JPWO2019236631A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019236631A5 JPWO2019236631A5 JP2020567845A JP2020567845A JPWO2019236631A5 JP WO2019236631 A5 JPWO2019236631 A5 JP WO2019236631A5 JP 2020567845 A JP2020567845 A JP 2020567845A JP 2020567845 A JP2020567845 A JP 2020567845A JP WO2019236631 A5 JPWO2019236631 A5 JP WO2019236631A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- och
- nhc
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- 150000002431 hydrogen Chemical class 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 125000004404 heteroalkyl group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- -1 2,2-difluorobutyl Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000004474 heteroalkylene group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 claims 2
- MNILDQSRDHCFJG-OLQVQODUSA-N (1s,5r)-3-oxa-8-azabicyclo[3.2.1]octane Chemical compound C1OC[C@@]2([H])CC[C@]1([H])N2 MNILDQSRDHCFJG-OLQVQODUSA-N 0.000 claims 1
- YHIIJNLSGULWAA-UHFFFAOYSA-N 1,4-thiazinane 1-oxide Chemical compound O=S1CCNCC1 YHIIJNLSGULWAA-UHFFFAOYSA-N 0.000 claims 1
- ZYVYEJXMYBUCMN-UHFFFAOYSA-N 1-methoxy-2-methylpropane Chemical compound COCC(C)C ZYVYEJXMYBUCMN-UHFFFAOYSA-N 0.000 claims 1
- QAPSIUMUNHNUPW-UHFFFAOYSA-N 1-methylsulfonylpropane Chemical compound CCCS(C)(=O)=O QAPSIUMUNHNUPW-UHFFFAOYSA-N 0.000 claims 1
- KVYOWXUQJLOCIA-UHFFFAOYSA-N 1-oxa-8-azaspiro[4.5]decane Chemical compound C1CCOC21CCNCC2 KVYOWXUQJLOCIA-UHFFFAOYSA-N 0.000 claims 1
- IIADOUMJKYSCPM-UHFFFAOYSA-N 2,2-difluorobutane Chemical compound CCC(C)(F)F IIADOUMJKYSCPM-UHFFFAOYSA-N 0.000 claims 1
- PMMOXYVVNPMPEK-UHFFFAOYSA-N 2,3-dihydrooxazin-4-one Chemical compound O=C1CNOC=C1 PMMOXYVVNPMPEK-UHFFFAOYSA-N 0.000 claims 1
- OXPIFHNJGOJJQZ-UHFFFAOYSA-N 2,7-diazaspiro[3.4]octane Chemical compound C1NCC11CNCC1 OXPIFHNJGOJJQZ-UHFFFAOYSA-N 0.000 claims 1
- IXHWZHXLJJPXIS-UHFFFAOYSA-N 2-fluorobutane Chemical compound CCC(C)F IXHWZHXLJJPXIS-UHFFFAOYSA-N 0.000 claims 1
- OQHQOOLVQDEIGL-UHFFFAOYSA-N 2-methyl-2,7-diazaspiro[4.4]nonane Chemical compound C1N(C)CCC11CNCC1 OQHQOOLVQDEIGL-UHFFFAOYSA-N 0.000 claims 1
- YHWMFDLNZGIJSD-UHFFFAOYSA-N 2h-1,4-oxazine Chemical compound C1OC=CN=C1 YHWMFDLNZGIJSD-UHFFFAOYSA-N 0.000 claims 1
- GYLMCBOAXJVARF-UHFFFAOYSA-N 3-azabicyclo[2.2.1]heptane Chemical compound C1C2CCC1NC2 GYLMCBOAXJVARF-UHFFFAOYSA-N 0.000 claims 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- VNKYTQGIUYNRMY-UHFFFAOYSA-N methoxypropane Chemical compound CCCOC VNKYTQGIUYNRMY-UHFFFAOYSA-N 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- ZUHZZVMEUAUWHY-UHFFFAOYSA-N n,n-dimethylpropan-1-amine Chemical compound CCCN(C)C ZUHZZVMEUAUWHY-UHFFFAOYSA-N 0.000 claims 1
- OHLUUHNLEMFGTQ-AZXPZELESA-N n-methylacetamide Chemical class C[15NH]C(C)=O OHLUUHNLEMFGTQ-AZXPZELESA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 150000007660 quinolones Chemical class 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- HVZJRWJGKQPSFL-UHFFFAOYSA-N tert-Amyl methyl ether Chemical compound CCC(C)(C)OC HVZJRWJGKQPSFL-UHFFFAOYSA-N 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862680891P | 2018-06-05 | 2018-06-05 | |
| US62/680,891 | 2018-06-05 | ||
| US201962831006P | 2019-04-08 | 2019-04-08 | |
| US62/831,006 | 2019-04-08 | ||
| PCT/US2019/035462 WO2019236631A1 (en) | 2018-06-05 | 2019-06-04 | Pyrazolo-pyrimidin-amino-cycloalkyl compounds and their therapeutic uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021527051A JP2021527051A (ja) | 2021-10-11 |
| JPWO2019236631A5 true JPWO2019236631A5 (https=) | 2022-06-27 |
| JP2021527051A5 JP2021527051A5 (https=) | 2022-06-27 |
Family
ID=67185700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020567845A Pending JP2021527051A (ja) | 2018-06-05 | 2019-06-04 | ピラゾロ−ピリミジン−アミノ−シクロアルキル化合物及びその治療的使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11046699B2 (https=) |
| EP (1) | EP3802544A1 (https=) |
| JP (1) | JP2021527051A (https=) |
| TW (1) | TW202016112A (https=) |
| WO (1) | WO2019236631A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111499644B (zh) * | 2020-04-24 | 2021-07-20 | 苏州大学 | 咪唑并[1,5-a]喹唑啉-5(4H)-酮类衍生物及其制备方法和用途 |
| GB202008749D0 (en) | 2020-06-09 | 2020-07-22 | Ip2Ipo Innovations Ltd | Novel compounds |
