanol (CLogP value: 0.0740), 1-butanol (CLogP value: 0.823), 2-pentanol (CRogP value: 1.13), etc.) have 2 or less carbon atoms. It is assumed that it is more lipophilic than alcohol (methanol (CLogP value: -0.764), ethanol (CRogP value: -0.235)) and has a high surface active function. Therefore, Examples 35 to 40 in which an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms are used in combination are based on alcohols and specific compounds as compared with Example 34 in which an alcohol having 2 or less carbon atoms is used alone. It is considered that the synergistic effect with the proton receptor formed by dissociation of hydrogen was further strengthened, the antiviral activity was improved, and the virus and dirt could be physically removed.

[Antiviral compositions of Examples 41-47 and Comparative Example 6]
[Preparation of antiviral compositions of Examples 41 to 47 and Comparative Example 6]
According to the method for preparing the antiviral composition of Example 1, the antiviral compositions of Examples 41 to 47 and Comparative Example 6 were prepared with the component formulations and pHs shown in Table 4. The content of the additive is the content (mass%) with respect to the total mass of the composition.

[Evaluation of Antiviral Compositions of Examples 41-47 and Comparative Example 6]
With respect to the antiviral compositions shown in Table 4 below, the antiviral activity in the wet wiper form and the wiping variation were evaluated by the same method as in Examples 34 to 40 and Comparative Example 5.

From the results in Table 4, it was found that when the antiviral composition contained a surfactant, the anti-catalicis virus activity was improved and the variation was small.

[Antiviral Compositions of Examples 48-53]
[Preparation of Antiviral Compositions of Examples 48-53]
According to the method for preparing the antiviral composition of Example 1, the antiviral compositions of Examples 48 to 53 were prepared with the component formulations and pHs shown in Table 5, and compared with Examples 34 to 40. The antiviral activity in the wet wiper form and the wiping variation were evaluated by the same method as in Example 5.

From the results shown in Table 5, it was found that when the antiviral composition contained a quaternary ammonium salt, the anti-nekocarisis virus activity was improved and the variation was small.

[Antiviral Compositions of Examples 54-56]
[Preparation of Antiviral Compositions of Examples 54-56]
According to the method for preparing the antiviral composition of Example 1, the antiviral compositions of Examples 54 to 56 were prepared with the component formulations and pHs shown in Table 6.

[Evaluation of Antiviral Compositions of Examples 54-56]
The antiviral compositions shown in Table 6 were evaluated for activity against influenza virus and general bacteria.

<Evaluation of anti-influenza virus activity>
A virus solution obtained by culturing an influenza virus (Influenza A virus (H3N2): ATCC VR-1679) in a MEM (Minimum Essential Media) medium is inoculated into the antiviral composition prepared above for 10 seconds. The mixture was stirred and allowed to stand at about 25 ° C. for 1 minute. Next, 0.1 mL of the antiviral composition after inoculation with the virus solution was collected, placed in 9.9 mL of SCDLP medium (Soybean-Casein Disease Brost with Lecithin & Polysorbate 80) and mixed well to obtain a test solution. It was. Next, MDCK cells (cells derived from canine renal tubular epithelium, ATCC CCL-34) cultured on an agar medium were inoculated with 0.1 mL of the above test solution and adsorbed at 34 ° C. for 1 hour. Next, the test solution on the MDCK cells was washed away, an agar medium was layered, and the cells were cultured for 2 to 3 days. After culturing, the number of plaques formed on the agar medium was counted, the infectious titer was calculated, and this was used as the "infectious titer of the antiviral composition". In addition, the infectious titer was calculated for a sample prepared in the same manner as above except that sterilized purified water was used instead of the antiviral composition, and this was used as the "control infectious titer".
The calculation and evaluation of the antiviral activity value were carried out in the same manner as in the evaluation of the antifeline calicivirus activity of Example 1.
The results are shown in Table 6.

<Sterilization (Escherichia coli / Staphylococcus aureus)>
The test was conducted using the "Test method for sterilization activity of synthetic detergents for houses and soap" established by the Japan Fair Trade Commission for Detergents and Soaps. The bacterial strains used in the test were Escherichia coli NBRC 3972 and Staphylococcus aureus NBRC 12732. The calculation and evaluation of the antibacterial activity value were carried out in the same manner as in the evaluation of the anti-feline calicivirus activity of Example 1.
The results are shown in Table 6.

