JPWO2019087883A1 - Antiviral composition, antinorovirus composition, spray, wiper - Google Patents

Abstract

An object of the present invention is to provide an antiviral composition having excellent antiviral activity. Another object of the present invention is to provide an anti-norovirus composition, a spray, and a wiper using the above anti-virus composition. The antiviral composition of the present invention contains a phenolic compound having a specific structure and a solvent containing alcohol, and has a pH of more than 9.5 and 14.0 or less.

Description

The present invention relates to antiviral compositions, antinorovirus compositions, sprays, and wipers.

A virus is a structure that does not have a cell structure and has a genome in an outer shell protein called a capsid, unlike microorganisms such as bacteria and fungi that have a cell structure. Viruses are roughly divided into two types depending on whether the genome is DNA (deoxyribonucleic acid) or RNA (ribonucleic acid), and capsids are enveloped with a lipid bilayer and are covered with an envelope. It is further classified according to whether it is a membrane virus. Specifically, the DNA type membrane virus includes human herpes virus and hepatitis B virus, and the DNA type membrane virus includes adenovirus and B19 virus, and the RNA type membrane virus includes. , Influenza virus, SARS (severe acute respiratory syndrome) coronavirus, and other RNA-type membraneless viruses include norovirus, poliovirus, enterovirus, and the like.

In recent years, there has been a demand for a drug capable of inactivating a virus (particularly norovirus) by a simpler means. For example, in Patent Document 1, as an antiviral composition, "a composition containing a combination of alcohol, docusate salt and geraniol, which is applied on a surface when the composition is applied to a certain surface. A composition comprising a combination of an effective amount of alcohol, docusate salt and geraniol capable of at least substantially reducing the number of viruses, bacteria, fungi, yeasts, molds or combinations thereof. " ..

Special Table 2013-506650 Gazette

The present inventors prepared the composition described in the Example column of Patent Document 1 to obtain feline calicivirus (a closely related species of norovirus, genomic composition similar to norovirus, capsid structure and biochemical properties). As a result of examining the antiviral activity against (which is the most widely used substitute virus at present), it was clarified that there is room for further improvement of the antiviral activity.

Therefore, an object of the present invention is to provide an antiviral composition having excellent antiviral activity.
Another object of the present invention is to provide an anti-norovirus composition, a spray, and a wiper using the above anti-virus composition.

As a result of diligent studies to solve the above problems, the present inventors have found that the above problems can be solved by an antiviral composition having a predetermined composition, and have completed the present invention.
That is, it was found that the above problem can be solved by the following configuration.

[1] One or more phenolic compounds selected from the group consisting of the following compound A, the following compound B, and the following compound C,
Containing with a solvent containing at least alcohol,
The pH is more than 9.5 and less than 14.0 and
Does not contain compounds having two or more hydroxyl groups in the same aromatic ring group.
Composition for antiviral.
Compound A: Compound represented by the formula (1) described later Compound B: Residue obtained by removing one or two hydrogen atoms other than the hydrogen atom in the hydroxyl group from the compound represented by the formula (2) described later. Compound C: A compound represented by the formula (3) described later [2] The pKa of the compound A, the pKa of the compound B, and the pKa of the compound C are all 10.0 or more. The antiviral composition according to [1].
[3] The antiviral composition according to [1] or [2], wherein the pKa of the compound A, the pKa of the compound B, and the pKa of the compound C are all 10.5 or more.
[4] The antiviral composition according to any one of [1] to [3], wherein the pKa of the compound A, the pKa of the compound B, and the pKa of the compound C are all 11.5 or more. ..
[5] The ClogP value of the compound A, the ClogP value of the compound B, and the ClogP value of the compound C are all 5.00 to 20.00, according to any one of [1] to [3]. Antiviral composition of.
[6] The ClogP value of the compound A, the ClogP value of the compound B, and the ClogP value of the compound C are all 7.00 to 15.00, according to any one of [1] to [5]. Antiviral composition of.
[7] The anti-virus according to any one of [1] to [6], wherein the compound represented by the above formula (1) is a compound represented by the formula (4) described later or the formula (5) described later. Viral composition.
[8] The antiviral composition according to any one of [1] to [7], wherein the content of the alcohol is 30 to 100% by volume based on the total volume of the solvent.
[9] The antiviral composition according to any one of [1] to [8], wherein the solvent contains an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms.
[10] The antiviral composition according to any one of [1] to [9], further containing a quaternary ammonium salt.
[11] The antiviral composition according to any one of [1] to [10], further comprising a surfactant.
[12] The antiviral composition according to any one of [1] to [11], wherein the content of the phenolic compound is 0.10% by mass or more with respect to the total mass of the composition.
[13] The antiviral composition according to any one of [1] to [12], which has a pH of 10.5 to 12.0.
[14] The antiviral composition according to any one of [1] to [13], which is a liquid preparation.
[15] The antiviral composition according to any one of [1] to [13], which is a gel agent.
[16] An anti-norovirus composition comprising the anti-virus composition according to any one of [1] to [15].
[17] A spray containing a spray container and the antiviral composition according to any one of [1] to [15] contained in the spray container.
[18] A wiper containing the base cloth and the antiviral composition according to any one of [1] to [15] impregnated in the base cloth.

According to the present invention, it is possible to provide an antiviral composition having excellent antiviral activity.
Further, according to the present invention, it is possible to provide an antinorovirus composition, a spray, and a wiper using the above antiviral composition.

Hereinafter, the present invention will be described in detail.
The description of the constituent elements described below may be based on typical embodiments of the present invention, but the present invention is not limited to such embodiments.
In the present specification, the numerical range represented by using "~" means a range including the numerical values before and after "~" as the lower limit value and the upper limit value.
As used herein, the term "(meth) acrylate" is a concept that includes either or both of acrylate and methacrylate.
In the present specification, when there are a plurality of substituents, linking groups, etc. (hereinafter referred to as substituents, etc.) represented by specific reference numerals, or when a plurality of substituents, etc. are specified at the same time, each of the substituents, etc. It means that they may be the same or different from each other. This also applies to the regulation of the number of substituents and the like.
Further, in the present specification, in the notation of a group (atomic group), the notation that does not describe substitution or non-substitution includes those having no substituent as well as those having a substituent. For example, the "alkyl group" includes not only an alkyl group having no substituent (unsubstituted alkyl group) but also an alkyl group having a substituent (substituted alkyl group).

[Antiviral composition]
The antiviral composition of the present invention (hereinafter, also referred to as "composition of the present invention") is
One or more phenolic compounds selected from the group consisting of the following compound A, the following compound B, and the following compound C (hereinafter, simply collectively referred to as "specific phenolic compounds"),
Containing with a solvent containing at least alcohol,
The pH is more than 9.5 and less than 14.0 and
It does not contain compounds having two or more hydroxyl groups in the same aromatic ring group.
Compound A: Compound represented by the formula (1) described later Compound B: Residue obtained by removing one or two hydrogen atoms other than the hydrogen atom in the hydroxyl group from the compound represented by the formula (2) described later. Compound C: A compound represented by the formula (3) described later.

Now, when the pH of a composition containing a specific phenolic compound and a solvent containing at least an alcohol is set within the above-mentioned predetermined range, the present inventors have made antiviral activity (particularly, against feline calicivirus (a closely related species of norovirus)). It has been confirmed that the antiviral activity) is remarkably excellent.
The term "antiviral" is intended to be used to act on a virus and reduce the activity of the virus.

This is not clear in detail, but the present inventors speculate as follows.
In the composition of the present invention, the specific phenolic compound functions as an active ingredient. It is presumed that the specific phenolic compound becomes a phenoxide anion in which the phenolic hydroxyl group is dissociated at a pH of more than 9.5, which inactivates the virus. The present inventors also believe that the alcohol in the composition also contributes to the inactivation of the virus. Due to the synergistic mechanism of action, the composition of the present invention is considered to be remarkably excellent in antiviral activity (particularly, antiviral activity against feline calicivirus (a closely related species of norovirus)). The pH is 14.0 or less. In particular, when the pH is 12.0 or less, metal corrosion is unlikely to occur, and the range of application of the object that can be disinfected by the composition of the present invention is wide. For example, corrosion is less likely to occur on metals such as aluminum, copper, and brass.
The composition of the present invention is particularly preferable to be used as an anti-norovirus composition because it has excellent antiviral activity against feline calicivirus (a closely related species of norovirus).

The antiviral composition of the present invention does not contain a compound having two or more hydroxyl groups in the same aromatic ring group. In other words, it does not contain a compound having an aromatic ring group having two or more hydroxyl groups (hereinafter, also referred to as "specific group X") (hereinafter, also referred to as "specific compound X").
The specific group X may be a monovalent group or a divalent or higher valent group.
Examples of the ring constituting the aromatic ring group include an aromatic hydrocarbon ring and an aromatic heterocycle.
The number of specific groups X contained in the specific compound X is not particularly limited, but may be one or two or more.
Examples of the specific compound X include gallic acid and gallic acid esters and derivatives thereof (for example, gallic acid epigallocatechin, tannin acid, persimmon astringent tannin, ellagic acid, etc.), anthocyanins (for example, aurantinidin, cyanidin, delphinidin, etc.) Europeanidin, luteolinidin, petunidin, proanthocyanidin, etc.), flavonoids and flavonoids (eg, quercetin, rutin, teaflavin, catechin, mylicetin, luteolin, gallocatechin, isoquercitrin, and myricitrin), phenolic terpenoids (rosmanol, carnosol, etc.) , And gallic acid, etc.), hematoxylin, chlorogenic acid, and tannin.

Hereinafter, each component contained in the composition of the present invention will be described in detail.
[Specific phenolic compounds]
The composition of the present invention contains one or more phenolic compounds selected from the group consisting of the following compound A, the following compound B, and the following compound C.
Compound A: Compound represented by the formula (1) Compound B: Two or more residues in the compound represented by the formula (2) excluding one or two hydrogen atoms other than the hydrogen atom in the hydroxyl group. Compounds containing Compound C: Among the compounds represented by the formula (3), the composition of the present invention is one or more phenolic compounds selected from the group consisting of Compound A, Compound B, and Compound C as phenolic compounds. It preferably contains only the compound.

<Compound A: Compound represented by formula (1)>

In the above formula (1), X ¹¹ represents a nitrogen atom or −CR ¹¹ =.

The above R ¹¹ represents a hydrogen atom or a monovalent substituent excluding a hydroxyl group and an alkoxycarbonyl group.
The monovalent substituent represented by R ¹¹ is not particularly limited, and examples thereof include those exemplified in the substituent group T shown below (however, hydroxyl groups and alkoxycarbonyl groups are excluded).

(Substituent group T)
Alkyl group (preferably an alkyl group having 1 to 20 carbon atoms), alkenyl group (preferably an alkenyl group having 2 to 20 carbon atoms), alkynyl group (preferably an alkynyl group having 2 to 20 carbon atoms), aryl group (preferably an aryl group having 2 to 20 carbon atoms). An aryl group having 6 to 26 carbon atoms), a heteroaryl group (preferably a heteroaryl group having 2 to 20 carbon atoms. A 5- or 6-membered heteroaryl group having at least one oxygen atom, sulfur atom, and nitrogen atom. As the heteroaryl group, for example, a pyridyl group, a pyrimidyl group, a pyrazil group, an oxazolyl group, an imidazolyl group, a pyrazolyl group, a thiazolyl group, a triazinyl group, a quinolyl group, an isoquinolyl group, a quinoxalyl group, a synnolyl group, and a pteridyl group. Groups and the like), alkoxy groups (preferably alkoxy groups having 1 to 20 carbon atoms), aryloxy groups (preferably aryloxy groups having 6 to 26 carbon atoms), heteroaryloxy groups (preferably 2 carbon atoms). ~ 20 heteroaryloxy groups; more preferably 5- or 6-membered heteroaryloxy groups having at least one oxygen atom, sulfur atom, nitrogen atom), alkylthio groups (preferably 1 to 20 carbon atoms). Alkylthio group), arylthio group (preferably arylthio group having 6 to 26 carbon atoms), heteroarylthio group (preferably heteroarylthio group having 2 to 20 carbon atoms. At least one oxygen atom, sulfur atom, nitrogen atom. A 5- or 6-membered thioheteroaryl group having is more preferable), an aralkyl group (preferably an aralkyl group having 7 to 25 carbon atoms), an amino group (preferably an amino group having 0 to 20 carbon atoms, an alkylamino group). , Or arylamino groups such as amino, N, N-dimethylamino, N, N-diethylamino, N-ethylamino, and anilino), hydroxyl groups, sulfonic acid groups, carboxy groups, phosphate groups, halogen atoms ( Fluorine, chlorine, bromine, or iodine is preferable), nitro group, cyano group, formyl group, perfluoroalkyl group (preferably perfluoroalkyl group having 1 to 20 carbon atoms), perfluoroaryl group (preferably carbon number of carbon atoms). 6-26 perfluoroaryl groups), perfluoroalkyloxy groups (preferably perfluoroalkyl groups with 1 to 20 carbon atoms), alkoxycarbonyl groups (-CO ₂ R ¹¹¹ ), acyl groups (-COR ¹¹² ), acyloxy Group (-OCOR ¹¹³ ), sulfonamide group (-SO) ₂ NR ¹¹⁴ R ¹¹⁵ , -NR ¹¹⁴ SO ₂ R ¹¹⁵ ), phosphonic acid ester group (-PO (OR ¹¹⁶ ) (OH), or -PO (OR ¹¹⁷ ) ₂ ), trialkoxysilyl group (-Si (OR ¹¹⁸ )) ) ₃ ), amide group (-CONR ¹¹⁹ R ¹²⁰ , -NR ¹²¹ COR ¹²² ), ammonium group (-N ⁺ R ¹²³ ₃ ), sulfonium group (-S ⁺ R ¹²⁴ R ¹²⁵ ), phosphonium group (-P ⁺ R) ¹²⁶ R ¹²⁷ ), oxonium group (-O ⁺ R ¹²⁸ R ¹²⁹ ), carbonium group (-C ⁺ R ¹³⁰ R ¹³¹ ), and halonium group (-X ⁺ R ¹³² : X represents a halogen atom. ), Imino group (-C = NR ¹³³ ), Alcan sulfonyl group (-SO ₂ R ¹³⁴ ), Alcan sulfonyloxy group (-OSO ₂ R ¹³⁵ ), Alcan sulfinyl group (-SOR ¹³⁶ ), aryl or heteroarylsulfonyl group (-SO ₂ Ar), aryl or heteroarylsulfonyl group (-OSO ₂ Ar), aryl or heteroaryl arylsulfinyl (-OSOAr), and, like an aryl or heteroaryl azo group (-N = N-Ar) is Be done.
The above R ^{111 to} R ¹¹⁸ each independently represent a monovalent substituent. Specific examples of the monovalent substituent represented by R ^{111 to} R ¹¹⁸ include an aliphatic hydrocarbon group (which may be linear, branched, or cyclic) or an aryl group. (Preferably an aryl group having 6 to 26 carbon atoms) or a heteroaryl group (preferably a heteroaryl group having 2 to 20 carbon atoms. A 5- or 6-membered ring having at least one oxygen atom, sulfur atom and nitrogen atom. The heteroaryl group of is more preferable.).
The above R ^{119 to} R ¹³³ each independently represent a hydrogen atom or a monovalent substituent.
Specific examples of the monovalent substituent represented by R ^{119 to} R ¹³³ include those exemplified as the monovalent substituent represented by R ^{111 to} R ¹¹⁸ .
The R ¹³⁴ to R ¹³⁶ each independently represent an aliphatic hydrocarbon group (linear, branched, and may be any of circular.).
The Ar is an aryl group (preferably an aryl group having 6 to 26 carbon atoms) or a heteroaryl group (preferably a heteroaryl group having 2 to 20 carbon atoms. At least one oxygen atom, sulfur atom and nitrogen atom. A 5- or 6-membered heteroaryl group having is more preferable).
Further, each of the groups listed in these substituent groups T, R ^{119 to} R ¹³³ , R ^{134 to} R ¹³⁶ , and Ar may be further substituted with the group exemplified in the above-mentioned substituent group T.
When the substituent is an acidic group or a basic group, a salt thereof may be formed.
When a compound, a substituent, a linking group, etc. contains an alkyl group, an alkylene group, an alkenyl group, an alkenylene group, an alkynyl group, an alkynylene group, etc., they are either linear, branched, or cyclic. It may be substituted or not substituted as described above.