| WO2022072783A1 (en) | 2020-10-02 | 2022-04-07 | Incyte Corporation | Bicyclic dione compounds as inhibitors of kras |
| CN114516828A (zh) * | 2020-11-19 | 2022-05-20 | 江苏威奇达药业有限公司 | 一种提高负氮杂提取率的提取工艺 |
| US20250000859A1 (en) * | 2021-08-25 | 2025-01-02 | Alesta Therapeutics BV | Use of gcn2 inhibitors in treating cancer |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| MX2024007328A (es) | 2021-12-14 | 2024-09-30 | Crossfire Oncology Holding B V | Inhibidores macrociclicos de btk. |
| WO2023110936A1 (en) | 2021-12-14 | 2023-06-22 | Netherlands Translational Research Center Holding B.V | Reversible macrocyclic kinase inhibitors |
| CN116478145B (zh) * | 2022-04-13 | 2024-02-02 | 杭州邦顺制药有限公司 | Alk2激酶抑制剂 |
| UY40234A (es) | 2022-04-22 | 2023-11-15 | Vertex Pharma | Compuestos heteroarilo para el tratamiento del dolor |
| WO2024126617A1 (en) | 2022-12-14 | 2024-06-20 | Crossfire Oncology Holding B.V. | Bifunctional compounds for degrading kinases via ubiquitin proteosome pathway |
| WO2024238570A1 (en) * | 2023-05-15 | 2024-11-21 | Aleksia Therapeutics, Inc. | Cdk2 inhibitor pyrazolopyrimidine compounds |
| CN117756677B (zh) * | 2023-12-21 | 2025-09-30 | 上海馨远医药科技有限公司 | 一种手性反式-n-boc-1-氨基环戊烷-3-甲酸的制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| BR9707495A (pt) | 1996-02-13 | 1999-07-27 | Zeneca Ltd | Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente |
| US6291455B1 (en) | 1996-03-05 | 2001-09-18 | Zeneca Limited | 4-anilinoquinazoline derivatives |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| NZ522074A (en) | 2000-05-31 | 2004-06-25 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| IL153484A0 (en) | 2000-07-07 | 2003-07-06 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors |
| CN1255392C (zh) | 2000-07-07 | 2006-05-10 | 安吉奥金尼药品有限公司 | 作为血管生成抑制剂的秋水仙醇衍生物 |
| ES2309206T3 (es) | 2001-10-02 | 2008-12-16 | Smithkline Beecham Corporation | Compuestos quimicos. |
| EP2108019A2 (en) * | 2007-01-30 | 2009-10-14 | Biogen Idec MA, Inc. | 1-h-pyrazolo[3,4b]pyrimidine derivatives and their use as modulators of mitotic kinases |
| US20130345268A1 (en) * | 2009-02-13 | 2013-12-26 | The Trustees Of Dartmouth College | Methods and Compositions for the Treatment of RAS Associated Disorders |
| US8362023B2 (en) * | 2011-01-19 | 2013-01-29 | Hoffmann-La Roche Inc. | Pyrazolo pyrimidines |
| AU2014224976B2 (en) * | 2013-03-05 | 2017-09-28 | Merck Patent Gmbh | 9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents |
| AU2014224975B2 (en) * | 2013-03-05 | 2017-09-14 | Merck Patent Gmbh | Triazolo(4,5-d)pyrimidine derivatives for the treatment of diseases such as cancer |
-
2019
- 2019-06-04 WO PCT/US2019/035462 patent/WO2019236631A1/en not_active Ceased
- 2019-06-04 US US16/431,504 patent/US11046699B2/en active Active
- 2019-06-04 EP EP19736849.1A patent/EP3802544A1/en not_active Withdrawn
- 2019-06-04 JP JP2020567845A patent/JP2021527051A/ja active Pending
- 2019-06-05 TW TW108119522A patent/TW202016112A/zh unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021527051A5 (https=) | ||
| JPWO2019236631A5 (https=) | ||
| JP2018519357A5 (https=) | ||
| JP2008505117A5 (https=) | ||
| JP2021514001A5 (https=) | ||
| RU2007109109A (ru) | Дигидроптеридиноны, предназначенные для лечения раковых заболеваний | |
| JP2024099041A5 (https=) | ||
| JP2006511490A5 (https=) | ||
| JP2020169171A5 (https=) | ||
| JP2021535104A5 (https=) | ||
| AR032569A1 (es) | Ligandos del receptor de canabinoide | |
| ES3046366T3 (en) | Antiplatelet drugs and uses thereof | |
| JP2015509927A5 (https=) | ||
| JP2005511699A5 (https=) | ||
| JP2006501292A5 (https=) | ||
| HRP20160046T1 (hr) | Poboljšana citotoksiäśna sredstva koja sadrže nove majtanzinoide | |
| JP2005505618A5 (https=) | ||
| JP2003506491A5 (https=) | ||
| AR040803A1 (es) | Ligandos de receptores canabinoides, composiciones farmaceuticas, un proceso para su elaboracion y el uso de dichos compuestos, solos o combinados, para la preparacion de medicamentos | |
| RU2006128589A (ru) | Стереоизомерные соединения и способы лечения желудочно-кишечных расстройств и расстройств центральной нервной системы | |
| JP2005513125A5 (https=) | ||
| JP2005514420A5 (https=) | ||
| AR129722A1 (es) | Compuestos inhibidores de axl | |
| JP2015527355A5 (https=) | ||
| JP2009541225A5 (https=) |