JPWO2019217646A5 - - Google Patents
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- Publication number
- JPWO2019217646A5 JPWO2019217646A5 JP2020563539A JP2020563539A JPWO2019217646A5 JP WO2019217646 A5 JPWO2019217646 A5 JP WO2019217646A5 JP 2020563539 A JP2020563539 A JP 2020563539A JP 2020563539 A JP2020563539 A JP 2020563539A JP WO2019217646 A5 JPWO2019217646 A5 JP WO2019217646A5
- Authority
- JP
- Japan
- Prior art keywords
- monocytes
- isolated
- optionally
- effective amount
- msc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000001616 monocyte Anatomy 0.000 claims 34
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 21
- 210000001808 exosome Anatomy 0.000 claims 17
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000003176 fibrotic effect Effects 0.000 claims 6
- 210000001185 bone marrow Anatomy 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 230000000770 proinflammatory effect Effects 0.000 claims 4
- 210000004271 bone marrow stromal cell Anatomy 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 2
- 241000283984 Rodentia Species 0.000 claims 2
- 210000000577 adipose tissue Anatomy 0.000 claims 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 2
- 235000015110 jellies Nutrition 0.000 claims 2
- 239000008274 jelly Substances 0.000 claims 2
- 230000035935 pregnancy Effects 0.000 claims 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 230000003510 anti-fibrotic effect Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000009787 cardiac fibrosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 239000003636 conditioned culture medium Substances 0.000 claims 1
- 239000000356 contaminant Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- XZXHXSATPCNXJR-ZIADKAODSA-N nintedanib Chemical group O=C1NC2=CC(C(=O)OC)=CC=C2\C1=C(C=1C=CC=CC=1)\NC(C=C1)=CC=C1N(C)C(=O)CN1CCN(C)CC1 XZXHXSATPCNXJR-ZIADKAODSA-N 0.000 claims 1
- 229960004378 nintedanib Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 1
- 229960003073 pirfenidone Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024058604A JP2024163978A (ja) | 2018-05-09 | 2024-04-01 | 間葉系間質細胞エキソソーム処置単球およびそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862669324P | 2018-05-09 | 2018-05-09 | |
| US62/669,324 | 2018-05-09 | ||
| PCT/US2019/031467 WO2019217646A1 (en) | 2018-05-09 | 2019-05-09 | Mesenchymal stromal cell exosome -treated monocytes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024058604A Division JP2024163978A (ja) | 2018-05-09 | 2024-04-01 | 間葉系間質細胞エキソソーム処置単球およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021522824A JP2021522824A (ja) | 2021-09-02 |
| JP2021522824A5 JP2021522824A5 (https=) | 2022-05-12 |
| JPWO2019217646A5 true JPWO2019217646A5 (https=) | 2022-05-12 |
Family
ID=68467835
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020563539A Pending JP2021522824A (ja) | 2018-05-09 | 2019-05-09 | 間葉系間質細胞エキソソーム処置単球およびそれらの使用 |
| JP2024058604A Pending JP2024163978A (ja) | 2018-05-09 | 2024-04-01 | 間葉系間質細胞エキソソーム処置単球およびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024058604A Pending JP2024163978A (ja) | 2018-05-09 | 2024-04-01 | 間葉系間質細胞エキソソーム処置単球およびそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20210213056A1 (https=) |
| EP (1) | EP3790560A4 (https=) |
| JP (2) | JP2021522824A (https=) |
| CN (1) | CN112469423A (https=) |
| CA (1) | CA3099042A1 (https=) |
| WO (1) | WO2019217646A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2949083C (en) | 2014-05-18 | 2023-10-10 | Children's Medical Center Corporation | Methods and compositions relating to exosomes |
| AU2018316166A1 (en) | 2017-08-07 | 2020-02-06 | The Regents Of The University Of California | Platform for generating safe cell therapeutics |
| CN112334190B (zh) | 2018-04-30 | 2024-09-20 | 儿童医学中心公司 | 间充质基质细胞外排体及其用途 |
| WO2021145395A1 (ja) * | 2020-01-15 | 2021-07-22 | 富士フイルム和光純薬株式会社 | 抗線維化剤、及び抗線維化作用を有する細胞外小胞の製造方法 |
| WO2021145396A1 (ja) | 2020-01-15 | 2021-07-22 | 富士フイルム和光純薬株式会社 | 血管新生剤、及び血管新生作用を有する細胞外小胞の製造方法 |
| US20230248773A1 (en) | 2020-07-09 | 2023-08-10 | Exo Biologics Sa | Extracellular Vesicles and Compositions Thereof |
| US20220127579A1 (en) * | 2020-10-22 | 2022-04-28 | Wisconsin Alumni Research Foundation | Use of Toll-Like Receptor 4 Agonists to Treat Inflammation and Tissue Injury |
| CN116999463A (zh) * | 2022-04-27 | 2023-11-07 | 中山大学附属第三医院 | 一种间充质干细胞来源外泌体在制备治疗间质性膀胱炎药物中的应用 |
| CN115475250B (zh) * | 2022-05-26 | 2024-03-26 | 南京鼓楼医院 | 一种靶向肝星状细胞并抑制其激活的载药外泌体及其制备和应用 |
| TW202417616A (zh) * | 2022-09-02 | 2024-05-01 | 財團法人醫藥工業技術發展中心 | 包含間質幹細胞的組成物在緩解骨髓纖維化上的用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1944361A1 (en) * | 2007-01-11 | 2008-07-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for expanding monocytes |
| US20130273011A1 (en) * | 2012-04-17 | 2013-10-17 | Medistem, Inc. | Stem cells and stem cell generated nanoparticles for treatment of inflammatory conditions and acute radiation syndrome |
| EP2687219A1 (en) * | 2012-07-18 | 2014-01-22 | Universität Duisburg-Essen | Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions |
| US10166254B2 (en) * | 2014-09-19 | 2019-01-01 | Wisconsin Alumni Research Foundation | Use of mesenchymal stem cell-educated macrophages to treat and prevent graft versus host disease and radiation-induced injury |
| WO2018183825A1 (en) * | 2017-03-31 | 2018-10-04 | Wisconsin Alumni Research Foundation | Generation of therapeutic cells using extracellular components of target organs |
| US10876753B2 (en) * | 2018-02-12 | 2020-12-29 | Watsco Ventures Llc | Integrated sensor and service port for HVAC equipment or HVAC system |
-
2019
- 2019-05-09 CA CA3099042A patent/CA3099042A1/en active Pending
- 2019-05-09 EP EP19800737.9A patent/EP3790560A4/en active Pending
- 2019-05-09 WO PCT/US2019/031467 patent/WO2019217646A1/en not_active Ceased
- 2019-05-09 JP JP2020563539A patent/JP2021522824A/ja active Pending
- 2019-05-09 US US17/053,752 patent/US20210213056A1/en active Pending
- 2019-05-09 CN CN201980031263.XA patent/CN112469423A/zh active Pending
-
2024
- 2024-04-01 JP JP2024058604A patent/JP2024163978A/ja active Pending
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