In addition, R ¹¹ does not represent a hydroxyl group and an alkoxycarbonyl group exemplified in the above-mentioned substituent group T. However, when the hydroxyl group and the alkoxycarbonyl group exemplified in the substituent group T are bonded to a residue obtained by removing one or more hydrogen atoms from the substituent exemplified in the substituent group T to form a substituent. , The above substituent is acceptable as the substituent represented by R ¹¹ .

Examples of the monovalent substituent represented by R ¹¹ in the above formula (1) include an alkyl group (preferably an alkyl group having 1 to 20 carbon atoms) and an alkenyl group (preferably an alkenyl group having 2 to 20 carbon atoms). , Alkinyl group (preferably alkynyl group having 2 to 20 carbon atoms), alkoxy group (preferably alkoxy group having 1 to 20 carbon atoms), amide group (-CONR ¹¹⁹ R ¹²⁰ , -NR ¹²¹ COR ¹²² ), acyl group (-CONR ¹¹⁹ R ¹²⁰ , -NR ¹²¹ COR ¹²² ) -COR ¹¹² ), acyloxy group (-OCOR ¹¹³ ), sulfonamide group (-SO ₂ NR ¹¹⁴ R ¹¹⁵ , -NR ¹¹⁴ SO ₂ R ¹¹⁵ ), sulfonic acid group or salt thereof, carboxy group or salt thereof, phosphate group Alternatively, a salt thereof, a halogen atom (preferably fluorine, chlorine, bromine, or iodine), an acetal group, a nitro group, or an aryl or heteroarylazo group (-N = N-Ar) is preferable.
These groups may be further substituted with the groups exemplified in the above-mentioned Substituent Group T. When the alkyl group, alkenyl group, alkynyl group, and aryl or heteroarylazo group have a substituent, the substituent is specifically a hydroxyl group and an alkoxy group (preferably having 1 to 20 carbon atoms). Aalkoxy group), a sulfonic acid group or a salt thereof, a carboxy group or a salt thereof, a phosphoric acid group or a salt thereof, an amino group (preferably an amino group having 0 to 20 carbon atoms), a halogen atom and the like.

The above X ^{12 to} X ¹⁵ independently represent a nitrogen atom or −CR ¹² =.
The above R ¹² represents a monovalent substituent excluding a hydrogen atom or a hydroxyl group.
The monovalent substituent represented by R ¹² is not particularly limited, and examples thereof include those exemplified in the above-mentioned Substituent Group T (excluding hydroxyl groups).

Examples of the monovalent substituent represented by R ¹² in the above formula (1) include an alkyl group (preferably an alkyl group having 1 to 20 carbon atoms) and an alkenyl group (preferably an alkenyl group having 2 to 20 carbon atoms). , Alkinyl group (preferably alkynyl group having 2 to 20 carbon atoms), alkoxy group (preferably alkoxy group having 1 to 20 carbon atoms), alcoholiccarbonyl group (-CO ₂ R ¹¹² ), amide group (-CONR ¹¹⁹ R). ¹²⁰ , -NR ¹²¹ COR ¹²² ), acyl group (-COR ¹¹² ), acyloxy group (-OCOR ¹¹³ ), sulfonamide group (-SO ₂ NR ¹¹⁴ R ¹¹⁵ , -NR ¹¹⁴ SO ₂ R ¹¹⁵ ), sulfonic acid group or The salt, a carboxy group or a salt thereof, a phosphoric acid group or a salt thereof, a halogen atom (preferably fluorine, chlorine, bromine, or iodine), an acetal group, a nitro group, an amino group (preferably an amino having 0 to 20 carbon atoms). Group), or aryl or heteroarylazo groups (-N = N-Ar) are preferred.
These groups may be further substituted with the groups exemplified in the above-mentioned Substituent Group T. When the alkyl group, alkenyl group, alkynyl group, and aryl or heteroarylazo group have a substituent, the substituents are specifically a hydroxyl group (excluding a phenolic hydroxyl group) and an alkoxy group (preferably). Is an alkoxy group having 1 to 20 carbon atoms), a sulfonic acid group or a salt thereof, a carboxy group or a salt thereof, a phosphoric acid group or a salt thereof, a halogen atom and the like.
When X ¹³ or X ¹⁴ represents −CR ¹² =, R ¹² is preferably a group other than the carboxy group, and a hydrogen atom is more preferable.

In addition, in the formula (1), a plurality of R ^12s and R ¹¹ and R ¹² may be connected to each other to form a ring structure. When a plurality of R ^12s or R ¹¹ and R ¹² are connected to each other to form a ring structure, the ring structure may be an aromatic ring or a non-aromatic ring. It may also contain a heteroatom.
The type of the hetero atom is not particularly limited, and examples thereof include an oxygen atom, a nitrogen atom, a sulfur atom, a selenium atom, and a tellurium atom. Of these, from the viewpoint of excellent by antiviral ^{activity, -Y 1 -, - N (} Ra) -, - C (= Y 2) -, - CON (Rb) -, - C (= Y 3) Y 4 -, It is preferably contained in the form of -SOt-, -SO ₂ N (Rc)-, or a combination thereof.
Y ^{1 to} Y ⁴ are independently selected from the group consisting of an oxygen atom, a sulfur atom, a selenium atom, and a tellurium atom. Of these, oxygen atoms or sulfur atoms are preferable because they are easier to handle. t represents an integer of 1 to 3. The Ra, Rb, and Rc are independently hydrogen atoms, alkyl groups having 1 to 10 carbon atoms, acyl groups having 1 to 10 carbon atoms, aryl groups having 6 to 16 carbon atoms, or 2 to 13 carbon atoms. Represents a heteroaryl group.
Further, when a plurality of R ^12s or R ¹¹ and R ¹² are connected to each other to form a ring structure, the ring structure further has a substituent (for example, those exemplified by the substituent group T). You may.
The mode in which a plurality of R ^12s are bonded to each other or R ¹¹ and R ¹² are bonded to each other to form a ring is not particularly limited, but for example, carbon in a monovalent substituent represented by R ¹¹ and R ^12. Examples thereof include an embodiment in which an atom selected from an atom, a nitrogen atom, an oxygen atom, and a sulfur atom is bonded to each other to form a ring. For example, when two adjacent R ^12s are both alkenyl groups (for example, vinyl groups), the terminal carbon atoms in each alkenyl group can be bonded to each other to form a benzene ring. Further, when two adjacent R ^12s are both alkyl groups, an aliphatic hydrocarbon ring can be formed when the terminal carbon atoms in each alkyl group are bonded to each other.

Further, in the equation (1), when a plurality of R ^12s exist, they may be the same or different from each other.

Among the compounds A, X ¹¹ represents -CR ¹¹ = and X ^{12 to} X ¹⁵ all represent -CR ¹² =, or among X ^{11 to} X ¹⁵ , in that the antiviral activity is high. One or two represent a nitrogen atom, the other represents -CR ¹¹ = or -CR ¹² =, is a compound represented by the formula (4) described later, or is represented by the formula (5) described later. It is preferably the compound represented.

Further, the compound A is preferably a compound containing only one phenolic hydroxyl group.

As the compound A, a compound represented by the following formula (4) or a compound represented by the following formula (5) is more preferable.

The formula (4) in, X ¹² and X ¹⁵ has the same meaning as X ¹² and X ¹⁵ in the formula (1) and its preferred embodiments are also the same.
Among them, X ¹² and X ¹⁵ preferably represent −CH =.
In the above formula (4), L ⁴ represents a single bond or a divalent linking group.
The divalent linking group represented by L ⁴ is not particularly limited, but for example, it may be a divalent aliphatic hydrocarbon group (linear, branched chain or cyclic, and has 1 to 20 carbon atoms. It is preferable that there is, for example, an alkylene group. In addition, an alkenylene group or an alkynylene group may be used), −O−, −S−, −SO ₂₋ , −NR ^A− , −. Examples thereof include CO- and a group in which two or more kinds thereof are combined (for example, -CH ₂ CO _2- , -CH ₂ CONR ^A-, etc.). Here, ^RA represents a hydrogen atom or an alkyl group (preferably having 1 to 20 carbon atoms). Examples of the divalent linking group represented by L ⁴ include a divalent aliphatic hydrocarbon group, -O-, -S-, -SO _2- , -NR ^A- , -CO-, or. A group in which two or more of these are combined is preferable, and an alkylene group, -O-, -CO-, -OCO-, -SO _2- NR ^A- , -NR ^A SO _2- , -CO-NR ^A- , -CH ₂ CO _2- , -CH ₂ CONR ^A- , or -NR ^A- CO- is more preferable.
The hydrogen atom in the divalent linking group may be substituted with another substituent such as a halogen atom.

In the above formula (4), R ⁴ represents a hydrogen atom or a monovalent substituent.
The monovalent substituent represented by R ⁴ is not particularly limited, and examples thereof include those exemplified in the above-mentioned Substituent Group T. However, in the formula (4), when L ⁴ represents a single bond, R ⁴ represents a monovalent substituent other than the hydroxyl group.

Examples of the monovalent substituent represented by R ⁴ in the above formula (4) include an alkyl group (preferably an alkyl group having 1 to 20 carbon atoms) and an alkenyl group (preferably an alkenyl group having 2 to 20 carbon atoms). , Alkinyl group (preferably alkynyl group having 2 to 20 carbon atoms), alkoxy group (preferably alkoxy group having 1 to 20 carbon atoms), sulfonic acid group or salt thereof, carboxy group or salt thereof, phosphoric acid group or salt thereof , Halogen atom (preferably fluorine, chlorine, bromine, or iodine), acetal group, nitro group, amino group (preferably amino group having 0 to 20 carbon atoms), or aryl or heteroarylazo group (-N = N). −Ar) is preferable.
These groups may be further substituted with the groups exemplified in the above-mentioned Substituent Group T. When the alkyl group, alkenyl group, alkynyl group, and aryl or heteroarylazo group have a substituent, the substituents are specifically a hydroxyl group (excluding a phenolic hydroxyl group) and an alkoxy group (preferably). Is an alkoxy group having 1 to 20 carbon atoms), a sulfonic acid group or a salt thereof, a carboxy group or a salt thereof, a phosphoric acid group or a salt thereof, a halogen atom and the like.

As the monovalent substituent represented by R ⁴ in the above formula (4), a hydrocarbon group is preferable, and an alkyl group, an alkenyl group, an alkynyl group, an aryl group, or an aralkyl group is preferable. The alkyl group contained in the alkyl group, the alkenyl group, the alkynyl group, and the aralkyl group may be linear, branched, or cyclic.
Examples of the aralkyl group include a group in which one of the hydrogen atoms in the above-mentioned alkyl group is replaced with the above-mentioned aryl group. Specific examples of the aralkyl group include a benzyl group, a phenethyl group, and a naphthylmethyl group.

However, the group represented by −L ⁴ −R ⁴ is neither a hydroxyl group nor an alkoxycarbonyl group. That is, the group represented by −L ⁴ −R ⁴ is neither a hydroxyl group nor an alkoxycarbonyl group.

When the monovalent substituent represented by R ⁴ is a hydrocarbon group, the number of carbon atoms of the hydrocarbon group is 7 or more in that the specific phenolic compound is more excellent in antiviral property due to the higher ClogP value. Is preferable, 8 or more is more preferable, 10 or more is further preferable, and 12 or more is particularly preferable. The upper limit of the number of carbon atoms is not particularly limited, but is, for example, 20 or less.
When the monovalent substituent represented by R ⁴ is a hydrocarbon group, the ClogP value of the hydrocarbon group is not particularly limited, but is, for example, 1.10 to 10.00, which is 4.00 to 10. .00 is preferred.

The formula (5) in, X ¹¹ and X ¹⁵ have the same meanings as X ¹¹ and X ¹⁵ in the formula (1) and its preferred embodiments are also the same.
Among them, X ¹¹ and X ¹⁵ preferably represent −CH =.
In the above formula (5), L ⁵ represents a single bond or a divalent linking group.
The divalent linking group represented by L ⁵ is not particularly limited, and examples thereof include those exemplified as the divalent linking group represented by L ⁴ .
In the above formula (5), R ⁵ represents a hydrogen atom or a monovalent substituent.
The monovalent substituent represented by R ⁵ has the same meaning as the monovalent substituent represented by R ⁴ in the formula (4), and the preferred embodiment is also the same.
However, the group represented by −L ⁵ −R ⁵ is not a hydroxyl group.

When the monovalent substituent represented by R ⁵ is a hydrocarbon group, the number of carbon atoms of the hydrocarbon group is 7 or more in that the specific phenolic compound is more excellent in antiviral property due to the higher ClogP value. Is preferable, 8 or more is more preferable, 10 or more is further preferable, and 12 or more is particularly preferable. The upper limit of the number of carbon atoms is not particularly limited, but is, for example, 20 or less.
When the monovalent substituent represented by R ⁵ is a hydrocarbon group, the ClogP value of the hydrocarbon group is not particularly limited, but is, for example, 1.10 to 10.00, which is 4.00 to 10. .00 is preferred.

<Compound B>
Compound B is also referred to as a residue obtained by removing one or two hydrogen atoms other than hydrogen atoms in the hydroxyl group from the compound represented by the following formula (2) (hereinafter, also referred to as “residue of formula (2)”. ) Is included in two or more.
Compound B may have a structure in which a plurality of residues of formula (2) are directly bonded to each other, or a structure in which a plurality of residues of formula (2) are bonded via a linking group. Further, the plurality of residues of formula (2) existing in compound B may be the same or different.
The number of residues of formula (2) in compound B is not particularly limited, but is preferably 2 to 10,000.
The molecular weight of compound B (weight average molecular weight when it has a molecular weight distribution) is not particularly limited, but is, for example, 185 to 1,000,000, preferably 185 to 500,000. When compound B is a polymer, the weight average molecular weight (Mw) is defined as a polystyrene-equivalent value by GPC (Gel Permeation Chromatography).
First, the residue of formula (2) will be described below.

In the above formula (2), X ²¹ represents a nitrogen atom or −CR ²¹ =. R ²¹ represents a monovalent substituent excluding a hydrogen atom or a hydroxyl group.
The monovalent substituent represented by R ²¹ is not particularly limited, and examples thereof include those exemplified in the above-mentioned Substituent Group T (excluding hydroxyl groups).

X ^{22 to} X ²⁵ each independently represent a nitrogen atom or −CR ²² =. R ²² represents a monovalent substituent excluding a hydrogen atom or a hydroxyl group.
The monovalent substituent represented by R ²² is not particularly limited, and examples thereof include those exemplified in the above-mentioned Substituent Group T (excluding hydroxyl groups).

In addition, in the formula (2), a plurality of R ^22s and R ²¹ and R ²² may be connected to each other to form a ring structure. When a plurality of R ^22s or R ²¹ and R ²² are connected to each other to form a ring structure, the ring structure may be an aromatic ring or a non-aromatic ring. It may also contain a heteroatom. The type of the hetero atom is not particularly limited, and examples thereof include an oxygen atom, a nitrogen atom, a sulfur atom, a selenium atom, and a tellurium atom. The mode in which a plurality of R ^22s or R ²¹ and R ²² are connected to each other to form a ring structure is the same as the mode in which the plurality of R ^12s described above are connected to each other to form a ring structure. ..
Further, in the equation (2), when a plurality of R ^22s exist, they may be the same or different from each other.
Among the compounds represented by the formula (2), X ²¹ represents -CR ²¹ = and X ^{22 to} X ²⁵ all represent -CR ²² = in that they have high antiviral activity. Alternatively, one or two of X ^{21 to} X ²⁵ preferably represent a nitrogen atom, the others preferably represent -CR ²¹ = or -CR ²² =, X ²¹ represents -CR ²¹ =, and X. It is more preferable that all of ^{22 to} X ²⁵ represent −CR ²² =.

