JPWO2019236998A5 - - Google Patents
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- JPWO2019236998A5 JPWO2019236998A5 JP2021518054A JP2021518054A JPWO2019236998A5 JP WO2019236998 A5 JPWO2019236998 A5 JP WO2019236998A5 JP 2021518054 A JP2021518054 A JP 2021518054A JP 2021518054 A JP2021518054 A JP 2021518054A JP WO2019236998 A5 JPWO2019236998 A5 JP WO2019236998A5
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- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 42
- 108020005004 Guide RNA Proteins 0.000 claims description 38
- 229920001184 polypeptide Polymers 0.000 claims description 36
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
- 125000006850 spacer group Chemical group 0.000 claims description 23
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- 230000004069 differentiation Effects 0.000 claims description 18
- 235000004252 protein component Nutrition 0.000 claims description 17
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims description 13
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims description 13
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims description 13
- 101000986086 Homo sapiens HLA class I histocompatibility antigen, A alpha chain Proteins 0.000 claims description 13
- 101000986087 Homo sapiens HLA class I histocompatibility antigen, B alpha chain Proteins 0.000 claims description 13
- 101000986084 Homo sapiens HLA class I histocompatibility antigen, C alpha chain Proteins 0.000 claims description 13
- 108091033409 CRISPR Proteins 0.000 claims description 12
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- 108010042215 OX40 Ligand Proteins 0.000 claims description 7
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- 102000015736 beta 2-Microglobulin Human genes 0.000 claims description 7
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims description 7
- 102000013462 Interleukin-12 Human genes 0.000 claims description 6
- 108010065805 Interleukin-12 Proteins 0.000 claims description 6
- 230000000139 costimulatory effect Effects 0.000 claims description 6
- 230000001939 inductive effect Effects 0.000 claims description 6
- 229940117681 interleukin-12 Drugs 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 5
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- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims description 4
- 102000001902 CC Chemokines Human genes 0.000 claims description 3
- 108010040471 CC Chemokines Proteins 0.000 claims description 3
- 102000005962 receptors Human genes 0.000 claims description 3
- 108020003175 receptors Proteins 0.000 claims description 3
- 102000004428 CCR7 Receptors Human genes 0.000 claims description 2
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- 108020001507 fusion proteins Proteins 0.000 description 7
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- 102100035186 DNA excision repair protein ERCC-1 Human genes 0.000 description 1
- 208000037595 EN1-related dorsoventral syndrome Diseases 0.000 description 1
- 102100021008 Endonuclease G, mitochondrial Human genes 0.000 description 1
- 102100037696 Endonuclease V Human genes 0.000 description 1
- 102100021957 Endonuclease domain-containing 1 protein Human genes 0.000 description 1
- 102100030011 Endoribonuclease Human genes 0.000 description 1
- 102100023148 Endoribonuclease YbeY Human genes 0.000 description 1
- 102100023882 Endoribonuclease ZC3H12A Human genes 0.000 description 1
- 101000876529 Homo sapiens DNA excision repair protein ERCC-1 Proteins 0.000 description 1
- 101000806846 Homo sapiens DNA-(apurinic or apyrimidinic site) endonuclease Proteins 0.000 description 1
- 101001137538 Homo sapiens Endonuclease G, mitochondrial Proteins 0.000 description 1
- 101000880860 Homo sapiens Endonuclease V Proteins 0.000 description 1
- 101000897352 Homo sapiens Endonuclease domain-containing 1 protein Proteins 0.000 description 1
- 101001010787 Homo sapiens Endoribonuclease Proteins 0.000 description 1
- 101000623216 Homo sapiens Endoribonuclease YbeY Proteins 0.000 description 1
- 101000976212 Homo sapiens Endoribonuclease ZC3H12A Proteins 0.000 description 1
- 101001014546 Homo sapiens Mitochondrial ribonuclease P catalytic subunit Proteins 0.000 description 1
- 101000813497 Homo sapiens Nuclease EXOG, mitochondrial Proteins 0.000 description 1
- 101000976215 Homo sapiens Probable ribonuclease ZC3H12D Proteins 0.000 description 1
- 101000780643 Homo sapiens Protein argonaute-2 Proteins 0.000 description 1
- 101000987488 Homo sapiens Protein pelota homolog Proteins 0.000 description 1
- 101000896788 Homo sapiens Putative cleavage and polyadenylation specificity factor subunit 4-like protein Proteins 0.000 description 1
- 101001109419 Homo sapiens RNA-binding protein NOB1 Proteins 0.000 description 1
- 101000800639 Homo sapiens Teneurin-1 Proteins 0.000 description 1
- 101000800633 Homo sapiens Teneurin-2 Proteins 0.000 description 1
- 101000782294 Homo sapiens Zinc finger protein 638 Proteins 0.000 description 1
- 102100032519 Mitochondrial ribonuclease P catalytic subunit Human genes 0.000 description 1