From the results in Table 6, it was found that the antiviral composition of the present invention exhibits excellent antibacterial activity against influenza virus and bacteria.

Claims (22)

A compound having a hydroxyl group bonded to sp ³ carbon and having a pKa of 9 to 15 and
Containing with solvent,
An antiviral composition having a pH of 9.0 to 14.0. The antiviral composition according to claim 1, wherein the compound is a compound represented by the following formula (1).

In formula (1), R ^{X1 to} R ^X3 each independently represent a hydrogen atom or a monovalent substituent. Provided that at least one of R ^X1 to R ^X3 represents -CF ₃ or a cyano group. The ^{monovalent substituent represented by R X1 to} R ^X3 is represented by a group represented by -C (= O) -O-R ^X4 and -C (= O) -NR ^X5- R ^X6. Group, aliphatic hydrocarbon group, aryl group, heteroaryl group, aralkyl group, carboxylic acid group, sulfonic acid group, phosphoric acid group, sulfonimide group, or cyano group, and ^RX4 and ^RX6 are independent of each other. The antiviral composition according to claim 2, wherein ^{R X5} represents a hydrogen atom or a monovalent substituent. Two of R ^X1 to R ^X3 represents a -CF ₃ group or a cyano group, an antiviral composition according to claim 2 or 3. The ^{monovalent substituent represented by R X1 to} R ^X3 is represented by a group represented by -C (= O) -O-R ^X4 and -C (= O) -NR ^X5- R ^X6. A group, −CF ₃ , or cyano group, wherein ^RX4 and ^RX6 are independently linear or branched aliphatic hydrocarbon groups, aryl groups, or heteroaryl groups, respectively. The antiviral composition according to any one of 2 to 4. The ^{monovalent substituent represented by R X1 to} R ^X3 is represented by a group represented by -C (= O) -O-R ^X4 and -C (= O) -NR ^X5- R ^X6. Any of claims 2 to 5, wherein the group is a group, −CF ₃ , or cyano group, and ^RX4 and ^RX6 are both linear or branched aliphatic hydrocarbon groups having 8 or more carbon atoms. The antiviral composition according to item 1. The antiviral composition according to any one of claims 1 to 6, wherein the pKa is 10 to 14. The antiviral composition according to any one of claims 1 to 7, wherein the ClogP of the compound is 5.00 or more. The antiviral composition according to any one of claims 1 to 8, wherein the ClogP of the compound is 7.00 or more. The antiviral composition according to any one of claims 1 to 9, wherein the solvent contains alcohol. The antiviral composition according to claim 10, wherein the content of the alcohol is 25 to 100% by volume based on the total volume of the solvent. The antiviral composition according to claim 10 or 11, wherein the alcohol comprises an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms. The antiviral composition according to claim 12, wherein the alcohol having 2 or less carbon atoms contains ethanol, and the alcohol having 3 or more carbon atoms contains isopropanol. The antiviral composition according to any one of claims 1 to 13, further comprising a surfactant. The antiviral composition according to any one of claims 1 to 14, further comprising a quaternary ammonium salt. The antiviral composition according to any one of claims 1 to 15, wherein the pH is 10.0 to 12.0. The antiviral composition according to any one of claims 1 to 16, which is a liquid preparation. The antiviral composition according to any one of claims 1 to 16, which is a gel agent. An anti-norovirus composition comprising the anti-virus composition according to any one of claims 1 to 18. A spray comprising a spray container and the antiviral composition according to any one of claims 1 to 18 contained in the spray container. A wiper containing a base cloth and the antiviral composition according to any one of claims 1 to 18, which is impregnated with the base cloth. A compound represented by the following formula (1A) or the following formula (1B).

Wherein (1A), X ¹ represents an oxygen atom or NR ^{A. RA} represents a hydrogen atom or a monovalent substituent. When X ¹ represents an oxygen atom, R ¹ represents a linear or branched aliphatic hydrocarbon group having 6 or more carbon atoms. When X ¹ represents NR ^A, R ¹ represents a linear or branched aliphatic hydrocarbon group having 5 or more carbon atoms.
In formula (1B), X ² represents an oxygen atom or NR ^B. R ^B represents a hydrogen atom or a monovalent substituent. When X ² represents an oxygen atom, R ² represents a linear or branched aliphatic hydrocarbon group having 12 or more carbon atoms. When X ² is NR ^B , R ² represents a linear or branched aliphatic hydrocarbon group having 6 or more carbon atoms. R ³ represents a hydrogen atom or a cyano group.