The compound represented by the above formula (2) forms a residue by removing one or two hydrogen atoms other than the hydrogen atom in the hydroxyl group specified in the formula. In other words, the compound represented by the formula (2) is either one or two of X ²¹ to X ²⁵ represents -CH =, or one or two of X ²¹ to X ²⁵ is , Represents -CR ²¹ = or -CR ²² =, which is a group having a hydrogen atom. That is, the compound represented by the above formula (2) forms a residue by removing the above one or two hydrogen atoms.
The compound represented by the above formula (2) is
• At least one or two of X ^{21 to} X ²⁵ represent −CH =, and the hydrogen atoms in one or two −CH = described above are removed to form a residue.
-X ²¹ represents -CR ²¹ =, X ²² represents -CR ²² =, and one or two hydrogen atoms on the ring structure formed by connecting the above R ²¹ and the above R ²² to each other are removed. By forming a residue or
-X ²² and X ²³ both represent -CR ²² =, and the residue is obtained by removing one or two hydrogen atoms on the ring structure formed by connecting these two R ^22s to each other. It is preferable to form.
Among them, in the compound represented by the above formula (2), at least one or two of X ^{21 to} X ²⁵ represent -CH =, and one or two of the above-mentioned -CH =. It is more preferable to form a residue by removing the hydrogen atom.

In addition, in the formula (2), it is preferable that it is not a glycoside in that it has more excellent antiviral properties.

Next, compound B will be described.
As described above, the compound B may have a structure in which a plurality of formula (2) residues are directly bonded to each other, or a structure in which a plurality of formula (2) residues are bonded via a linking group. Good.
When the compound B has a structure in which a plurality of residues of the formula (2) are bonded via a linking group, the compound represented by the following formula (2A-1) and the compound represented by the following formula (2A-2) , A compound represented by the following formula (2A-3) or a polymer containing a repeating unit represented by the following formula (2A-4) is preferable.
(Compound represented by the following formula (2A-1))

In the above formula (2A-1), Y ²¹ is represented by a group represented by the following formula (2-1), a group represented by the following formula (2-2), or a group represented by the following formula (2-3). Represents a group. The group represented by the following formula (2-1), the group represented by the following formula (2-2), and the group represented by the following formula (2-3) are represented by the above formula (2). It is a residue formed from the compound to be formed, in which at least one of X ^{21 to} X ²⁵ represents -CH = and one hydrogen atom in the above-CH = is removed. Corresponds to the residue.

Among the groups represented by the above formula (2-1), the groups represented by the above formula (2-2), and the groups represented by the above formula (2-3), X ^{21 to} X ²⁵ are , X ^{21 to} X ²⁵ in the above-mentioned equation (2).

In the above formula (2A-1), M ²¹ represents a p-valent linking group. That is, the formula (2A-1) is a group represented by the above formula (2-1), a group represented by the above formula (2-2), or a group represented by the above formula (2-3). It corresponds to a compound having p pieces.
p represents an integer of 2 or more, preferably 2 to 10, and more preferably 2 to 6.

The linking group represented by M ²¹ is not particularly limited, and examples thereof include the linking groups shown below.
(Divalent linking group)
The divalent linking group represented by M ²¹ is not particularly limited, and is, for example, a divalent hydrocarbon group (even if it is a divalent saturated hydrocarbon group, it is a divalent aromatic hydrocarbon ring group. The divalent saturated hydrocarbon group may be linear, branched or cyclic, and preferably has 1 to 20 carbon atoms, and examples thereof include an alkylene group. The valent aromatic hydrocarbon ring group preferably has 5 to 20 carbon atoms, and examples thereof include a phenylene group. In addition, an alkenylene group (preferably 2 to 20 carbon atoms) and an alkynylene group (preferably 2 to 20 carbon atoms). It may preferably have 2 to 20 carbon atoms)), divalent heterocyclic groups, -O-, -S-, -SO _2- , -NR ^A- , -CO-, -CO _2- and. Examples thereof include a group in which two or more of these are combined. Here, ^RA is a hydrogen atom or an alkyl group (preferably 1 to 10 carbon atoms), an acyl group (preferably 2 to 12 carbon atoms), an aryl group (preferably 1 to 16 carbon atoms), or a heteroaryl group. (Preferably, the number of carbon atoms is 2 to 13).
The heterocyclic ring and the heteroaryl group are preferably 5 to 7-membered rings having at least one nitrogen atom, oxygen atom, sulfur atom, or selenium atom in the ring structure, and 5 to 6-membered rings are preferable. More preferred.
The divalent linking group described above may be further substituted. The substituent is not particularly limited, and examples thereof include those exemplified by the above-mentioned Substituent Group T.

(Consolidating group of trivalent or higher)
The trivalent or higher valent linking group represented by M ²¹ is not particularly limited, and is, for example, a carbon atom, a silicon atom, a nitrogen atom, a p-valent aliphatic hydrocarbon group, a p-valent aromatic hydrocarbon group, or an aliphatic hydrocarbon. Examples thereof include a p-valent group consisting of a hydrogen group and an aromatic hydrocarbon group, or a p-valent heterocycle.
The number of carbon atoms contained in the aliphatic hydrocarbon group is preferably 3 to 15, more preferably 3 to 10, and even more preferably 5 to 10.
The number of carbon atoms contained in the aromatic hydrocarbon group is preferably 6 to 18, more preferably 6 to 14, and even more preferably 6 to 10.
The heterocycle is preferably a 5- to 7-membered ring having at least one nitrogen atom, oxygen atom, sulfur atom, or selenium atom in the ring structure, and more preferably a 5- to 6-membered ring.

Specific examples of the trivalent or higher valent linking group represented by M ²¹ include groups represented by the following formulas (M1) to (M11).
In the following formulas (M1) to (M11), L ^{24 to} L ⁶⁹ each independently represent a single bond or a divalent linking group. The divalent linking group represented by L ^{24 to} L ⁶⁹ is not particularly limited, and examples thereof include the same divalent linking group represented by M ²¹ described above.
R ^B represents a monovalent substituent. It is not particularly restricted but includes monovalent substituent represented by R ^B, for example, those illustrated in substituent group T described above.
q represents an integer of 1 to 3, and 1 or 2 is more preferable.
* Represents the connection position with Y ²¹ described above.

As a linking group represented by M ²¹ , a linear or branched carbon is particularly effective from the viewpoint of obtaining excellent antiviral properties by increasing the ClogP value of a specific phenolic compound as described later. A group containing a hydrocarbon group of several 7 or more is preferable, a linear or branched group containing a hydrocarbon group having 8 or more carbon atoms is more preferable, and a linear or branched hydrocarbon group having 10 or more carbon atoms is preferable. A group containing a hydrogen group is more preferable, a linear or branched group containing a hydrocarbon group having 12 or more carbon atoms is particularly preferable, and a branched group containing a hydrocarbon group having 12 or more carbon atoms is most preferable. .. The upper limit of the number of carbon atoms of the hydrocarbon group is not particularly limited, but is, for example, 30 or less.
Examples of the linear or branched chain-shaped group containing a hydrocarbon group having 7 or more carbon atoms include a linear or branched chain-shaped hydrocarbon group having 7 or more carbon atoms.
The ClogP value of the hydrocarbon group is not particularly limited, but is, for example, 1.00 or more, preferably 5.00 or more, and more preferably 7.00 or more. The upper limit is not particularly limited, and is, for example, 15.00 or less.
The ClogP value of the above hydrocarbon group can be determined by ChemBioDraw Ultra Ver13.

(Compound represented by the following formula (2A-2))

In the above formula (2A-2), Y ²² and Y ²³ are synonymous with Y ²¹ in the above formula (2A-1).
L ²¹ and L ²² represent a single bond or a divalent linking group. The divalent linking group represented by L ²¹ and L ²² is synonymous with the divalent linking group represented by M ²¹ in the above formula (2A-1). As L ²¹ and L ²² , a divalent linking group is preferable, an alkylene group having 1 to 10 carbon atoms is preferable, and an alkylene group having 1 to 3 carbon atoms is more preferable.

Z ²¹ is a residue formed from the compound represented by the above formula (2), two of X ^{21 to} X ²⁵ represent at least -CH =, and two of the above-CH = medium. It is preferable that the residue is formed by removing the hydrogen atom of. Examples of the residue represented by Z ²¹ include a group represented by the following formula (2-4).

Incidentally, in the group represented by the formula formula (2-4), X ^21, X ^22, and X ²⁵ has the same meaning as X ²¹ to X ²⁵ in the above-mentioned equation (2).

r represents an integer of 1 to 6. As r, 1 to 4 are preferable, and 1 or 2 is more preferable.

(Compound represented by the following formula (2A-3))

In the above formula (2A-3), Z ²² has the same meaning as Z ²¹ in the above formula (2A-2), and the preferred embodiment is also the same.
L ²³ represents a single bond or a divalent linking group. The divalent linking group represented by L ²³ is synonymous with the divalent linking group represented by M ²¹ in the above formula (2A-1). As L ²³ , a divalent linking group is preferable, an alkyl group having 1 to 10 carbon atoms is preferable, and an alkyl group having 1 to 3 carbon atoms is more preferable.

s represents an integer of 1 to 6. As r, 1 to 4 are preferable, and 1 or 2 is more preferable.

(Polymer containing a repeating unit represented by the following formula (2A-4))

In the above formula (2A-4), R ^{23 to} R ²⁵ each independently represent a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.
Y ²⁴ is synonymous with Y ²¹ in the above formula (2A-1).
L ⁷² represents a single bond or a divalent linking group. The divalent linking group represented by L ⁷² is synonymous with the divalent linking group represented by M ²¹ in the above formula (2A-1). As L ⁷² , a single bond, -CO _2- , -CONR ^A- , -O-, an alkylene group having 1 to 10 carbon atoms, and a divalent linking group combining these groups are preferable, and a single bond, -CO More preferably, _2- , -CONR ^A- , -O-, an alkylene group having 1 to 3 carbon atoms, and a divalent linking group combining these groups are preferable. The ^RA represents a hydrogen atom, an alkyl group (preferably 1 to 10 carbon atoms), an aryl group (preferably 6 to 10 carbon atoms), or a heteroaryl group (preferably 2 to 13 carbon atoms). The heteroaryl group is preferably a 5- to 7-membered ring having at least one nitrogen atom, oxygen atom, sulfur atom, or selenium atom in the ring structure, and more preferably a 5- to 6-membered ring.
The divalent linking group described above may be further substituted. The substituent is not particularly limited, and examples thereof include those exemplified by the above-mentioned Substituent Group T.

<Compound C: Compound represented by formula (3)>

In the above formula (3), X ^{31 to} X ³³ each independently represent a nitrogen atom or −CR ³¹ =.
The above R ³¹ represents a monovalent substituent excluding a hydrogen atom or a hydroxyl group.
The monovalent substituent represented by R ³¹ is not particularly limited, and examples thereof include those exemplified in the above-mentioned Substituent Group T (excluding hydroxyl groups).

Y ³¹ and Y ³² are each independently an oxygen atom, a sulfur ^{atom,> NR 32,> C =} O, -CR 33 = CR 34 -, or> represents a C = S. However, Y ³¹ is an oxygen atom, a sulfur atom,> NR ^32, or -CR ³³ = CR ³⁴ - may represent, Y ³² represents a> C = O, or> C = S. Further, when Y ³² represents an oxygen atom, a sulfur atom,> NR ³² , or −CR ³³ = CR ³⁴ −, Y ³¹ represents> C = O or> C = S.

R ³² , R ³³ , and R ³⁴ each independently represent a hydrogen atom or a monovalent substituent.
The monovalent substituent represented by R ³² is not particularly limited, and examples thereof include those exemplified in the above-mentioned Substituent Group T.
As R ³² , R ³³ , and R ³⁴ , a hydrogen atom, an aliphatic hydrocarbon group, an aryl group, or a heteroaryl group is preferable.

The aliphatic hydrocarbon group represented by R ³² , R ³³ , and R ³⁴ may be linear, branched, or cyclic.
Further, the aliphatic hydrocarbon group represented by R ³² , R ³³ , and R ³⁴ may contain a hetero atom. The type of the hetero atom is not particularly limited, and examples thereof include an oxygen atom, a nitrogen atom, a sulfur atom, a selenium atom, and a tellurium atom. Of these, from the viewpoint of excellent by antiviral ^{activity, -Y 1 -, - N (} Ra) -, - C (= Y 2) -, - CON (Rb) -, - C (= Y 3) Y 4 -, It is preferably contained in the form of -SOt-, -SO ₂ N (Rc)-, or a combination thereof.
Y ^{1 to} Y ⁴ are independently selected from the group consisting of an oxygen atom, a sulfur atom, a selenium atom, and a tellurium atom. Of these, oxygen atoms or sulfur atoms are preferable because they are easier to handle. t represents an integer of 1 to 3. The Ra, Rb, and Rc each independently represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, an aryl group having 1 to 16 carbon atoms, or a heteroaryl group having 2 to 13 carbon atoms.
When the aliphatic hydrocarbon group contains a hetero atom, −CH ₂ − is substituted with the hetero atom.

Specific examples of the aliphatic hydrocarbon group represented by R ³² , R ³³ , and R ³⁴ include an alkyl group (preferably 1 to 20 carbon atoms, more preferably 1 to 10 carbon atoms, and 1 to 1 carbon atom). 6 is more preferable), an alkenyl group (2 to 20 carbon atoms is preferable, 2 to 10 carbon atoms are more preferable, and 2 to 6 carbon atoms are more preferable), and an alkynyl group (2 to 20 carbon atoms are preferable and carbon number is more preferable). 2 to 10 is more preferable, and 2 to 6 carbon atoms are more preferable). Of these, an alkyl group is preferable.

Examples of the aryl group represented by R ³² , R ³³ , and R ³⁴ include an aryl group having 6 to 18 carbon atoms.
The aryl group may have a monocyclic structure or a condensed ring structure in which two or more rings are fused (condensed ring structure).
As the aryl group, for example, a phenyl group or a naphthyl group is preferable, and a phenyl group is more preferable.
Examples of the heteroaryl group represented by R ³² , R ³³ , and R ³⁴ include a frill group, a thiofryl group, a pyridyl group, a pyrazole group, an imidazolyl group, a benzoimidazolyl group, an indolyl group, a quinolyl group, an isoquinolyl group, and a purine group. , Pyrimidyl group, pyrazole group, oxazolyl group, thiazolyl group, triazil group, carbazolyl group, quinoxalyl group, thiazine group and the like.

As Y ³¹ and Y ^32, it is preferable that one of Y ³¹ and Y ³² is an oxygen atom or −CR ³³ = CR ³⁴ − and the other is> C = O in that it is superior in antiviral activity.

In the equation (3), between a plurality of R ³¹ may form a ring structure together. When multiple R ³¹ each other to form a cyclic structure each other, the ring structure, be an aromatic ring, it may be a non-aromatic ring. It may also contain a heteroatom. The type of the hetero atom is not particularly limited, and examples thereof include an oxygen atom, a nitrogen atom, a sulfur atom, a selenium atom, and a tellurium atom. As the aspects among multiple R ³¹ is form a cyclic structure each other, it is the same as the manner in which a plurality of R ¹² with each other as described above to form a ring structure together.
Further, in the equation (3), if R ³¹ there are a plurality, even in each same or may be different.
In compound C, among them, X ^{31 to} X ³³ all represent −CR ³¹ =, or one or two of X ^{31 to} X ³³ represent nitrogen atoms in that they have high antiviral activity. Others preferably represent −CR ³¹ =.