- 101100198353 Mus musculus Rnasel gene Proteins 0.000 description 1
- 102100039557 Nuclease EXOG, mitochondrial Human genes 0.000 description 1
- 102100023884 Probable ribonuclease ZC3H12D Human genes 0.000 description 1
- 102100034207 Protein argonaute-2 Human genes 0.000 description 1
- 102100028485 Protein pelota homolog Human genes 0.000 description 1
- 102100021744 Putative cleavage and polyadenylation specificity factor subunit 4-like protein Human genes 0.000 description 1
- 102100022491 RNA-binding protein NOB1 Human genes 0.000 description 1
- 102100039832 Ribonuclease pancreatic Human genes 0.000 description 1
- 238000010459 TALEN Methods 0.000 description 1
- 102100033213 Teneurin-1 Human genes 0.000 description 1
- 102100033227 Teneurin-2 Human genes 0.000 description 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 description 1
- 102100035806 Zinc finger protein 638 Human genes 0.000 description 1
- 108010062302 rac1 GTP Binding Protein Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862682276P | 2018-06-08 | 2018-06-08 | |
| US62/682,276 | 2018-06-08 | ||
| PCT/US2019/036050 WO2019236998A1 (en) | 2018-06-08 | 2019-06-07 | Compositions and methods for the modulation of adaptive immunity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021526860A JP2021526860A (ja) | 2021-10-11 |
| JPWO2019236998A5 true JPWO2019236998A5 (https=) | 2022-06-15 |
| JP2021526860A5 JP2021526860A5 (https=) | 2022-06-15 |
Family
ID=68769461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021518054A Pending JP2021526860A (ja) | 2018-06-08 | 2019-06-07 | 適応免疫をモジュレートするための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190382759A1 (https=) |
| EP (1) | EP3801641A4 (https=) |
| JP (1) | JP2021526860A (https=) |
| KR (1) | KR20210060429A (https=) |
| CN (1) | CN113286619A (https=) |
| AU (1) | AU2019281006A1 (https=) |
| CA (1) | CA3102783A1 (https=) |
| SG (1) | SG11202012015YA (https=) |
| WO (1) | WO2019236998A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9499805B2 (en) | 2010-06-18 | 2016-11-22 | The University Of North Carolina At Chapel Hill | Methods and compositions for synthetic RNA endonucleases |
| US20190284553A1 (en) | 2018-03-15 | 2019-09-19 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| JP2021526858A (ja) | 2018-06-08 | 2021-10-11 | ロックアネイビオ， インコーポレイテッド | Ｒｎａ標的化融合タンパク質組成物および使用方法 |
| AU2020208346B2 (en) | 2019-01-14 | 2026-01-29 | University Of Rochester | Targeted nuclear RNA cleavage and polyadenylation with CRISPR-cas |
| WO2021011504A1 (en) * | 2019-07-12 | 2021-01-21 | Duke University | Nanoparticle systems for targeted delivery of crispr/cas13 and methods of using same |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| AU2021392032A1 (en) | 2020-12-03 | 2023-06-22 | Century Therapeutics, Inc. | Genetically engineered cells and uses thereof |
| CN113136376B (zh) * | 2021-05-26 | 2022-10-21 | 武汉大学 | 一种Cas12a变体及其在基因编辑中的应用 |
| WO2023150131A1 (en) * | 2022-02-01 | 2023-08-10 | The Regents Of The University Of California | Method of regulating alternative polyadenylation in rna |
| CN114848808B (zh) * | 2022-03-24 | 2023-04-25 | 四川大学 | 基于阳离子脂多肽及细胞因子的免疫增强剂及制法、应用 |
| CN114720699A (zh) * | 2022-04-22 | 2022-07-08 | 浙江大学 | 一种结直肠癌早期预警血清指标及其检测方法和应用 |
| CN116949011A (zh) * | 2022-04-26 | 2023-10-27 | 中国科学院动物研究所 | 经分离的Cas13蛋白、基于它的基因编辑系统及其用途 |
| CN115068632A (zh) * | 2022-06-22 | 2022-09-20 | 华中科技大学同济医学院附属同济医院 | Ago2在制备治疗心衰的药物方面的用途及其蛋白、基因、转化体、药物与制备方法 |
| WO2024264035A2 (en) * | 2023-06-22 | 2024-12-26 | The General Hospital Corporation | Compositions and methods of generating endogenous tdr molecules |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019500899A (ja) * | 2015-11-23 | 2019-01-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ＣＲＩＳＰＲ／Ｃａｓ９の核送達を通じた細胞ＲＮＡの追跡と操作 |
| EA201891338A1 (ru) * | 2015-12-04 | 2018-12-28 | Новартис Аг | Композиции и способы для иммуноонкологии |
| US12180499B2 (en) * | 2016-10-31 | 2024-12-31 | University Of Florida Research Foundation, Inc. | Compositions and methods for impeding transcription of expanded microsatellite repeats |
| AU2018234825B2 (en) * | 2017-03-15 | 2020-12-17 | Massachusetts Institute Of Technology | Novel CAS13B orthologues CRISPR enzymes and systems |
| US11168322B2 (en) * | 2017-06-30 | 2021-11-09 | Arbor Biotechnologies, Inc. | CRISPR RNA targeting enzymes and systems and uses thereof |
-
2019
- 2019-06-07 US US16/434,787 patent/US20190382759A1/en not_active Abandoned
- 2019-06-07 CA CA3102783A patent/CA3102783A1/en active Pending
- 2019-06-07 AU AU2019281006A patent/AU2019281006A1/en not_active Abandoned
- 2019-06-07 CN CN201980051039.7A patent/CN113286619A/zh active Pending
- 2019-06-07 KR KR1020217000507A patent/KR20210060429A/ko not_active Ceased
- 2019-06-07 JP JP2021518054A patent/JP2021526860A/ja active Pending
- 2019-06-07 SG SG11202012015YA patent/SG11202012015YA/en unknown
- 2019-06-07 EP EP19814000.6A patent/EP3801641A4/en active Pending
- 2019-06-07 WO PCT/US2019/036050 patent/WO2019236998A1/en not_active Ceased
-
2023
- 2023-11-09 US US18/505,709 patent/US20240344060A1/en active Pending
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