JPWO2019219612A5 - - Google Patents
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- JPWO2019219612A5 JPWO2019219612A5 JP2020564247A JP2020564247A JPWO2019219612A5 JP WO2019219612 A5 JPWO2019219612 A5 JP WO2019219612A5 JP 2020564247 A JP2020564247 A JP 2020564247A JP 2020564247 A JP2020564247 A JP 2020564247A JP WO2019219612 A5 JPWO2019219612 A5 JP WO2019219612A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- biomarkers
- treatment
- sample
- inhibiting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000090 biomarker Substances 0.000 claims 26
- 238000000034 method Methods 0.000 claims 19
- 239000000523 sample Substances 0.000 claims 18
- 239000002246 antineoplastic agent Substances 0.000 claims 17
- 229940127089 cytotoxic agent Drugs 0.000 claims 17
- 230000002401 inhibitory effect Effects 0.000 claims 14
- 239000003795 chemical substances by application Substances 0.000 claims 12
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 7
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 230000009870 specific binding Effects 0.000 claims 6
- 108010029697 CD40 Ligand Proteins 0.000 claims 5
- 102100032937 CD40 ligand Human genes 0.000 claims 5
- 101100120663 Drosophila melanogaster fs(1)h gene Proteins 0.000 claims 5
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 claims 5
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 claims 5
- 102000014702 Haptoglobin Human genes 0.000 claims 5
- 108050005077 Haptoglobin Proteins 0.000 claims 5
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 5
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 5
- 101001050473 Homo sapiens Intelectin-1 Proteins 0.000 claims 5
- 101000973997 Homo sapiens Nucleosome assembly protein 1-like 4 Proteins 0.000 claims 5
- 101000947178 Homo sapiens Platelet basic protein Proteins 0.000 claims 5
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 5
- 108060003951 Immunoglobulin Proteins 0.000 claims 5
- 102100023353 Intelectin-1 Human genes 0.000 claims 5
- 102100022396 Nucleosome assembly protein 1-like 4 Human genes 0.000 claims 5
- -1 RAGE Proteins 0.000 claims 5
- 102100028848 Stromelysin-2 Human genes 0.000 claims 5
- 101710108792 Stromelysin-2 Proteins 0.000 claims 5
- 102000018358 immunoglobulin Human genes 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- KXMZDGSRSGHMMK-VWLOTQADSA-N 1-(6,7-dihydro-5h-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-yl)-3-n-[(7s)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5h-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine Chemical group N1([C@H]2CCC3=CC=C(C=C3CC2)NC=2N=C(N(N=2)C=2N=NC=3C4=CC=CC=C4CCCC=3C=2)N)CCCC1 KXMZDGSRSGHMMK-VWLOTQADSA-N 0.000 claims 2
- 238000009007 Diagnostic Kit Methods 0.000 claims 2
- 229950009568 bemcentinib Drugs 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000002405 diagnostic procedure Methods 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims 1
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical group O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 229960000684 cytarabine Drugs 0.000 claims 1
- 229960003603 decitabine Drugs 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1807789.1 | 2018-05-14 | ||
| GBGB1807789.1A GB201807789D0 (en) | 2018-05-14 | 2018-05-14 | Serum biomarkers |
| GBGB1816764.3A GB201816764D0 (en) | 2018-10-15 | 2018-10-15 | Serum biomarkers |
| GB1816764.3 | 2018-10-15 | ||
| GBGB1817024.1A GB201817024D0 (en) | 2018-10-19 | 2018-10-19 | Serum biomarkers |
| GB1817024.1 | 2018-10-19 | ||
| PCT/EP2019/062215 WO2019219612A1 (en) | 2018-05-14 | 2019-05-13 | Serum biomarkers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021523379A JP2021523379A (ja) | 2021-09-02 |
| JP2021523379A5 JP2021523379A5 (https=) | 2022-05-20 |
| JPWO2019219612A5 true JPWO2019219612A5 (https=) | 2022-05-20 |
Family
ID=66589527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564247A Pending JP2021523379A (ja) | 2018-05-14 | 2019-05-13 | 血清バイオマーカー |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20210215697A1 (https=) |
| EP (1) | EP3794352A1 (https=) |
| JP (1) | JP2021523379A (https=) |
| CN (1) | CN112639474A (https=) |
| WO (1) | WO2019219612A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202004189D0 (en) * | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
| AU2021409465A1 (en) | 2020-12-21 | 2023-08-03 | Freenome Holdings, Inc. | Markers for the early detection of colon cell proliferative disorders |
| WO2023059527A1 (en) * | 2021-10-04 | 2023-04-13 | Tintoria Piana, Inc. | Diagnostic system and methods of using and manufacturing the same |
| CN118359697A (zh) * | 2024-04-29 | 2024-07-19 | 上海硅羿生物技术有限公司 | β淀粉样蛋白40及β淀粉样蛋白42特异识别多肽及其应用 |
| CN121186348B (zh) * | 2025-11-25 | 2026-02-24 | 北京大学人民医院 | 瓜氨酸化内凝集素-1多肽在制备类风湿关节炎诊断产品中的应用 |
| CN121186360B (zh) * | 2025-11-25 | 2026-04-14 | 长兴固容生物科技有限公司 | 一种用于乳腺癌筛查、诊断的标志物组及其用途 |
| CN121186365B (zh) * | 2025-11-25 | 2026-04-14 | 长兴固容生物科技有限公司 | 一种用于胰腺癌筛查、诊断的标志物组及其用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| WO2006125143A2 (en) * | 2005-05-18 | 2006-11-23 | Novartis Ag | Methods for diagnosis and treatment of proliferative disorders mediated by cd40 signaling |
| WO2014055543A2 (en) * | 2012-10-01 | 2014-04-10 | Millennium Pharmaceuticals, Inc. | Biomarkers and methods to predict response to inhibitors and uses thereof |
| GB201410826D0 (en) * | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
| GB201410825D0 (en) * | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
| JP6931609B2 (ja) * | 2014-12-18 | 2021-09-08 | ベルゲン テクノロジオーヴァーフォリング エイエス | 抗Ａｘｌアンタゴニスト抗体 |
| CA2971763A1 (en) | 2014-12-23 | 2016-06-30 | Bergenbio Asa | Inhibitors of akt kinase |
| GB201506411D0 (en) * | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201512133D0 (en) * | 2015-07-10 | 2015-08-19 | Bergenbio As | Biomarkers |
-
2019
- 2019-05-13 JP JP2020564247A patent/JP2021523379A/ja active Pending
- 2019-05-13 US US17/054,193 patent/US20210215697A1/en not_active Abandoned
- 2019-05-13 EP EP19724776.0A patent/EP3794352A1/en not_active Withdrawn
- 2019-05-13 CN CN201980045744.6A patent/CN112639474A/zh active Pending
- 2019-05-13 WO PCT/EP2019/062215 patent/WO2019219612A1/en not_active Ceased
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