The pKa of the specific phenolic compound is preferably 10.0 or more in that it is superior in antiviral activity. That is, in other words, the pKa of compound A, the pKa of compound B, and the pKa of compound C are all preferably 10.0 or more. The range of pKa is more preferably 10.5 or more, further preferably 11.0 or more, and particularly preferably 11.5 or more.
When the pH of the antiviral composition is more than 9.5 and 14.0 or less, the phenolic hydroxyl group in the specific phenolic compound becomes a phenoxide anion due to the dissociation of hydrogen ions. It is presumed that this phenoxide anion deprotonates the acid group existing on the surface of the virus to inactivate the virus. At this time, when the pKa of the specific phenolic compound is 10.0 or more. It is presumed that the deprotonation reaction is more likely to occur. That is, when the pKa of the specific phenolic compound is 10.0 or more, the antiviral activity is more excellent.
When the compounds A to C are polyhydric acids with multi-step dissociation, the pKa based on any of the dissociations may be 10.0 or more, but the phenolic hydroxyl group in the specific phenolic compound. It is preferable that the pKa derived from the dissociation of is 10.0 or more.
The upper limit of pKa of the specific phenolic compound is not particularly limited, but is preferably 14.0 or less from the viewpoint that phenoxide anions are easily generated.

Further, the ClogP value of the specific phenolic compounds (Compound A, Compound B, and Compound C) is, for example, 0.50 or more, and is preferably 5.00 or more, preferably 7.00 or more, in that the antiviral activity is more excellent. The above is more preferable. The upper limit is not particularly limited, but is, for example, 20.00 or less, preferably 15.00 or less.
The ClogP value of the specific phenolic compound is preferably 5.00 to 20.00, more preferably 7.00 to 20.00, and even more preferably 7.00 to 15.00. When the specific phenolic compound is more hydrophobic (in other words, when the ClogP value of the specific compound is 5.00 or more), the antiviral activity is more excellent. Viruses generally have hydrophilic and hydrophobic sites. Therefore, when the specific phenolic compound is more hydrophobic, it is considered that the specific phenolic compound is easily adsorbed by the virus. As a result, the specific compound has better antiviral activity.
The ClogP of the specific phenolic compound can be determined by ChemBioDraw Ultra Ver13.

Among them, in that it is superior in antiviral activity, when the pH of the composition is 10.5 or less, the specific phenolic compound has a pKa of 10.5 or more and the ClogP value of the compound itself is 7.00 or more. It is preferable that the pKa is 11.5 or more and the ClogP value of the compound itself is 5.00 or more. When the pH of the composition is more than 10.5, the specific phenolic compound preferably has a pKa of 10.5 or more, and more preferably 11.5 or more.

As the specific phenolic compound, compound A or compound B is preferable, and compound A is more preferable, because it is superior in antiviral activity.

Specific phenolic compounds are illustrated below, but the present invention is not limited thereto.
In the following exemplified compounds, n and m represent molar ratios.

As the specific phenolic compound, those used as food additives can also be used from the viewpoint of safety. Specifically, 4-allyl-2,6-dimethoxyphenol, 4-allylphenol, carbachlor, creozole, 3-methylphenol, 2-methylphenol, 4-methylphenol, 2-methoxy-4-propylphenol, 2,6-dimethoxyphenol, 2,3-dimethylphenol, 2,6-dimethylphenol, 3,5-dimethylphenol, 4-ethoxyphenol, ethyl eugenyl ether, 4-ethyl-2-methoxyphenol, 4-ethyl -2-methoxyphenol, 2-ethylphenol, 3-ethylphenol, 4-ethylphenol, ethylvanillin propyleneglycol acetal, guaiacol, 4-Hydroxybenzoic Acid, 4-hydroxy Benzyl alcohol, 4- (ethoxymethyl) phenol, 4- (methoxymethyl) phenol, 4-hydroxyphenethyl alcohol, 2-isopropylphenol, 4-isopropylphenol, 3-methoxy-5-methylphenol, 3-methoxyphenol, 4 -Methoxyphenol, 4- (1-hydroxyethyl) phenol, 2,6-dimethoxy-4-methylphenol, 2,6-dimethoxy-4-methylphenol, 3,4-methylenedioxyphenol, 2-methoxy-5 -Methylphenol, 4- (methylthio) phenol, phenol, 4-propylphenol, 4-hydroxy-3,5-dimethoxybenzoic acid (4-Hydroxy-3,5-dimethoxybenzoic acid), Timor, 2- (methylthio) Phenol, Vanillic acid, vanillin propyleneglycol acetal, 4-hydroxy-3-methoxybenzyl alcohol, 4- (butoxymethyl) -2-methoxyphenol, 4- (ethoxymethyl) -2 -Methoxyphenol, 2-ethoxy-5- (1-propenyl) phenol, 4-ethenyl-2-methoxyphenol, 4-ethenylphenol, 2,4-dimethylphenol, 2,5-dimethylphenol, 3,4- Dimethylphenol, 3,4-dimethylphenol, 4-tert-butylphenol Le, 2,3,6-trimethylphenol, 2-propylphenol, 3-tert-butylphenol, N- (4-hydroxy-3-methoxybenzyl) nonaneamide, vanillin 2,3-butanediol acetal (vanillin 2,3-) butanediol acetal), 2- (3-hydroxy-4-methoxyphenyl) -3,4-dihydro-2H-chromen-7-ol, 4-allyl-2-methoxyphenol, tocopherol, naringin, maltor, 2-hydroxyben Zoic acid, curcumin, ferulic acid, ferulic acid ester, guayaconic acid, guayaletic acid, eugenol, gingerol, gingerol, luapricin, capsaicin, azorbin, amaranth, alla red AC, yellow 2G, isooigenol, eosin, orange GGN, orange RN, Edible Yellow No. 5, Citra Red No. 2, Sudan G, Scarlet GN, Edible Yellow No. 4, Edible Red No. 102, Bonso 2R, Bonso 6R, Edible Green No. 3, Red 10B, Edible Red 105, Edible Red No. 2, Edible Red No. 3, Edible Red 40 No., hesperidin, methyl hesperidin, folic acid, or salicylic acid is preferred, 4-allyl-2,6-dimethoxyphenol, 4-allylphenol, carbachlor, creozole, 3-methylphenol, 2-methylphenol, 4-methylphenol. , 2-methoxy-4-propylphenol, 2,6-dimethoxyphenol, 2,3-dimethylphenol, 2,6-dimethylphenol, 3,5-dimethylphenol, 4-ethoxyphenol, ethyleugenyl ether, 4- Ethyl-2-methoxyphenol, 4-ethyl-2-methoxyphenol, 2-ethylphenol, 3-ethylphenol, 4-ethylphenol, ethylvanillin propyleneglycol acetal, guaiacol, 4-hydroxybenzoic acid (4-Hydroxybenzoic Acid), 4-hydroxybenzyl alcohol, 4- (ethoxymethyl) phenol, 4- (methoxymethyl) phenol, 4-hydroxyphenethyl alcohol, 2-isopropylphenol, 4-isopropylphenol, 3-methoxy-5 -Methylphenol, 3-methoxyphenol, 4-methoxyphenol, 4- (1-hydroxyethyl) phenol, 2,6-dimethoxy-4-methylphenol, 2,6-dimethoxy-4-methylphenol, 3,4- Methylenedioxyphenol, 2-methoxy-5-methylphenol, 4- (methylthio) phenol, phenol, 4-propylphenol, 4-hydroxy-3,5-dimethoxybenzoic acid (4-Hydroxy-3,5-dimethoxybenzoic) acid), timol, 2- (methylthio) phenol, vanillic acid, vanillin propyleneglycol acetal, 4-hydroxy-3-methoxybenzyl alcohol, 4- (butoxymethyl) -2-methoxy Phenol, 4- (ethoxymethyl) -2-methoxyphenol, 2-ethoxy -5- (1-propenyl) phenol, 4-ethenyl-2-methoxyphenol, 4-ethenylphenol, 2,4-dimethylphenol, 2,5-dimethylphenol, 3,4-dimethylphenol, 3,4- Dimethylphenol, 4-tert-butylphenol, 2,3,6-trimethylphenol, 2-propylphenol, 3-tert-butylphenol, N- (4-hydroxy-3-methoxybenzyl) nonaneamide, vanillin 2,3-butanediol Acetal (vanillin 2,3-butanediol acetal), 2- (3-hydroxy-4-methoxyphenyl) -3,4-dihydro-2H-chromen-7-ol, 4-allyl-2-methoxyphenol, tocopherol, 2 -Hydroxybenzoic acid, curcumin, phenolic acid, ferulic acid ester, guayaconic acid, guayaletic acid, eugenol, gingerrol, gingerol, capsaicin, azorbin, amaranth, allaled AC, yellow 2G, isooigenol, eosin, orange GGN, orange RN , Edible Yellow No. 5, Citra Red No. 2, Sudan G, Scarlet GN, Edible Yellow No. 4, Edible Red No. 102, Bonso 2R, Bonso 6R, Edible Green No. 3, Red 10B, Edible Red 105, Edible Red No. 2, Edible Red No. 3, Edible Red 40 No., or folic acid is more preferable.

The specific phenolic compound may be used alone or in combination of two or more.
In the composition of the present invention, the content of the specific phenolic compound (if a plurality of types are present, the total thereof) is preferably 0.01% by mass or more, preferably 0.10% by mass or more, based on the total mass of the composition. Is more preferable, and 0.31% by mass or more is particularly preferable. The upper limit thereof is preferably 10% by mass or less, more preferably 5% by mass or less.

〔solvent〕
<Alcohol>
The composition of the present invention contains at least alcohol as a solvent.
The alcohol is not particularly limited, but for example, linear, branched, and cyclic alcohols having 1 to 20 carbon atoms (including ether alcohol) are preferable. Specifically, methanol, ethanol, n-propanol, isopropanol, polyethylene glycol, propylene glycol, propylene glycol acetate monoester, glycerin, n-butanol, 2-butanol, i-butanol, t-butanol, butane-1,3 -Diol, Diethylene Glycol, Diethylene Glycol Monoethyl Ether, Diethylene Glycol Monopropyl Ether, Dipropylene Glycol, n-Pentanol, 2-Pentanol, 3-Pentanol, t-Amil Alcohol, Isoamyl Alcohol, 2-Methylbutanol, 3-Methyl -2-butanol, 3-methyl-2-butenol, 3-methyl-3-butanol, 1-penten-3-ol, n-hexanol, capryl alcohol, 2-ethyl-1-hexanol, decanol, linalol, geraniol, Lauryl alcohol, myristyl alcohol, benzyl alcohol, phenylethyl alcohol, cinnamyl alcohol, 3-methoxypropanol, methoxymethoxyethanol, ethylene glycol, ethylene glycol mono-n-butyl ether, diethylene glycol mono-n-butyl ether, triethylene glycol mono-n -Butyl ether, tetraethylene glycol mono-n-butyl ether, dipropylene glycol monobutyl ether, citronellol, terpineol, hydroxycitroneral, hydroxycitronell dimethyl acetal, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol monomethyl ether, Examples thereof include propylene glycol monoethyl ether, diacetone alcohol, ethylene glycol monoisopropyl ether, and diethylene glycol monomethyl ether.

The alcohol is preferably a food additive from the viewpoint of safety, and among them, methanol, ethanol, propanol, isopropanol, polyethylene glycol, propylene glycol, propylene glycol acetate monoester, n-butanol, 2-butanol, butane. -1,3-diol, diethylene glycol, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, dipropylene glycol, 2-methyl-1-butanol, 1-decanol, 1-penten-3-ol, 2-ethyl1-hexanol, 2-Pentanol, 3-Pentanol, 3-Methyl-2-butanol, 3-Methyl-2-butenol, 3-Methyl-3-butanol, isoamyl alcohol, i-butanol, benzyl alcohol, citronellol, terpineol, hydroxycitro Neral or hydroxycitronellal dimethyl acetal is preferred.

The composition of the present invention preferably contains an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms as alcohols, in that the variation in antiviral activity value becomes smaller. Alcohol having 3 or more carbon atoms is more lipophilic than alcohol having 2 or less carbon atoms, and it is considered that the virus and the dirt lurking in the virus can be easily physically removed. Therefore, when the wiper is impregnated with a composition containing an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms and used for wiping, it is considered that the variation in the antiviral activity value becomes smaller. Further, since alcohols having 3 or more carbon atoms are assumed to have a higher surface active function than alcohols having 2 or less carbon atoms, the synergistic effect with phenoxide anions is further strengthened and the antiviral activity is improved. Is also possible.
When an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms are used in combination, the volume ratio of the alcohol having 3 or more carbon atoms to the alcohol having 2 or less carbon atoms (the volume of the alcohol having 3 or more carbon atoms / the volume of 2 or less carbon atoms) The volume of alcohol) is preferably 0.01 or more in that the antiviral activity is more excellent and / or the variation in the antiviral activity is smaller. The upper limit thereof is not particularly limited, but is, for example, 5 or less, preferably 1.5 or less.

<Solvents other than alcohol>
The composition of the present invention may contain a solvent other than alcohol.
Examples of the solvent other than alcohol include water and organic solvents (excluding alcohol).
The organic solvent is not particularly limited, but for example, acetone, methyl ethyl ketone, cyclohexane, ethyl acetate, isoamyl acetate, isopropyl acetate, geranyl acetate, cyclohexyl acetate, citronellyl acetate, cinnamyl acetate, terpinyl acetate, phenylethyl acetate, butyl acetate, acetic acid. Benzyl, menthyl acetate, linaryl acetate, butyric acid, ethyl butyrate, butyl butyrate, isoamyl butyrate, cyclohexyl butyrate, ethylene dichloride, tetrahydrofuran, toluene, ethylene glycol dimethyl ether, acetyl acetone, cyclohexanone, ethylene glycol monomethyl ether acetate, ethylene glycol ethyl ether acetate, ethylene Glycolmonobutyl ether acetate, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, propylene glycol monomethyl ether acetate, 2-methylpropanal, 2-methylbutylaldehyde, 3-methyl-2-butenal, 3-methylbutanal, L-perylaldehyde, acetaldehyde , Ethyl Acetate Acetate, Isoamyl Acetate, Isoamyl Butyrate, Isobarraldehyde, Isobutanal, Isopropyl Acetate, Isopropyl Mysterate, Isoamyl Isovalerate, Ethyl Isovalerate, Ethyl Lactate, Ethyl Heptate, Octanal, Ethyl Octanate, Octanal, Octanoic acid, ethyl octanate, octylaldehyde, formic acid, isoamyl formate, geranyl formate, citronellyl formate, silicate aldehyde, ethyl silicate, methyl silicate, citral, citronellal, diisopropyl ether, diisopropyldisulfide, diisopropyldisulfide, diethyl Ether, diethyl tartrate, diethyl pyrocarbonate, decanal, ethyl decanoate, triacetin, triethyl citrate, toluene, nonalactone, barrel aldehyde, paramethylacetophenone, paramethoxybenzaldehyde, castor oil, isoamyl phenylacetate, isobutyl phenylacetate, phenylacetic acid Ethyl, butanal, propionaldehyde, propionic acid, isoamyl propionate, ethyl propionate, benzyl propionate, hexane, heptane, benzaldehyde, eucalyptol, ionone, terpinyl acetate, α-amylcinnamaldehyde, brominated vegetable oil, acetic acid, di Dimethyl carbonate, ethyl lactate, large thermal oxidation Examples thereof include soybean oil, esters of thermally oxidized soybean oil and glycerin, and liquid paraffin.

The organic solvent is preferably a food additive from the viewpoint of safety, and is preferably an acetone, methyl ethyl ketone, ethyl acetate, isoamyl acetate, isopropyl acetate, geranyl acetate, cyclohexyl acetate, citronellyl acetate, cinnamyl acetate, terpinyl acetate, phenyl acetate. Ethyl, butyl acetate, benzyl acetate, menthyl acetate, linaryl acetate, butyric acid, ethyl butyrate, butyl butyrate, isoamyl butyrate, cyclohexyl butyrate, 2-methylpropanol, 2-methylbutylaldehyde, 3-methyl-2-butenal 3-methyl Butanal, l-perylaldehyde, acetaldehyde, ethyl acetoacetate, isoamyl acetate, isoamyl butyrate, isobarraldehyde, isobutanal, isopropyl acetate, isopropyl myrysterate, isoamyl isovalerate, ethyl isovalerate, ethyl lactate, ethyl heptate , Octanal, octanoic acid, ethyl octanoate, octylaldehyde, formic acid, isoamyl formate, geranyl formate, citronellyl formate, silicate aldehyde, ethyl silicate, methyl silicate, citral, citronellal, diisopropyl ether, diisopropyldisulfide, diisopropyl Disulfide, diethyl ether, diethyl tartrate, diethyl pyrocarbonate, decanal, ethyl decanoate, triacetin, triethyl citrate, toluene, nonalactone, barrelaldehyde, paramethylacetophenone, paramethoxybenzaldehyde, castor oil, isoamylphenylacetate, isobutylphenylacetate , Ethylphenylacetate, butanal, propionaldehyde, propionic acid, isoamyl propionate, ethyl propionate, benzyl propionate, hexane, heptane, benzaldehyde, eucalyptol, ionone, terpinyl acetate, α-amylcinnamaldehyde, brominated vegetable oil, Preferably, acetic acid, dimethyl dicarbonate, ethyl lactate, hot-oxidized soybean oil, ester of hot-oxidized soybean oil and glycerin, or liquid paraffin.

In the composition of the present invention, the content of the solvent (the total of a plurality of types, if present) is preferably 0.5 to 99.9% by mass, preferably 10 to 99.8% by mass, based on the total mass of the composition. % Is more preferable, 50 to 99.8% by mass is further preferable, and 80 to 99.8% by mass is particularly preferable.

In the composition of the present invention, the alcohol content (if a plurality of types are present, the total thereof) is preferably 30 to 100% by volume, preferably 40 to 100% by volume, based on the total volume of the solvent, in that it is superior in antiviral activity. By volume% is more preferable, 60 to 100% by volume or more is further preferable, and 70 to 100% by volume is particularly preferable.

[PH of composition]
The composition of the present invention has a pH of more than 9.5 and 14.0 or less. If the pH is 9.5 or less, the antiviral activity may be inferior. The pH is preferably 10.0 or higher, more preferably 10.5 or higher, in that it has more excellent antiviral activity. On the other hand, the pH is 14.0 or less, and 12.0 or less is preferable because the corrosiveness to metals can be further suppressed.
The pH can be measured using a desktop pH meter "F-72S" (manufactured by HORIBA, Ltd.) using a pH electrode "6337-10D" (manufactured by HORIBA, Ltd.). The specific measurement method will be described later.
In the present specification, the pH is intended to be a value at 25 ° C.

[Arbitrary component]
The composition of the present invention may contain components other than the above as long as the effects of the present invention are exhibited. The optional component is not particularly limited, but for example, a disinfectant, a disinfectant, a disinfectant, a surfactant, an antioxidant, a pH adjuster, an ultraviolet absorber, a chelating agent, a moisturizer, a thickener / gelling agent. , Preservatives, fragrances, pigments and the like. The composition of the present invention preferably contains a bactericidal agent, a disinfectant, a disinfectant, a surfactant, or an antioxidant in that it is superior in antiviral activity, and is preferably a quaternary ammonium salt (for example, chloride). Benzalkonium, etc.), surfactants, or antioxidants are more preferred.

<Fungicides, disinfectants, and disinfectants>
The disinfectant, disinfectant, and disinfectant are not particularly limited, and include, for example, a quaternary ammonium salt, an antibacterial agent containing a metal, a photocatalyst, an aldehyde compound, an iodo compound, a piganide compound, and an acrinol hydrate (for example). , Lactic acid 6,9-diamino-2-ethoxyacridin monohydrate) and the like. A quaternary ammonium salt is particularly preferable because it is more excellent in antiviral activity when combined with the composition of the present invention.

(Quaternary ammonium salt)
The quaternary ammonium salt is not particularly limited, and examples thereof include compounds represented by the following formulas (4) to (7).

In the formula (4), R ^{41 to} R ⁴⁴ each independently represent an aliphatic hydrocarbon group, an aryl group, an aralkyl group, or a heteroaryl group.
The aliphatic hydrocarbon group represented by R ^{41 to} R ⁴⁴ may be linear, branched chain, or cyclic.
Further, the aliphatic hydrocarbon group represented by R ^{41 to} R ⁴⁴ may contain a hetero atom. The type of the hetero atom is not particularly limited, and examples thereof include an oxygen atom, a nitrogen atom, a sulfur atom, a selenium atom, and a tellurium atom. Of these, from the viewpoint of excellent by antiviral ^{activity, -Y 1 -, - N (} Ra) -, - C (= Y 2) -, - CON (Rb) -, - C (= Y 3) Y 4 -, It is preferably contained in the form of -SOt-, -SO ₂ N (Rc)-, or a combination thereof.
Y ^{1 to} Y ⁴ are independently selected from the group consisting of an oxygen atom, a sulfur atom, a selenium atom, and a tellurium atom. Of these, oxygen atoms or sulfur atoms are preferable because they are easier to handle. t represents an integer of 1 to 3. The Ra, Rb, and Rc each independently represent a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.
When the aliphatic hydrocarbon group contains a hetero atom, −CH ₂ − is substituted with the hetero atom.

Specific examples of the aliphatic hydrocarbon group represented by R ^{41 to} R ⁴⁴ include an alkyl group (preferably 1 to 30 carbon atoms and more preferably 1 to 20 carbon atoms) and an alkenyl group (2 to 2 carbon atoms). 30 is preferable, and 2 to 20 carbon atoms are more preferable), or an alkynyl group (2 to 30 carbon atoms is preferable, and 2 to 20 carbon atoms are more preferable) and the like. Of these, an alkyl group is preferable.

Examples of the aryl group represented by R ^{41 to} R ⁴⁴ include an aryl group having 6 to 18 carbon atoms.
The aryl group may have a monocyclic structure or a condensed ring structure in which two or more rings are fused (condensed ring structure).
As the aryl group, for example, a phenyl group or a naphthyl group is preferable, and a phenyl group is more preferable.

The aralkyl group represented by R ^{41 to} R ⁴⁴ is not particularly limited, but for example, an aralkyl group having 7 to 15 carbon atoms is preferable, and specifically, a benzyl group, a phenethyl group, a 1-naphthylmethyl group, 1-. Examples thereof include a (1-naphthyl) ethyl group, a triphenylmethyl group, and a pyrenylmethyl group.

As the heteroaryl group represented by R ^{41 to} R ⁴⁴ , for example, a heteroaryl group having 3 to 12 carbon atoms is preferable, and for example, a frill group, a thiofryl group, a pyridyl group, a pyrazole group, an imidazolyl group, a benzoimidazolyl group and an indrill group. Examples thereof include a group, a quinolyl group, an isoquinolyl group, a purine group, a pyrimidyl group, a pyrazole group, an oxazolyl group, a thiazolyl group, a triazil group, a carbazolyl group, a quinoxalyl group, and a thiazine group.

The aliphatic hydrocarbon group represented by R ^{41 to} R ⁴⁴ , an aryl group, an aralkyl group, and a heteroaryl group may further have a substituent. Examples of the substituent include those exemplified in the Substituent Group W described later.

X ⁻ represents a monovalent anion other than the hydroxide ion.
Specifically, as X ⁻ , halide ions (for example, F ⁻ , Cl ⁻ , Br ⁻ , I ⁻ , Br ₃ ⁻ , Br ₂ Cl ⁻ , I ₃ ⁻ , IBr ₂ ⁻ , Cl ₂ Br ⁻ , HF ₂ ⁻ , H ₂ F ₃ ⁻ , AuBr ₂ ⁻ , AuCl ₂ ⁻ , AuI ₂ ⁻ , and FeCl ₄ ⁻ ), carboxylate anion, cyanide anion, sulfonimide anion (N ⁻ (SO ₂ R) ) ₂ : R includes a fluorine atom, a hydrocarbon group (for example, an alkyl group having 1 to 20 carbon atoms), or a perfluorohydrocarbon group (for example, a perfluoroalkyl group having 1 to 20 carbon atoms). ), Borohydride anion, dichloroiodate anion, tetrafluoroborate anion, hexafluorophosphate anion, perchlorate anion, sulfate anion, hydrocarbon anion, nitrate anion, disianamide anion [N ⁻ ( CN) ₂ ], azide anion (N ₃ ⁻ ), alcohol or aryl sulfonic acid anion, perfluoroalkane or aryl sulfonic acid anion, alkyl or aryl sulfate anion (ROSO ₃ ⁻ : R has 1 to 20 carbon atoms. Alkyl group or aryl group having 6 to 18 carbon atoms), alkyl or aryl phosphate anion ((RO) ₂ PO ₂ ⁻ : R is an alkyl group having 1 to 20 carbon atoms or carbon, respectively. . the number represents the 6-18 aryl group), thiocyanide anion ^(S - CN), triacetoxyborohydride anion perruthenate anion ^{_{(RuO 4 -), Cu (}} CF 3) 4 -, C (CN) 3 ^{− And} CF ₃ BF ₃ ⁻ .

Hereinafter, the compound represented by the formula (4) will be illustrated, but the present invention is not limited thereto.

In formula (5), X ⁻ has the same meaning as X ⁻ in formula (4), and the preferred embodiment is also the same.
Further, R ⁵¹ and R ⁵² have the same meanings as R ^{41 to} R ⁴⁴ in the formula (4), and the preferred embodiments are also the same.
Y ⁵¹ and Y ⁵² are each _{^{independently, -C (R 53) 2 -}} , - NR 54 -, - O -, - CO -, - CO 2 -, - S -, - SO-, or -SO ₂ Represents-. When there are a plurality of Y ^52s in the equation (5), the plurality of Y ^52s may be the same or different.
R ⁵³ represents a hydrogen atom or a monovalent organic group selected from the group consisting of an aliphatic hydrocarbon group, an aryl group, an aralkyl group, a heteroaryl group, and a halogen atom.
R ⁵⁴ represents a hydrogen atom or a monovalent organic group selected from the group consisting of an aliphatic hydrocarbon group, an aryl group, an aralkyl group, and a heteroaryl group.
The aliphatic hydrocarbon group, aryl group, aralkyl group, and heteroaryl group represented by R ⁵³ and R ⁵⁴ are aliphatic hydrocarbon groups and aryl groups represented by R ^{41 to} R ⁴⁴ in the formula (4). , Aralkyl group, or heteroaryl group, and preferred embodiments are also the same.
Examples of the halogen atom represented by R ⁵³ and R ⁵⁴ include a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom.

The aliphatic hydrocarbon group represented by R ⁵³ and R ⁵⁴ , an aryl group, an aralkyl group, or a heteroaryl group may further have a substituent. Examples of the substituent include those exemplified in the Substituent Group W described later.

When Y ⁵¹ or Y ⁵² represents −C (R ⁵³ ) ₂ − or −NR ⁵⁴ −, the monovalent organic group represented by R ⁵¹ is linked to R ⁵³ or R ^54. Aromatic or non-aromatic rings may be formed.
Further, R ⁵¹ and R ⁵² may be connected to each other to form an aromatic or non-aromatic ring.
n represents an integer of 1-18.

Hereinafter, the compound represented by the formula (5) will be illustrated, but the present invention is not limited thereto.

In the formula (6), X ^- is, X in Formula (4) ^- has the same meaning as, preferred embodiments are also the same.
Further, R ⁶¹ has the same meaning as R ^{41 to} R ⁴⁴ in the formula (4), and the preferred embodiment is also the same.
Y ^{61 to} Y ⁶⁵ each independently represent a nitrogen atom or = CR ⁶² −. R ⁶² represents a hydrogen atom or a monovalent substituent.
The monovalent substituent represented by R ⁶² is not particularly limited, and examples thereof include those exemplified in the substituent group W described later.
When two or more of Y ^{61 to} Y ⁶⁵ represent = CR ⁶² −, R ^62s substituted with adjacent carbon atoms are connected to each other to form an aromatic or non-aromatic ring. You may.
When Y ^{61 to} Y ⁶⁵ represent = CR ⁶² −, the monovalent substituent represented by R ⁶² is linked to R ⁶¹ to form an aromatic or non-aromatic ring. May be good.

Hereinafter, the compound represented by the formula (6) will be illustrated, but the present invention is not limited thereto.

In the formula (7), X ^- is, X in Formula (4) ^- has the same meaning as, preferred embodiments are also the same.
Y ^{71 to} Y ⁷³ have the same meaning as Y ⁶¹ to Y ⁶⁵ in the formula (6), and the preferred embodiments are also the same.
Y ⁷⁴ represents> NR ⁷¹ , sulfur atom, or oxygen atom.
R ⁷¹ and R ⁷² are synonymous with R ^{41 to} R ⁴⁴ in the formula (4), and the preferred embodiments are also the same.

Hereinafter, the compound represented by the formula (7) will be illustrated, but the present invention is not limited thereto.

(Substituent group W)
For example, halogen atom (fluorine atom, chlorine atom, bromine atom, iodine atom, etc.), alkyl group (including cycloalkyl group, bicycloalkyl group, and tricycloalkyl group), alkenyl group (cycloalkenyl group, and bicycloalkenyl group). (Including), alkynyl group, aryl group, heterocyclic group (may be called heterocyclic group, including heteroaryl group), cyano group, hydroxyl group, nitro group, alkoxy group, aryloxy group, silyloxy group, heterocycle Oxy group, acyloxy group, carbamoyloxy group, alkoxycarbonyloxy group, aryloxycarbonyloxy group, amino group (including anilino group), ammonio group, acylamino group, aminocarbonylamino group, alkoxycarbonylamino group, aryloxycarbonylamino Group, sulfamoylamino group, alkyl or arylsulfonylamino group, mercapto group, alkylthio group, arylthio group, heterocyclic thio group, acylthio group, sulfamoyl group, alkyl or arylsulfinyl group, alkyl or arylsulfonyl group, acyl group, Aryloxycarbonyl group, alkoxycarbonyl group, carbamoyl group, aryl or heterocyclic azo group, imide group, phosphino group, phosphinyl group, phosphinyloxy group, phosphinylamino group, phosphono group, silyl group, hydrazino group, ureido Examples include groups, boronic acid groups (-B (OH) ₂ ), sulfonic acid groups, carboxy groups, phosphoric acid groups and other known substituents.
Moreover, each group mentioned in these substituent group W may be further substituted with the group exemplified in the above-mentioned substituent group W. For example, the alkyl group may be substituted with a halogen atom.

(Antibacterial agent containing metal)
The antibacterial agent containing a metal is not particularly limited, and known ones can be used.
Examples of the metal include gold, silver, copper, mercury, zinc, iron, lead, bismuth, titanium, tin, nickel and the like. The mode of the metal contained in the antibacterial agent containing a metal is not particularly limited, and examples thereof include forms such as metal particles, metal ions, and metal salts (including metal complexes). Among them, the metal is preferably gold, silver or copper in that it has more excellent antibacterial properties.

Further, the antibacterial agent containing a metal may be a carrier and a metal-supported carrier containing the above-mentioned metal supported on the carrier.
The type of carrier is not particularly limited, and known carriers can be used. Examples of the carrier include inorganic oxides (for example, zeolite (crystalline aluminokeisan salt), silica gel, silicates such as clay minerals, glass (including water-soluble glass), zirconium phosphate, calcium phosphate, etc.) and activated carbon. , Metal carriers, organic metals and the like.

As the antibacterial agent containing a metal, an antibacterial agent containing silver is preferable because it is more excellent in antibacterial properties.
Specific examples of the antibacterial agent containing silver include silver salts such as silver nitrate, silver chloride, silver sulfate, silver lactate, and silver acetate; silver complexes such as silver ammonia complex, silver chloro complex, and silver thiosulfato complex; silver. Particles; silver ions; silver-supported carriers in which these are supported on the above carriers; and the like.

(photocatalyst)
The photocatalyst is not particularly limited as long as it is a substance known to exhibit a photocatalytic action, and examples thereof include TiO ₂ , SrTiO ₂ , ZnO, CdS, SnO ₂ , and WO ₃ .

(Aldehyde compound)
The aldehyde-based compound is not particularly limited, and examples thereof include glutaral, phthalal, and formalin.

(Iodine compound)
The iodine-based compound is not particularly limited, and examples thereof include povidone iodine and iodine tincture.

(Piguanide compound)
The piganide compound is not particularly limited, and examples thereof include chlorhexidine gluconate, chlorhexidine hydrochloride, and chlorhexidine acetate.

The disinfectant, disinfectant, and disinfectant may be used alone or in combination of two or more.
When the composition of the present invention contains a disinfectant, a disinfectant, and / or a disinfectant, the content of the disinfectant, the disinfectant, and the disinfectant (the total of a plurality of types, if present) is the composition. With respect to the total mass, 0.001 to 10% by mass is preferable, 0.01 to 3% by mass is more preferable, and 0.01 to 1% by mass is further preferable.

<Surfactants and emulsifiers>
The composition of the present invention preferably contains a surfactant and / or an emulsifier. When the composition of the present invention containing a surfactant and / or an emulsifier is impregnated into a base cloth and used as a wiper, there is little unwiped residue and the cleaning property is excellent.
The surfactant and the emulsifier are not particularly limited, but for example, an ionic surfactant such as an anionic surfactant and a cationic surfactant (however, the ionic surfactant referred to here is a quaternary ammonium salt. (Not included), and nonionic surfactants and the like.

Examples of the ionic surfactant include alkyl sulfate (sodium dodecyl sulfate, etc.), alkylbenzene sulfonate (sodium dodecylbenzene sulfonate, etc.), alkyl phosphate, and cholic acid salt (sodium deoxycholate, sodium lithocate). , And anionic surfactants such as sodium sulfonic acid); cationic surfactants such as alkyldiaminoethylglycine hydrochloride;

As the nonionic surfactant, a compound having more than 20 carbon atoms is preferable, and for example, fatty acid esters of mono-, di-, or polyglycerin, propylene glycol fatty acid monoesters, sorbitan fatty acid esters, sucrose fatty acid esters, etc. Ester type; Ether type such as polyoxyethylene alkyl ether, polyalkylene alkyl ether, and polyoxyethylene polyoxypropylene glycol (manufactured by Kao Co., Ltd., Emargen series, etc.); Fatty polyethylene glycol, fatty acid polyoxyethylene sorbitan, etc. Ester ether type; alkanolamide type such as fatty acid alkanolamide and the like can be mentioned.
Specific examples of the nonionic surfactant include polyethylene glycol monolauryl ether, polyethylene glycol monostearyl ether, polyethylene glycol monocetyl ether, polyethylene glycol monolauryl ester, and polyethylene glycol monostearyl ester.

The emulsifier is not particularly limited, but a nonionic emulsifier preferably has more than 20 carbon atoms. Specific examples of the emulsifier include lecithinate (forms of salt include calcium salt, sodium salt, and potassium salt), capricate (forms of salt include calcium salt, sodium salt, and salt). Potassium salt is included), caprylate (salt forms include calcium salt, sodium salt, and potassium salt), laurate (salt forms include calcium salt, sodium salt, and). Potassium salt.), Gumrosing lecithin ester, sodium octenyl succinate, stearyl citrate, monoglyceride citrate, lactic acid and fatty acid esters of glycerin, mono-, di-, or polyglycerin fatty acid esters, stearic acid. Salts (salt forms include calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt), myristate (salt forms include calcium salt, magnesium salt, ammonium salt) , Aluminum salt, potassium salt, and sodium salt.), Lecithinate (forms of the salt include calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt),. Calcium stearoyl lactate, sodium stearoyl lactate, sorbitan fatty acid ester, sodium dioctyl sulfosuccinate, lecithin, lecithin hydroxide, partially hydrolyzed lecithin, sunflower lecithin, enzyme-treated lecithin, propylene glycol fatty acid ester, polyoxyethylene sorbitan monolaurate, poly monostearate Oxyethylene sorbitan, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan oleate, Kiraya extract, vegetable sterol, sphingolipid, soybean saponin, bile powder, animal sterol, fractionated lecithin, yukkafoam extract, egg yolk lecithin , Thor oil, and rozing lecithin ester.

The surfactant and emulsifier are preferably food additives from the viewpoint of safety, and lecithin (forms of the salt include calcium salt, sodium salt, and potassium salt). , Deoxycholate (forms of the salt include calcium salt, sodium salt, and potassium salt), lecithinate (forms of the salt include calcium salt, sodium salt, and potassium salt). ), Caprinate (forms of the salt include calcium salt, sodium salt, and potassium salt), caprylate (forms of the salt include calcium salt, sodium salt, and potassium salt). ), Laurate (forms of salt include calcium salt, sodium salt, and potassium salt), gumrosing lecithin ester, sodium octenyl succinate, triethyl citrate, stearyl citrate, monoglyceride citrate, Lactic acid and fatty acid esters of glycerin, mono-, di-, or polyglycerin fatty acid esters, sucrose fatty acid esters, stearates (in the form of salts, calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium) Salts and sodium salts are included), myristate (forms of the salt include calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt), palmitate (salt). Examples include calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt), stearoyl calcium lactate, sodium stearoyl lactate, sorbitan fatty acid ester, sodium dioctyl sulfosuccinate, lecithin, hydroxylated. Lecithin, partially hydrolyzed lecithin, sunflower lecithin, enzyme-treated lecithin, propylene glycol fatty acid ester, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan oleate, Kiraya extraction Goods, vegetable stearic acid, sphingolipids, soybean saponin, bile powder, animal stearic acid, fractionated lecithin, yukkafoam extract, egg yolk lecithin, tall oil, or rosing lyserin ester are preferred.

The surfactant and emulsifier may be used alone or in combination of two or more.
When the composition of the present invention contains a surfactant and / or an emulsifier, the content of the surfactant and the emulsifier (the total of a plurality of types, if present) is 0.01 to the total mass of the composition. 2% by mass is preferable, 0.05 to 2% by mass is more preferable, and 0.05 to 1% by mass is further preferable.

<Antioxidant>
The composition of the present invention preferably contains an antioxidant. When the composition of the present invention contains an antioxidant, the antiviral activity is more excellent.
The antioxidant is not particularly limited as long as it is not a specific phenolic compound and a compound having two or more hydroxyl groups in the same aromatic ring group. For example, "Theory and Practice of Antioxidants" (Kajimoto, et al., Various antioxidants described in Sanshobo 1984) and "Handbook of Antioxidants" (Saruwatari, Nishino, Tabata, Taiseisha 1976) can be used.

Further, as the antioxidant, ascorbic acid, ascorbic acid derivatives, and salts thereof; erythorbic acid, erythorbic acid derivatives, and amine compounds such as salts thereof and phenylenediamine; can also be used.

Examples of the ascorbic acid, ascorbic acid derivative, and salts thereof include L-ascorbic acid, sodium L-ascorbate, potassium L-ascorbate, calcium L-ascorbate, L-ascorbic acid phosphate, and L-. Magnesium salt of ascorbic acid phosphate, L-ascorbic acid sulfate ester, L-ascorbic acid sulfuric acid ester disodium salt, L-ascorbic acid stearic acid ester, L-ascorbic acid 2-glucoside, L-ascorbic acid palmitate, And L-ascorvir tetraisopalmitate and the like.

Examples of the erythorbic acid, the erythorbic acid derivative, and salts thereof include erythorbic acid, sodium erythorbate, potassium erythorbic acid, calcium erythorbic acid, erythorbic acid phosphate, and erythorbic acid sulfate.

Examples of the amine compound include phenylenediamine, diphenyl-p-phenylenediamine, 4-amino-p-diphenylamine and the like.

The antioxidant is preferably a food additive from the viewpoint of safety, and is preferably sodium ethylenediamine tetraacetate, L-ascorbic acid, calcium L-ascorbic acid, and L-ascorbic acid stearate. , L-ascorbic acid sodium, L-ascorbic acid palmitate, isoascorbic acid, erythorbic acid, sodium erythorbicate, isopropyl citrate, dilauryl thiodipropionate, thiodipropionic acid, thiodipropionic acid distearyl ester, Sodium thiosulfite, potassium pyrosulfite, sodium pyrosulfite, potassium sulfite, sodium sulfite, potassium hydrogen sulfite, sodium hydrogen sulfite, or stannous chloride are preferred.
The antioxidant may be used alone or in combination of two or more.
When the composition of the present invention contains an antioxidant, the content of the antioxidant (the total of a plurality of types, if present) is preferably 0.001 to 2% by mass with respect to the total mass of the composition. 0.01 to 2% by mass is more preferable, and 0.01 to 0.5% by mass is further preferable.

<pH adjuster>
The pH adjuster is not particularly limited, but is limited to metal alkoxides (eg, sodium methoxydo, sodium ethoxydo, etc.), metal oxides (eg, calcium oxide, magnesium oxide, etc.), and bicarbonates (ammonium hydrogencarbonate, carbonate, etc.). Sodium hydrogen hydrogen, potassium hydrogen carbonate, calcium hydrogen carbonate, etc.), metal hydroxides (calcium hydroxide, magnesium hydroxide, potassium hydroxide, sodium hydroxide, lithium hydroxide, aluminum hydroxide, rubidium hydroxide, cesium hydroxide , Strontium hydroxide, barium hydroxide, uropyrium hydroxide (II), and tallium hydroxide (I), etc.), carbonates (ammonium carbonate, potassium carbonate, calcium carbonate, sodium carbonate, magnesium carbonate, cesium carbonate, etc.), Examples thereof include quaternary ammonium hydroxide, organic bases (guanidine derivatives, diazabicycloundecene, diazabicyclononen, etc.), phosphazene bases, proazaphosphatlan bases, and the like.
As the pH adjuster, those used as food additives are preferable from the viewpoint of safety, and sodium methoxydo, calcium oxide, magnesium oxide, ammonium hydrogencarbonate, sodium hydrogencarbonate, potassium hydrogencarbonate, calcium hydrogencarbonate, and hydroxide are preferable. Calcium, magnesium hydroxide, potassium hydroxide, sodium hydroxide, ammonium carbonate, potassium carbonate, calcium carbonate, sodium carbonate, or magnesium carbonate are preferred.

The pH adjuster may be used alone or in combination of two or more.
When the composition of the present invention contains a pH adjuster, the content of the pH adjuster (the total of a plurality of types, if present) is appropriately changed depending on the content of the compound represented by the formula (1) and the like. Although not limited, 0.001 to 30% by mass is preferable, and 0.005 to 20% by mass is more, based on the total mass of the composition so that the pH of the composition is more than 9.5. It is preferable, and 0.01 to 10% by mass is more preferable.

<UV absorber>
The ultraviolet absorber is not particularly limited, and is, for example, paraaminobenzoic acid, ethyldihydroxypropyl paraaminobenzoic acid, glyceryl paraaminobenzoic acid, octyldimethylparaaminobenzoic acid, amyl paradimethylaminobenzoate, and 2-ethyl paradimethylaminobenzoate. Paraaminobenzoic acid compounds such as hexyl; 2-ethylhexyl paramethoxycinnamic acid (also known as octyl paramethoxycinnamic acid), glyceryl diparamethoxycinnamic acid mono-2-ethylhexanoate, 2,5-diisopropylkei Methyl cinnamate, 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, trimethoxycinnamic acid methylbis (trimethylsiloxy) silylisopentyl, paramethoxy Cinnamic acid-based compounds such as isopropyl cinnamic acid-diisopropyl cinnamic acid ester mixture and p-methoxyhydro cinnamic acid diethanolamine salt; 2-phenyl-benzimidazole-5-sulfate, 4-isopropyldibenzoylmethane, and 4 Benoxylmethane compounds such as -tert-butyl-4'-methoxydibenzoylmethane; 2-cyano-3,3-diphenylpropa-2-enoic acid-2-ethylhexyl ester (also known as octocrylene), dimethoxybenzidendioxoimidazo 2-Ethylhexyl lysinepropionate, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentandione, cinoxate, methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano- 3,3-Diphenylacrylate, 3- (4-methylbenzylidene) camphor, octylriazone, 4- (3,4-dimethoxyphenylmethylene) -2,5-dioxo-1-imidazolidine propionate 2-ethylhexyl, these Examples of the polymer derivative and the silane derivative of the above.

The ultraviolet absorber may be used alone or in combination of two or more.
When the composition of the present invention contains an ultraviolet absorber, the content of the ultraviolet absorber (the total of a plurality of types, if present) is preferably 0.01 to 3% by mass with respect to the total mass of the composition. 0.01 to 2% by mass is more preferable, and 0.01 to 1% by mass is further preferable.

<Chelating agent>
The chelating agent is not particularly limited, and for example, an aminopolycarboxylic acid chelating agent, an aromatic or aliphatic carboxylic acid chelating agent, an amino acid chelating agent, a phosphonic acid chelating agent, a phosphoric acid chelating agent, and a hydroxycarboxylic acid. Examples thereof include chelating agents based on polymers, polymer chelating agents (including oligomeric electrolytes), dimethylglioxime, thioglycolic acid, phytic acid, glyoxylic acid, and glyoxal acid. Each of these chelating agents may be in the form of a free acid or a salt such as a sodium salt, a potassium salt or an ammonium salt.

Examples of the aminopolycarboxylic acid-based chelating agent include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diethylenetriaminepentaacetic acid, and N- (2). -Hydroxyethyl) ethylenediaminetriacetic acid, glycol etherdiaminetetraacetic acid, glutamate diacetic acid, aspartate diacetic acid, and salts thereof.

Examples of aromatic or aliphatic carboxylic acid-based chelating agents include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvate, and aminobenzoic acid. Examples thereof include acids (including anthranic acid), phthalic acid, fumaric acid, trimellitic acid, hexahydrophthalic acid, and salts thereof.

Examples of the amino acid-based chelating agent include glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine, and salts thereof.

Examples of the phosphonic acid-based chelating agent include iminodimethylphosphonic acid, alkyldiphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, and salts thereof.

Examples of the phosphoric acid-based chelating agent include orthophosphoric acid, pyrophosphoric acid, triphosphoric acid, polyphosphoric acid and the like.

Examples of the hydroxycarboxylic acid-based chelating agent include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartrate acid, lactic acid, and salts thereof.

Examples of the polymer electrolyte (including oligomeric electrolyte) chelating agent include an acrylic acid polymer, a maleic anhydride polymer, an α-hydroxyacrylic acid polymer, an itaconic acid polymer, and a constituent monomer 2 of these polymers. Examples thereof include copolymers composed of seeds and above, and epoxy succinic acid polymers.

The chelating agent may be used alone or in combination of two or more.
When the composition of the present invention contains a chelating agent, the content of the chelating agent (the total of a plurality of types, if present) is preferably 0.001 to 3% by mass with respect to the total mass of the composition. 001 to 2% by mass is more preferable, and 0.001 to 1% by mass is further preferable.

<Moisturizer>
The moisturizing agent is not particularly limited, and for example, deoxyribonucleic acid, mucopolysaccharide, hyaluronic acid, chondroitin sulfate, aloe extract, gelatin, elastin, chitin, chitosan, hydrolyzed eggshell membrane, polyoxyethylene methyl glucoside, polyoxypropylene methyl. Glucoside, sodium lactate, urea, sodium pyrrolidone carboxylate, betaine, whey and the like can be mentioned.

The moisturizer may be used alone or in combination of two or more.
When the composition of the present invention contains a moisturizer, the content of the moisturizer (the total of a plurality of types, if present) is preferably 0.001 to 3% by mass with respect to the total mass of the composition. 001 to 2% by mass is more preferable, and 0.001 to 1% by mass is further preferable.

<Thickener and gelling agent>
Examples of the thickener and gelling agent include maleic anhydride / methyl vinyl ether copolymer, dimethyldiallylammonium chloride / acrylamide copolymer, acrylamide / acrylic acid / dimethyldialylammonium chloride copolymer, cellulose or a derivative thereof. Keratin and collagen or derivatives thereof, calcium alginate, purulan, agar, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, starch gum, acacia gum, crystalline cellulose, arabinogalactan, Karaya gum, tragacanto gum, carob bean gum, gati gum, alginic acid and salts thereof (forms of salts include ammonium salt, potassium salt, calcium salt, and sodium salt), propylene glycol alginate, albumin, casein, curdran, β Glucane and β-glucan derivatives, locust bean gum, gellan gum, cassia gum, mannan, tara gum, tragant gum, tamarind gum, dextran, polydextrose, α-glucose, ethylhydroxyethyl cellulose, carboxymethyl cellulose and salts thereof (calcium salt in the form of salt) , And sodium salts.), Enzymatically degraded sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl starch, hydroxypropyl methyl cellulose, methyl ethyl cellulose, methyl cellulose, hydroxypropylated epi-crosslinked starch, hydroxypropylated phosphoric acid cross-linked starch, amylopectin, Hydroxypropylated phosphoric acid cross-linked starch, acetylated adipic acid cross-linked starch, oxidized hydroxypropylated epi-crosslinked starch, acetylated phosphoric acid cross-linked starch, acetylated oxidized starch, alkali-treated starch, oxidized hydroxypropylated epi-crosslinked starch, glycerol cross-linked starch , Acid-treated starch, phosphoric acid monoesterified phosphoric acid cross-linked starch, phosphorylated starch, acetate starch, bleached starch, enzyme-treated starch, oxidized starch, sodium starch glycolate, sodium starch succinate, glucomannan, cyclodextrin, dextrin, Examples thereof include purulan, starch, sodium polyacrylate, eukema, β-1,3-glucan agar, and derivatives of α-glucose.

The thickener and the gelling agent may be used alone or in combination of two or more.
When the composition of the present invention contains a thickener and / or a gelling agent, the content of the thickener and the gelling agent (the total of a plurality of types, if present) is based on the total mass of the composition. It is preferably 0.001 to 3% by mass, more preferably 0.001 to 2% by mass, and even more preferably 0.001 to 1% by mass.

<Preservative>
The preservative is not particularly limited, but for example, benzoic acid, sodium benzoate, potassium sorbate, sodium sorbate, sorbic acid, sodium dehydroacetate, hydrogen peroxide, formate, ethyl formate, sodium dichlorate, propionic acid. , Sodium propionate, calcium propionate, pectin degradation products, polylysine, phenoxyethanol, tiram, thiabendazole, imazaryl, diphenyl, natamycin, fludioxonyl, azoxistrovine, and tea tree oil.

The preservative may be used alone or in combination of two or more.
When the composition of the present invention contains a preservative, the content of the preservative (the total of a plurality of types, if present) is preferably 0.001 to 3% by mass with respect to the total mass of the composition. It is more preferably 001 to 2% by mass, and even more preferably 0.001 to 1% by mass.

<Fragrance>
The fragrance is not particularly limited, but for example, jako, acacia oil, anis oil, ylang ylang oil, jasmine oil, sweet orange oil, spare mint oil, geranium oil, neroli oil, peppermint oil, hinoki oil, fennel oil, peppermint oil, etc. Examples thereof include bergamot oil, lime oil, lavender oil, lemon oil, lemongrass oil, rose oil, rosewood oil, anisaldehyde, sibeton, muscon, and limonene.

The fragrance may be used alone or in combination of two or more.
When the composition of the present invention contains a fragrance, the content of the fragrance (the total of a plurality of types if present) is preferably 0.001 to 3% by mass, preferably 0.001 to 1% by mass, based on the total mass of the composition. 2% by mass is more preferable, and 0.001 to 1% by mass is further preferable.

<Dye>
The pigment is not particularly limited, and examples thereof include krill pigment, orange pigment, kaolin, gunjo, chromium oxide, iron oxide, titanium dioxide, and chlorophyll.

The dye may be used alone or in combination of two or more.
When the composition of the present invention contains a dye, the content of the fragrance (the total of a plurality of types, if present) is preferably 0.001 to 3% by mass, preferably 0.001 to 1% by mass, based on the total mass of the composition. 2% by mass is more preferable, and 0.001 to 1% by mass is further preferable.

[Method for producing composition]
The composition of the present invention can be prepared by appropriately mixing the above-mentioned essential components and optional components. The order of mixing the above components is not particularly limited.

[Dosage form]
The dosage form of the composition of the present invention is not particularly limited, and examples thereof include liquids, gels, aerosol sprays, and non-aerosol sprays.

[Use]
Since the composition of the present invention has an action of inactivating viruses belonging to, for example, Caliciviridae, Orthomixovirus, Coronaviridae, Herpesviruses, etc., it acts on the above viruses to cause the above viruses. Applications that reduce activity are preferred. Examples of the virus belonging to the family Caliciviridae include viruses belonging to the genus Norovirus, Sapovirus, Lagovirus, Nebovirus, and Vesivirus. The composition of the present invention exerts a good inactivating effect on viruses belonging to the genus Norovirus and viruses belonging to the genus Vesivirus.

The composition is preferably used as an anti-norovirus composition.
The method of using the above composition is not particularly limited, but it can be applied or pre-applied to a place where norovirus adheres or may adhere. The method of applying the composition is not particularly limited, but for example, a method of spraying the composition on the above-mentioned part, a method of wiping the above-mentioned part with a base cloth containing the composition, and a method of wiping the above-mentioned part with a composition which is a liquid cleaning agent are used. Examples include a cleaning method.

[spray]
The spray of the present invention includes a spray container and an antiviral composition contained in the spray container. The composition for antiviral is as described above.
The spray container may be an aerosol spray container or a non-aerosol spray container. As the spray container, a non-aerosol spray container is particularly preferable.
When the spray container is an aerosol spray container, for example, it is intended that the spray container contains a gas such as a liquid gas and a compressed gas in addition to the antiviral composition. Specific examples of the aerosol spray container include a spray container containing a gas such as liquefied petroleum gas (LPG), dimethyl ether (DME), carbon dioxide gas, nitrogen gas, and isopentan.
When the spray container is a non-aerosol spray container, the spray container does not substantially contain gas such as liquid gas and compressed gas, and the liquid contained in the container is in the form of mist or foam. It is intended to have a mechanism for ejecting out of the container. Examples of the non-aerosol spray container include a pump type and a pressure accumulator type spray container such as a trigger type.

[Wiper]
The wiper of the present invention includes a base cloth and an antiviral composition impregnated in the base cloth.
The composition for antiviral is as described above.
The base cloth is not particularly limited, and may be one made of natural fibers or one made of chemical fibers.
Examples of natural fibers include pulp, cotton, hemp, flax, wool, camel, cashmere, mohair, silk and the like.
Examples of the chemical fibers include polyethylene terephthalate, rayon, polynosic, acetate, triacetate, nylon, polyester, polyacrylonitrile, polyvinyl alcohol, polyvinyl chloride, polyvinylidene chloride, polyethylene, polypropylene, polyurethane, polyalkylene paraoxybenzoate, and polyclaral. Be done.
Of these base fabrics, hydrophilic base fabrics are preferable because they are easily impregnated with the composition. The hydrophilic base cloth is a base cloth containing a fiber having a hydrophilic group such as a hydroxyl group, an amino group, a carboxy group, an amide group, and a sulfonyl group. Specific examples of the hydrophilic base fabric include vegetable fibers, cotton, pulp, animal fibers, rayon, nylon, polyester, polyacrylonitrile, polyvinyl alcohol and the like.
Further, as the base cloth, non-woven fabric, cloth, towel, gauze, absorbent cotton and the like can be used, and non-woven fabric is preferable.

The basis weight (mass per unit area) of the base cloth is preferably 100 g / m ² or less. The amount of impregnation when the base cloth is impregnated with the above composition is preferably 1 times or more the mass of the base cloth.

The present invention will be described in more detail below based on examples. The materials, amounts used, ratios, treatment contents, treatment procedures, etc. shown in the following examples can be appropriately changed without departing from the spirit of the present invention. Therefore, the scope of the present invention should not be construed as limiting by the examples shown below.

[Examples 1 to 47, Comparative Examples 1 to 5]
[Preparation of antiviral composition]
<Preparation of composition for antiviral of Example 1>
To a glass container containing 90 mg (725 μmol) of 3-methoxyphenol, 24 mL of ethanol was added, and 3-methoxyphenol was dissolved in ethanol. Next, in the glass container, water and a 1 mol / L sodium hydroxide aqueous solution are placed in a total amount of water of 6 mL (ethanol concentration 80% by volume based on the total volume of the solvent) and for antivirus after preparation. The pH of the composition was adjusted to 9.6 to obtain an anti-viral composition.
The pH was measured by the following method.

(Measurement method of pH)
A pH standard solution using a pH meter (product name "pH / water quality analyzer LAQUA F-72S", manufactured by HORIBA, Ltd.) and a pH electrode (product name "6377-10D", manufactured by HORIBA, Ltd.). The pH was calibrated and then measured. After preparing the sample solution at a solution temperature of 25 ° C., the electrode was immersed in the sample solution and left for about 1 to 2 minutes, and the pH value when the numerical value became stable was read.

<Preparation of antiviral compositions of Examples 2 to 47 and Comparative Examples 1 to 5>
According to the method for preparing the antiviral composition of Example 1, the antiviral compositions of Examples 2 to 47 and Comparative Examples 1 to 5 were prepared with the component formulations and pHs shown in Table 1.
The grapefruit extract of Comparative Example 4 contains naringin (corresponding to compound B) and quercetin (corresponding to a compound having two or more hydroxyl groups in the same aromatic ring group).

[Evaluation]
The prepared antiviral compositions of Examples 1 to 47 and Comparative Examples 1 to 5 were evaluated for antiviral activity by the methods shown below.

<Evaluation of anti-feline calicivirus activity>
The virus solution obtained by culturing feline calicivirus (ATCC VR-782) in MEM (Minimum Essential Media) medium is inoculated into the composition prepared above, stirred for 10 seconds, and then about 25. It was allowed to stand at ° C. for 1 minute. Next, 0.1 mL of the composition solution after inoculation with the virus solution was collected, and 9.9 mL of SCDLP medium (Soybean. Casein Digest Agar with Lecithin and Polysorbate 80) was added so that the final concentration was 10%. ) And mixed well to obtain a test solution. Next, 0.1 mL of the above test solution was inoculated into CRFK cells (cat kidney-derived cell lines, ATCC CCL-94) cultured on an agar medium, and the cells were adsorbed at 37 ° C. for 1 hour. Next, the test solution on the CRFK cells was washed away, an agar medium was layered, and the cells were cultured for 2 to 3 days. After culturing, the number of plaques formed was counted, the infectious titer was calculated, and this was used as the "infectious titer of the antiviral composition". In addition, the infectious titer was calculated for the sample prepared in the same manner as above except that sterilized purified water was used instead of the antiviral composition, and this was used as the "control infectious titer".
The antiviral property (antiviral activity value) of the composition was calculated using the following formula 1, and the calculation result was evaluated using the following criteria. The results are shown in Table 1.

Equation 1: Antiviral activity value = AB
The above A represents a common logarithmic value of the control infectious titer.
The above B represents a common logarithmic value of the infectious titer of the antiviral composition.

(Evaluation criteria)
"A": Antiviral activity value is 4.0 or more "B": Antiviral activity value is 3.5 or more and less than 4.0 "C": Antiviral activity value is 3.0 or more and less than 3.5 "D" : Antiviral activity value is 2.0 or more and less than 3.0 "E": Antiviral activity value is less than 2.0

In Tables 1 to 6 below, the contents of the antiviral agent and the additive are based on mass% and represent the contents of the composition with respect to the total mass.
In each of the antiviral compositions of Examples and Comparative Examples shown in Tables 1 to 6 below, the content of the solvent was 95% by mass or more with respect to the total mass of the composition.

The compounds (1) to (5) in Table 1 are shown below.

From the results in Table 1, it was confirmed that the antiviral composition of the example showed excellent antiviral activity against feline calicivirus.
In addition, from the comparison of Examples 1 to 4, the antiviral composition shows more excellent antiviral activity against feline calicivirus when the pH is 10.0 or more (preferably 10.5 or more). Was confirmed.
Further, from the comparison of Examples 4 and 5 to 8, the composition for antiviral has an alcohol content of 30 to 100% by volume (preferably 40 to 100% by volume) with respect to the total volume of the solvent. In some cases, it was confirmed to show better antiviral activity against feline calicivirus.
Further, from the comparison of Examples 4 and 9 to 11, the content of the specific phenolic compound in the antiviral composition is 0.10% by mass or more (preferably) based on the total mass of the antiviral composition. Was 0.31% by mass or more), it was confirmed that it showed better antiviral activity against feline calicivirus.
Further, from the comparison of Examples 23 and 37 and 38 and 39, there is no substituent in the vicinity of the phenolic hydroxyl group (particularly, the ortho position of the phenolic hydroxyl group) (preferably, the antiviral agent is the formula (4) or the formula (preferably). In the case of (the compound represented by 5)), it was confirmed that it exhibits more excellent antiviral activity against feline calicivirus.
On the other hand, it is clear that the antiviral composition of the comparative example is inferior in antiviral activity against feline calicivirus.

[Examples 48 to 103]
[Preparation of antiviral composition]
<Preparation of antiviral composition of Examples 48 to 103>
According to the method for preparing the antiviral composition of Example 1, the antiviral composition of Examples 48 to 103 was prepared with the component composition and pH shown in Table 2, and the same evaluation as in Example 1 was performed. It was.

<Measurement of ClogP value>
The ClogP value of the compound and the ClogP value of the hydrocarbon group were calculated by ChemBioDrow Ultra Ver13. Here, the "hydrocarbon group", * ^-COOR _X1 ⁱⁿ each ^{compound, * - CONR X1 2, *} - CONHR X1, * - CONR X1 R Y1 or ^* -COOR X2 -O-CO- ^* intended site represented in the ^{"R X1", "R X2".} However, * - that portions represented by ^CONR X1 ^{R X2,} contemplates the total number of carbon atoms of ^{"R X1"} and ^{"R X2".}

<Measurement of pKa>
The pKa of the compound was measured by the following procedure. The measurement temperature was 25 ° C.
Device: Potential difference automatic titrator AT-610 (manufactured by Kyoto Electronics Industry Co., Ltd.)
(1) In the case of monovalent acid 1 mmol of the compound was dissolved in 40 mL of ethanol, and 10 mL of purified water was added. After adding 1 mL of 1 mol / L hydrochloric acid, pKa was calculated by titrating with 1 mol / L sodium hydroxide.
(2) In the case of divalent acid 1 mmol of the compound was dissolved in 40 mL of ethanol, and 10 mL of purified water was added. After adding 2 mL of 1 mol / L hydrochloric acid, pKa was calculated by titrating with 1 mol / L sodium hydroxide.

The compounds (5) to (7) in Table 2 are shown below.

From the comparison of Examples 48 to 87, when the pH is 10.5 or less, the pKa of the specific phenolic compound is 10.5 or more, and the ClogP value of the compound itself is 7.00 or more, or , PKa was 11.5 or more, and the ClogP value of the compound itself was 5.00 or more, it was confirmed that the compound exhibited better antiviral activity against feline calicivirus. With the above configuration, even when the alcohol content is relatively low (see Example 70) or the pH of the composition is relatively low (see Example 74, Example 78 and Example 87). , It was confirmed that it shows better antiviral activity against feline calicivirus.
From the comparison of Examples 88 to 103, when the pH is more than 10.5 (preferably 11.0 or more, more preferably 11.5 or more), the feline is a specific phenolic compound when pKa is 10.5 or more. It was confirmed that it showed more excellent antiviral activity against calicivirus, and when pKa was 11.5 or more, it showed particularly excellent antiviral activity.

[Examples 1 to 4, Examples 104 to 106, Comparative Example 6]
[Preparation of antiviral composition]
<Preparation of antiviral compositions of Examples 1 to 4, Examples 104 to 106, and Comparative Example 6>
The antiviral compositions of Examples 1 to 4, 104 to 106, and Comparative Example 6 shown in Table 3 were prepared, respectively. The antiviral compositions of Examples 1 to 4 shown in Table 3 are the same as the antiviral compositions of Examples 1 to 4 shown in Table 1.

[Evaluation]
<Evaluation of anti-feline calicivirus activity>
The evaluation of the anti-feline calicivirus activity was carried out in the same manner as the evaluation of the anti-feline calicivirus activity of Example 1. In Comparative Example 6, no evaluation was carried out.

<Evaluation of metal corrosiveness>
Next, about 100 mL of each antiviral composition was placed in a stainless steel vat, and aluminum, copper, and brass plates were immersed at room temperature under closed conditions. After one week, each plate was taken out, the surface of the plate was visually observed, and the evaluation was made according to the following evaluation criteria. The results are shown in Table 3.

(Evaluation criteria)
"A": No change.
"B": A decrease in gloss and a slight change in color were confirmed.
"C": Rust has occurred.

In the table below, "oleyl" is intended an unsaturated alkyl group represented by C ₁₈ H ₃₅ .

From the results in Table 3, it was found that when the pH of the antiviral composition was 12.0 or less, almost no corrosion on the aluminum plate, copper, and brass was observed.
On the other hand, when sodium hypochlorite (Comparative Example 6), which is widely used as a norovirus disinfectant, was used as an antiviral agent, slight corrosion on aluminum and severe corrosion on copper and brass were confirmed.

[Example 4, Examples 107 to 112, Comparative Examples 7 to 8]
[Preparation of antiviral composition]
<Preparation of antiviral compositions of Examples 4, 107 to 112, and Comparative Examples 7 to 8>
According to the method for preparing the antiviral composition of Example 1, the antiviral compositions of Examples 4, Examples 107 to 112, and Comparative Examples 7 to 8 were prepared with the component formulations and pHs shown in Table 4. did. The antiviral composition of Example 4 shown in Table 4 is the same as the antiviral composition of Example 4 shown in Table 1.

[Evaluation]
<Evaluation of antiviral activity in wet wiper form>
Examples 4, Examples 107 to 112, and Comparative Examples 7 to 8 with reference to "Test method for sterilization performance of wet wipers (revised on November 16, 2015)" established by the Japan Sanitary Materials Industry Association A wiping test was carried out on the antiviral composition of. As a specific procedure, MEM (stainless plate) is used for the test carrier (stainless plate) in accordance with the "Wet wiper sterilization performance test method (revised on November 16, 2015)" established by the Japan Sanitary Materials Industry Association. A virus solution obtained by culturing feline calicivirus (ATCC VR-782) in a medium (Minimum Essential Media) is inoculated, dried, and then Examples 4, Examples 107 to 112, and Comparative Example 7. Wipe off with a weight wrapped with a test cloth impregnated with the antiviral composition of ~ 8. Next, the test carrier (stainless steel plate) was placed in 20 mL of SCDLP medium, and the remaining virus was washed out from the test carrier to prepare a virus solution for sample preparation. Further, a virus solution for preparing a control sample was obtained in the same manner as described above except that a test cloth impregnated with sterilized purified water was used instead of the test cloth impregnated with the antiviral composition.
Next, 0.1 mL of the virus solution for preparing the sample was inoculated into CRFK cells cultured on an agar medium and adsorbed at 37 ° C. for 1 hour. Next, the test solution on the CRFK cells was washed away, an agar medium was layered, and the cells were cultured for 2 to 3 days. After culturing, the number of plaques formed on the agar medium was counted, the infectious titer was calculated, and this was used as the "infectious titer of the antiviral composition". In addition, the infectious titer was calculated for the sample prepared in the same manner as above except that the virus solution for preparing the control sample was used instead of the virus solution for preparing the sample, and this was used as the "control infectious titer".
The antiviral property (antiviral activity value) of the antiviral composition was calculated using the following formula 2, and the calculation result was evaluated using the following criteria. The results are shown in Table 4.

Equation 2: Antiviral activity value = AB
The above A represents a common logarithmic value of the control infectious titer.
The above B represents a common logarithmic value of the infectious titer of the antiviral composition.
(Evaluation criteria)
"A": Antiviral activity value is 2.5 or more "B": Antiviral activity value is 2.0 or more and less than 2.5 "C": Antiviral activity value is less than 2.0

<Evaluation of variation>
Five lots of each of the antiviral compositions of Examples 4, 107 to 112, and Comparative Examples 7 to 8 shown in Table 4 were prepared, and a wiping test was carried out on each of them by the same method as described above. .. Next, the antiviral activity value was calculated by the same method as that shown in the evaluation of the antiviral activity in the wet wiper form, and evaluated according to the following evaluation criteria. The results are shown in Table 4.
(Evaluation criteria)
"A": The difference between the maximum and minimum antiviral activity values is less than 0.3 "B": The difference between the maximum and minimum antiviral activity values is 0.3 or more and less than 0.5 "C" : The difference between the maximum and minimum antiviral activity values is 0.5 or more

From the results in Table 4, when alcohols having 2 or less carbon atoms (for example, ethanol or methanol) and alcohols having 3 or more carbon atoms (for example, isopropanol, 1-butanol, or 2-pentanol) are used in combination as alcohols. It was found that the anti-feline calicivirus activity value was improved and the variation was small.
Alcohols having 3 or more carbon atoms (isopropanol (CLogP value: 0.0740), 1-butanol (CLogP value: 0.823), 2-pentanol (CLogP value: 1.13), etc.) have 2 or less carbon atoms. It is assumed that it has higher lipophilicity and higher surface active function than alcohol (methanol (CLogP value: -0.764), ethanol (CRogP value: -0.235)). Therefore, in Examples 107 to 112 in which an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms are used in combination, alcohols and phenoxide anions are compared with Example 4 in which an alcohol having 2 or less carbon atoms is used alone. It is considered that the synergistic effect with and was further strengthened, the antiviral activity was improved, and the virus and dirt could be physically removed.

[Example 4, Examples 113 to 117, Comparative Example 9]
[Preparation of antiviral composition]
<Preparation of antiviral compositions of Examples 4, Examples 113 to 117, and Comparative Example 9>
According to the method for preparing the antiviral composition of Example 1, the antiviral compositions of Examples 4, Examples 113 to 117, and Comparative Example 9 were prepared with the component formulations and pHs shown in Table 5. The antiviral composition of Example 4 shown in Table 5 is the same as the antiviral composition of Example 4 shown in Table 1.

[Evaluation]
<Evaluation of antiviral activity value and its variation>
Evaluation of antiviral activity values and variations of the antiviral compositions of Examples 4, 113 to 117, and Comparative Example 9 by the same methods as in Examples 4, 107 to 112, and Comparative Examples 7 to 8. Was done. The results are shown in Table 5.

From the results in Table 5, it was found that when the antiviral composition contained a surfactant, the anti-catalicis virus activity was improved and the variation was small.

[Example 3, Example 4, Example 6, Example 23, Example 36, Example 118]
[Preparation of antiviral composition]
<Preparation of antiviral compositions of Examples 3, Example 4, Example 6, Example 23, Example 36, and Example 118>
According to the method for preparing the antiviral composition of Example 1, the composition of the components and the pH shown in Table 6 of Example 3, Example 4, Example 6, Example 23, Example 36, and Example 118. An antiviral composition was prepared. The antiviral compositions of Example 3, Example 4, Example 6, Example 23, and Example 36 shown in Table 6 are the compositions of Example 3, Example 4, and Example 6 shown in Table 1. , The same as the antiviral compositions of Example 23 and Example 36, respectively.

[Evaluation]
The compositions shown in Table 6 were evaluated for activity against influenza virus and general bacteria.
<Evaluation of anti-influenza virus activity>
A virus solution obtained by culturing influenza virus (Influenza A virus (H3N2): ATCC VR-1679) in MEM (Minimum Essential Media) medium was inoculated into the composition prepared above, and then stirred for 10 seconds. It was allowed to stand at about 25 ° C. for 1 minute. Next, 0.1 mL of the composition after inoculation with the virus solution was collected and placed in 9.9 mL of SCDLP medium (Soybean-Casein Disease Brost with Lecithin & Polysorbate 80) and mixed well to obtain a test solution. Next, MDCK cells (cells derived from canine renal tubular epithelium, ATCC CCL-34) cultured on an agar medium were inoculated with 0.1 mL of the above test solution and adsorbed at 34 ° C. for 1 hour. Next, the test solution on the MDCK cells was washed away, an agar medium was layered, and the cells were cultured for 2 to 3 days. After culturing, the number of plaques formed on the agar medium was counted, the infectious titer was calculated, and this was used as the "infectious titer of the composition". In addition, the infectious titer was calculated for the sample prepared in the same manner as above except that sterilized purified water was used instead of the composition, and this was used as the "control infectious titer".
The calculation and evaluation of the antiviral activity value were carried out in the same manner as in the evaluation of the antifeline calicivirus activity of Example 1.
The results are shown in Table 6.

<Sterilization (Escherichia coli / Staphylococcus aureus)>
The test was conducted using the "Test method for sterilization activity of synthetic detergents for houses and soap" established by the Detergent and Soap Fair Trade Council. The strains of the bacteria used in the test were Escherichia coli NBRC 3972 and Staphylococcus aureus NBRC 12732. The calculation and evaluation of the antibacterial activity value were carried out in the same manner as the evaluation of the anti-feline calicivirus activity of Example 1.
The results are shown in Table 6.

It was found that the antiviral composition of the present invention also exhibits high activity against influenza virus and bacteria.

Claims (18)

One or more phenolic compounds selected from the group consisting of the following compound A, the following compound B, and the following compound C,
Containing with a solvent containing at least alcohol,
The pH is more than 9.5 and less than 14.0 and
Does not contain compounds having two or more hydroxyl groups in the same aromatic ring group.
Composition for antiviral.
Compound A: Compound represented by the following formula (1) Compound B: Residues of the compound represented by the following formula (2) excluding one or two hydrogen atoms other than hydrogen atoms in the hydroxyl group are 2 Compounds containing more than one Compound C: Compound represented by the following formula (3)
In the above formula (1), X ¹¹ represents a nitrogen atom or −CR ¹¹ =. R ¹¹ represents a hydrogen atom or a monovalent substituent excluding a hydroxyl group and an alkoxycarbonyl group. X ^{12 to} X ¹⁵ each independently represent a nitrogen atom or −CR ¹² =. R ¹² represents a monovalent substituent excluding a hydrogen atom or a hydroxyl group. In addition, a plurality of R ^12s , and R ¹¹ and R ¹² may be connected to each other to form a ring structure.
In the above formula (2), X ²¹ represents a nitrogen atom or −CR ²¹ =. R ²¹ represents a monovalent substituent excluding a hydrogen atom or a hydroxyl group. X ^{22 to} X ²⁵ each independently represent a nitrogen atom or −CR ²² =. R ²² represents a monovalent substituent excluding a hydrogen atom or a hydroxyl group. In addition, a plurality of R ^22s , and R ²¹ and R ²² may be connected to each other to form a ring structure.
In the above formula (3), X ^{31 to} X ³³ each independently represent a nitrogen atom or −CR ³¹ =. R ³¹ represents a monovalent substituent excluding a hydrogen atom or a hydroxyl group. A plurality of R ³¹ together may form a ring structure together. Y ³¹ and Y ³² are each independently an oxygen atom, a sulfur ^{atom,> NR 32,> C =} O, -CR 33 = CR 34 -, or> represents a C = S. R ³² , R ³³ , and R ³⁴ each independently represent a monovalent substituent excluding a hydrogen atom or a hydroxyl group.
However, Y ³¹ is an oxygen atom, a sulfur atom,> NR ^32, or -CR ³³ = CR ³⁴ - may represent, Y ³² represents a> C = O, or> C = S. Further, when Y ³² represents an oxygen atom, a sulfur atom,> NR ³² , or −CR ³³ = CR ³⁴ −, Y ³¹ represents> C = O or> C = S. The antiviral composition according to claim 1, wherein the pKa of the compound A, the pKa of the compound B, and the pKa of the compound C are all 10.0 or more. The antiviral composition according to claim 1 or 2, wherein the pKa of the compound A, the pKa of the compound B, and the pKa of the compound C are all 10.5 or more. The antiviral composition according to any one of claims 1 to 3, wherein the pKa of the compound A, the pKa of the compound B, and the pKa of the compound C are all 11.5 or more. The antiviral according to any one of claims 1 to 4, wherein the ClogP value of the compound A, the ClogP value of the compound B, and the ClogP value of the compound C are all 5.00 to 20.00. Composition for. The antiviral according to any one of claims 1 to 5, wherein the ClogP value of the compound A, the ClogP value of the compound B, and the ClogP value of the compound C are all 7.00 to 15.00. Composition for. The antiviral composition according to any one of claims 1 to 6, wherein the compound represented by the formula (1) is a compound represented by the following formula (4) or the following formula (5).
In the above formula (4), X ¹² and X ¹⁵ each independently represent a nitrogen atom or −CR ¹² =. R ¹² represents a monovalent substituent excluding a hydrogen atom or a hydroxyl group. L ⁴ represents a single bond or a divalent linking group. R ⁴ represents a hydrogen atom or a monovalent substituent. However, the group represented by −L ⁴ −R ⁴ is neither a hydroxyl group nor an alkoxycarbonyl group.
In the above formula (5), X ¹¹ represents a nitrogen atom or −CR ¹¹ =. R ¹¹ represents a hydrogen atom or a monovalent substituent excluding a hydroxyl group and an alkoxycarbonyl group. X ¹⁵ represents a nitrogen atom, or −CR ¹² =. R ¹² represents a monovalent substituent excluding a hydrogen atom or a hydroxyl group. L ⁵ represents a single bond or a divalent linking group. R ⁵ represents a hydrogen atom or a monovalent substituent. However, the group represented by −L ⁵ −R ⁵ is not a hydroxyl group. The antiviral composition according to any one of claims 1 to 7, wherein the content of the alcohol is 30 to 100% by volume based on the total volume of the solvent. The antiviral composition according to any one of claims 1 to 8, wherein the solvent comprises an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms. The antiviral composition according to any one of claims 1 to 9, further comprising a quaternary ammonium salt. The antiviral composition according to any one of claims 1 to 10, further comprising a surfactant. The antiviral composition according to any one of claims 1 to 11, wherein the content of the phenolic compound is 0.10% by mass or more with respect to the total mass of the composition. The antiviral composition according to any one of claims 1 to 12, wherein the pH is 10.5 to 12.0. The antiviral composition according to any one of claims 1 to 13, which is a liquid preparation. The antiviral composition according to any one of claims 1 to 13, which is a gel agent. An anti-norovirus composition comprising the anti-virus composition according to any one of claims 1 to 15. A spray comprising a spray container and the antiviral composition according to any one of 1 to 15 contained in the spray container. A wiper containing a base cloth and the antiviral composition according to any one of 1 to 15 impregnated in the base cloth.